Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme

Biochemistry

Volumn 43, Issue 27, 2004, Pages 8718-8724

  Natesh, Ramanathan ^a,c   Schwager, Sylva L U ^b   Evans, Hazel R ^a   Sturrock, Edward D ^b   Acharya, K Ravi ^a  

^a University of Bath   (United Kingdom)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY ICGEB   (India)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; CRYSTAL STRUCTURE; DRUG DOSAGE; ENZYME INHIBITION; ENZYME KINETICS; TISSUE;

ANTIHYPERSENSITIVE DRUGS; BINDING POCKET; RENIN-ANGIOTENSIN SYSTEMS (RAS);

BIOCHEMISTRY;

ANTIHYPERTENSIVE AGENT; CAPTOPRIL; CHLORIDE ION; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL MALEATE; ENALAPRILAT; LISINOPRIL; ZINC ION;

ANIMAL CELL; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD PRESSURE REGULATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; HEART MUSCLE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SKELETAL MUSCLE; TESTIS;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BINDING SITES; CAPTOPRIL; CHLORIDES; CHO CELLS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; ENALAPRILAT; ENZYME INHIBITORS; HUMANS; MALE; MODELS, MOLECULAR; PEPTIDYL-DIPEPTIDASE A; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TESTIS;

ANIMALIA;

EID: 3042732126     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049480n     Document Type: Article

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