Isolation, purification and molecular mechanism of a peanut protein-derived ACE-inhibitory peptide

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Shi, Aimin ^a   Liu, Hongzhi ^a   Liu, Li ^a   Hu, Hui ^a   Wang, Qiang ^a   Adhikari, Benu ^b  

^a AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

^b RMIT UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LYSYLLEUCYLTYROSYLMETHIONYLARGINYLPROLINE; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; OLIGOPEPTIDE; PROTEIN BINDING; VEGETABLE PROTEIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG ISOLATION; DRUG MEGADOSE; DRUG PURIFICATION; DRUG STABILITY; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; HYDROLYSIS; HYPERTENSION; IC50; IN VIVO STUDY; LOW DRUG DOSE; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PEANUT; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; TREATMENT OUTCOME; ULTRAFILTRATION; ANIMAL; ARACHIS; BINDING SITE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; SPONTANEOUSLY HYPERTENSIVE RAT;

ARACHIS HYPOGAEA;

AMINO ACID SEQUENCE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; ARACHIS; BINDING SITES; HYPERTENSION; MALE; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDYL-DIPEPTIDASE A; PLANT PROTEINS; PROTEIN BINDING; RATS; RATS, INBRED SHR;

EID: 84908636860     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111188     Document Type: Article

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