메뉴 건너뛰기




Volumn 112, Issue 5, 2014, Pages 876-882

Protease-activated receptor signalling by coagulation proteases in endothelial cells

Author keywords

Activated protein C; Protease activated receptor; Signalling; Thrombin

Indexed keywords

ACTIVATED PROTEIN C; ADENOSINE RECEPTOR; BETA ARRESTIN; BLOOD CLOTTING FACTOR; ENDOTHELIAL PROTEIN C RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN C;

EID: 84908542525     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH14-02-0167     Document Type: Article
Times cited : (113)

References (78)
  • 1
    • 28344436780 scopus 로고    scopus 로고
    • Protease-activated receptors in hemostasis, thrombosis and vascular biology
    • Coughlin SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 2005; 3: 1800-1814.
    • (2005) J Thromb Haemost , vol.3 , pp. 1800-1814
    • Coughlin, S.R.1
  • 2
    • 0141498162 scopus 로고    scopus 로고
    • 2003. Specificity of coagulation factor signalling
    • Ruf W, Dorfleutner A, Riewald M. 2003. Specificity of coagulation factor signalling. J Thromb Haemost 2003; 1: 1495-1503.
    • (2003) J Thromb Haemost , vol.1 , pp. 1495-1503
    • Ruf, W.1    Dorfleutner, A.2    Riewald, M.3
  • 3
    • 33748495552 scopus 로고    scopus 로고
    • Protease-activated receptors in cardiovascular diseases
    • Leger AJ, Covic L, Kuliopulos A. Protease-activated receptors in cardiovascular diseases. Circulation 2006; 114: 1070-1077.
    • (2006) Circulation , vol.114 , pp. 1070-1077
    • Leger, A.J.1    Covic, L.2    Kuliopulos, A.3
  • 4
    • 79959602165 scopus 로고    scopus 로고
    • Protease-activated receptors and myocardial infarction
    • Antoniak S, Pawlinski R, Mackman N. Protease-activated receptors and myocardial infarction. IUBMB Life 2011; 63: 383-389.
    • (2011) IUBMB Life , vol.63 , pp. 383-389
    • Antoniak, S.1    Pawlinski, R.2    Mackman, N.3
  • 5
    • 0032499696 scopus 로고    scopus 로고
    • Cloning and characterisation of human protease-activated receptor 4
    • Xu WF, Andersen H, Whitmore TE, et al. Cloning and characterisation of human protease-activated receptor 4. Proc Natl Acad Sci USA 1998; 95: 6642-6646.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6642-6646
    • Xu, W.F.1    Andersen, H.2    Whitmore, T.E.3
  • 6
    • 29244436695 scopus 로고    scopus 로고
    • Protease-activated receptor-1 and-2 can mediate endothelial barrier protection: Role in factor Xa signalling
    • Feistritzer C, Lenta R, Riewald M. Protease-activated receptor-1 and-2 can mediate endothelial barrier protection: role in factor Xa signalling. J Thromb Haemost 2005; 3: 2798-2805.
    • (2005) J Thromb Haemost , vol.3 , pp. 2798-2805
    • Feistritzer, C.1    Lenta, R.2    Riewald, M.3
  • 7
    • 34249307505 scopus 로고    scopus 로고
    • Modulation of tissue factor-factor VIIa signalling by lipid rafts and caveolae
    • Awasthi V, Mandal SK, Papanna V, et al. Modulation of tissue factor-factor VIIa signalling by lipid rafts and caveolae. Arterioscler Thromb Vasc Biol 2007; 27: 1447-1455.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1447-1455
    • Awasthi, V.1    Mandal, S.K.2    Papanna, V.3
  • 8
    • 34247218063 scopus 로고    scopus 로고
    • Cytokine upregulation of proteinase-activated receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cells
    • Ritchie E, Saka M, MacKenzie C, et al. Cytokine upregulation of proteinase-activated receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cells. Br J Pharmacol 2007; 150: 1044-1054.
    • (2007) Br J Pharmacol , vol.150 , pp. 1044-1054
    • Ritchie, E.1    Saka, M.2    McKenzie, C.3
  • 9
    • 34248374907 scopus 로고    scopus 로고
    • Protease-activated receptor-3 (PAR3) regulates PAR1 signalling by receptor dimerisation
    • McLaughlin JN, Patterson MM, Malik AB. Protease-activated receptor-3 (PAR3) regulates PAR1 signalling by receptor dimerisation. Proc Natl Acad Sci USA 2007; 104: 5662-5667.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5662-5667
    • McLaughlin, J.N.1    Patterson, M.M.2    Malik, A.B.3
  • 10
    • 37049012509 scopus 로고    scopus 로고
    • The ligand occupancy of endothelial protein C receptor switches the PAR-1-dependent signalling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells
    • Bae JS, Yang L, Manithody C, et al. The ligand occupancy of endothelial protein C receptor switches the PAR-1-dependent signalling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells. Blood 2007; 110: 3909-3916.
    • (2007) Blood , vol.110 , pp. 3909-3916
    • Bae, J.S.1    Yang, L.2    Manithody, C.3
  • 11
    • 21644449969 scopus 로고    scopus 로고
    • Functional selectivity of G protein signalling by agonist peptides and thrombin for the protease-activated receptor-1
    • McLaughlin JN, Shen L, Holinstat M, et al. Functional selectivity of G protein signalling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem 2005; 280: 25048-25059.
    • (2005) J Biol Chem , vol.280 , pp. 25048-25059
    • McLaughlin, J.N.1    Shen, L.2    Holinstat, M.3
  • 12
    • 34147119744 scopus 로고    scopus 로고
    • The cytoprotective protein C pathway
    • Mosnier LO, Griffin JH. The cytoprotective protein C pathway. Blood 2007; 109: 3161-3172.
    • (2007) Blood , vol.109 , pp. 3161-3172
    • Mosnier, L.O.1    Griffin, J.H.2
  • 13
    • 84859718853 scopus 로고    scopus 로고
    • Protein C anticoagulant system-anti-inflammatory effects
    • Esmon CT. Protein C anticoagulant system-anti-inflammatory effects. Semin Immunopathol 2012; 34: 127-132.
    • (2012) Semin Immunopathol , vol.34 , pp. 127-132
    • Esmon, C.T.1
  • 14
    • 80052502628 scopus 로고    scopus 로고
    • Multiple receptor-mediated functions of activated protein C
    • Weiler H. Multiple receptor-mediated functions of activated protein C. Hamostaseologie 2011; 31: 185-195.
    • (2011) Hamostaseologie , vol.31 , pp. 185-195
    • Weiler, H.1
  • 15
    • 67849101852 scopus 로고    scopus 로고
    • The protein C pathway and pathologic processes
    • Castellino FJ, Ploplis VA. The protein C pathway and pathologic processes. J Thromb Haemost 2009; 7 (Suppl 1): 140-145.
    • (2009) J Thromb Haemost , vol.7 , pp. 140-145
    • Castellino, F.J.1    Ploplis, V.A.2
  • 16
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Eng J Med 2001; 344: 699-709.
    • (2001) N Eng J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 17
    • 83455234966 scopus 로고    scopus 로고
    • Drug for severe sepsis is withdrawn from market, fails to reduce mortality
    • Mitka M. Drug for severe sepsis is withdrawn from market, fails to reduce mortality. J Am Med Assoc 2011; 306: 2439-2440.
    • (2011) J Am Med Assoc , vol.306 , pp. 2439-2440
    • Mitka, M.1
  • 18
    • 84865278685 scopus 로고    scopus 로고
    • Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: A meta-analysis and metaregression
    • Kalil AC, LaRosa SP. Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: a meta-analysis and metaregression. Lancet Infect Dis 2012; 12: 678-686.
    • (2012) Lancet Infect Dis , vol.12 , pp. 678-686
    • Kalil, A.C.1    LaRosa, S.P.2
  • 20
    • 17044433166 scopus 로고    scopus 로고
    • APC signalling: Tickling PAR1 for barrier protection?
    • Camerer E, Coughlin SR. APC signalling: tickling PAR1 for barrier protection? Blood 2005; 105: 3004-3005.
    • (2005) Blood , vol.105 , pp. 3004-3005
    • Camerer, E.1    Coughlin, S.R.2
  • 21
    • 1642279517 scopus 로고    scopus 로고
    • Protease-activated receptors: Contribution to physiology and disease
    • Ossovskaya VS, Bunnett NW. Protease-activated receptors: Contribution to physiology and disease. Physiol Rev 2004; 84: 579-621.
    • (2004) Physiol Rev , vol.84 , pp. 579-621
    • Ossovskaya, V.S.1    Bunnett, N.W.2
  • 22
    • 0032529677 scopus 로고    scopus 로고
    • Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intracellular adhesion molecule-1 (ICAM-1; CD54) and vascular cell adhesion molecule-1 (VCAM-1; CD106)
    • Kaplanski G, Marin V, Fabrigoule M, et al. Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intracellular adhesion molecule-1 (ICAM-1; CD54) and vascular cell adhesion molecule-1 (VCAM-1; CD106). Blood 1998; 92: 1259-1267.
    • (1998) Blood , vol.92 , pp. 1259-1267
    • Kaplanski, G.1    Marin, V.2    Fabrigoule, M.3
  • 23
    • 0035815747 scopus 로고    scopus 로고
    • Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
    • Joyce DE, Gelbert L, Ciaccia A, et al. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 2001; 276: 11199-11203.
    • (2001) J Biol Chem , vol.276 , pp. 11199-11203
    • Joyce, D.E.1    Gelbert, L.2    Ciaccia, A.3
  • 24
    • 20444443508 scopus 로고    scopus 로고
    • Activated protein C mediates novel lung endothelial barrier enhancement: Role of sphingosine 1-phosphate receptor transactivation
    • Finigan JH, Dudek SM, Singleton PA, et al. Activated protein C mediates novel lung endothelial barrier enhancement: Role of sphingosine 1-phosphate receptor transactivation. J Biol Chem 2005; 280: 17286-17293.
    • (2005) J Biol Chem , vol.280 , pp. 17286-17293
    • Finigan, J.H.1    Dudek, S.M.2    Singleton, P.A.3
  • 25
    • 62549145323 scopus 로고    scopus 로고
    • Thrombin inhibits nuclear factor (B and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C
    • Bae JS, Rezaie AR. Thrombin inhibits nuclear factor B and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C. Thromb Haemost 2009; 101: 513-520.
    • (2009) Thromb Haemost , vol.101 , pp. 513-520
    • Bae, J.S.1    Rezaie, A.R.2
  • 26
    • 0027378281 scopus 로고
    • Internalisation and recycling of activated thrombin receptors
    • Hoxie JA, Ahuja M, Belmonte E, et al. Internalisation and recycling of activated thrombin receptors. J Biol Chem 1993; 268: 13756-13763.
    • (1993) J Biol Chem , vol.268 , pp. 13756-13763
    • Hoxie, J.A.1    Ahuja, M.2    Belmonte, E.3
  • 27
    • 0028053488 scopus 로고
    • Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitisation of a G proteincoupled receptor
    • Hein L, Ishii K, Coughlin SR, et al. Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitisation of a G proteincoupled receptor. J Biol Chem 1994; 269: 27719-27726.
    • (1994) J Biol Chem , vol.269 , pp. 27719-27726
    • Hein, L.1    Ishii, K.2    Coughlin, S.R.3
  • 28
    • 0020370172 scopus 로고
    • Use of endothelium cultured on microcarriers as a model for the microcirculation
    • Busch C, Cancilla PA, DeBault LE, et al. Use of endothelium cultured on microcarriers as a model for the microcirculation. Lab Invest 1982; 47: 498-504.
    • (1982) Lab Invest , vol.47 , pp. 498-504
    • Busch, C.1    Cancilla, P.A.2    DeBault, L.E.3
  • 29
    • 0028338559 scopus 로고
    • Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101
    • Ye J, Rezaie AR, Esmon CT. Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101. J Biol Chem 1994; 269: 17965-17970.
    • (1994) J Biol Chem , vol.269 , pp. 17965-17970
    • Ye, J.1    Rezaie, A.R.2    Esmon, C.T.3
  • 30
    • 34547108343 scopus 로고    scopus 로고
    • Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site
    • Nieman MT, Schmaier AH. Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site. Biochemistry 2007; 46: 8603-8610.
    • (2007) Biochemistry , vol.46 , pp. 8603-8610
    • Nieman, M.T.1    Schmaier, A.H.2
  • 31
    • 33847329718 scopus 로고    scopus 로고
    • Receptors of the protein C activation and activated protein C signalling pathways are colocalized in lipid rafts of endothelial cells
    • Bae JS, Yang L, Rezaie AR. Receptors of the protein C activation and activated protein C signalling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci USA 2007; 104: 2867-2872.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2867-2872
    • Bae, J.S.1    Yang, L.2    Rezaie, A.R.3
  • 32
    • 43749120051 scopus 로고    scopus 로고
    • Lipid raft localisation regulates the cleavage specificity of protease activated receptor 1 in endothelial cells
    • Bae JS, Yang L, Rezaie AR. Lipid raft localisation regulates the cleavage specificity of protease activated receptor 1 in endothelial cells. J Thromb Haemost 2008; 6: 954-961.
    • (2008) J Thromb Haemost , vol.6 , pp. 954-961
    • Bae, J.S.1    Yang, L.2    Rezaie, A.R.3
  • 33
    • 84871584695 scopus 로고    scopus 로고
    • Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46
    • Mosnier LO, Sinha RK, Burnier L, et al. Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46. Blood 2012; 120: 5237-5246.
    • (2012) Blood , vol.120 , pp. 5237-5246
    • Mosnier, L.O.1    Sinha, R.K.2    Burnier, L.3
  • 34
    • 84865210286 scopus 로고    scopus 로고
    • Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects
    • Schuepbach RA, Madon J, Ender M, et al. Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects. J Thromb Haemost 2012; 10: 1675-1684.
    • (2012) J Thromb Haemost , vol.10 , pp. 1675-1684
    • Schuepbach, R.A.1    Madon, J.2    Ender, M.3
  • 35
    • 16844383361 scopus 로고    scopus 로고
    • PAR1 cleavage and signalling in response to activated protein C and thrombin
    • Ludeman MJ, Kataoka H, Srinivasan Y, et al. PAR1 cleavage and signalling in response to activated protein C and thrombin. J Biol Chem 2005; 280: 13122-13128.
    • (2005) J Biol Chem , vol.280 , pp. 13122-13128
    • Ludeman, M.J.1    Kataoka, H.2    Srinivasan, Y.3
  • 36
    • 54949115420 scopus 로고    scopus 로고
    • Protective effects of activated protein C in sepsis
    • Toltl LJ, Swystun LL, Pepler L, et al. Protective effects of activated protein C in sepsis. Thromb Haemost 2008; 100: 582-592.
    • (2008) Thromb Haemost , vol.100 , pp. 582-592
    • Toltl, L.J.1    Swystun, L.L.2    Pepler, L.3
  • 37
    • 67649890872 scopus 로고    scopus 로고
    • Activated protein C: A promising drug with multiple effects?
    • Loubele ST, Spronk HM, Ten Cate H. Activated protein C: a promising drug with multiple effects? Mini Rev Med Chem 2009; 9: 620-626.
    • (2009) Mini Rev Med Chem , vol.9 , pp. 620-626
    • Loubele, S.T.1    Spronk, H.M.2    Ten Cate, H.3
  • 38
    • 0027943163 scopus 로고
    • Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor
    • Fukudome K, Esmon CT. Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem 1994; 269: 26486-26491.
    • (1994) J Biol Chem , vol.269 , pp. 26486-26491
    • Fukudome, K.1    Esmon, C.T.2
  • 39
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • Riewald M, Petrovan RJ, Donner A, et al. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 2002; 296: 1880-1882.
    • (2002) Science , vol.296 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3
  • 40
    • 0030666197 scopus 로고    scopus 로고
    • The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C
    • Regan LM, Mollica JS, Rezaie AR, et al. The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C. J Biol Chem 1997; 272: 26279-26284.
    • (1997) J Biol Chem , vol.272 , pp. 26279-26284
    • Regan, L.M.1    Mollica, J.S.2    Rezaie, A.R.3
  • 41
    • 33746017989 scopus 로고    scopus 로고
    • Protective signalling by activated protein C is mechanistically linked to protein C activation on endothelial cells
    • Feistritzer C, Schuepbach RA, Mosnier LO, et al. Protective signalling by activated protein C is mechanistically linked to protein C activation on endothelial cells. J Biol Chem 2006; 281: 20077-20084.
    • (2006) J Biol Chem , vol.281 , pp. 20077-20084
    • Feistritzer, C.1    Schuepbach, R.A.2    Mosnier, L.O.3
  • 42
    • 80053617611 scopus 로고    scopus 로고
    • Activated protein C inhibits high mobility group box 1 signalling in endothelial cells
    • Bae JS, Rezaie AR. Activated protein C inhibits high mobility group box 1 signalling in endothelial cells. Blood 2011; 118: 3952-3959.
    • (2011) Blood , vol.118 , pp. 3952-3959
    • Bae, J.S.1    Rezaie, A.R.2
  • 43
    • 79959580714 scopus 로고    scopus 로고
    • The occupancy of endothelial protein C receptor by its ligand modulates the PAR1-dependent signalling specificity of coagulation proteases
    • Rezaie AR. The occupancy of endothelial protein C receptor by its ligand modulates the PAR1-dependent signalling specificity of coagulation proteases. IUBMB Life 2011; 63: 390-396.
    • (2011) IUBMB Life , vol.63 , pp. 390-396
    • Rezaie, A.R.1
  • 44
    • 33751533776 scopus 로고    scopus 로고
    • New roles for (-arrestins in cell signalling: Not just for seven-transmembrane receptors
    • Lefkowitz RJ, Rajagopal K, Whalen EJ. New roles for -arrestins in cell signalling: Not just for seven-transmembrane receptors. Molecular Cell 2006; 24: 643-652.
    • (2006) Molecular Cell , vol.24 , pp. 643-652
    • Lefkowitz, R.J.1    Rajagopal, K.2    Whalen, E.J.3
  • 45
    • 80052359992 scopus 로고    scopus 로고
    • Emerging paradigms of arrestin-dependent seven transmembrane receptor signalling
    • Shukla AK, Xiao K, Lefkowitz RJ. Emerging paradigms of arrestin-dependent seven transmembrane receptor signalling. Trends Biochem Sci 2011; 36: 457-469.
    • (2011) Trends Biochem Sci , vol.36 , pp. 457-469
    • Shukla, A.K.1    Xiao, K.2    Lefkowitz, R.J.3
  • 46
    • 84055182505 scopus 로고    scopus 로고
    • Activated protein C promotes protease-activated receptor-1 cytoprotective signalling through arrestin and dishevelled-2 scaffolds
    • Soh UJ, Trejo J. Activated protein C promotes protease-activated receptor-1 cytoprotective signalling through arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci USA 2011; 108: E1372-1380.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. E1372-E1380
    • Soh, U.J.1    Trejo, J.2
  • 47
    • 84880617084 scopus 로고    scopus 로고
    • Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway
    • Bouwens EA, Stavenuiter F, Mosnier LO. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. J Thromb Haemost 2013; 11 (Suppl 1): 242-253.
    • (2013) J Thromb Haemost , vol.11 , pp. 242-253
    • Bouwens, E.A.1    Stavenuiter, F.2    Mosnier, L.O.3
  • 48
    • 41949096728 scopus 로고    scopus 로고
    • Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
    • Schuepbach RA, Feistritzer C, Brass LF, et al. Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin. Blood 2008; 111: 2667-2673.
    • (2008) Blood , vol.111 , pp. 2667-2673
    • Schuepbach, R.A.1    Feistritzer, C.2    Brass, L.F.3
  • 49
    • 38049101163 scopus 로고    scopus 로고
    • Inhibition of tissue factor signalling suppresses tumour growth
    • Versteeg HH, Schaffner F, Kerver M, et al. Inhibition of tissue factor signalling suppresses tumour growth. Blood 2008; 111: 190-199.
    • (2008) Blood , vol.111 , pp. 190-199
    • Versteeg, H.H.1    Schaffner, F.2    Kerver, M.3
  • 50
    • 84884644419 scopus 로고    scopus 로고
    • Activation of blood coagulation in cancer: Implications for tumour progression
    • Lima LG, Monteiro RQ. Activation of blood coagulation in cancer: implications for tumour progression. Biosci Rep 2013; 33: pii: e00064. doi: 10. 1042/BSR20130057.
    • (2013) Biosci Rep , vol.33
    • Lima, L.G.1    Monteiro, R.Q.2
  • 51
    • 2442647329 scopus 로고    scopus 로고
    • Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain
    • Ahamed J, Ruf W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain. J Biol Chem 2004; 279: 23038-23044.
    • (2004) J Biol Chem , vol.279 , pp. 23038-23044
    • Ahamed, J.1    Ruf, W.2
  • 52
    • 12844283269 scopus 로고    scopus 로고
    • Tissue factor cytoplasmic domain stimulates migration by activation of the GTPase Rac1 and the mitogen-activated protein kinase p38
    • Ott I, Weigand B, Michl R, et al. Tissue factor cytoplasmic domain stimulates migration by activation of the GTPase Rac1 and the mitogen-activated protein kinase p38. Circulation 2005; 111: 349-355.
    • (2005) Circulation , vol.111 , pp. 349-355
    • Ott, I.1    Weigand, B.2    Michl, R.3
  • 53
    • 34249998690 scopus 로고    scopus 로고
    • Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia
    • Ahamed J, Niessen F, Kurokawa T, et al. Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia. Blood 2007; 109: 5251-5259.
    • (2007) Blood , vol.109 , pp. 5251-5259
    • Ahamed, J.1    Niessen, F.2    Kurokawa, T.3
  • 54
    • 77949267709 scopus 로고    scopus 로고
    • Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor
    • Pendurthi UR, Rao LV. Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor. Thromb Res 2010; 125 (Suppl 1): S19-22.
    • (2010) Thromb Res , vol.125 , pp. S19-S22
    • Pendurthi, U.R.1    Rao, L.V.2
  • 55
    • 34249722192 scopus 로고    scopus 로고
    • Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium
    • Ghosh S, Pendurthi UR, Steinoe A, et al. Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium. J Biol Chem 2007; 282: 11849-11857.
    • (2007) J Biol Chem , vol.282 , pp. 11849-11857
    • Ghosh, S.1    Pendurthi, U.R.2    Steinoe, A.3
  • 56
    • 79953092222 scopus 로고    scopus 로고
    • Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signalling and barrier protection
    • Sen P, Gopalakrishnan R, Kothari H, et al. Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signalling and barrier protection. Blood 2011; 117: 3199-3208.
    • (2011) Blood , vol.117 , pp. 3199-3208
    • Sen, P.1    Gopalakrishnan, R.2    Kothari, H.3
  • 57
    • 0034933683 scopus 로고    scopus 로고
    • Mechanistic coupling of protease signalling and initiation of coagulation by tissue factor
    • Riewald M, Ruf W. Mechanistic coupling of protease signalling and initiation of coagulation by tissue factor. Proc Natl Acad Sci USA 2001; 98: 7742-7747.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7742-7747
    • Riewald, M.1    Ruf, W.2
  • 58
    • 41949107997 scopus 로고    scopus 로고
    • Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1
    • Bhattacharjee G, Ahamed J, Pawlinski R, et al. Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. Circ Res 2008; 102: 457-464.
    • (2008) Circ Res , vol.102 , pp. 457-464
    • Bhattacharjee, G.1    Ahamed, J.2    Pawlinski, R.3
  • 59
    • 84887099656 scopus 로고    scopus 로고
    • Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue
    • Bukowska A, Zacharias I, Weinert S, et al. Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue. Eur J Pharmacol 2013; 718: 114-123.
    • (2013) Eur J Pharmacol , vol.718 , pp. 114-123
    • Bukowska, A.1    Zacharias, I.2    Weinert, S.3
  • 60
    • 33746958348 scopus 로고    scopus 로고
    • Factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation
    • Daubie V, Cauwenberghs S, Senden NH, et al. Factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation. Biochim Biophys Acta 2006; 1763: 860-869.
    • (2006) Biochim Biophys Acta , vol.1763 , pp. 860-869
    • Daubie, V.1    Cauwenberghs, S.2    Senden, N.H.3
  • 61
    • 0032531987 scopus 로고    scopus 로고
    • Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells
    • Senden NH, Jeunhomme TM, Heemskerk JW, et al. Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells. J Immunol 1998; 161: 4318-4824.
    • (1998) J Immunol , vol.161 , pp. 4318-4824
    • Senden, N.H.1    Jeunhomme, T.M.2    Heemskerk, J.W.3
  • 62
    • 84863229975 scopus 로고    scopus 로고
    • Determinants of the specificity of proteaseactivated receptors 1 and 2 signalling by factor Xa and thrombin
    • Rana S, Yang L, Hassanian SM, et al. Determinants of the specificity of proteaseactivated receptors 1 and 2 signalling by factor Xa and thrombin. J Cell Biochem 2012; 113: 977-984.
    • (2012) J Cell Biochem , vol.113 , pp. 977-984
    • Rana, S.1    Yang, L.2    Hassanian, S.M.3
  • 63
    • 84859188873 scopus 로고    scopus 로고
    • Identification of exosite residues of factor Xa involved in recognition of PAR-2 on endothelial cells
    • Manithody C, Yang L, Rezaie AR. Identification of exosite residues of factor Xa involved in recognition of PAR-2 on endothelial cells. Biochemistry 2012; 51: 2551-2557.
    • (2012) Biochemistry , vol.51 , pp. 2551-2557
    • Manithody, C.1    Yang, L.2    Rezaie, A.R.3
  • 64
    • 0030934186 scopus 로고    scopus 로고
    • Activation-dependent exposure of the inter-EGF sequence Leu83-Leu88 in factor Xa mediates ligand binding to effector cell protease receptor-1
    • Ambrosini G, Plescia J, Chu KC, et al. Activation-dependent exposure of the inter-EGF sequence Leu83-Leu88 in factor Xa mediates ligand binding to effector cell protease receptor-1. J Biol Chem 1997; 272: 8340-8345.
    • (1997) J Biol Chem , vol.272 , pp. 8340-8345
    • Ambrosini, G.1    Plescia, J.2    Chu, K.C.3
  • 65
    • 78049357602 scopus 로고    scopus 로고
    • Factor X/Xa elicits protective signalling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1
    • Bae JS, Yang L, Rezaie AR. Factor X/Xa elicits protective signalling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. J Biol Chem 2010; 285: 34803-34812.
    • (2010) J Biol Chem , vol.285 , pp. 34803-34812
    • Bae, J.S.1    Yang, L.2    Rezaie, A.R.3
  • 66
    • 46749084607 scopus 로고    scopus 로고
    • Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand
    • Bae JS, Rezaie AR. Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand. Thromb Haemost 2008; 100: 101-109.
    • (2008) Thromb Haemost , vol.100 , pp. 101-109
    • Bae, J.S.1    Rezaie, A.R.2
  • 67
    • 36049027020 scopus 로고    scopus 로고
    • Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation
    • Slofstra SH, Bijlsma MF, Groot AP, et al. Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation. Blood 2007; 110: 3176-3182.
    • (2007) Blood , vol.110 , pp. 3176-3182
    • Slofstra, S.H.1    Bijlsma, M.F.2    Groot, A.P.3
  • 68
    • 17044427680 scopus 로고    scopus 로고
    • Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
    • Feistritzer C, Riewald, M. Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood 2005; 105: 3178-3184.
    • (2005) Blood , vol.105 , pp. 3178-3184
    • Feistritzer, C.1    Riewald, M.2
  • 69
    • 77952296543 scopus 로고    scopus 로고
    • Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function
    • Minhas N, Xue M, Fukudome K, et al. Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function. FASEB J 2010; 24: 873-881.
    • (2010) FASEB J , vol.24 , pp. 873-881
    • Minhas, N.1    Xue, M.2    Fukudome, K.3
  • 70
    • 77953806379 scopus 로고    scopus 로고
    • Thrombin upregulates the angiopoietin-Tie2 Axis: Endothelial protein C receptor occupancy prevents the thrombin mobilisation of angiopoietin 2 and P-selectin from Weibel-Palade bodies
    • Bae JS, Rezaie AR. Thrombin upregulates the angiopoietin-Tie2 Axis: endothelial protein C receptor occupancy prevents the thrombin mobilisation of angiopoietin 2 and P-selectin from Weibel-Palade bodies. J Thromb Haemost 2010; 8: 1107-1115.
    • (2010) J Thromb Haemost , vol.8 , pp. 1107-1115
    • Bae, J.S.1    Rezaie, A.R.2
  • 71
    • 58549121206 scopus 로고    scopus 로고
    • Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signalling in U937 cells
    • Yang XV, Banerjee Y, Fernández JA, et al. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signalling in U937 cells. Proc Natl Acad Sci USA 2009; 106: 274-279.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 274-279
    • Yang, X.V.1    Banerjee, Y.2    Fernández, J.A.3
  • 72
    • 77953202368 scopus 로고    scopus 로고
    • The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b
    • Cao C, Gao Y, Li Y, et al. The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Invest 2010; 120: 1971-1980.
    • (2010) J Clin Invest , vol.120 , pp. 1971-1980
    • Cao, C.1    Gao, Y.2    Li, Y.3
  • 73
    • 41649094810 scopus 로고    scopus 로고
    • Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation
    • Niessen F, Schaffner F, Furlan-Freguia C, et al. Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature 2008; 452: 654-658.
    • (2008) Nature , vol.452 , pp. 654-658
    • Niessen, F.1    Schaffner, F.2    Furlan-Freguia, C.3
  • 74
    • 1342269932 scopus 로고    scopus 로고
    • Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3
    • Guo H, Liu D, Gelbard H, et al. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron 2004; 41: 563-572.
    • (2004) Neuron , vol.41 , pp. 563-572
    • Guo, H.1    Liu, D.2    Gelbard, H.3
  • 75
    • 84872193981 scopus 로고    scopus 로고
    • Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc
    • Bock F, Shahzad K, Wang H, et al. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci USA 2013; 110: 648-653.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 648-653
    • Bock, F.1    Shahzad, K.2    Wang, H.3
  • 76
    • 84886430553 scopus 로고    scopus 로고
    • Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3
    • Burnier L, Mosnier LO. Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3. Blood 2013; 122: 807-816.
    • (2013) Blood , vol.122 , pp. 807-816
    • Burnier, L.1    Mosnier, L.O.2
  • 77
    • 84887491969 scopus 로고    scopus 로고
    • Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by thrombin
    • Arachiche A, Mumaw MM, de la Fuente M, et al. Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by thrombin. J Biol Chem 2013; 288: 32553-32562.
    • (2013) J Biol Chem , vol.288 , pp. 32553-32562
    • Arachiche, A.1    Mumaw, M.M.2    de la Fuente, M.3
  • 78
    • 84901236503 scopus 로고    scopus 로고
    • Adenosine Regulates the Proinflammatory Signalling Function of Thrombin in Endothelial Cells
    • Epub ahead of print
    • Hassanian SM, Dinarvand P, Rezaie AR. Adenosine Regulates the Proinflammatory Signalling Function of Thrombin in Endothelial Cells. J Cell Physiol 2014; Epub ahead of print.
    • (2014) J Cell Physiol
    • Hassanian, S.M.1    Dinarvand, P.2    Rezaie, A.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.