Mangiferin stimulates carbohydrate oxidation and protects against metabolic disorders induced by high-fat diets

Diabetes

Volumn 63, Issue 11, 2014, Pages 3626-3636

  Apontes, Pasha ^a   Liu, Zhongbo ^a   Su, Kai ^a   Benard, Outhiriaradjou ^a   Youn, Dou Y ^b   Li, Xisong ^a   Li, Wei ^b   Mirza, Raihan H ^a   Bastie, Claire C ^a   Jelicks, Linda A ^a   Pessin, Jeffrey E ^a   Muzumdar, Radhika H ^a   Sauve, Anthony A ^b   Chi, Yuling ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBOHYDRATE; GLUCOSE; INSULIN; LACTIC ACID; MANGIFERA INDICA EXTRACT; MANGIFERIN; PYRUVATE DEHYDROGENASE; PYRUVIC ACID; OXIDOREDUCTASE; PYRUVATE DEHYDROGENASE (NADP+); XANTHONE DERIVATIVE;

AEROBIC CAPACITY; ANAEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOHYDRATE OXIDATION; CONTROLLED STUDY; DRUG MECHANISM; EX VIVO STUDY; FATTY ACID OXIDATION; GLUCOSE INTOLERANCE; GLUCOSE OXIDATION; IN VIVO STUDY; INSULIN RESISTANCE; LACTIC ACIDOSIS; LIPID DIET; METABOLIC DISORDER; METABOLIC SYNDROME X; MITOCHONDRION; MOUSE; MUSCLE FIBRIL; NONHUMAN; OBESITY; OXIDATION; RESPIRATORY QUOTIENT; THERMOGENESIS; WEIGHT GAIN; ANIMAL; C57BL MOUSE; CARBOHYDRATE METABOLISM; DRUG EFFECTS; ENERGY METABOLISM; LIPID METABOLISM; METABOLISM; OXIDATION REDUCTION REACTION;

ANIMALS; CARBOHYDRATE METABOLISM; DIET, HIGH-FAT; ENERGY METABOLISM; KETONE OXIDOREDUCTASES; LIPID METABOLISM; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION; PYRUVIC ACID; XANTHONES;

EID: 84908617890     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0006     Document Type: Article

References (50)

1. Danaei G, Finucane MM, Lu Y, et al.; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Blood Glucose). National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2$7 million participants. Lancet 2011; 378:31-40
2. Smyth S, Heron A. Diabetes and obesity: the twin epidemics. Nat Med 2006;12:75-80
3. Cantó C, Houtkooper RH, Pirinen E, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat dietinduced obesity. Cell Metab 2012;15:838-847
4. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006;127:1109-1122
5. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963;1:785-789
6. Nuutila P, Koivisto VA, Knuuti J, et al. Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo. J Clin Invest 1992;89:1767-1774
7. Hue L, Taegtmeyer H. The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab 2009;297:E578-E591
8. Hancock CR, Han DH, Chen M, et al. High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc Natl Acad Sci U S A 2008;105: 7815-7820
9. Turner N, Bruce CR, Beale SM, et al. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes 2007;56:2085-2092
10. Kelley DE, Reilly JP, Veneman T, Mandarino LJ. Effects of insulin on skeletal muscle glucose storage, oxidation, and glycolysis in humans. Am J Physiol 1990; 258:E923-E929
11. Randle PJ, Priestman DA, Mistry S, Halsall A. Mechanisms modifying glucose oxidation in diabetes mellitus. Diabetologia 1994;37(Suppl. 2):S155-S161
12. Hall JL, Stanley WC, Lopaschuk GD, et al. Impaired pyruvate oxidation but normal glucose uptake in diabetic pig heart during dobutamine-induced work. Am J Physiol 1996;271:H2320-H2329
13. Olesen J, Kiilerich K, Pilegaard H. PGC-1alpha-mediated adaptations in skeletal muscle. Pflugers Arch 2010;460:153-162
14. Zhou L, Cabrera ME, Okere IC, Sharma N, Stanley WC. Regulation of myocardial substrate metabolism during increased energy expenditure: insights from computational studies. Am J Physiol Heart Circ Physiol 2006;291:H1036-H1046
15. Stacpoole PW, Moore GW, Kornhauser DM. Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia. N Engl J Med 1978;298:526-530
16. Jeoung NH, Harris RA. Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice. Am J Physiol Endocrinol Metab 2008;295:E46-E54
17. Stein DT, Babcock EE, Malloy CR, McGarry JD. Use of proton spectroscopy for detection of homozygous fatty ZDF-drt rats before weaning. Int J Obes Relat Metab Disord 1995;19:804-810
18. Blouet C, Liu SM, Jo YH, Chua S, Schwartz GJ. TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity. J Neurosci 2012;32:9870-9877
19. Muzumdar RH, Huffman DM, Atzmon G, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS ONE 2009;4:e6334
20. Shortreed KE, Krause MP, Huang JH, et al. Muscle-specific adaptations, impaired oxidative capacity and maintenance of contractile function characterize diet-induced obese mouse skeletal muscle. PLoS ONE 2009;4:e7293
21. Yamada E, Pessin JE, Kurland IJ, Schwartz GJ, Bastie CC. Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metab 2010;11:113-124
22. García-Martínez C, Marotta M, Moore-Carrasco R, et al. Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells. Am J Physiol Cell Physiol 2005;288: C1264-C1272
23. Abe Y, Sakairi T, Kajiyama H, Shrivastav S, Beeson C, Kopp JB. Bioenergetic characterization of mouse podocytes. Am J Physiol Cell Physiol 2010;299:C464-C476
24. Nicholls DG, Darley-Usmar VM, Wu M, Jensen PB, Rogers GW, Ferrick DA. Bioenergetic profile experiment using C2C12 myoblast cells. J Vis Exp 2010;(46): 2511
25. Han D, Chen C, Zhang C, Zhang Y, Tang X. Determination of mangiferin in rat plasma by liquid-liquid extraction with UPLC-MS/MS. J Pharm Biomed Anal 2010;51:260-263
26. Jeoung NH, Sanghani PC, Zhai L, Harris RA. Assay of the pyruvate dehydrogenase complex by coupling with recombinant chicken liver arylamine Nacetyltransferase. Anal Biochem 2006;356:44-50
27. Constantin-Teodosiu D, Cederblad G, Hultman E. A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue. Anal Biochem 1991;198:347-351
28. Hinman LM, Blass JP. An NADH-linked spectrophotometric assay for pyruvate dehydrogenase complex in crude tissue homogenates. J Biol Chem 1981; 256:6583-6586
29. Schwab MA, Kölker S, van den Heuvel LP, et al. Optimized spectrophotometric assay for the completely activated pyruvate dehydrogenase complex in fibroblasts. Clin Chem 2005;51:151-160
30. Sheu KF, Hu CW, Utter MF. Pyruvate dehydrogenase complex activity in normal and deficient fibroblasts. J Clin Invest 1981;67:1463-1471
31. Buffington CK, Kitabchi AE. Activation of pyruvate dehydrogenase complex (PDC) of rat heart mitochondria by glyburide. Biochem Biophys Res Commun 1984;123:202-209
32. Cate RL, Roche TE, Davis LC. Rapid intersite transfer of acetyl groups and movement of pyruvate dehydrogenase component in the kidney pyruvate dehydrogenase complex. J Biol Chem 1980;255:7556-7562
33. Miura T, Ichiki H, Hashimoto I, et al. Antidiabetic activity of a xanthone compound, mangiferin. Phytomedicine 2001;8:85-87
34. Heymsfield SB, Gonzalez MC, Shen W, Redman L, Thomas D. Weight loss composition is one-fourth fat-free mass: a critical review and critique of this widely cited rule. Obes Rev 2014;15:310-321
35. Garland T Jr, Schutz H, Chappell MA, et al. The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives. J Exp Biol 2011;214:206-229
36. Trajcevski KE, O'Neill HM, Wang DC, et al. Enhanced lipid oxidation and maintenance of muscle insulin sensitivity despite glucose intolerance in a dietinduced obesity mouse model. PLoS ONE 2013;8:e71747
37. Birkenstock T, Liebeke M, Winstel V, et al. Exometabolome analysis identifies pyruvate dehydrogenase as a target for the antibiotic triphenylbismuthdichloride in multiresistant bacterial pathogens. J Biol Chem 2012;287:2887-2895
38. Roche TE, Baker JC, Yan X, et al. Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. Prog Nucleic Acid Res Mol Biol 2001;70:33-75
39. Sugden MC, Holness MJ. Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases. Arch Physiol Biochem 2006;112:139-149
40. Constantin-Teodosiu D, Constantin D, Stephens F, Laithwaite D, Greenhaff PL. The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes. Diabetes 2012;61:1017-1024
41. Crewe C, Kinter M, Szweda LI. Rapid inhibition of pyruvate dehydrogenase: an initiating event in high dietary fat-induced loss of metabolic flexibility in the heart. PLoS ONE 2013;8:e77280
42. Niu Y, Li S, Na L, et al. Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK. PLoS ONE 2012;7: e30782
43. Lim J, Liu Z, Apontes P, et al. Dual mode action of mangiferin in mouse liver under high fat diet. PLoS ONE 2014;9:e90137
44. Eberlé D, Hegarty B, Bossard P, Ferré P, Foufelle F. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 2004;86:839-848
45. Kim JB, Spiegelman BM. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev 1996;10:1096-1107
46. Cantó C, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009;458: 1056-1060
47. Andreu GP, Delgado R, Velho JA, Curti C, Vercesi AE. Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-citrate. Eur J Pharmacol 2005;513: 47-55
48. Tabatabaie T, Potts JD, Floyd RA. Reactive oxygen species-mediated inactivation of pyruvate dehydrogenase. Arch Biochem Biophys 1996;336:290-296
49. Glushakova LG, Judge S, Cruz A, Pourang D, Mathews CE, Stacpoole PW. Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts. Mol Genet Metab 2011;104:255-260
50. Hou SY, Wang F, Li YM, et al. Pharmacokinetic study of mangiferin in human plasma after oral administration. Food Chem 2012;132:289-294