메뉴 건너뛰기




Volumn 12, Issue 9, 2012, Pages 678-686

Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: A meta-analysis and metaregression

Author keywords

[No Author keywords available]

Indexed keywords

DROTRECOGIN;

EID: 84865278685     PISSN: 14733099     EISSN: 14744457     Source Type: Journal    
DOI: 10.1016/S1473-3099(12)70157-3     Document Type: Article
Times cited : (74)

References (47)
  • 1
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29:1303-1310.
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 2
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin GS, Mannino DM, Eaton S, Moss M The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348:1546-1554.
    • (2003) N Engl J Med , vol.348 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 3
    • 84859208479 scopus 로고    scopus 로고
    • Inpatient care for septicemia or sepsis: a challenge for patients and hospitals
    • Hall MJ, Williams SN, DeFrances CJ, Golosinskiy A Inpatient care for septicemia or sepsis: a challenge for patients and hospitals. NCHS Data Brief 2011, 62:1-8.
    • (2011) NCHS Data Brief , vol.62 , pp. 1-8
    • Hall, M.J.1    Williams, S.N.2    DeFrances, C.J.3    Golosinskiy, A.4
  • 4
    • 21244502159 scopus 로고    scopus 로고
    • Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling
    • Riewald M, Ruf W Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling. J Biol Chem 2005, 280:19808-19814.
    • (2005) J Biol Chem , vol.280 , pp. 19808-19814
    • Riewald, M.1    Ruf, W.2
  • 6
  • 7
    • 0030034186 scopus 로고    scopus 로고
    • Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats
    • Murakami K, Okajima K, Uchiba M, et al. Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood 1996, 87:642-647.
    • (1996) Blood , vol.87 , pp. 642-647
    • Murakami, K.1    Okajima, K.2    Uchiba, M.3
  • 8
    • 25144462156 scopus 로고    scopus 로고
    • Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin
    • Li W, Zheng X, Gu J, et al. Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin. J Thromb Haemost 2005, 3:1351-1359.
    • (2005) J Thromb Haemost , vol.3 , pp. 1351-1359
    • Li, W.1    Zheng, X.2    Gu, J.3
  • 9
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • the Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
    • Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344:699-709. the Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group.
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 10
    • 0037251585 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis
    • the PROWESS Investigators
    • Ely EW, Laterre PF, Angus DC, et al. Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med 2003, 31:12-19. the PROWESS Investigators.
    • (2003) Crit Care Med , vol.31 , pp. 12-19
    • Ely, E.W.1    Laterre, P.F.2    Angus, D.C.3
  • 11
  • 12
    • 25444492831 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death
    • the Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group
    • Abraham E, Laterre PF, Garg R, et al. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med 2005, 353:1332-1341. the Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group.
    • (2005) N Engl J Med , vol.353 , pp. 1332-1341
    • Abraham, E.1    Laterre, P.F.2    Garg, R.3
  • 14
    • 48449093936 scopus 로고    scopus 로고
    • Why are clinicians not embracing the results from pivotal clinical trials in severe sepsis? A Bayesian analysis
    • Kalil AC, Sun J Why are clinicians not embracing the results from pivotal clinical trials in severe sepsis? A Bayesian analysis. PLoS One 2008, 3:e2291.
    • (2008) PLoS One , vol.3
    • Kalil, A.C.1    Sun, J.2
  • 15
    • 54449087049 scopus 로고    scopus 로고
    • Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock
    • Finfer S, Ranieri VM, Thompson BT, et al. Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med 2008, 34:1935-1947.
    • (2008) Intensive Care Med , vol.34 , pp. 1935-1947
    • Finfer, S.1    Ranieri, V.M.2    Thompson, B.T.3
  • 16
    • 84861665800 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) in adults with septic shock
    • the PROWESS-SHOCK Study Group
    • Ranieri VM, Thompson BT, Barie PS, et al. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 2012, 366:2055-2064. the PROWESS-SHOCK Study Group.
    • (2012) N Engl J Med , vol.366 , pp. 2055-2064
    • Ranieri, V.M.1    Thompson, B.T.2    Barie, P.S.3
  • 19
    • 0033667445 scopus 로고    scopus 로고
    • Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature
    • Sterne JA, Gavaghan D, Egger M Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol 2000, 53:1119-1129.
    • (2000) J Clin Epidemiol , vol.53 , pp. 1119-1129
    • Sterne, J.A.1    Gavaghan, D.2    Egger, M.3
  • 20
    • 33644683771 scopus 로고    scopus 로고
    • Results of severe sepsis treatment program using recombinant human activated protein C in Poland
    • Kübler A, Mayzner-Zawadzka E, Durek G, et al. Results of severe sepsis treatment program using recombinant human activated protein C in Poland. Med Sci Monit 2006, 12:CR107-CR112.
    • (2006) Med Sci Monit , vol.12
    • Kübler, A.1    Mayzner-Zawadzka, E.2    Durek, G.3
  • 21
    • 33847361454 scopus 로고    scopus 로고
    • Use of Drotrecogin alfa (activated) in Italian intensive care units: the results of a nationwide survey
    • Bertolini G, Rossi C, Anghileri A, Livigni S, Addis A, Poole D Use of Drotrecogin alfa (activated) in Italian intensive care units: the results of a nationwide survey. Intensive Care Med 2007, 33:426-434.
    • (2007) Intensive Care Med , vol.33 , pp. 426-434
    • Bertolini, G.1    Rossi, C.2    Anghileri, A.3    Livigni, S.4    Addis, A.5    Poole, D.6
  • 22
    • 35748929120 scopus 로고    scopus 로고
    • Cost-effectiveness of activated protein C in real-life clinical practice
    • the PREMISS Study Group
    • Dhainaut JF, Payet S, Vallet B, et al. Cost-effectiveness of activated protein C in real-life clinical practice. Crit Care 2007, 11:R99. the PREMISS Study Group.
    • (2007) Crit Care , vol.11
    • Dhainaut, J.F.1    Payet, S.2    Vallet, B.3
  • 23
    • 44249085375 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated): real-life use and outcomes for the UK
    • Rowan KM, Welch CA, North E, Harrison DA Drotrecogin alfa (activated): real-life use and outcomes for the UK. Crit Care 2008, 12:R58.
    • (2008) Crit Care , vol.12
    • Rowan, K.M.1    Welch, C.A.2    North, E.3    Harrison, D.A.4
  • 24
    • 39749127076 scopus 로고    scopus 로고
    • A registry of patients treated with drotrecogin alfa (activated) in Belgian intensive care units-an observational study
    • Vincent JL, Laterre PF, Decruyenaere J, et al. A registry of patients treated with drotrecogin alfa (activated) in Belgian intensive care units-an observational study. Acta Clin Belg 2008, 63:25-30.
    • (2008) Acta Clin Belg , vol.63 , pp. 25-30
    • Vincent, J.L.1    Laterre, P.F.2    Decruyenaere, J.3
  • 25
    • 67949120336 scopus 로고    scopus 로고
    • The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes
    • Martin G, Brunkhorst FM, Janes JM, et al. The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes. Crit Care 2009, 13:R103.
    • (2009) Crit Care , vol.13
    • Martin, G.1    Brunkhorst, F.M.2    Janes, J.M.3
  • 26
    • 70350463588 scopus 로고    scopus 로고
    • Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study
    • the Edusepsis Study Group
    • Ferrer R, Artigas A, Suarez D, et al. Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study. Am J Respir Crit Care Med 2009, 180:861-866. the Edusepsis Study Group.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 861-866
    • Ferrer, R.1    Artigas, A.2    Suarez, D.3
  • 29
    • 84864490907 scopus 로고    scopus 로고
    • Characteristics and outcomes of patients treated with drotrecogin alpha and other interventions of the " Surviving Sepsis" campaign in clinical practice
    • Hecksher CA, Lacerda HR, Maciel MA Characteristics and outcomes of patients treated with drotrecogin alpha and other interventions of the " Surviving Sepsis" campaign in clinical practice. RBTI 2008, 20:135-143.
    • (2008) RBTI , vol.20 , pp. 135-143
    • Hecksher, C.A.1    Lacerda, H.R.2    Maciel, M.A.3
  • 30
    • 37549009522 scopus 로고    scopus 로고
    • A retrospective observational study of drotrecogin alfa (activated) in adults with severe sepsis: comparison with a controlled clinical trial
    • Wheeler A, Steingrub J, Schmidt GA, et al. A retrospective observational study of drotrecogin alfa (activated) in adults with severe sepsis: comparison with a controlled clinical trial. Crit Care Med 2008, 36:14-23.
    • (2008) Crit Care Med , vol.36 , pp. 14-23
    • Wheeler, A.1    Steingrub, J.2    Schmidt, G.A.3
  • 31
    • 30944442628 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) in sepsis: initial experience with patient selection, cost, and clinical outcomes
    • Higgins TL, Steingrub JS, Tereso GJ, Tidswell MA, McGee WT Drotrecogin alfa (activated) in sepsis: initial experience with patient selection, cost, and clinical outcomes. J Intensive Care Med 2005, 20:339-345.
    • (2005) J Intensive Care Med , vol.20 , pp. 339-345
    • Higgins, T.L.1    Steingrub, J.S.2    Tereso, G.J.3    Tidswell, M.A.4    McGee, W.T.5
  • 32
    • 84865294943 scopus 로고    scopus 로고
    • Outcomes in patients with recombinant human activated protein c at an academic medical center versus the ENHANCE US trial
    • Bollinger J, Coley K, Rea R, Saul M Outcomes in patients with recombinant human activated protein c at an academic medical center versus the ENHANCE US trial. Crit Care Med 2006, 34:A111.
    • (2006) Crit Care Med , vol.34
    • Bollinger, J.1    Coley, K.2    Rea, R.3    Saul, M.4
  • 34
    • 84865306443 scopus 로고    scopus 로고
    • An open label study of drotrecogin alfa (activated) in adult patients with severe sepsis and multiple organ dysfunctions
    • Summary ID 7159:
    • Eli Lilly. An open label study of drotrecogin alfa (activated) in adult patients with severe sepsis and multiple organ dysfunctions, a phase IV protocol. 2006; Summary ID 7159: 1-6.
    • (2006) a phase IV protocol. , pp. 1-6
    • Eli, L.1
  • 35
    • 38649136365 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated): diffusion from clinical trials to clinical practice
    • Ridley S, Lwin A, Wyncoll D, et al. Drotrecogin alfa (activated): diffusion from clinical trials to clinical practice. Eur J Anaesthesiol 2008, 25:211-216.
    • (2008) Eur J Anaesthesiol , vol.25 , pp. 211-216
    • Ridley, S.1    Lwin, A.2    Wyncoll, D.3
  • 36
    • 33847422269 scopus 로고    scopus 로고
    • Evaluating the use of drotrecogin alfa (activated) in adult severe sepsis: a Canadian multicenter observational study
    • Kanji S, Perreault MM, Chant C, Williamson D, Burry L Evaluating the use of drotrecogin alfa (activated) in adult severe sepsis: a Canadian multicenter observational study. Intensive Care Med 2007, 33:517-523.
    • (2007) Intensive Care Med , vol.33 , pp. 517-523
    • Kanji, S.1    Perreault, M.M.2    Chant, C.3    Williamson, D.4    Burry, L.5
  • 37
    • 33846654603 scopus 로고    scopus 로고
    • Timing of drotrecogin alfa (activated) initiation in treatment of severe sepsis: a database cohort study of hospital mortality, length of stay, and costs
    • Ernst FR, Johnston JA, Pulgar S, et al. Timing of drotrecogin alfa (activated) initiation in treatment of severe sepsis: a database cohort study of hospital mortality, length of stay, and costs. Curr Med Res Opin 2007, 23:235-244.
    • (2007) Curr Med Res Opin , vol.23 , pp. 235-244
    • Ernst, F.R.1    Johnston, J.A.2    Pulgar, S.3
  • 38
    • 45449092671 scopus 로고    scopus 로고
    • A large, single-centre UK registry of drotrecogin alfa-activated use
    • Macchiavello L, Ellis G, Bowden S, Smithies M A large, single-centre UK registry of drotrecogin alfa-activated use. Crit Care 2007, 11(suppl 2):58.
    • (2007) Crit Care , vol.11 , Issue.SUPPL. 2 , pp. 58
    • Macchiavello, L.1    Ellis, G.2    Bowden, S.3    Smithies, M.4
  • 39
    • 61349089148 scopus 로고    scopus 로고
    • 90-day follow-up of patients treated with drotrecogin alfa (activated) for severe sepsis: a Belgian open label study
    • Decruyenaere J, De Backer D, Spapen H, et al. 90-day follow-up of patients treated with drotrecogin alfa (activated) for severe sepsis: a Belgian open label study. Acta Clin Belg 2009, 64:16-22.
    • (2009) Acta Clin Belg , vol.64 , pp. 16-22
    • Decruyenaere, J.1    De Backer, D.2    Spapen, H.3
  • 40
    • 84865285895 scopus 로고    scopus 로고
    • Evaluation of recombinant activated protein C in severe sepsis at a tertiary academic medical center
    • Anger K, DeGrado J, Greenwood B, Szumita P Evaluation of recombinant activated protein C in severe sepsis at a tertiary academic medical center. Crit Care Med 2009, 37:A235.
    • (2009) Crit Care Med , vol.37
    • Anger, K.1    DeGrado, J.2    Greenwood, B.3    Szumita, P.4
  • 41
    • 59649104743 scopus 로고    scopus 로고
    • Adverse outcomes associated with the use of drotrecogin alfa (activated) in patients with severe sepsis and baseline bleeding precautions
    • Gentry CA, Gross KB, Sud B, Drevets DA Adverse outcomes associated with the use of drotrecogin alfa (activated) in patients with severe sepsis and baseline bleeding precautions. Crit Care Med 2009, 37:19-25.
    • (2009) Crit Care Med , vol.37 , pp. 19-25
    • Gentry, C.A.1    Gross, K.B.2    Sud, B.3    Drevets, D.A.4
  • 42
    • 78649445694 scopus 로고    scopus 로고
    • A prospective, observational study of Xigris use in the United States (XEUS)
    • for the XEUS investigators, 660.16
    • Steingrub JS, Cheatham ML, Woodward B, Wang HT, Effron MB A prospective, observational study of Xigris use in the United States (XEUS). J Crit Care 2010, 25:660.e9. for the XEUS investigators, 660.16.
    • (2010) J Crit Care , vol.25
    • Steingrub, J.S.1    Cheatham, M.L.2    Woodward, B.3    Wang, H.T.4    Effron, M.B.5
  • 44
    • 26444604781 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment
    • Vincent JL, Bernard GR, Beale R, et al. Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment. Crit Care Med 2005, 33:2266-2277.
    • (2005) Crit Care Med , vol.33 , pp. 2266-2277
    • Vincent, J.L.1    Bernard, G.R.2    Beale, R.3
  • 45
    • 77950230614 scopus 로고    scopus 로고
    • Does recombinant activated protein C work in patients with severe sepsis?
    • Kalil AC Does recombinant activated protein C work in patients with severe sepsis?. Crit Care Med 2010, 38:1217-1220.
    • (2010) Crit Care Med , vol.38 , pp. 1217-1220
    • Kalil, A.C.1
  • 46
    • 84860232853 scopus 로고    scopus 로고
    • Evaluating the use of recombinant human activated protein C in adult severe sepsis: results of the Surviving Sepsis Campaign
    • Casserly B, Gerlach H, Phillips GS, Marshall JC, Lemeshow S, Levy MM Evaluating the use of recombinant human activated protein C in adult severe sepsis: results of the Surviving Sepsis Campaign. Crit Care Med 2012, 40:1417-1426.
    • (2012) Crit Care Med , vol.40 , pp. 1417-1426
    • Casserly, B.1    Gerlach, H.2    Phillips, G.S.3    Marshall, J.C.4    Lemeshow, S.5    Levy, M.M.6
  • 47
    • 80052968260 scopus 로고    scopus 로고
    • Influence of severity of illness on the effects of eritoran tetrasodium (E5564) and on other therapies for severe sepsis
    • the Eritoran Sepsis Study Group
    • Kalil AC, LaRosa SP, Gogate J, Lynn M, Opal SM Influence of severity of illness on the effects of eritoran tetrasodium (E5564) and on other therapies for severe sepsis. Shock 2011, 36:327-331. the Eritoran Sepsis Study Group.
    • (2011) Shock , vol.36 , pp. 327-331
    • Kalil, A.C.1    LaRosa, S.P.2    Gogate, J.3    Lynn, M.4    Opal, S.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.