Activated protein C cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin

Blood

Volumn 111, Issue 5, 2008, Pages 2667-2673

  Schuepbach, Reto A ^a   Feistritzer, Clemens ^a   Brass, Lawrence F ^b   Riewald, Matthias ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; PROTEIN C;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; HEMOSTASIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION; SURFACE PROPERTY; CELL CULTURE; CHEMISTRY; CYTOLOGY; DOWN REGULATION; DRUG EFFECT; IMMUNOASSAY; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROCESSING;

CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIAL CELLS; HUMANS; IMMUNOASSAY; PROTEIN BINDING; PROTEIN C; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR, PAR-1; SIGNAL TRANSDUCTION; THROMBIN;

EID: 41949096728     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-09-113076     Document Type: Article

References (42)

1. Bernard GR, Vincent JL, Laterre PR et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001; 344:699-709.
2. Esmon CT. The protein C pathway. Chest. 2003; 124:26S-32S.
3. Warren BL, Eid A, Singer P, et al. Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA. 2001;286:1869-1878.
4. Abraham E. Reinhart K. Opal S. et al. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA. 2003:290:238-247.
5. Taylor FB, Jr., Chang AC, Peer GT, et al. DEGFt- factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage. Blood. 1991;78: 364-368.
6. Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science. 2002;296:1880-1882.
7. Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood. 2007;109: 3161-3172.
8. Riewald M, Ruf W. Protease-activated receptor-1 signaling by activated protein C in cytokine-per-turbed endothelial cells is distinct from thrombin signaling. J Biol Chem. 2005;280:19808-19814.
9. Cheng T, Liu D, Griffin JH, et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003;9:338-342.
10. Mosnier LO, Griffin JH. Inhibition of staurospor-ine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. Biochem J. 2003;373:65-70.
11. Feistritzer C, Riewald M. Endothelial barrier protection by activated protein C through PARI-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood. 2005;105:3178-3184.
12. Guo H, Liu D, Gelbard H, et al. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. 2004;41:563-572.
13. Cheng T, Petraglia AL, Li Z, et al. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med. 2006;12: 1278-1285.
14. Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991;64:1057-1068.
15. Vu TK, Wheaton VI, Hung DT, Charo I, Goughlin SR. Domains specifying thrombin-receptor interaction. Nature. 1991;353:674-677.
16. Ludeman MJ, Kataoka H, Srinivasan Y, Esmon NL, Esmon CT, Goughlin SR. PARI cleavage and signaling in response to activated protein C and thrombin. J Biol Chem. 2005;280:13122-13128.
17. Esmon CT. Is APC activation of endothelial cell PARI important in severe sepsis?: No. J Thromb Haemost. 2005;3:1910-1911.
18. Riewald M, Ruf W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci USA. 2001;98: 7742-7747.
19. Fernandez JA, Xu X, Liu D, Zlokovic BV, Griffin JH. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells Mol Dis. 2003;30:271-276.
20. Hoxie JA, Ahuja M, Belmonte E, Pizarro S, Parton R, Brass LF. Internalization and recycling of activated thrombin receptors. J Biol Chem. 1993;268: 13756-13763.
21. Brass LF Pizarro S, Ahuja M, et al. Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling. J Biol Chem. 1994;269:2943- 2952.
22. Ye X, Fukudome K, Tsuneyoshi N, et al. The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries. Biochem Biophys Res Commun. 1999;259:671-677.
23. Feistritzer C, Schuepbach RA, Mosnier LO, et al. Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells. J Biol Chem. 2006;281:20077- 20084.
24. Edgell CJ, McDonald CC, Graham JB. Permanent cell line expressing human factor VIll-related antigen established by hybridization. Proc Natl Acad Sci U S A. 1983;80:3734-3737.
25. Woolkalis MJ, DeMelfi TM, Jr., Blanchard N, Hoxie JA, Brass LF. Regulation of thrombin receptors on human umbilical vein endothelial cells. J Biol Chem. 1995;270:9868-9875.
26. Bae JS, Yang L, RezaieAR. Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci USA. 2007;104: 2867-2872.
27. Shapiro MJ. Coughlin SR. Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor 1. J Biol Chem. 1998;273:29009-29014.
28. Kuliopulos A. Covic L. Seeley SK, Sheridan PJ, Helin J, Costello CE. Plasmin desensitization of the PARI thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy. Biochemistry. 1999;38:4572-4585.
29. Vouret-Craviari V, Grall D, Chambard JC, Rasmussen UB, Pouyssegur J, Van Obberghen-Schilling E. Post-translational and activation-dependent modifications of the G protein-coupled thrombin receptor. J Biol Chem. 1995;270:8367-8372.
30. Klausner RD, Donaldson JG, Lippincott-Schwartz J. Brefeldin A: insights into the control of membrane traffic and organelle structure. J Gell Biol. 1992;116:1071-1080.
31. McLaughlin JN, Shen L Holinstat M, Brooks JD, Dibenedetto E. Hamm HE. Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem. 2005;280:25048-25059.
32. Bae JS, Yang L, Manithody C, Rezaie AR. The ligand occupancy of endothelial protein C receptor switches the PAR-1 -dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells. Blood. 2007;110:3909-3916.
33. Pawlinski R, Pedersen B. Schabbauer G. et al. Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia. Blood. 2004;103:1342-1347.
34. Gamerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin SR. Roles of protease-activated receptors in a mouse model of endotoxemia. Blood. 2006;107:3912-3921.
35. Cunningham MA, Rondeau E, Chen X, Coughlin SR, Holdsworth SR. Tipping PG. Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J Exp Med. 2000;191:455- 462.
36. Vergnolle N, Cellars L Mencarelli A, et al. A role for proteinase-activated receptor-1 in inflammatory bowel diseases. J Clin Invest. 2004;114: 1444-1456.
37. Sevastos J, Kennedy SE, Davis DR, et al. Tissue factor deficiency and PAR-1 deficiency are protective against renal ischemia reperfusion injury. Blood. 2007;109:577-583.
38. Kerschen EJ. Fernandez JA. Cooley BC, et al. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med. 2007;204:2439-2448.
39. Kaneider NC, Leger AJ, Agarwal A. et al. 'Role reversal' for the receptor PARI in sepsis-induced vascular damage. Nat Immunol. 2007;8:1303- 1312.
40. Nakanishi-Matsui M, Zheng YW. Sulciner DJ. Weiss EJ, Ludeman MJ, Coughlin SR. PAR3 is a cofactor for PAR4 activation by thrombin. Nature. 2000;404:609-613.
41. Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature. 2001;413:74-78.
42. Weiss EJ, Hamilton JR, Lease KE, Coughlin SR. Protection against thrombosis in mice lacking PARS. Blood. 2002;100:3240-3244.