메뉴 건너뛰기




Volumn 289, Issue 45, 2014, Pages 31349-31360

Nerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3β (GSK3β) pathway

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CHEMICAL ACTIVATION; DEPOLARIZATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYMES; GENE EXPRESSION; GENES; T-CELLS; TRANSCRIPTION;

EID: 84909606193     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.587188     Document Type: Article
Times cited : (52)

References (75)
  • 2
    • 55849130994 scopus 로고    scopus 로고
    • Communication between the synapse and the nucleus in neuronal development, plasticity, and disease
    • Cohen, S., and Greenberg, M. E. (2008) Communication between the synapse and the nucleus in neuronal development, plasticity, and disease. Annu. Rev. Cell Dev. Biol. 24, 183-209
    • (2008) Annu. Rev. Cell Dev. Biol. , vol.24 , pp. 183-209
    • Cohen, S.1    Greenberg, M.E.2
  • 4
    • 0037806030 scopus 로고    scopus 로고
    • Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons
    • Graef, I. A., Wang, F., Charron, F., Chen, L., Neilson, J., Tessier-Lavigne, M., and Crabtree, G. R. (2003) Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell 113, 657-670
    • (2003) Cell , vol.113 , pp. 657-670
    • Graef, I.A.1    Wang, F.2    Charron, F.3    Chen, L.4    Neilson, J.5    Tessier-Lavigne, M.6    Crabtree, G.R.7
  • 6
    • 39149105604 scopus 로고    scopus 로고
    • NFAT signaling in neural development and axon growth
    • Nguyen, T., and Di Giovanni, S. (2008) NFAT signaling in neural development and axon growth. Int. J. Dev. Neurosci. 26, 141-145
    • (2008) Int. J. Dev. Neurosci. , vol.26 , pp. 141-145
    • Nguyen, T.1    Di Giovanni, S.2
  • 7
    • 70349624835 scopus 로고    scopus 로고
    • 2+ cycling facilitates activation of the transcription factor NFAT in sensory neurons
    • 2+ cycling facilitates activation of the transcription factor NFAT in sensory neurons. J. Neurosci. 29, 12101-12114
    • (2009) J. Neurosci. , vol.29 , pp. 12101-12114
    • Kim, M.S.1    Usachev, Y.M.2
  • 8
    • 84871377149 scopus 로고    scopus 로고
    • + channels by AKAP79/150-mediated NFAT actions
    • + channels by AKAP79/150-mediated NFAT actions. Neuron 76, 1133-1146
    • (2012) Neuron , vol.76 , pp. 1133-1146
    • Zhang, J.1    Shapiro, M.S.2
  • 11
    • 66449131559 scopus 로고    scopus 로고
    • Neural activity regulates synaptic properties and dendritic structure in vivo through calcineurin/NFAT signaling
    • Schwartz, N., Schohl, A., and Ruthazer, E. S. (2009) Neural activity regulates synaptic properties and dendritic structure in vivo through calcineurin/NFAT signaling. Neuron 62, 655-669
    • (2009) Neuron , vol.62 , pp. 655-669
    • Schwartz, N.1    Schohl, A.2    Ruthazer, E.S.3
  • 12
    • 72849145265 scopus 로고    scopus 로고
    • Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription inNMDA receptor-stimulated cortical neurons
    • Vashishta, A., Habas, A., Pruunsild, P., Zheng, J. J., Timmusk, T., and Hetman, M. (2009) Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription inNMDA receptor-stimulated cortical neurons. J. Neurosci. 29, 15331-15340
    • (2009) J. Neurosci. , vol.29 , pp. 15331-15340
    • Vashishta, A.1    Habas, A.2    Pruunsild, P.3    Zheng, J.J.4    Timmusk, T.5    Hetman, M.6
  • 14
    • 34547193818 scopus 로고    scopus 로고
    • Bradykinin-induced nuclear factor of activated T-cells-dependent transcription in rat dorsal root ganglion neurons
    • Jackson, J. G., Usachev, Y. M., and Thayer, S. A. (2007) Bradykinin-induced nuclear factor of activated T-cells-dependent transcription in rat dorsal root ganglion neurons. Mol. Pharmacol. 72, 303-310
    • (2007) Mol. Pharmacol. , vol.72 , pp. 303-310
    • Jackson, J.G.1    Usachev, Y.M.2    Thayer, S.A.3
  • 15
    • 34547177480 scopus 로고    scopus 로고
    • Neurotrophin activation of NFAT-dependent transcription contributes to the regulation of pro-nociceptive genes
    • Groth, R. D., Coicou, L. G., Mermelstein, P. G., and Seybold, V. S. (2007) Neurotrophin activation of NFAT-dependent transcription contributes to the regulation of pro-nociceptive genes. J. Neurochem. 102, 1162-1174
    • (2007) J. Neurochem. , vol.102 , pp. 1162-1174
    • Groth, R.D.1    Coicou, L.G.2    Mermelstein, P.G.3    Seybold, V.S.4
  • 16
    • 84875464198 scopus 로고    scopus 로고
    • Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain
    • Cai, Y. Q., Chen, S. R., and Pan, H. L. (2013) Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. J. Pharmacol. Exp. Ther. 345, 161-168
    • (2013) J. Pharmacol. Exp. Ther. , vol.345 , pp. 161-168
    • Cai, Y.Q.1    Chen, S.R.2    Pan, H.L.3
  • 17
    • 34547916107 scopus 로고    scopus 로고
    • Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia
    • Shioda, N., Han, F., Moriguchi, S., and Fukunaga, K. (2007) Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia. J. Neurochem. 102, 1506-1517
    • (2007) J. Neurochem. , vol.102 , pp. 1506-1517
    • Shioda, N.1    Han, F.2    Moriguchi, S.3    Fukunaga, K.4
  • 20
    • 84895086250 scopus 로고    scopus 로고
    • Differential effect of traumatic brain injury on the nuclear factor of activatedTcells C3 and C4 isoforms in the rat hippocampus
    • Yan, H. Q., Shin, S. S., Ma, X., Li, Y., and Dixon, C. E. (2014) Differential effect of traumatic brain injury on the nuclear factor of activatedTcells C3 and C4 isoforms in the rat hippocampus. Brain Res. 1548, 63-72
    • (2014) Brain Res. , vol.1548 , pp. 63-72
    • Yan, H.Q.1    Shin, S.S.2    Ma, X.3    Li, Y.4    Dixon, C.E.5
  • 21
    • 0036234543 scopus 로고    scopus 로고
    • NFAT signaling: Choreographing the social lives of cells
    • Crabtree, G. R., and Olson, E. N. (2002) NFAT signaling: choreographing the social lives of cells. Cell 109, S67-S79
    • (2002) Cell , vol.109 , pp. S67-S79
    • Crabtree, G.R.1    Olson, E.N.2
  • 22
    • 0141483523 scopus 로고    scopus 로고
    • Transcriptional regulation by calcium, calcineurin, and NFAT
    • Hogan, P. G., Chen, L., Nardone, J., and Rao, A. (2003) Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev. 17, 2205-2232
    • (2003) Genes Dev. , vol.17 , pp. 2205-2232
    • Hogan, P.G.1    Chen, L.2    Nardone, J.3    Rao, A.4
  • 25
    • 0030890234 scopus 로고    scopus 로고
    • Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
    • Beals, C. R., Sheridan, C. M., Turck, C. W., Gardner, P., and Crabtree, G. R. (1997) Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275, 1930-1934
    • (1997) Science , vol.275 , pp. 1930-1934
    • Beals, C.R.1    Sheridan, C.M.2    Turck, C.W.3    Gardner, P.4    Crabtree, G.R.5
  • 26
    • 0033580477 scopus 로고    scopus 로고
    • NF-AT activation requires suppression of Crm1-dependent export by calcineurin
    • Zhu, J., and McKeon, F. (1999) NF-AT activation requires suppression of Crm1-dependent export by calcineurin. Nature 398, 256-260
    • (1999) Nature , vol.398 , pp. 256-260
    • Zhu, J.1    McKeon, F.2
  • 28
    • 0041835836 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor activation of NFAT (nuclear factor of activated T-cells)-dependent transcription: A role for the transcription factor NFATc4 in neurotrophin-mediated gene expression
    • Groth, R. D., and Mermelstein, P. G. (2003) Brain-derived neurotrophic factor activation of NFAT (nuclear factor of activated T-cells)-dependent transcription: a role for the transcription factor NFATc4 in neurotrophin-mediated gene expression. J. Neurosci. 23, 8125-8134
    • (2003) J. Neurosci. , vol.23 , pp. 8125-8134
    • Groth, R.D.1    Mermelstein, P.G.2
  • 29
    • 84879374129 scopus 로고    scopus 로고
    • NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect
    • Stefos, G. C., Soppa, U., Dierssen, M., and Becker, W. (2013) NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. PLoS One 8, e67470
    • (2013) PLoS One , vol.8 , pp. e67470
    • Stefos, G.C.1    Soppa, U.2    Dierssen, M.3    Becker, W.4
  • 31
    • 2642533432 scopus 로고    scopus 로고
    • NFATc3-induced reductions in voltage-gated K+ currents after myocardial infarction
    • Rossow, C. F., Minami, E., Chase, E. G., Murry, C. E., and Santana, L. F. (2004) NFATc3-induced reductions in voltage-gated K+ currents after myocardial infarction. Circ. Res. 94, 1340-1350
    • (2004) Circ. Res. , vol.94 , pp. 1340-1350
    • Rossow, C.F.1    Minami, E.2    Chase, E.G.3    Murry, C.E.4    Santana, L.F.5
  • 33
    • 84868316950 scopus 로고    scopus 로고
    • Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons
    • Ulrich, J. D., Kim, M. S., Houlihan, P. R., Shutov, L. P., Mohapatra, D. P., Strack, S., and Usachev, Y. M. (2012) Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons. J. Biol. Chem. 287, 37594-37609
    • (2012) J. Biol. Chem. , vol.287 , pp. 37594-37609
    • Ulrich, J.D.1    Kim, M.S.2    Houlihan, P.R.3    Shutov, L.P.4    Mohapatra, D.P.5    Strack, S.6    Usachev, Y.M.7
  • 35
    • 0028918408 scopus 로고
    • Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
    • Hu, Q., Klippel, A., Muslin, A. J., Fantl, W. J., and Williams, L. T. (1995) Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 268, 100-102
    • (1995) Science , vol.268 , pp. 100-102
    • Hu, Q.1    Klippel, A.2    Muslin, A.J.3    Fantl, W.J.4    Williams, L.T.5
  • 36
    • 77954874401 scopus 로고    scopus 로고
    • GSK3 signalling in neural development
    • Hur, E. M., and Zhou, F. Q. (2010) GSK3 signalling in neural development. Nat. Rev. Neurosci. 11, 539-551
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 539-551
    • Hur, E.M.1    Zhou, F.Q.2
  • 38
    • 0025331705 scopus 로고
    • Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro
    • Thayer, S. A., and Miller, R. J. (1990) Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro. J. Physiol. 425, 85-115
    • (1990) J. Physiol. , vol.425 , pp. 85-115
    • Thayer, S.A.1    Miller, R.J.2
  • 39
    • 0024206340 scopus 로고
    • Regulation of calcium homeostasis in sensory neurons by bradykinin
    • Thayer, S. A., Perney, T. M., and Miller, R. J. (1988) Regulation of calcium homeostasis in sensory neurons by bradykinin. J. Neurosci. 8, 4089-4097
    • (1988) J. Neurosci. , vol.8 , pp. 4089-4097
    • Thayer, S.A.1    Perney, T.M.2    Miller, R.J.3
  • 42
    • 12944314765 scopus 로고    scopus 로고
    • Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons
    • Verkhratsky, A. (2005) Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol. Rev. 85, 201-279
    • (2005) Physiol. Rev. , vol.85 , pp. 201-279
    • Verkhratsky, A.1
  • 43
    • 0035369840 scopus 로고    scopus 로고
    • Trk receptors: Mediators of neurotrophin action
    • Patapoutian, A., and Reichardt, L. F. (2001) Trk receptors: mediators of neurotrophin action. Curr. Opin. Neurobiol. 11, 272-280
    • (2001) Curr. Opin. Neurobiol. , vol.11 , pp. 272-280
    • Patapoutian, A.1    Reichardt, L.F.2
  • 44
    • 0037762690 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: A convergence point for many signalling pathways
    • Chao, M. V. (2003) Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat. Rev. Neurosci. 4, 299-309
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 299-309
    • Chao, M.V.1
  • 45
    • 0028199799 scopus 로고
    • Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses
    • Stephens, R. M., Loeb, D. M., Copeland, T. D., Pawson, T., Greene, L. A., and Kaplan, D. R. (1994) Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses. Neuron 12, 691-705
    • (1994) Neuron , vol.12 , pp. 691-705
    • Stephens, R.M.1    Loeb, D.M.2    Copeland, T.D.3    Pawson, T.4    Greene, L.A.5    Kaplan, D.R.6
  • 47
    • 0842302965 scopus 로고    scopus 로고
    • Discovery and in vitro evaluation of potent TrkA kinase inhibitors: Oxindole and aza-oxindoles
    • Wood, E. R., Kuyper, L., Petrov, K. G., Hunter, R. N., 3rd, Harris, P. A., and Lackey, K. (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg. Med. Chem. Lett. 14, 953-957
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 953-957
    • Wood, E.R.1    Kuyper, L.2    Petrov, K.G.3    Hunter, R.N.4    Harris, P.A.5    Lackey, K.6
  • 48
    • 79957845538 scopus 로고    scopus 로고
    • Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays
    • Martin, K. J., Shpiro, N., Traynor, R., Elliott, M., and Arthur, J. S. (2011) Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays. Neuropharmacology 61, 148-155
    • (2011) Neuropharmacology , vol.61 , pp. 148-155
    • Martin, K.J.1    Shpiro, N.2    Traynor, R.3    Elliott, M.4    Arthur, J.S.5
  • 49
    • 0026595294 scopus 로고
    • K-252 compounds: Modulators of neurotrophin signal transduction
    • Knüsel, B., and Hefti, F. (1992) K-252 compounds: modulators of neurotrophin signal transduction. J. Neurochem. 59, 1987-1996
    • (1992) J. Neurochem. , vol.59 , pp. 1987-1996
    • Knüsel, B.1    Hefti, F.2
  • 50
    • 56149111648 scopus 로고    scopus 로고
    • Targeting nerve growth factor in pain: What is the therapeutic potential?
    • Watson, J. J., Allen, S. J., and Dawbarn, D. (2008) Targeting nerve growth factor in pain: what is the therapeutic potential? BioDrugs 22, 349-359
    • (2008) BioDrugs , vol.22 , pp. 349-359
    • Watson, J.J.1    Allen, S.J.2    Dawbarn, D.3
  • 51
    • 84870295768 scopus 로고    scopus 로고
    • Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor
    • Eibl, J. K., Strasser, B. C., and Ross, G. M. (2012) Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor. Neurochem. Int. 61, 1266-1275
    • (2012) Neurochem. Int. , vol.61 , pp. 1266-1275
    • Eibl, J.K.1    Strasser, B.C.2    Ross, G.M.3
  • 52
    • 2942735115 scopus 로고    scopus 로고
    • NGF-induced axon growth is mediated by localized inactivation of GSK-3β and functions of the microtubule plus end binding protein APC
    • Zhou, F. Q., Zhou, J., Dedhar, S., Wu, Y. H., and Snider, W. D. (2004) NGF-induced axon growth is mediated by localized inactivation of GSK-3β and functions of the microtubule plus end binding protein APC. Neuron 42, 897-912
    • (2004) Neuron , vol.42 , pp. 897-912
    • Zhou, F.Q.1    Zhou, J.2    Dedhar, S.3    Wu, Y.H.4    Snider, W.D.5
  • 53
    • 0041430783 scopus 로고    scopus 로고
    • The synergistic effects of NGF and IGF-1 on neurite growth in adult sensory neurons: Convergence on the PI 3-kinase signaling pathway
    • Jones, D. M., Tucker, B. A., Rahimtula, M., and Mearow, K. M. (2003) The synergistic effects of NGF and IGF-1 on neurite growth in adult sensory neurons: convergence on the PI 3-kinase signaling pathway. J. Neurochem. 86, 1116-1128
    • (2003) J. Neurochem. , vol.86 , pp. 1116-1128
    • Jones, D.M.1    Tucker, B.A.2    Rahimtula, M.3    Mearow, K.M.4
  • 54
    • 0347747970 scopus 로고    scopus 로고
    • Achemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells
    • Kau, T. R., Schroeder, F., Ramaswamy, S., Wojciechowski, C. L., Zhao, J. J., Roberts, T. M., Clardy, J., Sellers, W. R., and Silver, P. A. (2003)Achemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell 4, 463-476
    • (2003) Cancer Cell , vol.4 , pp. 463-476
    • Kau, T.R.1    Schroeder, F.2    Ramaswamy, S.3    Wojciechowski, C.L.4    Zhao, J.J.5    Roberts, T.M.6    Clardy, J.7    Sellers, W.R.8    Silver, P.A.9
  • 55
    • 0027960448 scopus 로고
    • Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation
    • Stambolic, V., and Woodgett, J. R. (1994) Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation. Biochem. J. 303, 701-704
    • (1994) Biochem. J. , vol.303 , pp. 701-704
    • Stambolic, V.1    Woodgett, J.R.2
  • 57
    • 33646352668 scopus 로고    scopus 로고
    • (McMahon, S. B., and Koltzenburg, M., eds) Elsevier, Amsterdam
    • Meyer, R. A., Ringhamp, M., Campbell, J. N., and Raja, S. N. (2006) in Textbook of Pain (McMahon, S. B., and Koltzenburg, M., eds) pp 3-34, Elsevier, Amsterdam
    • (2006) Textbook of Pain , pp. 3-34
    • Meyer, R.A.1    Ringhamp, M.2    Campbell, J.N.3    Raja, S.N.4
  • 58
    • 0036837672 scopus 로고    scopus 로고
    • Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth
    • Wilkins, B. J., De Windt, L. J., Bueno, O. F., Braz, J. C., Glascock, B. J., Kimball, T. F., and Molkentin, J. D. (2002) Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Mol. Cell Biol. 22, 7603-7613
    • (2002) Mol. Cell Biol. , vol.22 , pp. 7603-7613
    • Wilkins, B.J.1    De Windt, L.J.2    Bueno, O.F.3    Braz, J.C.4    Glascock, B.J.5    Kimball, T.F.6    Molkentin, J.D.7
  • 59
    • 0036884163 scopus 로고    scopus 로고
    • Regulation of transcription factors by neuronal activity
    • West, A. E., Griffith, E. C., and Greenberg, M. E. (2002) Regulation of transcription factors by neuronal activity. Nat. Rev. Neurosci. 3, 921-931
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 921-931
    • West, A.E.1    Griffith, E.C.2    Greenberg, M.E.3
  • 60
    • 77956175013 scopus 로고    scopus 로고
    • NFAT, immunity and cancer: A transcription factor comes of age
    • Müller, M. R., and Rao, A. (2010) NFAT, immunity and cancer: a transcription factor comes of age. Nat. Rev. Immunol. 10, 645-656
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 645-656
    • Müller, M.R.1    Rao, A.2
  • 63
    • 0348048793 scopus 로고    scopus 로고
    • Differences in calcium signalling in rat peripheral sensory neurons
    • Kress, M., and Distler, C. (2004) Differences in calcium signalling in rat peripheral sensory neurons. Neurosci. Lett. 354, 127-130
    • (2004) Neurosci. Lett. , vol.354 , pp. 127-130
    • Kress, M.1    Distler, C.2
  • 64
    • 0037466261 scopus 로고    scopus 로고
    • The inflammatory mediators serotonin, prostaglandin E2 and bradykinin evoke calcium influx in rat sensory neurons
    • Linhart, O., Obreja, O., and Kress, M. (2003) The inflammatory mediators serotonin, prostaglandin E2 and bradykinin evoke calcium influx in rat sensory neurons. Neuroscience 118, 69-74
    • (2003) Neuroscience , vol.118 , pp. 69-74
    • Linhart, O.1    Obreja, O.2    Kress, M.3
  • 65
    • 0030254111 scopus 로고    scopus 로고
    • Prostaglandin E2 increases the proportion of neonatal rat dorsal root ganglion neurons that respond to bradykinin
    • Stucky, C. L., Thayer, S. A., and Seybold, V. S. (1996) Prostaglandin E2 increases the proportion of neonatal rat dorsal root ganglion neurons that respond to bradykinin. Neuroscience 74, 1111-1123
    • (1996) Neuroscience , vol.74 , pp. 1111-1123
    • Stucky, C.L.1    Thayer, S.A.2    Seybold, V.S.3
  • 66
    • 0037146652 scopus 로고    scopus 로고
    • 2+ influx in intermediate-size primary afferent neurons of adult rats
    • 2+ influx in intermediate-size primary afferent neurons of adult rats. Neuroscience 115, 613-625
    • (2002) Neuroscience , vol.115 , pp. 613-625
    • Khasabova, I.A.1    Simone, D.A.2    Seybold, V.S.3
  • 67
    • 1242296787 scopus 로고    scopus 로고
    • Differential effects of CB1 and opioid agonists on two populations of adult rat dorsal root ganglion neurons
    • Khasabova, I. A., Harding-Rose, C., Simone, D. A., and Seybold, V. S. (2004) Differential effects of CB1 and opioid agonists on two populations of adult rat dorsal root ganglion neurons. J. Neurosci. 24, 1744-1753
    • (2004) J. Neurosci. , vol.24 , pp. 1744-1753
    • Khasabova, I.A.1    Harding-Rose, C.2    Simone, D.A.3    Seybold, V.S.4
  • 68
    • 0035878073 scopus 로고    scopus 로고
    • Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons
    • Oh, S. B., Tran, P. B., Gillard, S. E., Hurley, R. W., Hammond, D. L., and Miller, R. J. (2001) Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J. Neurosci. 21, 5027-5035
    • (2001) J. Neurosci. , vol.21 , pp. 5027-5035
    • Oh, S.B.1    Tran, P.B.2    Gillard, S.E.3    Hurley, R.W.4    Hammond, D.L.5    Miller, R.J.6
  • 69
    • 33748126653 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo
    • Malin, S. A., Molliver, D. C., Koerber, H. R., Cornuet, P., Frye, R., Albers, K. M., and Davis, B. M. (2006) Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo. J. Neurosci. 26, 8588-8599
    • (2006) J. Neurosci. , vol.26 , pp. 8588-8599
    • Malin, S.A.1    Molliver, D.C.2    Koerber, H.R.3    Cornuet, P.4    Frye, R.5    Albers, K.M.6    Davis, B.M.7
  • 70
    • 0033560120 scopus 로고    scopus 로고
    • Akt-dependent potentiation of L channels by insulinlike growth factor-1 is required for neuronal survival
    • Blair, L. A., Bence-Hanulec, K. K., Mehta, S., Franke, T., Kaplan, D., and Marshall, J. (1999) Akt-dependent potentiation of L channels by insulinlike growth factor-1 is required for neuronal survival. J. Neurosci. 19, 1940-1951
    • (1999) J. Neurosci. , vol.19 , pp. 1940-1951
    • Blair, L.A.1    Bence-Hanulec, K.K.2    Mehta, S.3    Franke, T.4    Kaplan, D.5    Marshall, J.6
  • 71
    • 38049134604 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 suppresses myogenic differentiation through negative regulation of NFATc3
    • van der Velden, J. L., Schols, A. M., Willems, J., Kelders, M. C., and Langen, R. C. (2008) Glycogen synthase kinase 3 suppresses myogenic differentiation through negative regulation of NFATc3. J. Biol. Chem. 283, 358-366
    • (2008) J. Biol. Chem. , vol.283 , pp. 358-366
    • Van Der Velden, J.L.1    Schols, A.M.2    Willems, J.3    Kelders, M.C.4    Langen, R.C.5
  • 72
    • 77954966128 scopus 로고    scopus 로고
    • NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy
    • Gómez-Sintes, R., and Lucas, J. J. (2010) NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J. Clin. Invest. 120, 2432-2445
    • (2010) J. Clin. Invest. , vol.120 , pp. 2432-2445
    • Gómez-Sintes, R.1    Lucas, J.J.2
  • 73
    • 12944250922 scopus 로고    scopus 로고
    • Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
    • Fang, X., Yu, S. X., Lu, Y., Bast, R. C., Jr., Woodgett, J. R., and Mills, G. B. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. U.S.A. 97, 11960-11965
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 11960-11965
    • Fang, X.1    Yu, S.X.2    Lu, Y.3    Bast, R.C.4    Woodgett, J.R.5    Mills, G.B.6
  • 74
    • 43249085035 scopus 로고    scopus 로고
    • Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4
    • Yang, T. T., Yu, R. Y., Agadir, A., Gao, G. J., Campos-Gonzalez, R., Tournier, C., and Chow, C. W. (2008) Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. Mol. Cell Biol. 28, 3489-3501
    • (2008) Mol. Cell Biol. , vol.28 , pp. 3489-3501
    • Yang, T.T.1    Yu, R.Y.2    Agadir, A.3    Gao, G.J.4    Campos-Gonzalez, R.5    Tournier, C.6    Chow, C.W.7
  • 75
    • 40349098058 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 (GSK3) in the heart: A point of integration in hypertrophic signalling and a therapeutic target? A critical analysis
    • Sugden, P. H., Fuller, S. J., Weiss, S. C., and Clerk, A. (2008) Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis. Br. J. Pharmacol. 153, S137-S153
    • (2008) Br. J. Pharmacol. , vol.153 , pp. S137-S153
    • Sugden, P.H.1    Fuller, S.J.2    Weiss, S.C.3    Clerk, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.