메뉴 건너뛰기




Volumn 109, Issue 23, 2012, Pages

Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus

Author keywords

Adult neurogenesis; Long term potentiation; Neural stem cells; Transcription

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CALCINEURIN; CYCLOSPORIN A; NUCLEAR FACTOR OF ACTIVATED T CELLS C4; PROTEIN; TRANSCRIPTION FACTOR; TRKB FC PROTEIN; UNCLASSIFIED DRUG;

EID: 84861895157     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1202068109     Document Type: Article
Times cited : (52)

References (60)
  • 1
    • 33847163934 scopus 로고    scopus 로고
    • Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
    • Kee N, Teixeira CM, Wang AH, Frankland PW (2007) Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat Neurosci 10:355-362.
    • (2007) Nat Neurosci , vol.10 , pp. 355-362
    • Kee, N.1    Teixeira, C.M.2    Wang, A.H.3    Frankland, P.W.4
  • 2
    • 34548249099 scopus 로고    scopus 로고
    • Spatial learning depends on both the addition and removal of new hippocampal neurons
    • Dupret D, et al. (2007) Spatial learning depends on both the addition and removal of new hippocampal neurons. PLoS Biol 5:e214.
    • (2007) PLoS Biol , vol.5
    • Dupret, D.1
  • 3
    • 77952382816 scopus 로고    scopus 로고
    • Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons
    • Tronel S, et al. (2010) Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons. Proc Natl Acad Sci USA 107:7963-7968.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7963-7968
    • Tronel, S.1
  • 4
    • 79955526702 scopus 로고    scopus 로고
    • Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
    • Sahay A, et al. (2011) Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472:466-470.
    • (2011) Nature , vol.472 , pp. 466-470
    • Sahay, A.1
  • 5
    • 0036734833 scopus 로고    scopus 로고
    • Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
    • Lee J, Duan W, Mattson MP (2002) Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 82:1367-1375.
    • (2002) J Neurochem , vol.82 , pp. 1367-1375
    • Lee, J.1    Duan, W.2    Mattson, M.P.3
  • 6
    • 0038452619 scopus 로고    scopus 로고
    • Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways
    • Barnabé-Heider F, Miller FD (2003) Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways. J Neurosci 23:5149-5160. (Pubitemid 36793243)
    • (2003) Journal of Neuroscience , vol.23 , Issue.12 , pp. 5149-5160
    • Barnabe-Heider, F.1    Miller, F.D.2
  • 7
    • 13944257674 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus
    • DOI 10.1523/JNEUROSCI.3741-04.2005
    • Sairanen M, Lucas G, Ernfors P, Castrén M, Castrén E (2005) Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. J Neurosci 25:1089-1094. (Pubitemid 40268949)
    • (2005) Journal of Neuroscience , vol.25 , Issue.5 , pp. 1089-1094
    • Sairanen, M.1    Lucas, G.2    Ernfors, P.3    Castren, M.4    Castren, E.5
  • 8
    • 55749104726 scopus 로고    scopus 로고
    • Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior
    • Bergami M, et al. (2008) Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior. Proc Natl Acad Sci USA 105:15570-15575.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15570-15575
    • Bergami, M.1
  • 9
    • 31844447757 scopus 로고    scopus 로고
    • GABA regulates synaptic integration of newly generated neurons in the adult brain
    • DOI 10.1038/nature04404, PII NATURE04404
    • Ge S, et al. (2006) GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature 439:589-593. (Pubitemid 43185382)
    • (2006) Nature , vol.439 , Issue.7076 , pp. 589-593
    • Ge, S.1    Goh, E.L.K.2    Sailor, K.A.3    Kitabatake, Y.4    Ming, G.-L.5    Song, H.6
  • 10
    • 33747827189 scopus 로고    scopus 로고
    • NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus
    • DOI 10.1038/nature05028, PII NATURE05028
    • Tashiro A, Sandler VM, Toni N, Zhao C, Gage FH (2006) NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature 442:929-933. (Pubitemid 44285949)
    • (2006) Nature , vol.442 , Issue.7105 , pp. 929-933
    • Tashiro, A.1    Sandler, V.M.2    Toni, N.3    Zhao, C.4    Gage, F.H.5
  • 11
    • 51549093751 scopus 로고    scopus 로고
    • SnapShot: Ca(2+)-dependent transcription in neurons
    • Zieg J, Greer PL, Greenberg ME (2008) SnapShot: Ca(2+)-dependent transcription in neurons. Cell 134(6):1080-1080.e2.
    • (2008) Cell , vol.134 , Issue.6
    • Zieg, J.1    Greer, P.L.2    Greenberg, M.E.3
  • 12
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
    • Clipstone NA, Crabtree GR (1992) Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357:695-697.
    • (1992) Nature , vol.357 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 13
    • 67649667324 scopus 로고    scopus 로고
    • SnapShot: Ca2+-calcineurin-NFAT signaling
    • Crabtree GR, Schreiber SL (2009) SnapShot: Ca2+-calcineurin-NFAT signaling. Cell 138 (1):210-210.e1.
    • (2009) Cell , vol.138 , Issue.1
    • Crabtree, G.R.1    Schreiber, S.L.2
  • 14
    • 39149105604 scopus 로고    scopus 로고
    • NFAT signaling in neural development and axon growth
    • Nguyen T, Di Giovanni S (2008) NFAT signaling in neural development and axon growth. Int J Dev Neurosci 26:141-145.
    • (2008) Int J Dev Neurosci , vol.26 , pp. 141-145
    • Nguyen, T.1    Di Giovanni, S.2
  • 15
    • 76849112151 scopus 로고    scopus 로고
    • Cyclosporine A reduces dendritic outgrowth of neuroblasts in the subgranular zone of the dentate gyrus in C57BL/6 mice
    • Hwang IK, et al. (2010) Cyclosporine A reduces dendritic outgrowth of neuroblasts in the subgranular zone of the dentate gyrus in C57BL/6 mice. Neurochem Res 35: 465-472.
    • (2010) Neurochem Res , vol.35 , pp. 465-472
    • Hwang, I.K.1
  • 17
    • 0033554699 scopus 로고    scopus 로고
    • L-type calcium channels and GSK-3 regulate the activity of NFATc4 in hippocampal neurons
    • Graef IA, et al. (1999) L-type calcium channels and GSK-3 regulate the activity of NFATc4 in hippocampal neurons. Nature 401:703-708.
    • (1999) Nature , vol.401 , pp. 703-708
    • Graef, I.A.1
  • 18
    • 72849145265 scopus 로고    scopus 로고
    • Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons
    • Vashishta A, et al. (2009) Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons. J Neurosci 29:15331-15340.
    • (2009) J Neurosci , vol.29 , pp. 15331-15340
    • Vashishta, A.1
  • 20
    • 0028049767 scopus 로고
    • Expression of polysialylated neural cell adhesion molecule by proliferating cells in the subependymal layer of the adult rat, in its rostral extension and in the olfactory bulb
    • DOI 10.1016/0306-4522(94)90333-6
    • Bonfanti L, Theodosis DT (1994) Expression of polysialylated neural cell adhesion molecule by proliferating cells in the subependymal layer of the adult rat, in its rostral extension and in the olfactory bulb. Neuroscience 62:291-305. (Pubitemid 24287364)
    • (1994) Neuroscience , vol.62 , Issue.1 , pp. 291-305
    • Bonfanti, L.1
  • 22
    • 0035967887 scopus 로고    scopus 로고
    • 2+/calcineurin and NFATc3/c4 pattern the developing vasculature
    • DOI 10.1016/S0092-8674(01)00396-8
    • Graef IA, Chen F, Chen L, Kuo A, Crabtree GR (2001) Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell 105:863-875. (Pubitemid 32635088)
    • (2001) Cell , vol.105 , Issue.7 , pp. 863-875
    • Graef, I.A.1    Chen, F.2    Chen, L.3    Kuo, A.4    Crabtree, G.R.5
  • 23
    • 43649084786 scopus 로고    scopus 로고
    • Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output
    • Hodge RD, et al. (2008) Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output. J Neurosci 28: 3707-3717.
    • (2008) J Neurosci , vol.28 , pp. 3707-3717
    • Hodge, R.D.1
  • 24
    • 0037806030 scopus 로고    scopus 로고
    • Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons
    • DOI 10.1016/S0092-8674(03)00390-8
    • Graef IA, et al. (2003) Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell 113:657-670. (Pubitemid 36694190)
    • (2003) Cell , vol.113 , Issue.5 , pp. 657-670
    • Graef, I.A.1    Wang, F.2    Charron, F.3    Chen, L.4    Neilson, J.5    Tessier-Lavigne, M.6    Crabtree, G.R.7
  • 25
    • 0041835836 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor activation of NFAT (nuclear factor of activated T-cells)-dependent transcription: A role for the transcription factor NFATc4 in neurotrophin-mediated gene expression
    • Groth RD, Mermelstein PG (2003) Brain-derived neurotrophic factor activation of NFAT (nuclear factor of activated T-cells)-dependent transcription: A role for the transcription factor NFATc4 in neurotrophin-mediated gene expression. J Neurosci 23: 8125-8134. (Pubitemid 37082466)
    • (2003) Journal of Neuroscience , vol.23 , Issue.22 , pp. 8125-8134
    • Groth, R.D.1    Mermelstein, P.G.2
  • 26
    • 0034666105 scopus 로고    scopus 로고
    • The role of brain-derived neurotrophic factor receptors in the mature hippocampus: MModulation of long-term potentiation through a presynaptic mechanism involving TrkB
    • Xu B, et al. (2000) The role of brain-derived neurotrophic factor receptors in the mature hippocampus: mModulation of long-term potentiation through a presynaptic mechanism involving TrkB. J Neurosci 20:6888-6897.
    • (2000) J Neurosci , vol.20 , pp. 6888-6897
    • Xu, B.1
  • 27
    • 77951498581 scopus 로고    scopus 로고
    • New neurons and new memories: How does adult hippocampal neurogenesis affect learning and memory?
    • Deng W, Aimone JB, Gage FH; (2010) New neurons and new memories: How does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 11: 339-350.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 339-350
    • Deng, W.1    Aimone, J.B.2    Gage, F.H.3
  • 28
    • 0022521577 scopus 로고
    • The role of amygdaloid central nucleus in the retention of differential pavlovian conditioning of bradycardia in rabbits
    • DOI 10.1016/0166-4328(86)90226-3
    • Gentile CG, Jarrell TW, Teich A, McCabe PM, Schneiderman N (1986) The role of amygdaloid central nucleus in the retention of differential pavlovian conditioning of bradycardia in rabbits. Behav Brain Res 20:263-273. (Pubitemid 16079800)
    • (1986) Behavioural Brain Research , vol.20 , Issue.3 , pp. 263-273
    • Gentile, C.G.1    Jarrell, T.W.2    Teich, A.3
  • 30
    • 0026635574 scopus 로고
    • Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning
    • Phillips RG, LeDoux JE (1992) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106:274-285.
    • (1992) Behav Neurosci , vol.106 , pp. 274-285
    • Phillips, R.G.1    LeDoux, J.E.2
  • 31
    • 0026514823 scopus 로고
    • Modality-specific retrograde amnesia of fear
    • Kim JJ, Fanselow MS (1992) Modality-specific retrograde amnesia of fear. Science 256: 675-677.
    • (1992) Science , vol.256 , pp. 675-677
    • Kim, J.J.1    Fanselow, M.S.2
  • 32
    • 11844289586 scopus 로고    scopus 로고
    • A role for adult neurogenesis in spatial long-term memory
    • DOI 10.1016/j.neuroscience.2004.10.009, PII S0306452204009285
    • Snyder JS, Hong NS, McDonald RJ, Wojtowicz JM (2005) A role for adult neurogenesis in spatial long-term memory. Neuroscience 130:843-852. (Pubitemid 40094618)
    • (2005) Neuroscience , vol.130 , Issue.4 , pp. 843-852
    • Snyder, J.S.1    Hong, N.S.2    McDonald, R.J.3    Wojtowicz, J.M.4
  • 33
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47-60.
    • (1984) J Neurosci Methods , vol.11 , pp. 47-60
    • Morris, R.1
  • 34
    • 0022374863 scopus 로고
    • Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
    • DOI 10.1016/0165-0270(85)90031-7
    • Pellow S, Chopin P, File SE, Briley M (1985) Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14: 149-167. (Pubitemid 16239568)
    • (1985) Journal of Neuroscience Methods , vol.14 , Issue.3 , pp. 149-167
    • Pellow, S.1    Chopin, P.2    File, S.E.3    Briley, M.4
  • 36
    • 0034995459 scopus 로고    scopus 로고
    • Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus
    • Snyder JS, Kee N, Wojtowicz JM (2001) Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. J Neurophysiol 85:2423-2431. (Pubitemid 32525520)
    • (2001) Journal of Neurophysiology , vol.85 , Issue.6 , pp. 2423-2431
    • Snyder, J.S.1    Kee, N.2    Wojtowicz, J.M.3
  • 37
    • 79955639851 scopus 로고    scopus 로고
    • Conditional reduction of adult neurogenesis impairs bidirectional hippocampal synaptic plasticity
    • Massa F, et al. (2011) Conditional reduction of adult neurogenesis impairs bidirectional hippocampal synaptic plasticity. Proc Natl Acad Sci USA 108:6644-6649.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 6644-6649
    • Massa, F.1
  • 38
    • 79955077994 scopus 로고    scopus 로고
    • Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice
    • Singer BH, et al. (2011) Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice. Proc Natl Acad Sci USA 108:5437-5442.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 5437-5442
    • Singer, B.H.1
  • 39
    • 2442642871 scopus 로고    scopus 로고
    • Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
    • DOI 10.1038/nature02553
    • Schmidt-Hieber C, Jonas P, Bischofberger J (2004) Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature 429:184-187. (Pubitemid 38656194)
    • (2004) Nature , vol.429 , Issue.6988 , pp. 184-187
    • Schmidt-Hieber, C.1    Jones, P.2    Bischofberger, J.3
  • 40
    • 0037018145 scopus 로고    scopus 로고
    • NFAT: Ubiquitous regulator of cell differentiation and adaptation
    • DOI 10.1083/jcb.200111073
    • Horsley V, Pavlath GK (2002) NFAT: uUbiquitous regulator of cell differentiation and adaptation. J Cell Biol 156:771-774. (Pubitemid 34839859)
    • (2002) Journal of Cell Biology , vol.156 , Issue.5 , pp. 771-774
    • Horsley, V.1    Pavlath, G.K.2
  • 41
    • 84861867390 scopus 로고    scopus 로고
    • NFAT-dependent gene expression in the nervous system: A critical mediator of neurotrophin-induced plasticity
    • ed Dudek SM (Springer, NewYork), 1st Ed
    • Groth RD, Mermelstein PG (2008) NFAT-dependent gene expression in the nervous system: A critical mediator of neurotrophin-induced plasticity. Transcriptional Regulation by Neuronal Activity, ed Dudek SM (Springer, NewYork), 1st Ed, pp 187-207.
    • (2008) Transcriptional Regulation by Neuronal Activity , pp. 187-207
    • Groth, R.D.1    Mermelstein, P.G.2
  • 42
    • 74849094086 scopus 로고    scopus 로고
    • Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF
    • Choi SH, Li Y, Parada LF, Sisodia SS (2009) Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. Mol Neurodegener 4:52.
    • (2009) Mol Neurodegener , vol.4 , pp. 52
    • Choi, S.H.1    Li, Y.2    Parada, L.F.3    Sisodia, S.S.4
  • 43
    • 0028866230 scopus 로고
    • Neurotrophins and neuronal plasticity
    • Thoenen H (1995) Neurotrophins and neuronal plasticity. Science 270:593-598.
    • (1995) Science , vol.270 , pp. 593-598
    • Thoenen, H.1
  • 44
    • 33751252577 scopus 로고    scopus 로고
    • A theoretical network model to analyse neurogenesis and synaptogenesis in the dentate gyrus
    • DOI 10.1016/j.neunet.2006.07.007, PII S0893608006001869
    • Butz M, Lehmann K, Dammasch IE, Teuchert-Noodt G (2006) A theoretical network model to analyse neurogenesis and synaptogenesis in the dentate gyrus. Neural Netw 19:1490-1505. (Pubitemid 44793173)
    • (2006) Neural Networks , vol.19 , Issue.10 , pp. 1490-1505
    • Butz, M.1    Lehmann, K.2    Dammasch, I.E.3    Teuchert-Noodt, G.4
  • 45
    • 53649105089 scopus 로고    scopus 로고
    • Alternative splicing and expression of human and mouse NFAT genes
    • Vihma H, Pruunsild P, Timmusk T (2008) Alternative splicing and expression of human and mouse NFAT genes. Genomics 92:279-291.
    • (2008) Genomics , vol.92 , pp. 279-291
    • Vihma, H.1    Pruunsild, P.2    Timmusk, T.3
  • 46
    • 59149101536 scopus 로고    scopus 로고
    • Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation
    • Kao SC, et al. (2009) Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science 323:651-654.
    • (2009) Science , vol.323 , pp. 651-654
    • Kao, S.C.1
  • 47
    • 78650972892 scopus 로고    scopus 로고
    • Calcineurin-NFAT signaling critically regulates early lineage specification in mouse embryonic stem cells and embryos
    • Li X, et al. (2011) Calcineurin-NFAT signaling critically regulates early lineage specification in mouse embryonic stem cells and embryos. Cell Stem Cell 8:46-58.
    • (2011) Cell Stem Cell , vol.8 , pp. 46-58
    • Li, X.1
  • 48
    • 76149121821 scopus 로고    scopus 로고
    • Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth
    • Rauskolb S, et al. (2010) Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth. J Neurosci 30: 1739-1749.
    • (2010) J Neurosci , vol.30 , pp. 1739-1749
    • Rauskolb, S.1
  • 49
    • 39149136525 scopus 로고    scopus 로고
    • Imaging activation of adult-generated granule cells in spatial memory
    • Kee N, Teixeira CM, Wang AH, Frankland PW (2007) Imaging activation of adult-generated granule cells in spatial memory. Nat Protoc 2:3033-3044.
    • (2007) Nat Protoc , vol.2 , pp. 3033-3044
    • Kee, N.1    Teixeira, C.M.2    Wang, A.H.3    Frankland, P.W.4
  • 50
    • 0036455153 scopus 로고    scopus 로고
    • Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task
    • DOI 10.1046/j.1460-9568.2002.02042.x
    • Kempermann G, Gage FH (2002) Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task. Eur J Neurosci 16:129-136. (Pubitemid 35463603)
    • (2002) European Journal of Neuroscience , vol.16 , Issue.1 , pp. 129-136
    • Kempermann, G.1    Gage, F.H.2
  • 51
    • 39149099035 scopus 로고    scopus 로고
    • A role for adult TLX-positive neural stem cells in learning and behaviour
    • DOI 10.1038/nature06562, PII NATURE06562
    • Zhang CL, Zou Y, He W, Gage FH, Evans RM (2008) A role for adult TLX-positive neural stem cells in learning and behaviour. Nature 451:1004-1007. (Pubitemid 351301727)
    • (2008) Nature , vol.451 , Issue.7181 , pp. 1004-1007
    • Zhang, C.-L.1    Zou, Y.2    He, W.3    Gage, F.H.4    Evans, R.M.5
  • 52
    • 59649095732 scopus 로고    scopus 로고
    • Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
    • Jessberger S, et al. (2009) Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem 16:147-154.
    • (2009) Learn Mem , vol.16 , pp. 147-154
    • Jessberger, S.1
  • 53
    • 67650450542 scopus 로고    scopus 로고
    • A functional role for adult hippocampal neurogenesis in spatial pattern separation
    • Clelland CD, et al. (2009) A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 325:210-213.
    • (2009) Science , vol.325 , pp. 210-213
    • Clelland, C.D.1
  • 54
    • 65549133778 scopus 로고    scopus 로고
    • Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies
    • Garthe A, Behr J, Kempermann G (2009) Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies. PLoS ONE 4:e5464.
    • (2009) PLoS ONE , vol.4
    • Garthe, A.1    Behr, J.2    Kempermann, G.3
  • 55
    • 82055202901 scopus 로고    scopus 로고
    • Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory
    • Stone SS, et al. (2011) Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory. Hippocampus 12:1348-1362.
    • (2011) Hippocampus , vol.12 , pp. 1348-1362
    • Stone, S.S.1
  • 56
    • 0346874151 scopus 로고    scopus 로고
    • Differential effects of learning on neurogenesis: Learning increases or decreases the number of newly born cells depending on their birth date
    • DOI 10.1038/sj.mp.4001419
    • Döbrössy MD, et al. (2003) Differential effects of learning on neurogenesis: Learning increases or decreases the number of newly born cells depending on their birth date. Mol Psychiatry 8:974-982. (Pubitemid 37523909)
    • (2003) Molecular Psychiatry , vol.8 , Issue.12 , pp. 974-982
    • Dobrossy, M.D.1    Drapeau, E.2    Aurousseau, C.3    Le, M.M.4    Piazza, P.V.5    Abrous, D.N.6
  • 57
    • 45849151100 scopus 로고    scopus 로고
    • Spatial relational memory requires hippocampal adult neurogenesis
    • Dupret D, et al. (2008) Spatial relational memory requires hippocampal adult neurogenesis. PLoS One 3(4):e1959.
    • (2008) PLoS One , vol.3 , Issue.4
    • Dupret, D.1
  • 58
    • 33745698913 scopus 로고    scopus 로고
    • Potential role for adult neurogenesis in the encoding of time in new memories
    • Aimone JB, Wiles J, Gage FH (2006) Potential role for adult neurogenesis in the encoding of time in new memories. Nat Neurosci 9:723-727.
    • (2006) Nat Neurosci , vol.9 , pp. 723-727
    • Aimone, J.B.1    Wiles, J.2    Gage, F.H.3
  • 59
    • 0036837672 scopus 로고    scopus 로고
    • Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth
    • Wilkins BJ, et al. (2002) Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Mol Cell Biol 22: 7603-7613.
    • (2002) Mol Cell Biol , vol.22 , pp. 7603-7613
    • Wilkins, B.J.1
  • 60
    • 62149105144 scopus 로고    scopus 로고
    • Viral-mediated expression of a constitutively active form of CREB in hippocampal neurons increases memory
    • Restivo L, Tafi E, Ammassari-Teule M, Marie H (2009) Viral-mediated expression of a constitutively active form of CREB in hippocampal neurons increases memory. Hippocampus 19:228-234.
    • (2009) Hippocampus , vol.19 , pp. 228-234
    • Restivo, L.1    Tafi, E.2    Ammassari-Teule, M.3    Marie, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.