Discovery and in vitro evaluation of potent TrkA kinase inhibitors: Oxindole and aza-oxindoles

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 4, 2004, Pages 953-957

  Wood, Edgar R ^a   Kuyper, Lee ^a   Petrov, Kimberly G ^a   Hunter III, Robert N ^a   Harris, Philip A ^a   Lackey, Karen ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

TrkA kinase inhibitors

Indexed keywords

3 [(1 METHYL 1H INDOL 3 YL)METHYLENE] 1,3 DIHYDRO 2H PYRROLO[3,2 B]PYRIDIN 2 ONE; 3 [3 BROMO 4 HYDROXY 5 (2' METHOXYPHENYL)BENZYLIDENE] 5 BROMO 1,3 DIHYDROPYRROLO[2,3 B]PYRIDIN 2 ONE; ANTINEOPLASTIC AGENT; NERVE GROWTH FACTOR RECEPTOR INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

EID: 0842302965     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.12.002     Document Type: Article

References (21)

1. Bardeesy N., DePinto R.A. Nature Rev. Cancer. 2:2002;897.
2. Schneider M.B., Standop J., Ulrich A., Wittel W., Friess H., Andrén-Sandberg A., Pour P.M. J. Histochem. Cytochem. 49:2001;1205.
3. Guate J.L., Fernandez N., Lanzas J.M., Escaf S., Vega J. A BJU Int. 84:1999;495.
4. Tagliabue E., Castiglioni F., Ghirelli C., Modugno M., Asnaghi L., Somenzi G., Melani C., Menard S. J. Biol. Chem. 275:2000;5388.
5. Frade J.M., Barde Y.A. BioEssays. 20:1998;137.
6. Kaplan D.R., Miller F.D. Curr. Opin. Cell Biol. 9:1997;213.
7. LeSauteur L., Beglova N., Gehring K., Saragovi H.U. Adv. Behav. Biol. 49:1998;615.
8. Zhu Z., Friess H., diMola F.F., Zimmermann A., Graber H.U., Korc M., Buchler M.W. J. Clin. Oncol. 17:1999;2419.
9. Descamps S., Pawlowski V., Revillion F., Hornez L., Hebbar M., Boilly B., Hondermarck H., Peyrat J.-P. Cancer Res. 61:2001;4337.
10. Nakagawara A. Cancer Lett. 169:2001;107.
11. Rende M., Brizi E., Conner J., Treves S., Censier K., Provenzano C., Taglialatela G., Sanna P.P., Donato R. Int. J. Dev. Neurosci. 18:2000;869.
12. Dionne C.A., Camoratto A.M., Jani J.P., Emerson E., Neff N., Vaught J.L., Murakata C., Djakiew D., Lamb J., Bova S., George D., Isaacs J.T. Clin. Cancer Res. 4:1998;1887. 89th AACR, abstract # 4387.
13. Miknyoczki S.J., Chang H., Klein-Szanto A., Dione C.A., Ruggeri B.A. Clin. Cancer Res. 5:1999;2205.
14. 10th NCI-EORTC Symp New Drugs Cancer Therapy (Amsterdam) 1998, abstract 424.
15. 4.
16. Angeles T.S., Yang S.X., Steffler C., Dione C.A. Arch. Biochem. Biophys. 349:1998;267.
17. Suzuki Y., Takahashi H. Chem. Pharm. Bull. 31:1983;1751.
18. Wolfbeis O.S., Junck H.Z. Naturforsch, B: Anorg. Chem., Org Chem. 34B:1979;283.
19. Lackey K., Cory M., Davis R., Frye S.V., Harris P.A., Hunter R.N., Jung D.K., McDonald O.B., McNutt R.W., Peel M.R., Rutkowske R.D., Veal J.M., Wood E.R. Bioorg. Med. Chem. Lett. 10:2000;223.
20. Bramson H.N., Corona J., Davis S.T., Dickerson S.H., Edelstein M., Frye S.V., Gampe R.T. Jr., Harris P.A., Hassell A., Holmes W.D., Hunter R.N., Lackey K.E., Lovejoy B., Luzzio M.J., Montana V., Rocque W.J., Rusnak D., Shewchuk L., Veal J.M., Walker D.H., Kuyper L.F. J. Med. Chem. 44:2001;4339.
21. Sun L., Tran N., Liang C., Hubbard S., Tang F., Lipson K., Schreck R., Zhou Y., McMahon G., Tang C. J. Med. Chem. 43:2000;2655.