Weight loss composition is one-fourth fat-free mass: A critical review and critique of this widely cited rule

Obesity Reviews

Volumn 15, Issue 4, 2014, Pages 310-321

  Heymsfield, S B ^a   Gonzalez, M C C ^b   Shen, W ^c   Redman, L ^a   Thomas, D ^d  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b CATHOLIC UNIVERSITY OF PELOTAS   (Brazil)

^c New York Obesity Research Center St Luke's Roosevelt Hospital College of Physicians and Surgeons Columbia University ^*  (United States)

^d MONTCLAIR STATE UNIVERSITY   (United States)

Author keywords

Body composition; Energy expenditure; Mathematical model; Obesity

Indexed keywords

AEROBIC EXERCISE; ARTICLE; BODY COMPOSITION; BODY FAT; BODY HEIGHT; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CALORIC RESTRICTION; CARBOHYDRATE DIET; CLINICAL PROTOCOL; DENSITOMETRY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENERGY BALANCE; EXERCISE; EXTRACELLULAR FLUID; FAT FREE MASS; FOOD INTAKE; HUMAN; LEAN BODY WEIGHT; LOW CALORY DIET; META ANALYSIS; PROTEIN DEPLETION; PROTEIN METABOLISM; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESISTANCE TRAINING; SEX DIFFERENCE; SYSTEMATIC REVIEW (TOPIC); TOTAL BODY POTASSIUM; TOTAL BODY WATER; WEIGHT CHANGE; WEIGHT REDUCTION; ADIPOSE TISSUE; AGING; ANATOMY AND HISTOLOGY; ENERGY METABOLISM; HOMEOSTASIS; NUTRITION; OBESITY; PATHOLOGY; REPRODUCIBILITY; WEIGHT GAIN;

ADIPOSE TISSUE; AGING; BODY COMPOSITION; CALORIC RESTRICTION; ENERGY METABOLISM; EXERCISE; HOMEOSTASIS; HUMANS; NUTRITIONAL PHYSIOLOGICAL PHENOMENA; OBESITY; REPRODUCIBILITY OF RESULTS; THINNESS; WEIGHT GAIN; WEIGHT LOSS;

EID: 84895930996     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/obr.12143     Document Type: Article

References (75)

1. Phillips SM, Zemel MB. Effect of protein, dairy components and energy balance in optimizing body composition. Nestle Nutr Inst Workshop Ser 2011; 69: 97-108, discussion 108-113.
2. Friedl K. Variability of Fat and Lean Tissue Loss during Physical Exertion with Energy Deficit. Lippincott-Raven: Philadelphia, 1997.
3. Hansen D, Dendale P, Berger J, van Loon LJ, Meeusen R. The effects of exercise training on fat-mass loss in obese patients during energy intake restriction. Sports Med 2007; 37: 31-46.
4. Prado CM, Antoun S, Sawyer MB, Baracos VE. Two faces of drug therapy in cancer: drug-related lean tissue loss and its adverse consequences to survival and toxicity. Curr Opin Clin Nutr Metab Care 2011; 14: 250-254.
5. Saad F, Aversa A, Isidori AM, Gooren LJ. Testosterone as potential effective therapy in treatment of obesity in men with testosterone deficiency: a review. Curr Diabetes Rev 2012; 8: 131-143.
6. Thomas DM, Martin CK, Lettieri S etal. Can a weight loss of one pound a week be achieved with a 3500-kcal deficit? Commentary on a commonly accepted rule. Int J Obes (Lond) 2013; 37: 1611-1613.
7. Hall KD, Sacks G, Chandramohan D etal. Quantification of the effect of energy imbalance on bodyweight. Lancet 2011; 378: 826-837.
8. Prentice AM, Goldberg GR, Jebb SA, Black AE, Murgatroyd PR, Diaz EO. Physiological responses to slimming. Proc Nutr Soc 1991; 50: 441-458.
9. Berkhan M Intermittent fasting for weight loss preserves muscle mass? 2011.
10. Varady KA. Intermittent versus daily calorie restriction: which diet regimen is more effective for weight loss? Obes Rev 2011; 12: e593-e601.
11. Garrow JS, Summerbell CD. Meta-analysis: effect of exercise, with or without dieting, on the body composition of overweight subjects. Eur J Clin Nutr 1995; 49: 1-10.
12. Chaston TB, Dixon JB, O'Brien PE. Changes in fat-free mass during significant weight loss: a systematic review. Int J Obes (Lond) 2007; 31: 743-750.
13. Weinheimer EM, Sands LP, Campbell WW. A systematic review of the separate and combined effects of energy restriction and exercise on fat-free mass in middle-aged and older adults: implications for sarcopenic obesity. Nutr Rev 2010; 68: 375-388.
14. Stiegler P, Cunliffe A. The role of diet and exercise for the maintenance of fat-free mass and resting metabolic rate during weight loss. Sports Med 2006; 36: 239-262.
15. Heymsfield S. Physical Activity, Weight Loss, and Maintenance of Lean Mass, 2nd edn. Human Kinetics: Champaign, IL, 2010.
16. Keys A, Brozek J. Body fat in adult man. Physiol Rev 1953; 33: 245-325.
17. University of Minnesota, Laboratory of Physiological Hygiene, Keys A. The Biology of Human Starvation. University of Minnesota Press: Minneapolis, MN, 1950.
18. Grande F, Henschel A. Nutrition and Energy Balance in Body Composition Studies. National Academy of Sciences-National Research Council: Washington, DC, 1961.
19. Brozek J, Grande F, Anderson JT, Keys A. Densitometric analysis of body composition: revision of some quantitative assumptions. Ann N Y Acad Sci 1963; 110: 113-140.
20. Wishnofsky M. Caloric equivalents of gained or lost weight. Am J Clin Nutr 1958; 6: 542-546.
21. Bozenraad O. Ueber den Wassergehalt des menschlichen Fettgewebes unter verschiedenen bedingungen. Deutsch Arch f kiln Med 1911; 103: 120-123.
22. Webster JD, Hesp R, Garrow JS. The composition of excess weight in obese women estimated by body density, total body water and total body potassium. Hum Nutr Clin Nutr 1984; 38: 299-306.
23. Brown MR, Klish WJ, Hollander J, Campbell MA, Forbes GB. A high protein, low calorie liquid diet in the treatment of very obese adolescents: long-term effect on lean body mass. Am J Clin Nutr 1983; 38: 20-31.
24. Forbes GB, Gallup J, Hursh JB. Estimation of total body fat from potassium-40 content. Science 1961; 133: 101-102.
25. Wang ZM, Pierson RN Jr, Heymsfield SB. The five-level model: a new approach to organizing body-composition research. Am J Clin Nutr 1992; 56: 19-28.
26. Wang Z, Pi-Sunyer FX, Kotler DP, Wang J, Pierson RN Jr, Heymsfield SB. Magnitude and variation of ratio of total body potassium to fat-free mass: a cellular level modeling study. Am J Physiol Endocrinol Metab 2001; 281: E1-E7.
27. Forbes GB, Brown MR, Welle SL, Lipinski BA. Deliberate overfeeding in women and men: energy cost and composition of the weight gain. Br J Nutr 1986; 56: 1-9.
28. Forbes GB. Lean body mass-body fat interrelationships in humans. Nutr Rev 1987; 45: 225-231.
29. Thomas D, Das SK, Levine JA etal. New fat free mass - fat mass model for use in physiological energy balance equations. Nutr Metab (Lond) 2010; 7: 39.
30. Hall KD. Body fat and fat-free mass inter-relationships: Forbes's theory revisited. Br J Nutr 2007; 97: 1059-1063.
31. Hall KD. Predicting metabolic adaptation, body weight change, and energy intake in humans. Am J Physiol Endocrinol Metab 2010; 298: E449-E466.
32. Thomas DM, Martin CK, Heymsfield SB, Redman LM, Schoeller DA, Levine JA. A simple model predicting individual weight change in humans. J Biol Dynam 2011; 5: 579-599.
33. Thomas DM, Schoeller DA, Redman LA, Martin CK, Levine JA, Heymsfield SB. A computational model to determine energy intake during weight loss. Am J Clin Nutr 2010; 92: 1326-1331.
34. Silva AM, Shen W, Heo M etal. Ethnicity-related skeletal muscle differences across the lifespan. Am J Hum Biol 2010; 22: 76-82.
35. Jones A Jr, Shen W, St-Onge MP etal. Body-composition differences between African American and white women: relation to resting energy requirements. Am J Clin Nutr 2004; 79: 780-786.
36. Allison DB, Nathan JS, Albu JB, Heymsfield SB, Duprat LJ, Pi-Sunyer FX. Measurement challenges and other practical concerns when studying massively obese individuals. Int J Eat Disord 1998; 24: 275-284.
37. Bell JD, Margen S, Calloway DH. Ketosis, weight loss, uric acid, and nitrogen balance in obese women fed single nutrients at low caloric levels. Metabolism 1969; 18: 193-208.
38. van den Oever IA, van Sijl AM, Nurmohamed MT. Management of cardiovascular risk in patients with rheumatoid arthritis: evidence and expert opinion. Ther Adv Musculoskelet Dis 2013; 5: 166-181.
39. Ruberg RL. Protein and energy requirements of the hospitalized patient. Ohio State Med J 1981; 77: 382-384.
40. Van Loan MD, Strawford A, Jacob M, Hellerstein M. Monitoring changes in fat-free mass in HIV-positive men with hypotestosteronemia and AIDS wasting syndrome treated with gonadal hormone replacement therapy. AIDS 1999; 13: 241-248.
41. Hoffer LJ. Clinical nutrition: 1. Protein-energy malnutrition in the inpatient. CMAJ 2001; 165: 1345-1349.
42. Schulman RC, Mechanick JI. Metabolic and nutrition support in the chronic critical illness syndrome. Respir Care 2012; 57: 958-977, discussion 977-978.
43. Pingleton SK. Nutrition in chronic critical illness. Clin Chest Med 2001; 22: 149-163.
44. Alley DE, Koster A, Mackey D etal. Hospitalization and change in body composition and strength in a population-based cohort of older persons. J Am Geriatr Soc 2010; 58: 2085-2091.
45. Yang MU, Van Itallie TB. Composition of weight lost during short-term weight reduction. Metabolic responses of obese subjects to starvation and low-calorie ketogenic and nonketogenic diets. J Clin Invest 1976; 58: 722-730.
46. Heymsfield SB, Thomas D, Nguyen AM etal. Voluntary weight loss: systematic review of early phase body composition changes. Obes Rev 2011; 12: e348-e361.
47. Benedict FG. An experiment on a fasting man. Science 1912; 35: 865.
48. Forbes GB. Weight loss during fasting: implications for the obese. Am J Clin Nutr 1970; 23: 1212-1219.
49. Forbes GB, Drenick EJ. Loss of body nitrogen on fasting. Am J Clin Nutr 1979; 32: 1570-1574.
50. Hall KD, Butte NF, Swinburn BA, Chow CC. Quantifying the dynamics of childhood growth and obesity. Lancet Diabetes Endocrinol 2013; 1: 97-105.
51. Forbes GB. Longitudinal changes in adult fat-free mass: influence of body weight. Am J Clin Nutr 1999; 70: 1025-1031.
52. Goodpaster BH, Park SW, Harris TB etal. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci 2006; 61: 1059-1064.
53. Krasnoff J, Painter P. The physiological consequences of bed rest and inactivity. Adv Ren Replace Ther 1999; 6: 124-132.
54. LeBlanc AD, Schneider VS, Evans HJ, Pientok C, Rowe R, Spector E. Regional changes in muscle mass following 17 weeks of bed rest. J Appl Physiol 1992; 73: 2172-2178.
55. Bouchard C, Tremblay A, Despres JP etal. The response to exercise with constant energy intake in identical twins. Obes Res 1994; 2: 400-410.
56. Ross R, Dagnone D, Jones PJ etal. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med 2000; 133: 92-103.
57. Ross R, Janssen I, Dawson J etal. Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obes Res 2004; 12: 789-798.
58. Martins C, Kulseng B, Rehfeld JF, King NA, Blundell JE. Impact of chronic exercise on appetite control in overweight and obese individuals. Med Sci Sports Exerc 2012.
59. King NA, Caudwell P, Hopkins M etal. Metabolic and behavioral compensatory responses to exercise interventions: barriers to weight loss. Obesity (Silver Spring) 2007; 15: 1373-1383.
60. Thomas DM, Bouchard C, Church T etal. Why do individuals not lose more weight from an exercise intervention at a defined dose? An energy balance analysis. Obes Rev 2012; 13: 835-847.
61. Church TS, Earnest CP, Thompson AM etal. Exercise without weight loss does not reduce C-reactive protein: the INFLAME study. Med Sci Sports Exerc 2010; 42: 708-716.
62. Forbes GB. Exercise and lean weight: the influence of body weight. Nutr Rev 1992; 50: 157-161.
63. Forbes GB. Exercise and body composition. J Appl Physiol 1991; 70: 994-997.
64. Forbes GB. Body fat content influences the body composition response to nutrition and exercise. Ann N Y Acad Sci 2000; 904: 359-365.
65. Redman LM, Heilbronn LK, Martin CK, Alfonso A, Smith SR, Ravussin E. Effect of calorie restriction with or without exercise on body composition and fat distribution. J Clin Endocrinol Metab 2007; 92: 865-872.
66. Racette SB, Das SK, Bhapkar M etal. Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE study. Am J Physiol Endocrinol Metab 2012; 302: E441-E448.
67. Janssen I, Ross R. Effects of sex on the change in visceral, subcutaneous adipose tissue and skeletal muscle in response to weight loss. Int J Obes Relat Metab Disord 1999; 23: 1035-1046.
68. Janssen I, Fortier A, Hudson R, Ross R. Effects of an energy-restrictive diet with or without exercise on abdominal fat, intermuscular fat, and metabolic risk factors in obese women. Diabetes Care 2002; 25: 431-438.
69. Rice B, Janssen I, Hudson R, Ross R. Effects of aerobic or resistance exercise and/or diet on glucose tolerance and plasma insulin levels in obese men. Diabetes Care 1999; 22: 684-691.
70. Johannsen DL, Knuth ND, Huizenga R etal. Metabolic slowing with massive weight loss despite preservation of fat-free mass. J Clin Endocrinol Metab 2012; 97: 2489-2496.
71. Hall KD. Diet versus exercise in 'the biggest loser' weight loss competition. Obesity (Silver Spring) 2013; 21: 957-959.
72. Redman LM, Huffman KM, Landerman LR etal. Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women. J Clin Endocrinol Metab 2011; 96: E312-E321.
73. Hoyt RW, Friedl KE. Field studies of exercise and food deprivation. Curr Opin Clin Nutr Metab Care 2006; 9: 685-690.
74. Galgani JE, Smith SR, Ravussin E. Assessment of EchoMRI-AH versus dual-energy X-ray absorptiometry to measure human body composition. Int J Obes (Lond) 2011; 35: 1241-1246.
75. Baracos V, Caserotti P, Earthman CP etal. Advances in the science and application of body composition measurement. JPEN J Parenter Enteral Nutr 2012; 36: 96-107.