-
1
-
-
76149091152
-
Mitochondrial dysfunction and lipotoxicity
-
2-s2.0-76149091152
-
Schrauwen P., Schrauwen-Hinderling V., Hoeks J., Hesselink M. K. C., Mitochondrial dysfunction and lipotoxicity. Biochimica et Biophysica Acta 2010 1801 3 266 271 10.1016/j.bbalip.2009.09.011 2-s2.0-76149091152
-
(2010)
Biochimica et Biophysica Acta
, vol.1801
, Issue.3
, pp. 266-271
-
-
Schrauwen, P.1
Schrauwen-Hinderling, V.2
Hoeks, J.3
Hesselink, M.K.C.4
-
2
-
-
70449484092
-
The role of mitochondria in health and disease
-
2-s2.0-70449484092
-
Johannsen D. L., Ravussin E., The role of mitochondria in health and disease. Current Opinion in Pharmacology 2009 9 6 780 786 10.1016/j.coph.2009.09.002 2-s2.0-70449484092
-
(2009)
Current Opinion in Pharmacology
, vol.9
, Issue.6
, pp. 780-786
-
-
Johannsen, D.L.1
Ravussin, E.2
-
3
-
-
77249156847
-
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
-
2-s2.0-77249156847
-
Cantó C., Jiang L. Q., Deshmukh A. S., Mataki C., Coste A., Lagouge M., Zierath J. R., Auwerx J., Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metabolism 2010 11 3 213 219 10.1016/j.cmet.2010.02.006 2-s2.0-77249156847
-
(2010)
Cell Metabolism
, vol.11
, Issue.3
, pp. 213-219
-
-
Cantó, C.1
Jiang, L.Q.2
Deshmukh, A.S.3
Mataki, C.4
Coste, A.5
Lagouge, M.6
Zierath, J.R.7
Auwerx, J.8
-
4
-
-
67349276169
-
+ metabolism and SIRT1 activity
-
2-s2.0-67349276169
-
+ metabolism and SIRT1 activity. Nature 2009 458 7241 1056 1060 10.1038/nature07813 2-s2.0-67349276169
-
(2009)
Nature
, vol.458
, Issue.7241
, pp. 1056-1060
-
-
Cantó, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
Lagouge, M.4
Noriega, L.5
Milne, J.C.6
Elliott, P.J.7
Puigserver, P.8
Auwerx, J.9
-
5
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
2-s2.0-0141719702
-
Howitz K. T., Bitterman K. J., Cohen H. Y., Lamming D. W., Lavu S., Wood J. G., Zipkin R. E., Chung P., Kisielewski A., Zhang L.-L., Scherer B., Sinclair D. A., Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003 425 6954 191 196 10.1038/nature01960 2-s2.0-0141719702
-
(2003)
Nature
, vol.425
, Issue.6954
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
Wood, J.G.6
Zipkin, R.E.7
Chung, P.8
Kisielewski, A.9
Zhang, L.-L.10
Scherer, B.11
Sinclair, D.A.12
-
6
-
-
38649123072
-
Conserved metabolic regulatory functions of sirtuins
-
2-s2.0-38649123072
-
Schwer B., Verdin E., Conserved metabolic regulatory functions of sirtuins. Cell Metabolism 2008 7 2 104 112 10.1016/j.cmet.2007.11.006 2-s2.0-38649123072
-
(2008)
Cell Metabolism
, vol.7
, Issue.2
, pp. 104-112
-
-
Schwer, B.1
Verdin, E.2
-
8
-
-
77952547233
-
Ten years of NAD-dependent SIR2 family deacetylases: Implications for metabolic diseases
-
2-s2.0-77952547233
-
Imai S.-I., Guarente L., Ten years of NAD-dependent SIR2 family deacetylases: Implications for metabolic diseases. Trends in Pharmacological Sciences 2010 31 5 212 220 10.1016/j.tips.2010.02.003 2-s2.0-77952547233
-
(2010)
Trends in Pharmacological Sciences
, vol.31
, Issue.5
, pp. 212-220
-
-
Imai, S.-I.1
Guarente, L.2
-
9
-
-
78649482634
-
SIRT1: Recent lessons from mouse models
-
2-s2.0-78649482634
-
Herranz D., Serrano M., SIRT1: recent lessons from mouse models. Nature Reviews Cancer 2010 10 12 819 823 10.1038/nrc2962 2-s2.0-78649482634
-
(2010)
Nature Reviews Cancer
, vol.10
, Issue.12
, pp. 819-823
-
-
Herranz, D.1
Serrano, M.2
-
10
-
-
0037326196
-
Peroxisome proliferator-activated receptor- γ coactivator 1 α (PGC-1 α): Transcriptional coactivator and metabolic regulator
-
2-s2.0-0037326196
-
Puigserver P., Spiegelman B. M., Peroxisome proliferator-activated receptor- γ coactivator 1 α (PGC-1 α): transcriptional coactivator and metabolic regulator. Endocrine Reviews 2003 24 1 78 90 10.1210/er.2002-0012 2-s2.0-0037326196
-
(2003)
Endocrine Reviews
, vol.24
, Issue.1
, pp. 78-90
-
-
Puigserver, P.1
Spiegelman, B.M.2
-
11
-
-
79959453305
-
Dietary leucine - An environmental modifier of insulin resistance acting on multiple levels of metabolism
-
e21187 2-s2.0-79959453305
-
Macotela Y., Emanuelli B., Bång A. M., Espinoza D. O., Boucher J., Beebe K., Gall W., Kahn C. R., Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS ONE 2011 6 6 e21187 10.1371/journal.pone.0021187 2-s2.0-79959453305
-
(2011)
PLoS ONE
, vol.6
, Issue.6
-
-
Macotela, Y.1
Emanuelli, B.2
Bång, A.M.3
Espinoza, D.O.4
Boucher, J.5
Beebe, K.6
Gall, W.7
Kahn, C.R.8
-
12
-
-
34247573364
-
Leucine and protein synthesis: MTOR and beyond
-
2-s2.0-34247573364
-
Stipanuk M. H., Leucine and protein synthesis: mTOR and beyond. Nutrition Reviews 2007 65 3 122 129 10.1301/nr.2007.mar.122-129 2-s2.0-34247573364
-
(2007)
Nutrition Reviews
, vol.65
, Issue.3
, pp. 122-129
-
-
Stipanuk, M.H.1
-
13
-
-
34247579321
-
Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells
-
2-s2.0-34247579321
-
Sun X., Zemel M. B., Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells. Lipids 2007 42 4 297 305 10.1007/s11745-007-3029-5 2-s2.0-34247579321
-
(2007)
Lipids
, vol.42
, Issue.4
, pp. 297-305
-
-
Sun, X.1
Zemel, M.B.2
-
14
-
-
33645996993
-
Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction
-
2-s2.0-33645996993
-
Donato J. Jr., Pedrosa R. G., Cruzat V. F., Pires I. S. D. O., Tirapegui J., Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction. Nutrition 2006 22 5 520 527 10.1016/j.nut.2005.12.008 2-s2.0-33645996993
-
(2006)
Nutrition
, vol.22
, Issue.5
, pp. 520-527
-
-
Donato, J.1
Pedrosa, R.G.2
Cruzat, V.F.3
Pires, I.S.D.O.4
Tirapegui, J.5
-
15
-
-
84856511715
-
L-Leucine alters pancreatic β -cell differentiation and function via the mTor signaling pathway
-
2-s2.0-84856511715
-
Rachdi L., Aïello V., Duvillié B., Scharfmann R., L-Leucine alters pancreatic β -cell differentiation and function via the mTor signaling pathway. Diabetes 2012 61 2 409 417 10.2337/db11-0765 2-s2.0-84856511715
-
(2012)
Diabetes
, vol.61
, Issue.2
, pp. 409-417
-
-
Rachdi, L.1
Aïello, V.2
Duvillié, B.3
Scharfmann, R.4
-
16
-
-
48349086611
-
Potential antiproteolytic effects of L-leucine: Observations of in vitro and in vivo studies
-
ARTICLE 20 2-s2.0-48349086611
-
Zanchi N. E., Nicastro H., Lancha A. H. Jr., Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies. Nutrition and Metabolism 2008 5 1, article 20 10.1186/1743-7075-5-20 2-s2.0-48349086611
-
(2008)
Nutrition and Metabolism
, vol.5
, Issue.1
-
-
Zanchi, N.E.1
Nicastro, H.2
Lancha, A.H.3
-
17
-
-
84885326218
-
Leucine treatment enhances oxidative capacity through complete carbohydrate oxidation and increased mitochondrial density in skeletal muscle cells
-
2-s2.0-84885326218
-
Vaughan R. A., Garcia-Smith R., Gannon N. P., Bisoffi M., Trujillo K. A., Conn C. A., Leucine treatment enhances oxidative capacity through complete carbohydrate oxidation and increased mitochondrial density in skeletal muscle cells. Amino Acids 2013 45 4 901 911 10.1007/s00726-013-1538-5 2-s2.0-84885326218
-
(2013)
Amino Acids
, vol.45
, Issue.4
, pp. 901-911
-
-
Vaughan, R.A.1
Garcia-Smith, R.2
Gannon, N.P.3
Bisoffi, M.4
Trujillo, K.A.5
Conn, C.A.6
-
18
-
-
84865278230
-
Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects
-
2-s2.0-84865278230
-
Zemel M. B., Bruckbauer A., Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects. Nutrients 2012 4 6 529 541 10.3390/nu4060529 2-s2.0-84865278230
-
(2012)
Nutrients
, vol.4
, Issue.6
, pp. 529-541
-
-
Zemel, M.B.1
Bruckbauer, A.2
-
19
-
-
74049117071
-
Effects of dairy compared with soy on oxidative and inflammatory stress in overweight and obese subjects
-
2-s2.0-74049117071
-
Zemel M. B., Sun X., Sobhani T., Wilson B., Effects of dairy compared with soy on oxidative and inflammatory stress in overweight and obese subjects. The American Journal of Clinical Nutrition 2010 91 1 16 22 10.3945/ajcn.2009.28468 2-s2.0-74049117071
-
(2010)
The American Journal of Clinical Nutrition
, vol.91
, Issue.1
, pp. 16-22
-
-
Zemel, M.B.1
Sun, X.2
Sobhani, T.3
Wilson, B.4
-
20
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 α
-
2-s2.0-33845399894
-
Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., Auwerx J., Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 α Cell 2006 127 6 1109 1122 10.1016/j.cell.2006.11.013 2-s2.0-33845399894
-
(2006)
Cell
, vol.127
, Issue.6
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
Geny, B.11
Laakso, M.12
Puigserver, P.13
Auwerx, J.14
-
21
-
-
84865296096
-
Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice
-
ARTICLE 77 2-s2.0-84865296096
-
Bruckbauer A., Zemel M. B., Thorpe T., Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutrition & Metabolism 2012 9 1, article 77 10.1186/1743-7075-9-77 2-s2.0-84865296096
-
(2012)
Nutrition & Metabolism
, vol.9
, Issue.1
-
-
Bruckbauer, A.1
Zemel, M.B.2
Thorpe, T.3
-
22
-
-
84873947174
-
Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity
-
2-s2.0-84873947174
-
Bruckbauer A., Zemel M. B., Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2013 6 93 102 10.2147/DMSO.S40840 2-s2.0-84873947174
-
(2013)
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
, vol.6
, pp. 93-102
-
-
Bruckbauer, A.1
Zemel, M.B.2
-
23
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase- β is an alternative upstream kinase for AMP-activated protein kinase
-
2-s2.0-23044432463
-
Hawley S. A., Pan D. A., Mustard K. J., Ross L., Bain J., Edelman A. M., Frenguelli B. G., Hardie D. G., Calmodulin-dependent protein kinase kinase- β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metabolism 2005 2 1 9 19 10.1016/j.cmet.2005.05.009 2-s2.0-23044432463
-
(2005)
Cell Metabolism
, vol.2
, Issue.1
, pp. 9-19
-
-
Hawley, S.A.1
Pan, D.A.2
Mustard, K.J.3
Ross, L.4
Bain, J.5
Edelman, A.M.6
Frenguelli, B.G.7
Hardie, D.G.8
-
24
-
-
0024588251
-
D-glucose and L-leucine transport by human intestinal brush-border membrane vesicles
-
2-s2.0-0024588251
-
Harig J. M., Barry J. A., Rajendran V. M., Soergel K. H., Ramaswamy K., D-glucose and L-leucine transport by human intestinal brush-border membrane vesicles. The American Journal of Physiology-Gastrointestinal and Liver Physiology 1989 256 3, part 1 G618 G623 2-s2.0-0024588251
-
(1989)
The American Journal of Physiology - Gastrointestinal and Liver Physiology
, vol.256
, Issue.3
, pp. G618-G623
-
-
Harig, J.M.1
Barry, J.A.2
Rajendran, V.M.3
Soergel, K.H.4
Ramaswamy, K.5
-
25
-
-
83655197747
-
Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells
-
2-s2.0-83655197747
-
Bruckbauer A., Zemel M. B., Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells. Nutrition and Metabolism 2011 8, article 91 10.1186/1743-7075-8-91 2-s2.0-83655197747
-
(2011)
Nutrition and Metabolism
, vol.891
-
-
Bruckbauer, A.1
Zemel, M.B.2
-
26
-
-
68149162719
-
Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes
-
2-s2.0-68149162719
-
Sun X., Zemel M. B., Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes. Nutrition & Metabolism 2009 6, article 26 10.1186/1743-7075-6-26 2-s2.0-68149162719
-
(2009)
Nutrition & Metabolism
, vol.626
-
-
Sun, X.1
Zemel, M.B.2
-
27
-
-
78751575751
-
An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions
-
2-s2.0-78751575751
-
Nicastro H., Artioli G. G., Dos Santos Costa A., Solis M. Y., Da Luz C. R., Blachier F., Lancha A. H. Jr., An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions. Amino Acids 2011 40 2 287 300 10.1007/s00726-010-0636-x 2-s2.0-78751575751
-
(2011)
Amino Acids
, vol.40
, Issue.2
, pp. 287-300
-
-
Nicastro, H.1
Artioli, G.G.2
Dos Santos Costa, A.3
Solis, M.Y.4
Da Luz, C.R.5
Blachier, F.6
Lancha, A.H.7
-
28
-
-
84884928903
-
Distinct effects of leucine or a mixture of the branched-chain amino acids (leucine, isoleucine, and valine) supplementation on resistance to fatigue, and muscle and liver-glycogen degradation, in trained rats
-
2-s2.0-84884928903
-
Campos-Ferraz P. L., Bozza T., Nicastro H., Lancha A. H., Distinct effects of leucine or a mixture of the branched-chain amino acids (leucine, isoleucine, and valine) supplementation on resistance to fatigue, and muscle and liver-glycogen degradation, in trained rats. Nutrition 2013 29 11-12 1388 1394 10.1016/j.nut.2013.05.003 2-s2.0-84884928903
-
(2013)
Nutrition
, vol.29
, Issue.11-12
, pp. 1388-1394
-
-
Campos-Ferraz, P.L.1
Bozza, T.2
Nicastro, H.3
Lancha, A.H.4
-
29
-
-
0033785071
-
Uncoupling to survive? the role of mitochondrial inefficiency in ageing
-
2-s2.0-0033785071
-
Brand M. D., Uncoupling to survive? The role of mitochondrial inefficiency in ageing. Experimental Gerontology 2000 35 6-7 811 820 10.1016/S0531-5565(00)00135-2 2-s2.0-0033785071
-
(2000)
Experimental Gerontology
, vol.35
, Issue.6-7
, pp. 811-820
-
-
Brand, M.D.1
-
30
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
2-s2.0-33751072349
-
Baur J. A., Pearson K. J., Price N. L., Jamieson H. A., Lerin C., Kalra A., Prabhu V. V., Allard J. S., Lopez-Lluch G., Lewis K., Pistell P. J., Poosala S., Becker K. G., Boss O., Gwinn D., Wang M., Ramaswamy S., Fishbein K. W., Spencer R. G., Lakatta E. G., Le Couteur D., Shaw R. J., Navas P., Puigserver P., Ingram D. K., De Cabo R., Sinclair D. A., Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006 444 7117 337 342 10.1038/nature05354 2-s2.0-33751072349
-
(2006)
Nature
, vol.444
, Issue.7117
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
Pistell, P.J.11
Poosala, S.12
Becker, K.G.13
Boss, O.14
Gwinn, D.15
Wang, M.16
Ramaswamy, S.17
Fishbein, K.W.18
Spencer, R.G.19
Lakatta, E.G.20
Le Couteur, D.21
Shaw, R.J.22
Navas, P.23
Puigserver, P.24
Ingram, D.K.25
De Cabo, R.26
Sinclair, D.A.27
more..
-
31
-
-
69749123362
-
Ingestion of whey hydrolysate, casein, or soy protein isolate: Effects on mixed muscle protein synthesis at rest and following resistance exercise in young men
-
2-s2.0-69749123362
-
Tang J. E., Moore D. R., Kujbida G. W., Tarnopolsky M. A., Phillips S. M., Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. Journal of Applied Physiology 2009 107 3 987 992 10.1152/japplphysiol.00076.2009 2-s2.0-69749123362
-
(2009)
Journal of Applied Physiology
, vol.107
, Issue.3
, pp. 987-992
-
-
Tang, J.E.1
Moore, D.R.2
Kujbida, G.W.3
Tarnopolsky, M.A.4
Phillips, S.M.5
-
32
-
-
84869192260
-
Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
-
2-s2.0-84869192260
-
Li H., Xu M., Lee J., He C., Xie Z., Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice. American Journal of Physiology: Endocrinology and Metabolism 2012 303 10 E1234 E1244 10.1152/ajpendo.00198.2012 2-s2.0-84869192260
-
(2012)
American Journal of Physiology: Endocrinology and Metabolism
, vol.303
, Issue.10
, pp. E1234-E1244
-
-
Li, H.1
Xu, M.2
Lee, J.3
He, C.4
Xie, Z.5
-
33
-
-
84860477354
-
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
-
2-s2.0-84860477354
-
Price N. L., Gomes A. P., Ling A. J. Y., Duarte F. V., Martin-Montalvo A., North B. J., Agarwal B., Ye L., Ramadori G., Teodoro J. S., Hubbard B. P., Varela A. T., Davis J. G., Varamini B., Hafner A., Moaddel R., Rolo A. P., Coppari R., Palmeira C. M., De Cabo R., Baur J. A., Sinclair D. A., SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metabolism 2012 15 5 675 690 10.1016/j.cmet.2012.04.003 2-s2.0-84860477354
-
(2012)
Cell Metabolism
, vol.15
, Issue.5
, pp. 675-690
-
-
Price, N.L.1
Gomes, A.P.2
Ling, A.J.Y.3
Duarte, F.V.4
Martin-Montalvo, A.5
North, B.J.6
Agarwal, B.7
Ye, L.8
Ramadori, G.9
Teodoro, J.S.10
Hubbard, B.P.11
Varela, A.T.12
Davis, J.G.13
Varamini, B.14
Hafner, A.15
Moaddel, R.16
Rolo, A.P.17
Coppari, R.18
Palmeira, C.M.19
De Cabo, R.20
Baur, J.A.21
Sinclair, D.A.22
more..
-
34
-
-
84880681461
-
+-dependent deacetylation mechanism
-
2-s2.0-84880681461
-
+-dependent deacetylation mechanism. Proceedings of the National Academy of Sciences of the United States of America 2013 110 30 E2772 E2781 10.1073/pnas.1303628110 2-s2.0-84880681461
-
(2013)
Proceedings of the National Academy of Sciences of the United States of America
, vol.110
, Issue.30
, pp. E2772-E2781
-
-
Gertz, M.1
Fischer, F.2
Nguyen, G.T.T.3
Lakshminarasimhan, M.4
Schutkowski, M.5
Weyand, M.6
Steegborn, C.7
-
35
-
-
79953239122
-
SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model
-
2-s2.0-79953239122
-
Wang Y., Liang Y., Vanhoutte P. M., SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model. FEBS Letters 2011 585 7 986 994 10.1016/j.febslet.2010.11.047 2-s2.0-79953239122
-
(2011)
FEBS Letters
, vol.585
, Issue.7
, pp. 986-994
-
-
Wang, Y.1
Liang, Y.2
Vanhoutte, P.M.3
-
36
-
-
84863011114
-
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
-
2-s2.0-84863011114
-
Park S.-J., Ahmad F., Philp A., Baar K., Williams T., Luo H., Ke H., Rehmann H., Taussig R., Brown A. L., Kim M. K., Beaven M. A., Burgin A. B., Manganiello V., Chung J. H., Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 2012 148 3 421 433 10.1016/j.cell.2012.01.017 2-s2.0-84863011114
-
(2012)
Cell
, vol.148
, Issue.3
, pp. 421-433
-
-
Park, S.-J.1
Ahmad, F.2
Philp, A.3
Baar, K.4
Williams, T.5
Luo, H.6
Ke, H.7
Rehmann, H.8
Taussig, R.9
Brown, A.L.10
Kim, M.K.11
Beaven, M.A.12
Burgin, A.B.13
Manganiello, V.14
Chung, J.H.15
-
37
-
-
84879621442
-
AMPK, insulin resistance, and the metabolic syndrome
-
2-s2.0-84879621442
-
Ruderman N. B., Carling D., Prentki M., Cacicedo J. M., AMPK, insulin resistance, and the metabolic syndrome. Journal of Clinical Investigation 2013 123 7 2764 2772 10.1172/JCI67227 2-s2.0-84879621442
-
(2013)
Journal of Clinical Investigation
, vol.123
, Issue.7
, pp. 2764-2772
-
-
Ruderman, N.B.1
Carling, D.2
Prentki, M.3
Cacicedo, J.M.4
-
38
-
-
24144446404
-
Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
-
2-s2.0-24144446404
-
Tremblay F., Krebs M., Dombrowski L., Brehm A., Bernroider E., Roth E., Nowotny P., Waldhäusl W., Marette A., Roden M., Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 2005 54 9 2674 2684 10.2337/diabetes.54.9.2674 2-s2.0-24144446404
-
(2005)
Diabetes
, vol.54
, Issue.9
, pp. 2674-2684
-
-
Tremblay, F.1
Krebs, M.2
Dombrowski, L.3
Brehm, A.4
Bernroider, E.5
Roth, E.6
Nowotny, P.7
Waldhäusl, W.8
Marette, A.9
Roden, M.10
-
39
-
-
63449111894
-
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
-
2-s2.0-63449111894
-
Newgard C. B., An J., Bain J. R., A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metabolism 2009 9 4 311 326 10.1016/j.cmet.2009.02.002 2-s2.0-63449111894
-
(2009)
Cell Metabolism
, vol.9
, Issue.4
, pp. 311-326
-
-
Newgard, C.B.1
An, J.2
Bain, J.R.3
-
40
-
-
0034463918
-
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
-
2-s2.0-0034463918
-
Haruta T., Uno T., Kawahara J., Takano A., Egawa K., Sharma P. M., Olefsky J. M., Kobayashi M., A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Molecular Endocrinology 2000 14 6 783 794 10.1210/me.14.6.783 2-s2.0-0034463918
-
(2000)
Molecular Endocrinology
, vol.14
, Issue.6
, pp. 783-794
-
-
Haruta, T.1
Uno, T.2
Kawahara, J.3
Takano, A.4
Egawa, K.5
Sharma, P.M.6
Olefsky, J.M.7
Kobayashi, M.8
-
41
-
-
77958488312
-
SIRT1 activation by small molecules: Kinetic and biophysical evidence for direct interaction of enzyme and activator
-
2-s2.0-77958488312
-
Dai H., Kustigian L., Carney D., Case A., Considine T., Hubbard B. P., Perni R. B., Riera T. V., Szczepankiewicz B., Vlasuk G. P., Stein R. L., SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator. Journal of Biological Chemistry 2010 285 43 32695 32703 10.1074/jbc.M110.133892 2-s2.0-77958488312
-
(2010)
Journal of Biological Chemistry
, vol.285
, Issue.43
, pp. 32695-32703
-
-
Dai, H.1
Kustigian, L.2
Carney, D.3
Case, A.4
Considine, T.5
Hubbard, B.P.6
Perni, R.B.7
Riera, T.V.8
Szczepankiewicz, B.9
Vlasuk, G.P.10
Stein, R.L.11
-
42
-
-
70350524083
-
Resveratrol is not a direct activator of sirt1 enzyme activity
-
2-s2.0-70350524083
-
Beher D., Wu J., Cumine S., Kim K. W., Lu S.-C., Atangan L., Wang M., Resveratrol is not a direct activator of sirt1 enzyme activity. Chemical Biology and Drug Design 2009 74 6 619 624 10.1111/j.1747-0285.2009.00901.x 2-s2.0-70350524083
-
(2009)
Chemical Biology and Drug Design
, vol.74
, Issue.6
, pp. 619-624
-
-
Beher, D.1
Wu, J.2
Cumine, S.3
Kim, K.W.4
Lu, S.-C.5
Atangan, L.6
Wang, M.7
-
43
-
-
84869816787
-
A molecular mechanism for direct sirtuin activation by resveratrol
-
e49761 2-s2.0-84869816787
-
Gertz M., Nguyen G. T. T., Fischer F., Suenkel B., Schlicker C., Fränzel B., Tomaschewski J., Aladini F., Becker C., Wolters D., Steegborn C., A molecular mechanism for direct sirtuin activation by resveratrol. PLoS ONE 2012 7 11 e49761 10.1371/journal.pone.0049761 2-s2.0-84869816787
-
(2012)
PLoS ONE
, vol.7
, Issue.11
-
-
Gertz, M.1
Nguyen, G.T.T.2
Fischer, F.3
Suenkel, B.4
Schlicker, C.5
Fränzel, B.6
Tomaschewski, J.7
Aladini, F.8
Becker, C.9
Wolters, D.10
Steegborn, C.11
-
44
-
-
84874721105
-
Evidence for a common mechanism of SIRT1 regulation by allosteric activators
-
2-s2.0-84874721105
-
Hubbard B. P., Gomes A. P., Dai H., Li J., Case A. W., Considine T., Riera T. V., Lee J. E., Yen E S., Lamming D. W., Pentelute B. L., Schuman E. R., Stevens L. A., Ling A. J. Y., Armour S. M., Michan S., Zhao H., Jiang Y., Sweitzer S. M., Blum C. A., Disch J. S., Ng P. Y., Howitz K. T., Rolo A. P., Hamuro Y., Moss J., Perni R. B., Ellis J. L., Vlasuk G. P., Sinclair D. A., Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science 2013 339 6124 1216 1219 10.1126/science.1231097 2-s2.0-84874721105
-
(2013)
Science
, vol.339
, Issue.6124
, pp. 1216-1219
-
-
Hubbard, B.P.1
Gomes, A.P.2
Dai, H.3
Li, J.4
Case, A.W.5
Considine, T.6
Riera, T.V.7
Lee, J.E.8
Yen, E.S.9
Lamming, D.W.10
Pentelute, B.L.11
Schuman, E.R.12
Stevens, L.A.13
Ling, A.J.Y.14
Armour, S.M.15
Michan, S.16
Zhao, H.17
Jiang, Y.18
Sweitzer, S.M.19
Blum, C.A.20
Disch, J.S.21
Ng, P.Y.22
Howitz, K.T.23
Rolo, A.P.24
Hamuro, Y.25
Moss, J.26
Perni, R.B.27
Ellis, J.L.28
Vlasuk, G.P.29
Sinclair, D.A.30
more..
-
45
-
-
84895893720
-
Synergistic effects of polyphenols and methylxanthines with leucine on AMPK/sirtuin-mediated metabolism in muscle cells and adipocytes
-
e89166
-
Bruckbauer A., Zemel M. B., Synergistic effects of polyphenols and methylxanthines with leucine on AMPK/sirtuin-mediated metabolism in muscle cells and adipocytes. PLoS ONE 2014 9 2 e89166
-
(2014)
PLoS ONE
, vol.9
, Issue.2
-
-
Bruckbauer, A.1
Zemel, M.B.2
|