Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Crewe, Clair ^a,b   Kinter, Michael ^a,b   Szweda, Luke I ^a,b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE TRANSPORTER 4; GLYCOLYTIC ENZYME; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE 4; PYRUVIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DIET RESTRICTION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; GLYCOLYSIS; HEART METABOLIC FLEXIBILITY; HEART MITOCHONDRION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE METABOLISM; KNOCKOUT MOUSE; LIPID DIET; LOW FAT DIET; MALE; METABOLIC REGULATION; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; DIET, FAT-RESTRICTED; DIET, HIGH-FAT; DIETARY FATS; INSULIN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MYOCARDIUM; PROTEIN KINASES; PYRUVIC ACID;

EID: 84885041766     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077280     Document Type: Article

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