-
1
-
-
28344436780
-
Protease-activated receptors in hemostasis, thrombosis and vascular biology
-
Coughlin SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 2005; 3: 1800-1814.
-
(2005)
J Thromb Haemost
, vol.3
, pp. 1800-1814
-
-
Coughlin, S.R.1
-
2
-
-
0141498162
-
2003. Specificity of coagulation factor signalling
-
Ruf W, Dorfleutner A, Riewald M. 2003. Specificity of coagulation factor signalling. J Thromb Haemost 2003; 1: 1495-1503.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 1495-1503
-
-
Ruf, W.1
Dorfleutner, A.2
Riewald, M.3
-
3
-
-
33748495552
-
Protease-activated receptors in cardiovascular diseases
-
Leger AJ, Covic L, Kuliopulos A. Protease-activated receptors in cardiovascular diseases. Circulation 2006; 114: 1070-1077.
-
(2006)
Circulation
, vol.114
, pp. 1070-1077
-
-
Leger, A.J.1
Covic, L.2
Kuliopulos, A.3
-
4
-
-
79959602165
-
Protease-activated receptors and myocardial infarction
-
Antoniak S, Pawlinski R, Mackman N. Protease-activated receptors and myocardial infarction. IUBMB Life 2011; 63: 383-389.
-
(2011)
IUBMB Life
, vol.63
, pp. 383-389
-
-
Antoniak, S.1
Pawlinski, R.2
Mackman, N.3
-
5
-
-
0032499696
-
Cloning and characterisation of human protease-activated receptor 4
-
Xu WF, Andersen H, Whitmore TE, et al. Cloning and characterisation of human protease-activated receptor 4. Proc Natl Acad Sci USA 1998; 95: 6642-6646.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6642-6646
-
-
Xu, W.F.1
Andersen, H.2
Whitmore, T.E.3
-
6
-
-
29244436695
-
Protease-activated receptor-1 and-2 can mediate endothelial barrier protection: Role in factor Xa signalling
-
Feistritzer C, Lenta R, Riewald M. Protease-activated receptor-1 and-2 can mediate endothelial barrier protection: role in factor Xa signalling. J Thromb Haemost 2005; 3: 2798-2805.
-
(2005)
J Thromb Haemost
, vol.3
, pp. 2798-2805
-
-
Feistritzer, C.1
Lenta, R.2
Riewald, M.3
-
7
-
-
34249307505
-
Modulation of tissue factor-factor VIIa signalling by lipid rafts and caveolae
-
Awasthi V, Mandal SK, Papanna V, et al. Modulation of tissue factor-factor VIIa signalling by lipid rafts and caveolae. Arterioscler Thromb Vasc Biol 2007; 27: 1447-1455.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 1447-1455
-
-
Awasthi, V.1
Mandal, S.K.2
Papanna, V.3
-
8
-
-
34247218063
-
Cytokine upregulation of proteinase-activated receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cells
-
Ritchie E, Saka M, MacKenzie C, et al. Cytokine upregulation of proteinase-activated receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cells. Br J Pharmacol 2007; 150: 1044-1054.
-
(2007)
Br J Pharmacol
, vol.150
, pp. 1044-1054
-
-
Ritchie, E.1
Saka, M.2
McKenzie, C.3
-
9
-
-
34248374907
-
Protease-activated receptor-3 (PAR3) regulates PAR1 signalling by receptor dimerisation
-
McLaughlin JN, Patterson MM, Malik AB. Protease-activated receptor-3 (PAR3) regulates PAR1 signalling by receptor dimerisation. Proc Natl Acad Sci USA 2007; 104: 5662-5667.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5662-5667
-
-
McLaughlin, J.N.1
Patterson, M.M.2
Malik, A.B.3
-
10
-
-
37049012509
-
The ligand occupancy of endothelial protein C receptor switches the PAR-1-dependent signalling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells
-
Bae JS, Yang L, Manithody C, et al. The ligand occupancy of endothelial protein C receptor switches the PAR-1-dependent signalling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells. Blood 2007; 110: 3909-3916.
-
(2007)
Blood
, vol.110
, pp. 3909-3916
-
-
Bae, J.S.1
Yang, L.2
Manithody, C.3
-
11
-
-
21644449969
-
Functional selectivity of G protein signalling by agonist peptides and thrombin for the protease-activated receptor-1
-
McLaughlin JN, Shen L, Holinstat M, et al. Functional selectivity of G protein signalling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem 2005; 280: 25048-25059.
-
(2005)
J Biol Chem
, vol.280
, pp. 25048-25059
-
-
McLaughlin, J.N.1
Shen, L.2
Holinstat, M.3
-
12
-
-
34147119744
-
The cytoprotective protein C pathway
-
Mosnier LO, Griffin JH. The cytoprotective protein C pathway. Blood 2007; 109: 3161-3172.
-
(2007)
Blood
, vol.109
, pp. 3161-3172
-
-
Mosnier, L.O.1
Griffin, J.H.2
-
13
-
-
84859718853
-
Protein C anticoagulant system-anti-inflammatory effects
-
Esmon CT. Protein C anticoagulant system-anti-inflammatory effects. Semin Immunopathol 2012; 34: 127-132.
-
(2012)
Semin Immunopathol
, vol.34
, pp. 127-132
-
-
Esmon, C.T.1
-
14
-
-
80052502628
-
Multiple receptor-mediated functions of activated protein C
-
Weiler H. Multiple receptor-mediated functions of activated protein C. Hamostaseologie 2011; 31: 185-195.
-
(2011)
Hamostaseologie
, vol.31
, pp. 185-195
-
-
Weiler, H.1
-
15
-
-
67849101852
-
The protein C pathway and pathologic processes
-
Castellino FJ, Ploplis VA. The protein C pathway and pathologic processes. J Thromb Haemost 2009; 7 (Suppl 1): 140-145.
-
(2009)
J Thromb Haemost
, vol.7
, pp. 140-145
-
-
Castellino, F.J.1
Ploplis, V.A.2
-
16
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Eng J Med 2001; 344: 699-709.
-
(2001)
N Eng J Med
, vol.344
, pp. 699-709
-
-
Bernard, G.R.1
Vincent, J.L.2
Laterre, P.F.3
-
17
-
-
83455234966
-
Drug for severe sepsis is withdrawn from market, fails to reduce mortality
-
Mitka M. Drug for severe sepsis is withdrawn from market, fails to reduce mortality. J Am Med Assoc 2011; 306: 2439-2440.
-
(2011)
J Am Med Assoc
, vol.306
, pp. 2439-2440
-
-
Mitka, M.1
-
18
-
-
84865278685
-
Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: A meta-analysis and metaregression
-
Kalil AC, LaRosa SP. Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: a meta-analysis and metaregression. Lancet Infect Dis 2012; 12: 678-686.
-
(2012)
Lancet Infect Dis
, vol.12
, pp. 678-686
-
-
Kalil, A.C.1
LaRosa, S.P.2
-
20
-
-
17044433166
-
APC signalling: Tickling PAR1 for barrier protection?
-
Camerer E, Coughlin SR. APC signalling: tickling PAR1 for barrier protection? Blood 2005; 105: 3004-3005.
-
(2005)
Blood
, vol.105
, pp. 3004-3005
-
-
Camerer, E.1
Coughlin, S.R.2
-
21
-
-
1642279517
-
Protease-activated receptors: Contribution to physiology and disease
-
Ossovskaya VS, Bunnett NW. Protease-activated receptors: Contribution to physiology and disease. Physiol Rev 2004; 84: 579-621.
-
(2004)
Physiol Rev
, vol.84
, pp. 579-621
-
-
Ossovskaya, V.S.1
Bunnett, N.W.2
-
22
-
-
0032529677
-
Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intracellular adhesion molecule-1 (ICAM-1; CD54) and vascular cell adhesion molecule-1 (VCAM-1; CD106)
-
Kaplanski G, Marin V, Fabrigoule M, et al. Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intracellular adhesion molecule-1 (ICAM-1; CD54) and vascular cell adhesion molecule-1 (VCAM-1; CD106). Blood 1998; 92: 1259-1267.
-
(1998)
Blood
, vol.92
, pp. 1259-1267
-
-
Kaplanski, G.1
Marin, V.2
Fabrigoule, M.3
-
23
-
-
0035815747
-
Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
-
Joyce DE, Gelbert L, Ciaccia A, et al. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 2001; 276: 11199-11203.
-
(2001)
J Biol Chem
, vol.276
, pp. 11199-11203
-
-
Joyce, D.E.1
Gelbert, L.2
Ciaccia, A.3
-
24
-
-
20444443508
-
Activated protein C mediates novel lung endothelial barrier enhancement: Role of sphingosine 1-phosphate receptor transactivation
-
Finigan JH, Dudek SM, Singleton PA, et al. Activated protein C mediates novel lung endothelial barrier enhancement: Role of sphingosine 1-phosphate receptor transactivation. J Biol Chem 2005; 280: 17286-17293.
-
(2005)
J Biol Chem
, vol.280
, pp. 17286-17293
-
-
Finigan, J.H.1
Dudek, S.M.2
Singleton, P.A.3
-
25
-
-
62549145323
-
Thrombin inhibits nuclear factor (B and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C
-
Bae JS, Rezaie AR. Thrombin inhibits nuclear factor B and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C. Thromb Haemost 2009; 101: 513-520.
-
(2009)
Thromb Haemost
, vol.101
, pp. 513-520
-
-
Bae, J.S.1
Rezaie, A.R.2
-
26
-
-
0027378281
-
Internalisation and recycling of activated thrombin receptors
-
Hoxie JA, Ahuja M, Belmonte E, et al. Internalisation and recycling of activated thrombin receptors. J Biol Chem 1993; 268: 13756-13763.
-
(1993)
J Biol Chem
, vol.268
, pp. 13756-13763
-
-
Hoxie, J.A.1
Ahuja, M.2
Belmonte, E.3
-
27
-
-
0028053488
-
Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitisation of a G proteincoupled receptor
-
Hein L, Ishii K, Coughlin SR, et al. Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitisation of a G proteincoupled receptor. J Biol Chem 1994; 269: 27719-27726.
-
(1994)
J Biol Chem
, vol.269
, pp. 27719-27726
-
-
Hein, L.1
Ishii, K.2
Coughlin, S.R.3
-
28
-
-
0020370172
-
Use of endothelium cultured on microcarriers as a model for the microcirculation
-
Busch C, Cancilla PA, DeBault LE, et al. Use of endothelium cultured on microcarriers as a model for the microcirculation. Lab Invest 1982; 47: 498-504.
-
(1982)
Lab Invest
, vol.47
, pp. 498-504
-
-
Busch, C.1
Cancilla, P.A.2
DeBault, L.E.3
-
29
-
-
0028338559
-
Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101
-
Ye J, Rezaie AR, Esmon CT. Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101. J Biol Chem 1994; 269: 17965-17970.
-
(1994)
J Biol Chem
, vol.269
, pp. 17965-17970
-
-
Ye, J.1
Rezaie, A.R.2
Esmon, C.T.3
-
30
-
-
34547108343
-
Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site
-
Nieman MT, Schmaier AH. Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site. Biochemistry 2007; 46: 8603-8610.
-
(2007)
Biochemistry
, vol.46
, pp. 8603-8610
-
-
Nieman, M.T.1
Schmaier, A.H.2
-
31
-
-
33847329718
-
Receptors of the protein C activation and activated protein C signalling pathways are colocalized in lipid rafts of endothelial cells
-
Bae JS, Yang L, Rezaie AR. Receptors of the protein C activation and activated protein C signalling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci USA 2007; 104: 2867-2872.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 2867-2872
-
-
Bae, J.S.1
Yang, L.2
Rezaie, A.R.3
-
32
-
-
43749120051
-
Lipid raft localisation regulates the cleavage specificity of protease activated receptor 1 in endothelial cells
-
Bae JS, Yang L, Rezaie AR. Lipid raft localisation regulates the cleavage specificity of protease activated receptor 1 in endothelial cells. J Thromb Haemost 2008; 6: 954-961.
-
(2008)
J Thromb Haemost
, vol.6
, pp. 954-961
-
-
Bae, J.S.1
Yang, L.2
Rezaie, A.R.3
-
33
-
-
84871584695
-
Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46
-
Mosnier LO, Sinha RK, Burnier L, et al. Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46. Blood 2012; 120: 5237-5246.
-
(2012)
Blood
, vol.120
, pp. 5237-5246
-
-
Mosnier, L.O.1
Sinha, R.K.2
Burnier, L.3
-
34
-
-
84865210286
-
Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects
-
Schuepbach RA, Madon J, Ender M, et al. Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects. J Thromb Haemost 2012; 10: 1675-1684.
-
(2012)
J Thromb Haemost
, vol.10
, pp. 1675-1684
-
-
Schuepbach, R.A.1
Madon, J.2
Ender, M.3
-
35
-
-
16844383361
-
PAR1 cleavage and signalling in response to activated protein C and thrombin
-
Ludeman MJ, Kataoka H, Srinivasan Y, et al. PAR1 cleavage and signalling in response to activated protein C and thrombin. J Biol Chem 2005; 280: 13122-13128.
-
(2005)
J Biol Chem
, vol.280
, pp. 13122-13128
-
-
Ludeman, M.J.1
Kataoka, H.2
Srinivasan, Y.3
-
36
-
-
54949115420
-
Protective effects of activated protein C in sepsis
-
Toltl LJ, Swystun LL, Pepler L, et al. Protective effects of activated protein C in sepsis. Thromb Haemost 2008; 100: 582-592.
-
(2008)
Thromb Haemost
, vol.100
, pp. 582-592
-
-
Toltl, L.J.1
Swystun, L.L.2
Pepler, L.3
-
37
-
-
67649890872
-
Activated protein C: A promising drug with multiple effects?
-
Loubele ST, Spronk HM, Ten Cate H. Activated protein C: a promising drug with multiple effects? Mini Rev Med Chem 2009; 9: 620-626.
-
(2009)
Mini Rev Med Chem
, vol.9
, pp. 620-626
-
-
Loubele, S.T.1
Spronk, H.M.2
Ten Cate, H.3
-
38
-
-
0027943163
-
Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor
-
Fukudome K, Esmon CT. Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem 1994; 269: 26486-26491.
-
(1994)
J Biol Chem
, vol.269
, pp. 26486-26491
-
-
Fukudome, K.1
Esmon, C.T.2
-
39
-
-
0037036069
-
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
-
Riewald M, Petrovan RJ, Donner A, et al. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 2002; 296: 1880-1882.
-
(2002)
Science
, vol.296
, pp. 1880-1882
-
-
Riewald, M.1
Petrovan, R.J.2
Donner, A.3
-
40
-
-
0030666197
-
The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C
-
Regan LM, Mollica JS, Rezaie AR, et al. The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C. J Biol Chem 1997; 272: 26279-26284.
-
(1997)
J Biol Chem
, vol.272
, pp. 26279-26284
-
-
Regan, L.M.1
Mollica, J.S.2
Rezaie, A.R.3
-
41
-
-
33746017989
-
Protective signalling by activated protein C is mechanistically linked to protein C activation on endothelial cells
-
Feistritzer C, Schuepbach RA, Mosnier LO, et al. Protective signalling by activated protein C is mechanistically linked to protein C activation on endothelial cells. J Biol Chem 2006; 281: 20077-20084.
-
(2006)
J Biol Chem
, vol.281
, pp. 20077-20084
-
-
Feistritzer, C.1
Schuepbach, R.A.2
Mosnier, L.O.3
-
42
-
-
80053617611
-
Activated protein C inhibits high mobility group box 1 signalling in endothelial cells
-
Bae JS, Rezaie AR. Activated protein C inhibits high mobility group box 1 signalling in endothelial cells. Blood 2011; 118: 3952-3959.
-
(2011)
Blood
, vol.118
, pp. 3952-3959
-
-
Bae, J.S.1
Rezaie, A.R.2
-
43
-
-
79959580714
-
The occupancy of endothelial protein C receptor by its ligand modulates the PAR1-dependent signalling specificity of coagulation proteases
-
Rezaie AR. The occupancy of endothelial protein C receptor by its ligand modulates the PAR1-dependent signalling specificity of coagulation proteases. IUBMB Life 2011; 63: 390-396.
-
(2011)
IUBMB Life
, vol.63
, pp. 390-396
-
-
Rezaie, A.R.1
-
44
-
-
33751533776
-
New roles for (-arrestins in cell signalling: Not just for seven-transmembrane receptors
-
Lefkowitz RJ, Rajagopal K, Whalen EJ. New roles for -arrestins in cell signalling: Not just for seven-transmembrane receptors. Molecular Cell 2006; 24: 643-652.
-
(2006)
Molecular Cell
, vol.24
, pp. 643-652
-
-
Lefkowitz, R.J.1
Rajagopal, K.2
Whalen, E.J.3
-
45
-
-
80052359992
-
Emerging paradigms of arrestin-dependent seven transmembrane receptor signalling
-
Shukla AK, Xiao K, Lefkowitz RJ. Emerging paradigms of arrestin-dependent seven transmembrane receptor signalling. Trends Biochem Sci 2011; 36: 457-469.
-
(2011)
Trends Biochem Sci
, vol.36
, pp. 457-469
-
-
Shukla, A.K.1
Xiao, K.2
Lefkowitz, R.J.3
-
46
-
-
84055182505
-
Activated protein C promotes protease-activated receptor-1 cytoprotective signalling through arrestin and dishevelled-2 scaffolds
-
Soh UJ, Trejo J. Activated protein C promotes protease-activated receptor-1 cytoprotective signalling through arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci USA 2011; 108: E1372-1380.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. E1372-E1380
-
-
Soh, U.J.1
Trejo, J.2
-
47
-
-
84880617084
-
Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway
-
Bouwens EA, Stavenuiter F, Mosnier LO. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. J Thromb Haemost 2013; 11 (Suppl 1): 242-253.
-
(2013)
J Thromb Haemost
, vol.11
, pp. 242-253
-
-
Bouwens, E.A.1
Stavenuiter, F.2
Mosnier, L.O.3
-
48
-
-
41949096728
-
Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
-
Schuepbach RA, Feistritzer C, Brass LF, et al. Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin. Blood 2008; 111: 2667-2673.
-
(2008)
Blood
, vol.111
, pp. 2667-2673
-
-
Schuepbach, R.A.1
Feistritzer, C.2
Brass, L.F.3
-
49
-
-
38049101163
-
Inhibition of tissue factor signalling suppresses tumour growth
-
Versteeg HH, Schaffner F, Kerver M, et al. Inhibition of tissue factor signalling suppresses tumour growth. Blood 2008; 111: 190-199.
-
(2008)
Blood
, vol.111
, pp. 190-199
-
-
Versteeg, H.H.1
Schaffner, F.2
Kerver, M.3
-
50
-
-
84884644419
-
Activation of blood coagulation in cancer: Implications for tumour progression
-
Lima LG, Monteiro RQ. Activation of blood coagulation in cancer: implications for tumour progression. Biosci Rep 2013; 33: pii: e00064. doi: 10. 1042/BSR20130057.
-
(2013)
Biosci Rep
, vol.33
-
-
Lima, L.G.1
Monteiro, R.Q.2
-
51
-
-
2442647329
-
Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain
-
Ahamed J, Ruf W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain. J Biol Chem 2004; 279: 23038-23044.
-
(2004)
J Biol Chem
, vol.279
, pp. 23038-23044
-
-
Ahamed, J.1
Ruf, W.2
-
52
-
-
12844283269
-
Tissue factor cytoplasmic domain stimulates migration by activation of the GTPase Rac1 and the mitogen-activated protein kinase p38
-
Ott I, Weigand B, Michl R, et al. Tissue factor cytoplasmic domain stimulates migration by activation of the GTPase Rac1 and the mitogen-activated protein kinase p38. Circulation 2005; 111: 349-355.
-
(2005)
Circulation
, vol.111
, pp. 349-355
-
-
Ott, I.1
Weigand, B.2
Michl, R.3
-
53
-
-
34249998690
-
Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia
-
Ahamed J, Niessen F, Kurokawa T, et al. Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia. Blood 2007; 109: 5251-5259.
-
(2007)
Blood
, vol.109
, pp. 5251-5259
-
-
Ahamed, J.1
Niessen, F.2
Kurokawa, T.3
-
54
-
-
77949267709
-
Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor
-
Pendurthi UR, Rao LV. Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor. Thromb Res 2010; 125 (Suppl 1): S19-22.
-
(2010)
Thromb Res
, vol.125
, pp. S19-S22
-
-
Pendurthi, U.R.1
Rao, L.V.2
-
55
-
-
34249722192
-
Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium
-
Ghosh S, Pendurthi UR, Steinoe A, et al. Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium. J Biol Chem 2007; 282: 11849-11857.
-
(2007)
J Biol Chem
, vol.282
, pp. 11849-11857
-
-
Ghosh, S.1
Pendurthi, U.R.2
Steinoe, A.3
-
56
-
-
79953092222
-
Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signalling and barrier protection
-
Sen P, Gopalakrishnan R, Kothari H, et al. Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signalling and barrier protection. Blood 2011; 117: 3199-3208.
-
(2011)
Blood
, vol.117
, pp. 3199-3208
-
-
Sen, P.1
Gopalakrishnan, R.2
Kothari, H.3
-
57
-
-
0034933683
-
Mechanistic coupling of protease signalling and initiation of coagulation by tissue factor
-
Riewald M, Ruf W. Mechanistic coupling of protease signalling and initiation of coagulation by tissue factor. Proc Natl Acad Sci USA 2001; 98: 7742-7747.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 7742-7747
-
-
Riewald, M.1
Ruf, W.2
-
58
-
-
41949107997
-
Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1
-
Bhattacharjee G, Ahamed J, Pawlinski R, et al. Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. Circ Res 2008; 102: 457-464.
-
(2008)
Circ Res
, vol.102
, pp. 457-464
-
-
Bhattacharjee, G.1
Ahamed, J.2
Pawlinski, R.3
-
59
-
-
84887099656
-
Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue
-
Bukowska A, Zacharias I, Weinert S, et al. Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue. Eur J Pharmacol 2013; 718: 114-123.
-
(2013)
Eur J Pharmacol
, vol.718
, pp. 114-123
-
-
Bukowska, A.1
Zacharias, I.2
Weinert, S.3
-
60
-
-
33746958348
-
Factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation
-
Daubie V, Cauwenberghs S, Senden NH, et al. Factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation. Biochim Biophys Acta 2006; 1763: 860-869.
-
(2006)
Biochim Biophys Acta
, vol.1763
, pp. 860-869
-
-
Daubie, V.1
Cauwenberghs, S.2
Senden, N.H.3
-
61
-
-
0032531987
-
Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells
-
Senden NH, Jeunhomme TM, Heemskerk JW, et al. Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells. J Immunol 1998; 161: 4318-4824.
-
(1998)
J Immunol
, vol.161
, pp. 4318-4824
-
-
Senden, N.H.1
Jeunhomme, T.M.2
Heemskerk, J.W.3
-
62
-
-
84863229975
-
Determinants of the specificity of proteaseactivated receptors 1 and 2 signalling by factor Xa and thrombin
-
Rana S, Yang L, Hassanian SM, et al. Determinants of the specificity of proteaseactivated receptors 1 and 2 signalling by factor Xa and thrombin. J Cell Biochem 2012; 113: 977-984.
-
(2012)
J Cell Biochem
, vol.113
, pp. 977-984
-
-
Rana, S.1
Yang, L.2
Hassanian, S.M.3
-
63
-
-
84859188873
-
Identification of exosite residues of factor Xa involved in recognition of PAR-2 on endothelial cells
-
Manithody C, Yang L, Rezaie AR. Identification of exosite residues of factor Xa involved in recognition of PAR-2 on endothelial cells. Biochemistry 2012; 51: 2551-2557.
-
(2012)
Biochemistry
, vol.51
, pp. 2551-2557
-
-
Manithody, C.1
Yang, L.2
Rezaie, A.R.3
-
64
-
-
0030934186
-
Activation-dependent exposure of the inter-EGF sequence Leu83-Leu88 in factor Xa mediates ligand binding to effector cell protease receptor-1
-
Ambrosini G, Plescia J, Chu KC, et al. Activation-dependent exposure of the inter-EGF sequence Leu83-Leu88 in factor Xa mediates ligand binding to effector cell protease receptor-1. J Biol Chem 1997; 272: 8340-8345.
-
(1997)
J Biol Chem
, vol.272
, pp. 8340-8345
-
-
Ambrosini, G.1
Plescia, J.2
Chu, K.C.3
-
65
-
-
78049357602
-
Factor X/Xa elicits protective signalling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1
-
Bae JS, Yang L, Rezaie AR. Factor X/Xa elicits protective signalling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. J Biol Chem 2010; 285: 34803-34812.
-
(2010)
J Biol Chem
, vol.285
, pp. 34803-34812
-
-
Bae, J.S.1
Yang, L.2
Rezaie, A.R.3
-
66
-
-
46749084607
-
Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand
-
Bae JS, Rezaie AR. Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand. Thromb Haemost 2008; 100: 101-109.
-
(2008)
Thromb Haemost
, vol.100
, pp. 101-109
-
-
Bae, J.S.1
Rezaie, A.R.2
-
67
-
-
36049027020
-
Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation
-
Slofstra SH, Bijlsma MF, Groot AP, et al. Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation. Blood 2007; 110: 3176-3182.
-
(2007)
Blood
, vol.110
, pp. 3176-3182
-
-
Slofstra, S.H.1
Bijlsma, M.F.2
Groot, A.P.3
-
68
-
-
17044427680
-
Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
-
Feistritzer C, Riewald, M. Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood 2005; 105: 3178-3184.
-
(2005)
Blood
, vol.105
, pp. 3178-3184
-
-
Feistritzer, C.1
Riewald, M.2
-
69
-
-
77952296543
-
Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function
-
Minhas N, Xue M, Fukudome K, et al. Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function. FASEB J 2010; 24: 873-881.
-
(2010)
FASEB J
, vol.24
, pp. 873-881
-
-
Minhas, N.1
Xue, M.2
Fukudome, K.3
-
70
-
-
77953806379
-
Thrombin upregulates the angiopoietin-Tie2 Axis: Endothelial protein C receptor occupancy prevents the thrombin mobilisation of angiopoietin 2 and P-selectin from Weibel-Palade bodies
-
Bae JS, Rezaie AR. Thrombin upregulates the angiopoietin-Tie2 Axis: endothelial protein C receptor occupancy prevents the thrombin mobilisation of angiopoietin 2 and P-selectin from Weibel-Palade bodies. J Thromb Haemost 2010; 8: 1107-1115.
-
(2010)
J Thromb Haemost
, vol.8
, pp. 1107-1115
-
-
Bae, J.S.1
Rezaie, A.R.2
-
71
-
-
58549121206
-
Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signalling in U937 cells
-
Yang XV, Banerjee Y, Fernández JA, et al. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signalling in U937 cells. Proc Natl Acad Sci USA 2009; 106: 274-279.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 274-279
-
-
Yang, X.V.1
Banerjee, Y.2
Fernández, J.A.3
-
72
-
-
77953202368
-
The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b
-
Cao C, Gao Y, Li Y, et al. The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Invest 2010; 120: 1971-1980.
-
(2010)
J Clin Invest
, vol.120
, pp. 1971-1980
-
-
Cao, C.1
Gao, Y.2
Li, Y.3
-
73
-
-
41649094810
-
Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation
-
Niessen F, Schaffner F, Furlan-Freguia C, et al. Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature 2008; 452: 654-658.
-
(2008)
Nature
, vol.452
, pp. 654-658
-
-
Niessen, F.1
Schaffner, F.2
Furlan-Freguia, C.3
-
74
-
-
1342269932
-
Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3
-
Guo H, Liu D, Gelbard H, et al. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron 2004; 41: 563-572.
-
(2004)
Neuron
, vol.41
, pp. 563-572
-
-
Guo, H.1
Liu, D.2
Gelbard, H.3
-
75
-
-
84872193981
-
Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc
-
Bock F, Shahzad K, Wang H, et al. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci USA 2013; 110: 648-653.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 648-653
-
-
Bock, F.1
Shahzad, K.2
Wang, H.3
-
76
-
-
84886430553
-
Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3
-
Burnier L, Mosnier LO. Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3. Blood 2013; 122: 807-816.
-
(2013)
Blood
, vol.122
, pp. 807-816
-
-
Burnier, L.1
Mosnier, L.O.2
-
77
-
-
84887491969
-
Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by thrombin
-
Arachiche A, Mumaw MM, de la Fuente M, et al. Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by thrombin. J Biol Chem 2013; 288: 32553-32562.
-
(2013)
J Biol Chem
, vol.288
, pp. 32553-32562
-
-
Arachiche, A.1
Mumaw, M.M.2
de la Fuente, M.3
-
78
-
-
84901236503
-
Adenosine Regulates the Proinflammatory Signalling Function of Thrombin in Endothelial Cells
-
Epub ahead of print
-
Hassanian SM, Dinarvand P, Rezaie AR. Adenosine Regulates the Proinflammatory Signalling Function of Thrombin in Endothelial Cells. J Cell Physiol 2014; Epub ahead of print.
-
(2014)
J Cell Physiol
-
-
Hassanian, S.M.1
Dinarvand, P.2
Rezaie, A.R.3
|