Leucine treatment enhances oxidative capacity through complete carbohydrate oxidation and increased mitochondrial density in skeletal muscle cells

Amino Acids

Volumn 45, Issue 4, 2013, Pages 901-911

  Vaughan, Roger A ^a,b   Garcia Smith, Randi ^b   Gannon, Nicholas P ^b   Bisoffi, Marco ^b   Trujillo, Kristina A ^b   Conn, Carole A ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

Dietary supplements; Extracellular acidification and oxygen consumption rates; Mitochondrial biosynthesis; Oxidative phosphorylation; PGC

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBOHYDRATE; CYTOCHROME C; LACTIC ACID; LEUCINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; CELL DENSITY; CELL STRAIN C2C12; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENERGY EXPENDITURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; METABOLIC RATE; MITOCHONDRIAL DENSITY; MOUSE; MUSCLE CELL; MYOBLAST; NONHUMAN; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHABDOMYOSARCOMA CELL; SARCOMA CELL; SKELETAL MUSCLE;

MURINAE;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CARBOHYDRATE METABOLISM; CELL SURVIVAL; CELLS, CULTURED; HUMANS; LEUCINE; MICE; MITOCHONDRIA; MUSCLE, SKELETAL; OXIDATION-REDUCTION;

EID: 84885326218     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-013-1538-5     Document Type: Article

References (22)

1. Araki M, Maeda M, Motojima K (2012) Hydrophobic statins induce autophagy and cell death in human rhabdomyosarcoma cells by depleting geranylgeranyl diphosphate. Eur J Pharmacol 674:95-103
2. Armoni M, Quon MJ, Maor G, Avigad S, Shapiro DN, Harel C, Esposito D, Goshen Y, Yaniv I, Karnieli E (2002) PAX3/Forkhead homolog in rhabdomyosarcoma oncoprotein activates glucose transporter 4 gene expression in vivo and in vitro. J Clin Endocrinol Metab 87:5312-5324
3. Atherton PJ, Smith K, Etheridge T, Rankin D, Rennie MJ (2010) Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells. Amino Acids 38:1533-1539
4. Bruckbauer A, Zemel MB (2011) Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells. Nutr Metab 8:91
5. Deldicque L, Canedo CS, Horman S, De Potter I, Bertrand L, Hue L, Francaux M (2008) Antagonistic effects of leucine and glutamine on the mTOR pathway in myogenic C2C12 cells. Amino Acids 35:147-155
6. Du M, Shen QW, Zhu MJ, Ford SP (2007) Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase. J Anim Sci 85:919-927
7. Giulivi C, Ross-Inta C, Horton AA, Luckhart S (2008) Metabolic pathways in Anopheles stephensi mitochondria. Biochem J 415:309-316
8. Glynn EL, Fry CS, Drummond MJ, Timmerman KL, Dhanani S, Volpi E, Rasmussen BB (2010) Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr 140:1970-1976
9. Haegens A, Schols AM, van Essen AL, van Loon LJ, Langen RC (2012) Leucine induces myofibrillar protein accretion in cultured skeletal muscle through mTOR dependent and -independent control of myosin heavy chain mRNA levels. Mol Nutr Food Res 56:741-752
10. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646-674
11. Lendoye E, Sibille B, Rousseau AS, Murdaca J, Grimaldi PA, Lopez P (2011) PPAR beta activation induces rapid changes of both AMPK subunit expression and AMPK activation in mouse skeletal muscle. Mol Endocrinol 25:1487-1498
12. Pagel-Langenickel I, Bao JJ, Joseph JJ, Schwartz DR, Mantell BS, Xu XL, Raghavachari N, Sack MN (2008) PGC-1 alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle. J Biol Chem 283:22464-22472
13. Philp A, Belew MY, Evans A, Pham D, Sivia I, Chen A, Schenk S, Baar K (2011) The PGC-1 alpha-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes. Am J Physiol Regul Integr Comp Physiol 301:R864-R872
14. Rohas LM, St-Pierre J, Uldry M, Jager S, Handschin C, Spiegelman BM (2007) A fundamental system of cellular energy homeostasis regulated by PGC-1 alpha. Proc Natl Acad Sci USA 104:7933-7938
15. Singh P, Kohr D, Kaps M, Blaes F (2010) Skeletal muscle cell MHC I expression: implications for statin-induced myopathy. Muscle Nerve 41:179-184
16. Sun X, Zemel MB (2007) Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells. Lipids 42:297-305
17. Sun X, Zemel MB (2009) Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes. Nutr Metab 6:26
18. Vaughan RA, Garcia-Smith R, Bisoffi M, Conn CA, Trujillo KA (2012a) Conjugated linoleic acid or omega 3 fatty acids increase mitochondrial biosynthesis and metabolism in skeletal muscle cells. Lipids Health Dis 11:142
19. Vaughan RA, Garcia-Smith R, Bisoffi M, Trujillo KA, Conn CA (2012b) Effects of caffeine on metabolism and mitochondria biogenesis in rhabdomyosarcoma cells compared with 2,4-dinitrophenol. Nutr Metab Insights 5:59
20. Vaughan RA, Garcia-Smith R, Bisoffi M, Trujillo KA, Conn CA (2012c) Treatment of human muscle cells with popular dietary supplements increase mitochondrial function and metabolic rate. Nutr Metab 9:101
21. Wikstrom JD, Sereda SB, Stiles L, Elorza A, Allister EM, Neilson A, Ferrick DA, Wheeler MB, Shirihai OS (2012) A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets. PLoS One 7:e33023
22. Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH (2007) Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 56:2174-2177