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Volumn 31, Issue 3, 2011, Pages 185-195

Multiple receptor-mediated functions of activated protein C

Author keywords

Activated protein C; Anticoagulation; ApoER2; Cell signaling; Integrin; Protease activated receptors; Protein C

Indexed keywords

ACTIVATED PROTEIN C; APOLIPOPROTEIN E2 RECEPTOR; BETA1 INTEGRIN; BETA3 INTEGRIN; CD11B ANTIGEN; ENDOTHELIAL PROTEIN C RECEPTOR; HISTONE; INTEGRIN; PROTEINASE ACTIVATED RECEPTOR; RECEPTOR; UNCLASSIFIED DRUG;

EID: 80052502628     PISSN: 07209355     EISSN: None     Source Type: Journal    
DOI: 10.5482/ha-1166     Document Type: Review
Times cited : (32)

References (110)
  • 1
    • 0017283234 scopus 로고
    • A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization
    • Stenflo J. A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization. J Biol Chem 1976; 251: 355-363.
    • (1976) J Biol Chem , vol.251 , pp. 355-363
    • Stenflo, J.1
  • 2
    • 0017111698 scopus 로고
    • A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase
    • Esmon CT, Stenflo J, Suttie JW. A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase. J Biol Chem 1976; 251: 3052-3056.
    • (1976) J Biol Chem , vol.251 , pp. 3052-3056
    • Esmon, C.T.1    Stenflo, J.2    Suttie, J.W.3
  • 3
    • 0017099639 scopus 로고
    • Proteolytic activation of protein C from bovine plasma
    • Kisiel W, Ericsson LH, Davie EW. Proteolytic activation of protein C from bovine plasma. Biochemistry 1976; 15: 4893-4900.
    • (1976) Biochemistry , vol.15 , pp. 4893-4900
    • Kisiel, W.1    Ericsson, L.H.2    Davie, E.W.3
  • 4
    • 0017567792 scopus 로고
    • Anticoagulant properties of bovine plasma protein C following activation by thrombin
    • Kisiel W, Canfield WM, Ericsson LH, Davie EW. Anticoagulant properties of bovine plasma protein C following activation by thrombin. Biochemistry 1977; 16: 5824-5831.
    • (1977) Biochemistry , vol.16 , pp. 5824-5831
    • Kisiel, W.1    Canfield, W.M.2    Ericsson, L.H.3    Davie, E.W.4
  • 6
    • 0000650903 scopus 로고
    • Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C
    • Esmon CT, Owen WG. Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci U S A 1981; 78: 2249-2252.
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 2249-2252
    • Esmon, C.T.1    Owen, W.G.2
  • 7
    • 0020063793 scopus 로고
    • Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C
    • Esmon NL, Owen WG, Esmon CT. Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C. J Biol Chem 1982; 257: 859-864.
    • (1982) J Biol Chem , vol.257 , pp. 859-864
    • Esmon, N.L.1    Owen, W.G.2    Esmon, C.T.3
  • 8
    • 0014032952 scopus 로고
    • Activation of purified prothrombin in ammonium sulfate solutions: purification of autoprothrombin C
    • Seegers WH, Heene DL, Marciniak E. Activation of purified prothrombin in ammonium sulfate solutions: purification of autoprothrombin C. Thromb Diath Haemorrh 1966; 15: 1-11.
    • (1966) Thromb Diath Haemorrh , vol.15 , pp. 1-11
    • Seegers, W.H.1    Heene, D.L.2    Marciniak, E.3
  • 10
    • 0014959979 scopus 로고
    • Coagulation inhibitor elicited by thrombin
    • Marciniak E. Coagulation inhibitor elicited by thrombin. Science 1970; 170: 452-453.
    • (1970) Science , vol.170 , pp. 452-453
    • Marciniak, E.1
  • 11
    • 21544447526 scopus 로고    scopus 로고
    • Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition
    • Dahlback B, Villoutreix BO. Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition. Arterioscler Thromb Vasc Biol 2005; 25: 1311-1320.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1311-1320
    • Dahlback, B.1    Villoutreix, B.O.2
  • 12
    • 33646480218 scopus 로고    scopus 로고
    • Inflammation and the activated protein C anticoagulant pathway
    • Esmon CT. Inflammation and the activated protein C anticoagulant pathway. Semin Thromb Hemost 32 Suppl 2006; 1: 49-60.
    • (2006) Semin Thromb Hemost , vol.32 , Issue.SUPPL. 1 , pp. 49-60
    • Esmon, C.T.1
  • 14
    • 27144469582 scopus 로고    scopus 로고
    • New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated)
    • Macias WL, Yan SB, Williams MD et al. New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated). Crit Care 9 Suppl 2005; 4: S38-45.
    • (2005) Crit Care , vol.4 , Issue.SUPPL. 9
    • Macias, W.L.1    Yan, S.B.2    Williams, M.D.3
  • 15
    • 34147119744 scopus 로고    scopus 로고
    • The cytoprotective protein C pathway
    • Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood 2007; 109: 3161-3172.
    • (2007) Blood , vol.109 , pp. 3161-3172
    • Mosnier, L.O.1    Zlokovic, B.V.2    Griffin, J.H.3
  • 16
    • 3943060904 scopus 로고    scopus 로고
    • Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation
    • Van de Wouwer M, Collen D, Conway EM. Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation. Arterioscler Thromb Vasc Biol 2004; 24: 1374-1383.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1374-1383
    • Van de Wouwer, M.1    Collen, D.2    Conway, E.M.3
  • 17
    • 40649084076 scopus 로고    scopus 로고
    • The protein C pathway: implications for the design of the RESPOND study
    • Vangerow B, Shorr AF, Wyncoll D et al. The protein C pathway: implications for the design of the RESPOND study. Crit Care 11 Suppl 2007; 5: S4.
    • (2007) Crit Care , vol.5 , Issue.SUPPL. 11
    • Vangerow, B.1    Shorr, A.F.2    Wyncoll, D.3
  • 18
    • 74949109112 scopus 로고    scopus 로고
    • Regulation of inflammation by the protein C system
    • Weiler H. Regulation of inflammation by the protein C system. Crit Care Med 2010; 38: S18-S25.
    • (2010) Crit Care Med , vol.38
    • Weiler, H.1
  • 19
    • 55249086326 scopus 로고    scopus 로고
    • Activated protein C in sepsis: the promise of nonanticoagulant activated protein C
    • Weiler H, Ruf W. Activated protein C in sepsis: the promise of nonanticoagulant activated protein C. Curr Opin Hematol 2008; 15: 487-493.
    • (2008) Curr Opin Hematol , vol.15 , pp. 487-493
    • Weiler, H.1    Ruf, W.2
  • 20
    • 0017074479 scopus 로고
    • Twenty-four hour membrane oxygenation in dogs without anticoagulation
    • Fletcher JR, McKee AE, Mills M et al. Twenty-four hour membrane oxygenation in dogs without anticoagulation. Surgery 1976; 80: 214-223.
    • (1976) Surgery , vol.80 , pp. 214-223
    • Fletcher, J.R.1    McKee, A.E.2    Mills, M.3
  • 21
    • 0018767197 scopus 로고
    • Recovery from endotoxin shock after extracorporeal perfusion without anticoagulation
    • Beller-Todd B, Archer LT, Hinshaw LB. Recovery from endotoxin shock after extracorporeal perfusion without anticoagulation. Circ Shock 1979; 6: 261-269.
    • (1979) Circ Shock , vol.6 , pp. 261-269
    • Beller-Todd, B.1    Archer, L.T.2    Hinshaw, L.B.3
  • 22
    • 0023122016 scopus 로고
    • Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon
    • Taylor FB Jr, Chang A, Esmon CT et al. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest 1987; 79: 918-925.
    • (1987) J Clin Invest , vol.79 , pp. 918-925
    • Taylor Jr., F.B.1    Chang, A.2    Esmon, C.T.3
  • 23
    • 0021171729 scopus 로고
    • A model for thrombin protection against endotoxin
    • Taylor FB Jr, Chang A, Hinshaw LB et al.. A model for thrombin protection against endotoxin. Thromb Res 1984; 36: 177-185.
    • (1984) Thromb Res , vol.36 , pp. 177-185
    • Taylor Jr., F.B.1    Chang, A.2    Hinshaw, L.B.3
  • 25
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Bernard GR, Vincent JL, Laterre PF et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 26
    • 78649735165 scopus 로고    scopus 로고
    • Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study
    • Tang W, Basu S, Kong X et al. Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study. Blood 2010; 116: 5032-5036.
    • (2010) Blood , vol.116 , pp. 5032-5036
    • Tang, W.1    Basu, S.2    Kong, X.3
  • 27
    • 77953504483 scopus 로고    scopus 로고
    • Regulation of the protein C anticoagulant and antiinflammatory pathways
    • Rezaie AR. Regulation of the protein C anticoagulant and antiinflammatory pathways. Curr Med Chem 2010; 17: 2059-2069.
    • (2010) Curr Med Chem , vol.17 , pp. 2059-2069
    • Rezaie, A.R.1
  • 28
    • 32244444849 scopus 로고    scopus 로고
    • Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C
    • Yang L, Manithody C, Rezaie AR. Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C. Proc Natl Acad Sci USA 2006; 103: 879-884.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 879-884
    • Yang, L.1    Manithody, C.2    Rezaie, A.R.3
  • 29
    • 33749378618 scopus 로고    scopus 로고
    • Multifunctional specificity of the protein C/activated protein C Gla domain
    • Preston RJ, Ajzner E, Razzari C et al. Multifunctional specificity of the protein C/activated protein C Gla domain. J Biol Chem 2006; 281: 28850-28857.
    • (2006) J Biol Chem , vol.281 , pp. 28850-28857
    • Preston, R.J.1    Ajzner, E.2    Razzari, C.3
  • 30
    • 0030666197 scopus 로고    scopus 로고
    • The interaction between the endothelial cell protein C receptor and protein C is dictated by the gammacarboxyglutamic acid domain of protein C
    • Regan LM, Mollica JS, Rezaie AR, Esmon CT. The interaction between the endothelial cell protein C receptor and protein C is dictated by the gammacarboxyglutamic acid domain of protein C. J Biol Chem 1997; 272: 26279-26284.
    • (1997) J Biol Chem , vol.272 , pp. 26279-26284
    • Regan, L.M.1    Mollica, J.S.2    Rezaie, A.R.3    Esmon, C.T.4
  • 31
    • 0029670444 scopus 로고    scopus 로고
    • The Gla26 residue of protein C is required for the binding of protein C to thrombomodulin and endothelial cell protein C receptor, but not to protein S and factor Va
    • Nishioka J, Ido M, Hayashi T, Suzuki K. The Gla26 residue of protein C is required for the binding of protein C to thrombomodulin and endothelial cell protein C receptor, but not to protein S and factor Va. Thromb Haemost 1996; 75: 275-282.
    • (1996) Thromb Haemost , vol.75 , pp. 275-282
    • Nishioka, J.1    Ido, M.2    Hayashi, T.3    Suzuki, K.4
  • 32
    • 0024203037 scopus 로고
    • Interference of blood-coagulation vitamin K-dependent proteins in the activation of human protein C. Involvement of the 4-carboxyglutamic acid domain in two distinct interactions with the thrombinthrombomodulin complex and with phospholipids
    • Freyssinet JM, Beretz A, Klein-Soyer C et al. Interference of blood-coagulation vitamin K-dependent proteins in the activation of human protein C. Involvement of the 4-carboxyglutamic acid domain in two distinct interactions with the thrombinthrombomodulin complex and with phospholipids. Biochem J 1988; 256: 501-507.
    • (1988) Biochem J , vol.256 , pp. 501-507
    • Freyssinet, J.M.1    Beretz, A.2    Klein-Soyer, C.3
  • 33
    • 11444268040 scopus 로고    scopus 로고
    • Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation
    • Preston RJ, Villegas-Mendez A, Sun YH et al. Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation. FEBS J 2005; 272: 97-108.
    • (2005) FEBS J , vol.272 , pp. 97-108
    • Preston, R.J.1    Villegas-Mendez, A.2    Sun, Y.H.3
  • 34
    • 9144220292 scopus 로고    scopus 로고
    • Enhanced rate of cleavage at Arg-306 and Arg-506 in coagulation factor Va by Gla domain-mutated human-activated protein C
    • Sun YH, Tran S, Norstrom EA, Dahlback B. Enhanced rate of cleavage at Arg-306 and Arg-506 in coagulation factor Va by Gla domain-mutated human-activated protein C. J Biol Chem 2004; 279: 47528-47535.
    • (2004) J Biol Chem , vol.279 , pp. 47528-47535
    • Sun, Y.H.1    Tran, S.2    Norstrom, E.A.3    Dahlback, B.4
  • 35
    • 0037443444 scopus 로고    scopus 로고
    • Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding
    • Sun YH, Shen L, Dahlback B. Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding. Blood 2003; 101: 2277-2284.
    • (2003) Blood , vol.101 , pp. 2277-2284
    • Sun, Y.H.1    Shen, L.2    Dahlback, B.3
  • 36
    • 0027230866 scopus 로고
    • General features of the heparin-binding serpins antithrombin, heparin cofactor II and protein C inhibitor
    • Pratt CW, Church FC. General features of the heparin-binding serpins antithrombin, heparin cofactor II and protein C inhibitor. Blood Coagul Fibrinolysis 1993; 4: 479-490.
    • (1993) Blood Coagul Fibrinolysis , vol.4 , pp. 479-490
    • Pratt, C.W.1    Church, F.C.2
  • 37
    • 0025954824 scopus 로고
    • Identification of divalent metal ion-dependent inhibition of activated protein C by alpha 2-macroglobulin and alpha 2-antiplasmin in blood and comparisons to inhibition of factor Xa, thrombin, and plasmin
    • Heeb MJ, Gruber A, Griffin JH. Identification of divalent metal ion-dependent inhibition of activated protein C by alpha 2-macroglobulin and alpha 2-antiplasmin in blood and comparisons to inhibition of factor Xa, thrombin, and plasmin. J Biol Chem 1991; 266: 17606-17612.
    • (1991) J Biol Chem , vol.266 , pp. 17606-17612
    • Heeb, M.J.1    Gruber, A.2    Griffin, J.H.3
  • 38
    • 0025848885 scopus 로고
    • In vivo and in vitro complexes of activated protein C with two inhibitors in baboons
    • Espana F, Gruber A, Heeb MJ et al. In vivo and in vitro complexes of activated protein C with two inhibitors in baboons. Blood 1991; 77: 1754-1760.
    • (1991) Blood , vol.77 , pp. 1754-1760
    • Espana, F.1    Gruber, A.2    Heeb, M.J.3
  • 39
    • 0023755722 scopus 로고
    • Physiologic inhibition of human activated protein C by alpha 1-antitrypsin
    • Heeb MJ, Griffin JH. Physiologic inhibition of human activated protein C by alpha 1-antitrypsin. J Biol Chem 1988; 263: 11613-11616.
    • (1988) J Biol Chem , vol.263 , pp. 11613-11616
    • Heeb, M.J.1    Griffin, J.H.2
  • 40
    • 0023897083 scopus 로고
    • Competition of activated protein C and urokinase for a heparin-dependent inhibitor
    • Geiger M, Heeb MJ, Binder BR, Griffin JH. Competition of activated protein C and urokinase for a heparin-dependent inhibitor. FASEB J 1988; 2: 2263-2267.
    • (1988) FASEB J , vol.2 , pp. 2263-2267
    • Geiger, M.1    Heeb, M.J.2    Binder, B.R.3    Griffin, J.H.4
  • 41
    • 0022910521 scopus 로고
    • Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor
    • Sakata Y, Loskutoff DJ, Gladson C et al. Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor. Blood 1986; 68: 1218-1223.
    • (1986) Blood , vol.68 , pp. 1218-1223
    • Sakata, Y.1    Loskutoff, D.J.2    Gladson, C.3
  • 42
    • 0035844272 scopus 로고    scopus 로고
    • Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C
    • Rezaie AR. Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C. J Biol Chem 2001; 276: 15567-15570.
    • (2001) J Biol Chem , vol.276 , pp. 15567-15570
    • Rezaie, A.R.1
  • 43
    • 0028845757 scopus 로고
    • Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex
    • Rezaie AR, Cooper ST, Church FC, Esmon CT. Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex. J Biol Chem 1995; 270: 25336-25339.
    • (1995) J Biol Chem , vol.270 , pp. 25336-25339
    • Rezaie, A.R.1    Cooper, S.T.2    Church, F.C.3    Esmon, C.T.4
  • 44
    • 33750222459 scopus 로고    scopus 로고
    • Regulation of fibrinolysis by thrombin activatable fibrinolysis inhibitor, an unstable carboxypeptidase B that unites the pathways of coagulation and fibrinolysis
    • Mosnier LO, Bouma BN. Regulation of fibrinolysis by thrombin activatable fibrinolysis inhibitor, an unstable carboxypeptidase B that unites the pathways of coagulation and fibrinolysis. Arterioscler Thromb Vasc Biol 2006; 26: 2445-2453.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 2445-2453
    • Mosnier, L.O.1    Bouma, B.N.2
  • 45
    • 39849101009 scopus 로고    scopus 로고
    • Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets
    • Han MH, Hwang SI, Roy DB et al. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature 2008; 451: 1076-1081.
    • (2008) Nature , vol.451 , pp. 1076-1081
    • Han, M.H.1    Hwang, S.I.2    Roy, D.B.3
  • 46
    • 56749104482 scopus 로고    scopus 로고
    • The multi-functional serpin, protein C inhibitor: beyond thrombosis and hemostasis
    • Suzuki K. The multi-functional serpin, protein C inhibitor: beyond thrombosis and hemostasis. J Thromb Haemost 2008; 6: 2017-2026.
    • (2008) J Thromb Haemost , vol.6 , pp. 2017-2026
    • Suzuki, K.1
  • 47
    • 15044355644 scopus 로고    scopus 로고
    • Platelet factor 4: a chemokine enigma
    • Slungaard A. Platelet factor 4: a chemokine enigma. Int J Biochem Cell Biol 2005; 37: 1162-1167.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 1162-1167
    • Slungaard, A.1
  • 48
    • 0028113453 scopus 로고
    • Platelet factor 4 stimulates thrombomodulin protein C-activating cofactor activity. A structure-function analysis
    • Slungaard A, Key NS. Platelet factor 4 stimulates thrombomodulin protein C-activating cofactor activity. A structure-function analysis. J Biol Chem 1994; 269: 25549-25556.
    • (1994) J Biol Chem , vol.269 , pp. 25549-25556
    • Slungaard, A.1    Key, N.S.2
  • 49
    • 34548843000 scopus 로고    scopus 로고
    • Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge
    • Kowalska MA, Mahmud SA, Lambert MP et al. Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge. Blood 2007; 110: 1903-1905.
    • (2007) Blood , vol.110 , pp. 1903-1905
    • Kowalska, M.A.1    Mahmud, S.A.2    Lambert, M.P.3
  • 50
    • 0037630133 scopus 로고    scopus 로고
    • Platelet factor 4 enhances generation of activated protein C in vitro and in vivo
    • Slungaard A, Fernandez JA, Griffin JH et al.. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. Blood 2003; 102: 146-151.
    • (2003) Blood , vol.102 , pp. 146-151
    • Slungaard, A.1    Fernandez, J.A.2    Griffin, J.H.3
  • 51
    • 0031467316 scopus 로고    scopus 로고
    • Platelet factor 4 binds to glycanated forms of thrombomodulin and to protein C. A potential mechanism for enhancing generation of activated protein C
    • Dudek AZ, Pennell CA, Decker TD et al. Platelet factor 4 binds to glycanated forms of thrombomodulin and to protein C. A potential mechanism for enhancing generation of activated protein C. J Biol Chem 1997; 272: 31785-31792.
    • (1997) J Biol Chem , vol.272 , pp. 31785-31792
    • Dudek, A.Z.1    Pennell, C.A.2    Decker, T.D.3
  • 52
    • 65549096799 scopus 로고    scopus 로고
    • Platelet factor 4 impairs the anticoagulant activity of activated protein C
    • Preston RJ, Tran S, Johnson JA et al. Platelet factor 4 impairs the anticoagulant activity of activated protein C. J Biol Chem 2009; 284: 5869-5875.
    • (2009) J Biol Chem , vol.284 , pp. 5869-5875
    • Preston, R.J.1    Tran, S.2    Johnson, J.A.3
  • 53
    • 78650934956 scopus 로고    scopus 로고
    • Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin
    • Mosnier LO. Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin. J Biol Chem 2011; 286: 502-510.
    • (2011) J Biol Chem , vol.286 , pp. 502-510
    • Mosnier, L.O.1
  • 54
    • 73049099489 scopus 로고    scopus 로고
    • Novel APC-cleavage sites in FVa provide insights into mechanisms of action of APC and its cofactor protein S
    • Tran S, Dahlback B. Novel APC-cleavage sites in FVa provide insights into mechanisms of action of APC and its cofactor protein S. J Thromb Haemost 2010; 8: 129-136.
    • (2010) J Thromb Haemost , vol.8 , pp. 129-136
    • Tran, S.1    Dahlback, B.2
  • 55
    • 0037100417 scopus 로고    scopus 로고
    • Functional characterization of recombinant FV Hong Kong and FV Cambridge
    • Norstrom E, Thorelli E, Dahlback B. Functional characterization of recombinant FV Hong Kong and FV Cambridge. Blood 2002; 100: 524-530.
    • (2002) Blood , vol.100 , pp. 524-530
    • Norstrom, E.1    Thorelli, E.2    Dahlback, B.3
  • 56
    • 0036526619 scopus 로고    scopus 로고
    • The activated protein C (APC)-resistant phenotype of APC cleavage site mutants of recombinant factor V in a reconstituted plasma model
    • van der Neut Kolfschoten M, Dirven RJ, Tans G et al. The activated protein C (APC)-resistant phenotype of APC cleavage site mutants of recombinant factor V in a reconstituted plasma model. Blood Coagul Fibrinolysis 2002; 13: 207-215.
    • (2002) Blood Coagul Fibrinolysis , vol.13 , pp. 207-215
    • van der Neut Kolfschoten, M.1    Dirven, R.J.2    Tans, G.3
  • 57
    • 0036124011 scopus 로고    scopus 로고
    • Factor V and thrombotic disease: description of a janus-faced protein
    • Nicolaes GA, Dahlback B. Factor V and thrombotic disease: description of a janus-faced protein. Arterioscler Thromb Vasc Biol 2002; 22: 530-538.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 530-538
    • Nicolaes, G.A.1    Dahlback, B.2
  • 58
    • 0035030340 scopus 로고    scopus 로고
    • Factor V: Dr. Jeckyll and Mr. Hyde
    • Kalafatis M, Mann KG. Factor V: Dr. Jeckyll and Mr. Hyde. Adv Exp Med Biol 2001; 489: 31-43.
    • (2001) Adv Exp Med Biol , vol.489 , pp. 31-43
    • Kalafatis, M.1    Mann, K.G.2
  • 59
    • 3242695796 scopus 로고    scopus 로고
    • Factor V Leiden: a disorder of factor V anticoagulant function
    • Castoldi E, Rosing J. Factor V Leiden: a disorder of factor V anticoagulant function. Curr Opin Hematol 2004; 11: 176-181.
    • (2004) Curr Opin Hematol , vol.11 , pp. 176-181
    • Castoldi, E.1    Rosing, J.2
  • 60
    • 79959459236 scopus 로고    scopus 로고
    • Activated protein C upregulates procoagulant tissue factor activity on endothelial cells by shedding TFPI's Kunitz 1 domain
    • Schuepbach RA, Velez K, Riewald M. Activated protein C upregulates procoagulant tissue factor activity on endothelial cells by shedding TFPI's Kunitz 1 domain. Blood 2011; 117: 6338-6346.
    • (2011) Blood , vol.117 , pp. 6338-6346
    • Schuepbach, R.A.1    Velez, K.2    Riewald, M.3
  • 61
    • 77949305755 scopus 로고    scopus 로고
    • Inflammation, innate immunity and blood coagulation
    • Xu J, Lupu F, Esmon CT. Inflammation, innate immunity and blood coagulation. Hämostaseologie 2010; 30: 5-9.
    • (2010) Hämostaseologie , vol.30 , pp. 5-9
    • Xu, J.1    Lupu, F.2    Esmon, C.T.3
  • 62
    • 70449107044 scopus 로고    scopus 로고
    • Extracellular histones are major mediators of death in sepsis
    • Xu J, Zhang X, Pelayo R et al. Extracellular histones are major mediators of death in sepsis. Nat Med 2009; 15: 1318-1321.
    • (2009) Nat Med , vol.15 , pp. 1318-1321
    • Xu, J.1    Zhang, X.2    Pelayo, R.3
  • 63
    • 39549099917 scopus 로고    scopus 로고
    • Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis
    • Ma AC, Kubes P. Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis. J Thromb Haemost 2008; 6: 415-420.
    • (2008) J Thromb Haemost , vol.6 , pp. 415-420
    • Ma, A.C.1    Kubes, P.2
  • 65
    • 0027943163 scopus 로고
    • Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor
    • Fukudome K, Esmon CT. Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem 1994; 269: 26486-26491.
    • (1994) J Biol Chem , vol.269 , pp. 26486-26491
    • Fukudome, K.1    Esmon, C.T.2
  • 66
    • 0037067752 scopus 로고    scopus 로고
    • The crystal structure of the endothelial protein C receptor and a bound phospholipid
    • Oganesyan V, Oganesyan N, Terzyan S. The crystal structure of the endothelial protein C receptor and a bound phospholipid. J Biol Chem 2002; 277: 24851-24854.
    • (2002) J Biol Chem , vol.277 , pp. 24851-24854
    • Oganesyan, V.1    Oganesyan, N.2    Terzyan, S.3
  • 67
    • 2942720560 scopus 로고    scopus 로고
    • Structure and functions of the endothelial cell protein C receptor
    • Esmon CT. Structure and functions of the endothelial cell protein C receptor. Crit Care Med 2004; 32: S298-301.
    • (2004) Crit Care Med , vol.32
    • Esmon, C.T.1
  • 68
    • 34249722192 scopus 로고    scopus 로고
    • Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium
    • Ghosh S, Pendurthi UR, Steinoe A et al. Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium. J Biol Chem 2007; 282: 11849-11857.
    • (2007) J Biol Chem , vol.282 , pp. 11849-11857
    • Ghosh, S.1    Pendurthi, U.R.2    Steinoe, A.3
  • 69
    • 34250758543 scopus 로고    scopus 로고
    • Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia
    • Zheng X, Li W, Song Y et al. Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia. J Thromb Haemost 2007; 5: 1394-1400.
    • (2007) J Thromb Haemost , vol.5 , pp. 1394-1400
    • Zheng, X.1    Li, W.2    Song, Y.3
  • 70
    • 70349263943 scopus 로고    scopus 로고
    • Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications
    • Nayak RC, Sen P, Ghosh S et al. Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications. Blood 2009; 114: 1974-1986.
    • (2009) Blood , vol.114 , pp. 1974-1986
    • Nayak, R.C.1    Sen, P.2    Ghosh, S.3
  • 71
    • 48449097568 scopus 로고    scopus 로고
    • Factor VIIa binding to endothelial cell protein C receptor
    • Rao LV, Pendurthi UR. Factor VIIa binding to endothelial cell protein C receptor. Thromb Res 2008; 122 (Suppl 1): S3-S6.
    • (2008) Thromb Res , vol.122 , Issue.SUPPL. 1
    • Rao, L.V.1    Pendurthi, U.R.2
  • 72
    • 44649189077 scopus 로고    scopus 로고
    • Factor VIIa interaction with tissue factor and endothelial cell protein C receptor on cell surfaces
    • Pendurthi UR, Rao LV. Factor VIIa interaction with tissue factor and endothelial cell protein C receptor on cell surfaces. Semin Hematol 2008; 45: S21-S24.
    • (2008) Semin Hematol , vol.45
    • Pendurthi, U.R.1    Rao, L.V.2
  • 73
    • 34548076281 scopus 로고    scopus 로고
    • Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity
    • Lopez-Sagaseta J, Montes R, Puy C et al. Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity. J Thromb Haemost 2007; 5: 1817-1824.
    • (2007) J Thromb Haemost , vol.5 , pp. 1817-1824
    • Lopez-Sagaseta, J.1    Montes, R.2    Puy, C.3
  • 74
    • 74749096059 scopus 로고    scopus 로고
    • Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor
    • Schuepbach RA, Riewald M. Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor. J Thromb Haemost 2010; 8: 379-388.
    • (2010) J Thromb Haemost , vol.8 , pp. 379-388
    • Schuepbach, R.A.1    Riewald, M.2
  • 75
    • 77949382071 scopus 로고    scopus 로고
    • The endothelial cells downregulate the generation of factor VIIa through EPCR binding
    • Puy C, Lopez-Sagaseta J, Hermida J, Montes R. The endothelial cells downregulate the generation of factor VIIa through EPCR binding. Br J Haematol 2010; 149: 111-117.
    • (2010) Br J Haematol , vol.149 , pp. 111-117
    • Puy, C.1    Lopez-Sagaseta, J.2    Hermida, J.3    Montes, R.4
  • 76
    • 74749095228 scopus 로고    scopus 로고
    • Biodistribution of pharmacologically administered recombinant factor VIIa (rFVIIa)
    • Gopalakrishnan R, Hedner U, Ghosh S et al. Biodistribution of pharmacologically administered recombinant factor VIIa (rFVIIa). J Thromb Haemost 2010; 8: 301-310.
    • (2010) J Thromb Haemost , vol.8 , pp. 301-310
    • Gopalakrishnan, R.1    Hedner, U.2    Ghosh, S.3
  • 77
    • 77956372381 scopus 로고    scopus 로고
    • Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice
    • Kerschen E, Hernandez I, Zogg M et al. Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest 2010; 120: 3167-3178.
    • (2010) J Clin Invest , vol.120 , pp. 3167-3178
    • Kerschen, E.1    Hernandez, I.2    Zogg, M.3
  • 78
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • Riewald M, Petrovan RJ, Donner A et al. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 2002; 296: 1880-1882.
    • (2002) Science , vol.296 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3
  • 79
    • 1342269932 scopus 로고    scopus 로고
    • Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3
    • Guo H, Liu D, Gelbard H et al. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron 2004; 41: 563-572.
    • (2004) Neuron , vol.41 , pp. 563-572
    • Guo, H.1    Liu, D.2    Gelbard, H.3
  • 80
    • 61849178125 scopus 로고    scopus 로고
    • Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity
    • Guo H, Singh I, Wang Y et al. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. Eur J Neurosci 2009; 29: 1119-1130.
    • (2009) Eur J Neurosci , vol.29 , pp. 1119-1130
    • Guo, H.1    Singh, I.2    Wang, Y.3
  • 81
    • 70449433875 scopus 로고    scopus 로고
    • Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells
    • Zhong Z, Ilieva H, Hallagan L et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest 2009; 119: 3437-3449.
    • (2009) J Clin Invest , vol.119 , pp. 3437-3449
    • Zhong, Z.1    Ilieva, H.2    Hallagan, L.3
  • 82
    • 77951219667 scopus 로고    scopus 로고
    • A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization
    • Swift S, Xu J, Trivedi V et al. A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization. J Biol Chem 2010; 285: 11402-11410.
    • (2010) J Biol Chem , vol.285 , pp. 11402-11410
    • Swift, S.1    Xu, J.2    Trivedi, V.3
  • 83
    • 0033596749 scopus 로고    scopus 로고
    • Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells
    • Hammes SR, Coughlin SR. Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells. Biochemistry 1999; 38: 2486-2493.
    • (1999) Biochemistry , vol.38 , pp. 2486-2493
    • Hammes, S.R.1    Coughlin, S.R.2
  • 84
    • 78049357602 scopus 로고    scopus 로고
    • Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1
    • Bae JS, Yang L, Rezaie AR. Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. J Biol Chem 2010; 285: 34803-34812.
    • (2010) J Biol Chem , vol.285 , pp. 34803-34812
    • Bae, J.S.1    Yang, L.2    Rezaie, A.R.3
  • 85
    • 79953092222 scopus 로고    scopus 로고
    • Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection
    • Sen P, Gopalakrishnan R, Kothari H et al. Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood 2011; 117: 3199-3208.
    • (2011) Blood , vol.117 , pp. 3199-3208
    • Sen, P.1    Gopalakrishnan, R.2    Kothari, H.3
  • 86
    • 79953155300 scopus 로고    scopus 로고
    • The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors
    • Disse J, Petersen HH, Larsen KS et al. The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. J Biol Chem 2011; 286: 5756-5767.
    • (2011) J Biol Chem , vol.286 , pp. 5756-5767
    • Disse, J.1    Petersen, H.H.2    Larsen, K.S.3
  • 87
    • 77953202368 scopus 로고    scopus 로고
    • The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b
    • Cao C, Gao Y, Li Y et al. The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Invest 2010; 120: 1971-1980.
    • (2010) J Clin Invest , vol.120 , pp. 1971-1980
    • Cao, C.1    Gao, Y.2    Li, Y.3
  • 88
    • 65449167251 scopus 로고    scopus 로고
    • Recombinant human activated protein C inhibits integrinmediated neutrophil migration
    • Elphick GF, Sarangi PP, Hyun YM et al. Recombinant human activated protein C inhibits integrinmediated neutrophil migration. Blood 2009; 113: 4078-4085.
    • (2009) Blood , vol.113 , pp. 4078-4085
    • Elphick, G.F.1    Sarangi, P.P.2    Hyun, Y.M.3
  • 89
    • 40749112792 scopus 로고    scopus 로고
    • Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin
    • Pereira C, Schaer DJ, Bachli EB et al. Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin- Arterioscler Thromb Vasc Biol 2008; 28: 504-510.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 504-510
    • Pereira, C.1    Schaer, D.J.2    Bachli, E.B.3
  • 90
    • 65449123456 scopus 로고    scopus 로고
    • The wnt pathway: a macrophage effector molecule that triggers inflammation
    • Pereira CP, Bachli EB, Schoedon G. The wnt pathway: a macrophage effector molecule that triggers inflammation. Curr Atheroscler Rep 2009; 11: 236-242.
    • (2009) Curr Atheroscler Rep , vol.11 , pp. 236-242
    • Pereira, C.P.1    Bachli, E.B.2    Schoedon, G.3
  • 91
    • 14644391560 scopus 로고    scopus 로고
    • Targeting leukocyte integrins in human diseases
    • Yonekawa K, Harlan JM. Targeting leukocyte integrins in human diseases. J Leukoc Biol 2005; 77: 129-140.
    • (2005) J Leukoc Biol , vol.77 , pp. 129-140
    • Yonekawa, K.1    Harlan, J.M.2
  • 92
    • 0034668005 scopus 로고    scopus 로고
    • The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18
    • Kurosawa S, Esmon CT, Stearns-Kurosawa DJ. The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18. J Immunol 2000; 165: 4697-4703.
    • (2000) J Immunol , vol.165 , pp. 4697-4703
    • Kurosawa, S.1    Esmon, C.T.2    Stearns-Kurosawa, D.J.3
  • 93
    • 0034161458 scopus 로고    scopus 로고
    • Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo
    • Gu JM, Katsuura Y, Ferrell GL et al. Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo. Blood 2000; 95: 1687-1693.
    • (2000) Blood , vol.95 , pp. 1687-1693
    • Gu, J.M.1    Katsuura, Y.2    Ferrell, G.L.3
  • 94
    • 0034009976 scopus 로고    scopus 로고
    • Metalloproteolytic release of endothelial cell protein C receptor
    • Xu J, Qu D, Esmon NL, Esmon CT. Metalloproteolytic release of endothelial cell protein C receptor. J Biol Chem 2000; 275: 6038-6044.
    • (2000) J Biol Chem , vol.275 , pp. 6038-6044
    • Xu, J.1    Qu, D.2    Esmon, N.L.3    Esmon, C.T.4
  • 95
    • 43549096946 scopus 로고    scopus 로고
    • Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma
    • Saposnik B, Lesteven E, Lokajczyk A et al. Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma. Blood 2008; 111: 3442-3451.
    • (2008) Blood , vol.111 , pp. 3442-3451
    • Saposnik, B.1    Lesteven, E.2    Lokajczyk, A.3
  • 96
    • 0022000553 scopus 로고
    • Protein S is required for bovine platelets to support activated protein C binding and activity
    • Harris KW, Esmon CT. Protein S is required for bovine platelets to support activated protein C binding and activity. J Biol Chem 1985; 260: 2007-2010.
    • (1985) J Biol Chem , vol.260 , pp. 2007-2010
    • Harris, K.W.1    Esmon, C.T.2
  • 97
    • 43749119174 scopus 로고    scopus 로고
    • Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2
    • White TC, Berny MA, Tucker EI et al. Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2. J Thromb Haemost 2008; 6: 995-1002.
    • (2008) J Thromb Haemost , vol.6 , pp. 995-1002
    • White, T.C.1    Berny, M.A.2    Tucker, E.I.3
  • 98
    • 33747023522 scopus 로고    scopus 로고
    • Antibeta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V
    • Shi T, Giannakopoulos B, Yan X et al. Antibeta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V. Arthritis Rheum 2006; 54: 2558-2567.
    • (2006) Arthritis Rheum , vol.54 , pp. 2558-2567
    • Shi, T.1    Giannakopoulos, B.2    Yan, X.3
  • 99
    • 33846443236 scopus 로고    scopus 로고
    • Platelet adhesion to dimeric beta-glycoprotein I under conditions of flow is mediated by at least two receptors
    • Pennings MT, Derksen RH, van Lummel M et al. Platelet adhesion to dimeric beta-glycoprotein I under conditions of flow is mediated by at least two receptors. J Thromb Haemost 2007; 5: 369-377.
    • (2007) J Thromb Haemost , vol.5 , pp. 369-377
    • Pennings, M.T.1    Derksen, R.H.2    van Lummel, M.3
  • 100
    • 34250757023 scopus 로고    scopus 로고
    • Platelets express three different splice variants of ApoER2 that are all involved in signaling
    • Pennings MT, Derksen RH, Urbanus RT et al. Platelets express three different splice variants of ApoER2 that are all involved in signaling. J Thromb Haemost 2007; 5: 1538-1544.
    • (2007) J Thromb Haemost , vol.5 , pp. 1538-1544
    • Pennings, M.T.1    Derksen, R.H.2    Urbanus, R.T.3
  • 101
    • 10444222547 scopus 로고    scopus 로고
    • Antiphospholipid antibodies and thrombosis: association with acquired activated protein C resistance in venous thrombosis and with hyperhomocysteinemia in arterial thrombosis
    • Kassis J, Neville C, Rauch J et al. Antiphospholipid antibodies and thrombosis: association with acquired activated protein C resistance in venous thrombosis and with hyperhomocysteinemia in arterial thrombosis. Thromb Haemost 2004; 92: 1312-1319.
    • (2004) Thromb Haemost , vol.92 , pp. 1312-1319
    • Kassis, J.1    Neville, C.2    Rauch, J.3
  • 102
    • 3042787713 scopus 로고    scopus 로고
    • The contribution of inherited and acquired thrombophilic defects, alone or combined with antiphospholipid antibodies, to venous and arterial thromboembolism in patients with systemic lupus erythematosus
    • Brouwer JL, Bijl M, Veeger NJ et al. The contribution of inherited and acquired thrombophilic defects, alone or combined with antiphospholipid antibodies, to venous and arterial thromboembolism in patients with systemic lupus erythematosus. Blood 2004; 104: 143-148.
    • (2004) Blood , vol.104 , pp. 143-148
    • Brouwer, J.L.1    Bijl, M.2    Veeger, N.J.3
  • 103
    • 70349569047 scopus 로고    scopus 로고
    • Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2)
    • White-Adams TC, Berny MA, Tucker EI et al. Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arterioscler Thromb Vasc Biol 2009; 29: 1602-1607.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1602-1607
    • White-Adams, T.C.1    Berny, M.A.2    Tucker, E.I.3
  • 104
    • 71149116751 scopus 로고    scopus 로고
    • Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo
    • Muller F, Mutch NJ, Schenk WA et al. Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell 2009; 139: 1143-1156.
    • (2009) Cell , vol.139 , pp. 1143-1156
    • Muller, F.1    Mutch, N.J.2    Schenk, W.A.3
  • 105
    • 58549121206 scopus 로고    scopus 로고
    • Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells
    • Yang XV, Banerjee Y, Fernandez JA et al. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proc Natl Acad Sci U S A 2009; 106: 274-279.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 274-279
    • Yang, X.V.1    Banerjee, Y.2    Fernandez, J.A.3
  • 106
    • 0034698261 scopus 로고    scopus 로고
    • Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor-dependent manner
    • Shua F, Kobayashia H, Fukudomeb K et al. Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor-dependent manner. FEBS Lett 2000; 477: 208-212.
    • (2000) FEBS Lett , vol.477 , pp. 208-212
    • Shua, F.1    Kobayashia, H.2    Fukudomeb, K.3
  • 107
    • 0027998013 scopus 로고
    • Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester
    • Grey ST, Tsuchida A, Hau H et al. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester. J Immunol 1994; 153: 3664-3672.
    • (1994) J Immunol , vol.153 , pp. 3664-3672
    • Grey, S.T.1    Tsuchida, A.2    Hau, H.3
  • 108
    • 0029626658 scopus 로고
    • Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses
    • Hancock WW, Grey ST, Hau L et al. Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses. Transplantation 1995; 60: 1525-1532.
    • (1995) Transplantation , vol.60 , pp. 1525-1532
    • Hancock, W.W.1    Grey, S.T.2    Hau, L.3
  • 109
    • 77649224137 scopus 로고    scopus 로고
    • Activated protein C action in inflammation
    • Sarangi PP, Lee HW, Kim M. Activated protein C action in inflammation. Br J Haematol 2010; 148: 817-833.
    • (2010) Br J Haematol , vol.148 , pp. 817-833
    • Sarangi, P.P.1    Lee, H.W.2    Kim, M.3
  • 110
    • 80052429410 scopus 로고    scopus 로고
    • The evolving plasticity of coagulation protease-dependent cytoprotective signalling
    • Shahzad K, Isermann B. The evolving plasticity of coagulation protease-dependent cytoprotective signalling. Hämostaseologie 2011; 31: 179-184.
    • (2011) Hämostaseologie , vol.31 , pp. 179-184
    • Shahzad, K.1    Isermann, B.2


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