Exometabolome analysis identifies pyruvate dehydrogenase as a target for the antibiotic triphenylbismuthdichloride in multiresistant bacterial pathogens

Journal of Biological Chemistry

Volumn 287, Issue 4, 2012, Pages 2887-2895

  Birkenstock, Timo ^a   Liebeke, Manuel ^b,c   Winstel, Volker ^a   Krismer, Bernhard ^a   Gekeler, Cordula ^a   Niemiec, Maria J ^a   Bisswanger, Hans ^a   Lalk, Michael ^b   Peschel, Andreas ^a,d  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; METABOLITES;

ANTI-MICROBIAL ACTIVITY; ANTIBACTERIAL PROPERTIES; ANTIBIOTIC-RESISTANT BACTERIA; ANTIMICROBIAL COMPOUNDS; BACTERIAL PATHOGENS; MULTIDRUG RESISTANTS; PYRUVATE DEHYDROGENASE COMPLEX; STANDARD TECHNOLOGY;

BACTERIA;

ANTIBIOTIC AGENT; PYRUVATE DEHYDROGENASE; TRIPHENYLBISMUTHDICHLORIDE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CATABOLISM; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG TARGETING; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ENZYME INHIBITION; ESCHERICHIA COLI; EXOMETABOLOME; IC 50; METABOLITE; METABOLOME; METABOLOMICS; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 84856077934     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.288894     Document Type: Article

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