메뉴 건너뛰기




Volumn 40, Issue 2, 2011, Pages 287-300

An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions

Author keywords

Atrophy; Branched chain amino acids; Disuse; Leucine; Skeletal muscle

Indexed keywords

BRANCHED CHAIN AMINO ACID; ESSENTIAL AMINO ACID; LEUCINE; PLACEBO;

EID: 78751575751     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-010-0636-x     Document Type: Review
Times cited : (68)

References (125)
  • 1
    • 0344845330 scopus 로고    scopus 로고
    • Skeletal muscle unweighting: Spaceflight and ground-based models
    • 14600160
    • GR Adams VJ Caiozzo KM Baldwin 2003 Skeletal muscle unweighting: spaceflight and ground-based models J Appl Physiol 95 2185 2201 14600160
    • (2003) J Appl Physiol , vol.95 , pp. 2185-2201
    • Adams, G.R.1    Caiozzo, V.J.2    Baldwin, K.M.3
  • 2
    • 3042700474 scopus 로고    scopus 로고
    • Efficacy of a gravity-independent resistance exercise device as a countermeasure to muscle atrophy during 29-day bed rest
    • 1:CAS:528:DC%2BD2cXlslSqtr8%3D 15196095
    • BA Alkner PA Tesch 2004 Efficacy of a gravity-independent resistance exercise device as a countermeasure to muscle atrophy during 29-day bed rest Acta Physiol Scand 181 345 357 1:CAS:528:DC%2BD2cXlslSqtr8%3D 15196095
    • (2004) Acta Physiol Scand , vol.181 , pp. 345-357
    • Alkner, B.A.1    Tesch, P.A.2
  • 3
    • 0015365016 scopus 로고
    • Quantitative efficacy of dietary isoleucine and valine for chick growth as influenced by variable quantities of excess dietary leucine
    • 1:CAS:528:DyaE38XltFars78%3D 4647585
    • NK Allen DH Baker 1972 Quantitative efficacy of dietary isoleucine and valine for chick growth as influenced by variable quantities of excess dietary leucine Poult Sci 51 1292 1298 1:CAS:528:DyaE38XltFars78%3D 4647585
    • (1972) Poult Sci , vol.51 , pp. 1292-1298
    • Allen, N.K.1    Baker, D.H.2
  • 4
    • 0033052802 scopus 로고    scopus 로고
    • Bed rest increases the amount of mismatched fibers in human skeletal muscle
    • 1:CAS:528:DyaK1MXhtlamtbc%3D 9931176
    • JL Andersen T Gruschy-Knudsen C Sandri L Larsson S Schiaffino 1999 Bed rest increases the amount of mismatched fibers in human skeletal muscle J Appl Physiol 86 455 460 1:CAS:528:DyaK1MXhtlamtbc%3D 9931176
    • (1999) J Appl Physiol , vol.86 , pp. 455-460
    • Andersen, J.L.1    Gruschy-Knudsen, T.2    Sandri, C.3    Larsson, L.4    Schiaffino, S.5
  • 5
    • 0033980371 scopus 로고    scopus 로고
    • Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation
    • 1:CAS:528:DC%2BD3cXhtVSmsbY%3D 10720160
    • JC Anthony TG Anthony SR Kimball TC Vary LS Jefferson 2000 Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation J Nutr 130 139 145 1:CAS:528:DC%2BD3cXhtVSmsbY%3D 10720160
    • (2000) J Nutr , vol.130 , pp. 139-145
    • Anthony, J.C.1    Anthony, T.G.2    Kimball, S.R.3    Vary, T.C.4    Jefferson, L.S.5
  • 6
    • 0033808169 scopus 로고    scopus 로고
    • Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway
    • 1:CAS:528:DC%2BD3cXntVShtb0%3D 11015466
    • JC Anthony F Yoshizawa TG Anthony TC Vary LS Jefferson SR Kimball 2000 Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway J Nutr 130 2413 2419 1:CAS:528: DC%2BD3cXntVShtb0%3D 11015466
    • (2000) J Nutr , vol.130 , pp. 2413-2419
    • Anthony, J.C.1    Yoshizawa, F.2    Anthony, T.G.3    Vary, T.C.4    Jefferson, L.S.5    Kimball, S.R.6
  • 7
    • 27144513240 scopus 로고    scopus 로고
    • Cancer-associated malnutrition
    • 16437757
    • JM Argiles 2005 Cancer-associated malnutrition Eur J Oncol Nurs 9 Suppl 2 S39 S50 16437757
    • (2005) Eur J Oncol Nurs , vol.9 , Issue.SUPPL 2
    • Argiles, J.M.1
  • 8
    • 23944525331 scopus 로고    scopus 로고
    • Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods
    • 1:CAS:528:DC%2BD2MXpsVWmsrg%3D 15905114
    • D Attaix L Mosoni D Dardevet L Combaret PP Mirand J Grizard 2005 Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods Int J Biochem Cell Biol 37 1962 1973 1:CAS:528: DC%2BD2MXpsVWmsrg%3D 15905114
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 1962-1973
    • Attaix, D.1    Mosoni, L.2    Dardevet, D.3    Combaret, L.4    Mirand, P.P.5    Grizard, J.6
  • 10
    • 20344369557 scopus 로고    scopus 로고
    • Tolerance for branched-chain amino acids in experimental animals and humans
    • 1:CAS:528:DC%2BD2MXltFaiurk%3D 15930474
    • DH Baker 2005 Tolerance for branched-chain amino acids in experimental animals and humans J Nutr 135 1585S 1590S 1:CAS:528:DC%2BD2MXltFaiurk%3D 15930474
    • (2005) J Nutr , vol.135
    • Baker, D.H.1
  • 11
    • 31544457307 scopus 로고    scopus 로고
    • Investigations of branched-chain amino acids and their metabolites in animal models of cancer
    • 1:CAS:528:DC%2BD28XivFSjug%3D%3D 16365090
    • VE Baracos ML Mackenzie 2006 Investigations of branched-chain amino acids and their metabolites in animal models of cancer J Nutr 136 237S 242S 1:CAS:528:DC%2BD28XivFSjug%3D%3D 16365090
    • (2006) J Nutr , vol.136
    • Baracos, V.E.1    MacKenzie, M.L.2
  • 13
    • 0024348166 scopus 로고
    • Nitrogen excretion in cancer cachexia and its modification by a high fat diet in mice
    • 1:CAS:528:DyaL1MXkvFKjt78%3D 2736521
    • SA Beck MJ Tisdale 1989 Nitrogen excretion in cancer cachexia and its modification by a high fat diet in mice Cancer Res 49 3800 3804 1:CAS:528:DyaL1MXkvFKjt78%3D 2736521
    • (1989) Cancer Res , vol.49 , pp. 3800-3804
    • Beck, S.A.1    Tisdale, M.J.2
  • 14
  • 15
    • 0021213269 scopus 로고
    • Valine metabolism in vivo: Effects of high dietary levels of leucine and isoleucine
    • 1:CAS:528:DyaL2cXktlOnu7Y%3D 6727655
    • KP Block AE Harper 1984 Valine metabolism in vivo: effects of high dietary levels of leucine and isoleucine Metabolism 33 559 566 1:CAS:528:DyaL2cXktlOnu7Y%3D 6727655
    • (1984) Metabolism , vol.33 , pp. 559-566
    • Block, K.P.1    Harper, A.E.2
  • 16
    • 0025873397 scopus 로고
    • Administration of branched-chain amino acids during sustained exercise: Effects on performance and on plasma concentration of some amino acids
    • 1:STN:280:DyaK38%2FotlyltQ%3D%3D 1748109
    • E Blomstrand P Hassmen B Ekblom EA Newsholme 1991 Administration of branched-chain amino acids during sustained exercise: effects on performance and on plasma concentration of some amino acids Eur J Appl Physiol Occup Physiol 63 83 88 1:STN:280:DyaK38%2FotlyltQ%3D%3D 1748109
    • (1991) Eur J Appl Physiol Occup Physiol , vol.63 , pp. 83-88
    • Blomstrand, E.1    Hassmen, P.2    Ekblom, B.3    Newsholme, E.A.4
  • 17
    • 67649962153 scopus 로고    scopus 로고
    • Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit
    • 1:CAS:528:DC%2BD1MXosFeksb0%3D 19571121
    • C Blouet YH Jo X Li GJ Schwartz 2009 Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit J Neurosci 29 8302 8311 1:CAS:528:DC%2BD1MXosFeksb0%3D 19571121
    • (2009) J Neurosci , vol.29 , pp. 8302-8311
    • Blouet, C.1    Jo, Y.H.2    Li, X.3    Schwartz, G.J.4
  • 18
    • 0142062041 scopus 로고    scopus 로고
    • Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: A dose-response study
    • 1:CAS:528:DC%2BD3sXovFCns7k%3D 12909668
    • J Bohe A Low RR Wolfe MJ Rennie 2003 Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study J Physiol 552 315 324 1:CAS:528:DC%2BD3sXovFCns7k%3D 12909668
    • (2003) J Physiol , vol.552 , pp. 315-324
    • Bohe, J.1    Low, A.2    Wolfe, R.R.3    Rennie, M.J.4
  • 20
    • 50649116617 scopus 로고    scopus 로고
    • Resistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit
    • 1:CAS:528:DC%2BD1cXps12htLY%3D 18483167
    • N Brooks GJ Cloutier SM Cadena JE Layne CA Nelsen AM Freed R Roubenoff C Castaneda-Sceppa 2008 Resistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit J Appl Physiol 105 241 248 1:CAS:528:DC%2BD1cXps12htLY%3D 18483167
    • (2008) J Appl Physiol , vol.105 , pp. 241-248
    • Brooks, N.1    Cloutier, G.J.2    Cadena, S.M.3    Layne, J.E.4    Nelsen, C.A.5    Freed, A.M.6    Roubenoff, R.7    Castaneda-Sceppa, C.8
  • 21
    • 66349103681 scopus 로고    scopus 로고
    • Exercise training and protein metabolism: Influences of contraction, protein intake, and sex-based differences
    • 1:CAS:528:DC%2BD1MXlvFOgsLY%3D 19036897
    • NA Burd JE Tang DR Moore SM Phillips 2009 Exercise training and protein metabolism: influences of contraction, protein intake, and sex-based differences J Appl Physiol 106 1692 1701 1:CAS:528:DC%2BD1MXlvFOgsLY%3D 19036897
    • (2009) J Appl Physiol , vol.106 , pp. 1692-1701
    • Burd, N.A.1    Tang, J.E.2    Moore, D.R.3    Phillips, S.M.4
  • 22
    • 0016824053 scopus 로고
    • Leucine. A possible regulator of protein turnover in muscle
    • 1:CAS:528:DyaE28XjvFejsw%3D%3D 1237498
    • MG Buse SS Reid 1975 Leucine. A possible regulator of protein turnover in muscle J Clin Invest 56 1250 1261 1:CAS:528:DyaE28XjvFejsw%3D%3D 1237498
    • (1975) J Clin Invest , vol.56 , pp. 1250-1261
    • Buse, M.G.1    Reid, S.S.2
  • 23
    • 0033900166 scopus 로고    scopus 로고
    • Branched-chain amino acids inhibit proteolysis in rat skeletal muscle: Mechanisms involved
    • 1:CAS:528:DC%2BD3cXlsl2lsrY%3D 10911370
    • S Busquets B Alvarez M Llovera N Agell FJ Lopez-Soriano JM Argiles 2000 Branched-chain amino acids inhibit proteolysis in rat skeletal muscle: mechanisms involved J Cell Physiol 184 380 384 1:CAS:528:DC%2BD3cXlsl2lsrY%3D 10911370
    • (2000) J Cell Physiol , vol.184 , pp. 380-384
    • Busquets, S.1    Alvarez, B.2    Llovera, M.3    Agell, N.4    Lopez-Soriano, F.J.5    Argiles, J.M.6
  • 24
    • 33846658434 scopus 로고    scopus 로고
    • Beta-hydoxy-beta-methylbutyrate supplementation affects Walker 256 tumor-bearing rats in a time-dependent manner
    • 1:CAS:528:DC%2BD2sXhtlamsr0%3D 17011676
    • EC Caperuto RV Tomatieli A Colquhoun MC Seelaender LF Costa Rosa 2007 Beta-hydoxy-beta-methylbutyrate supplementation affects Walker 256 tumor-bearing rats in a time-dependent manner Clin Nutr 26 117 122 1:CAS:528: DC%2BD2sXhtlamsr0%3D 17011676
    • (2007) Clin Nutr , vol.26 , pp. 117-122
    • Caperuto, E.C.1    Tomatieli, R.V.2    Colquhoun, A.3    Seelaender, M.C.4    Costa Rosa, L.F.5
  • 25
    • 3543098004 scopus 로고    scopus 로고
    • Skeletal muscle protein composition following 5 weeks of ULLS and resistance exercise countermeasures
    • 1:STN:280:DC%2BD2c7ht1emuw%3D%3D 15002527
    • JA Carrithers PA Tesch J Trieschmann A Ekberg TA Trappe 2002 Skeletal muscle protein composition following 5 weeks of ULLS and resistance exercise countermeasures J Gravit Physiol 9 P155 P156 1:STN:280:DC%2BD2c7ht1emuw%3D%3D 15002527
    • (2002) J Gravit Physiol , vol.9
    • Carrithers, J.A.1    Tesch, P.A.2    Trieschmann, J.3    Ekberg, A.4    Trappe, T.A.5
  • 26
    • 67349274955 scopus 로고    scopus 로고
    • Catabolism of nitritionally essential amino acids in developing porcine enterocytes
    • 1:CAS:528:DC%2BD1MXltlemtb8%3D 19291365
    • L Chen P Li J Wang X Li H Gao Y Yin Y Hou G Wu 2009 Catabolism of nitritionally essential amino acids in developing porcine enterocytes Amino Acids 37 143 152 1:CAS:528:DC%2BD1MXltlemtb8%3D 19291365
    • (2009) Amino Acids , vol.37 , pp. 143-152
    • Chen, L.1    Li, P.2    Wang, J.3    Li, X.4    Gao, H.5    Yin, Y.6    Hou, Y.7    Wu, G.8
  • 27
    • 0014368503 scopus 로고
    • Effect of l-leucine on amino acid levels in plasma and tissue of normal and diabetic rats
    • 1:CAS:528:DyaF1MXhvVagtw%3D%3D 5722991
    • AJ Clark C Yamada ME Swendseid 1968 Effect of l-leucine on amino acid levels in plasma and tissue of normal and diabetic rats Am J Physiol 215 1324 1328 1:CAS:528:DyaF1MXhvVagtw%3D%3D 5722991
    • (1968) Am J Physiol , vol.215 , pp. 1324-1328
    • Clark, A.J.1    Yamada, C.2    Swendseid, M.E.3
  • 28
    • 29244439931 scopus 로고    scopus 로고
    • A leucine-supplemented diet restores the defective postprandial inhibition of proteasome-dependent proteolysis in aged rat skeletal muscle
    • 1:CAS:528:DC%2BD28XhsVagtQ%3D%3D 16195315
    • L Combaret D Dardevet I Rieu MN Pouch D Bechet D Taillandier J Grizard D Attaix 2005 A leucine-supplemented diet restores the defective postprandial inhibition of proteasome-dependent proteolysis in aged rat skeletal muscle J Physiol 569 489 499 1:CAS:528:DC%2BD28XhsVagtQ%3D%3D 16195315
    • (2005) J Physiol , vol.569 , pp. 489-499
    • Combaret, L.1    Dardevet, D.2    Rieu, I.3    Pouch, M.N.4    Bechet, D.5    Taillandier, D.6    Grizard, J.7    Attaix, D.8
  • 30
    • 14944341734 scopus 로고    scopus 로고
    • Oral leucine administration stimulates protein synthesis in rat skeletal muscle
    • 1:CAS:528:DC%2BD2MXit12nsbw%3D 15735066
    • SJ Crozier SR Kimball SW Emmert JC Anthony LS Jefferson 2005 Oral leucine administration stimulates protein synthesis in rat skeletal muscle J Nutr 135 376 382 1:CAS:528:DC%2BD2MXit12nsbw%3D 15735066
    • (2005) J Nutr , vol.135 , pp. 376-382
    • Crozier, S.J.1    Kimball, S.R.2    Emmert, S.W.3    Anthony, J.C.4    Jefferson, L.S.5
  • 31
    • 33646083955 scopus 로고    scopus 로고
    • Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise
    • 1:CAS:528:DC%2BD28Xks1Slsrg%3D 16263770
    • DJ Cuthbertson J Babraj K Smith E Wilkes MJ Fedele K Esser M Rennie 2006 Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise Am J Physiol Endocrinol Metab 290 E731 E738 1:CAS:528:DC%2BD28Xks1Slsrg%3D 16263770
    • (2006) Am J Physiol Endocrinol Metab , vol.290
    • Cuthbertson, D.J.1    Babraj, J.2    Smith, K.3    Wilkes, E.4    Fedele, M.J.5    Esser, K.6    Rennie, M.7
  • 32
    • 77952384876 scopus 로고    scopus 로고
    • Leucine supplementation enhances glutamate dehydrogenase expression and restores glucose-induced insulin secretion in protein-malnourished rats
    • 20015523
    • PM da Silva CC Zoppi E Filiputti LR Silveira I Quesada AC Boschero EM Carneiro 2009 Leucine supplementation enhances glutamate dehydrogenase expression and restores glucose-induced insulin secretion in protein-malnourished rats Metabolism 59 911 913 20015523
    • (2009) Metabolism , vol.59 , pp. 911-913
    • Da Silva, P.M.1    Zoppi, C.C.2    Filiputti, E.3    Silveira, L.R.4    Quesada, I.5    Boschero, A.C.6    Carneiro, E.M.7
  • 33
    • 0020575905 scopus 로고
    • Effects of postoperative infusion of branched chain amino acids on nitrogen balance and forearm muscle substrate flux
    • 1:CAS:528:DyaL3sXltlymtrk%3D 6348986
    • JM Daly MH Mihranian JE Kehoe MF Brennan 1983 Effects of postoperative infusion of branched chain amino acids on nitrogen balance and forearm muscle substrate flux Surgery 94 151 158 1:CAS:528:DyaL3sXltlymtrk%3D 6348986
    • (1983) Surgery , vol.94 , pp. 151-158
    • Daly, J.M.1    Mihranian, M.H.2    Kehoe, J.E.3    Brennan, M.F.4
  • 34
    • 0033735644 scopus 로고    scopus 로고
    • Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age
    • 1:CAS:528:DC%2BD3cXnvVOlsbs%3D 11053498
    • D Dardevet C Sornet M Balage J Grizard 2000 Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age J Nutr 130 2630 2635 1:CAS:528:DC%2BD3cXnvVOlsbs%3D 11053498
    • (2000) J Nutr , vol.130 , pp. 2630-2635
    • Dardevet, D.1    Sornet, C.2    Balage, M.3    Grizard, J.4
  • 37
    • 0026316130 scopus 로고
    • Proteolysis in skeletal muscle and whole body in response to euglycemic hyperinsulinemia in normal adults
    • 1:CAS:528:DyaK38Xns1yjsQ%3D%3D 1767841
    • SC Denne EA Liechty YM Liu G Brechtel AD Baron 1991 Proteolysis in skeletal muscle and whole body in response to euglycemic hyperinsulinemia in normal adults Am J Physiol 261 E809 E814 1:CAS:528:DyaK38Xns1yjsQ%3D%3D 1767841
    • (1991) Am J Physiol , vol.261
    • Denne, S.C.1    Liechty, E.A.2    Liu, Y.M.3    Brechtel, G.4    Baron, A.D.5
  • 39
    • 0141566914 scopus 로고    scopus 로고
    • Invited review: Aging and sarcopenia
    • 1:CAS:528:DC%2BD3sXotFyrtrc%3D 12970377
    • TJ Doherty 2003 Invited review: aging and sarcopenia J Appl Physiol 95 1717 1727 1:CAS:528:DC%2BD3sXotFyrtrc%3D 12970377
    • (2003) J Appl Physiol , vol.95 , pp. 1717-1727
    • Doherty, T.J.1
  • 40
    • 16844382376 scopus 로고    scopus 로고
    • Role of protein and amino acids in the pathophysiology and treatment of sarcopenia
    • 1:CAS:528:DC%2BD2MXjvVWiurc%3D 15798081
    • HC Dreyer E Volpi 2005 Role of protein and amino acids in the pathophysiology and treatment of sarcopenia J Am Coll Nutr 24 140S 145S 1:CAS:528:DC%2BD2MXjvVWiurc%3D 15798081
    • (2005) J Am Coll Nutr , vol.24
    • Dreyer, H.C.1    Volpi, E.2
  • 41
    • 0036790065 scopus 로고    scopus 로고
    • The branched-chain amino acid requirement of parenterally fed neonatal piglets is less than enteral requirement
    • 1:CAS:528:DC%2BD38Xnsl2ktrg%3D 12368405
    • R Elango PB Pencharz RO Ball 2002 The branched-chain amino acid requirement of parenterally fed neonatal piglets is less than enteral requirement J Nutr 132 3123 3129 1:CAS:528:DC%2BD38Xnsl2ktrg%3D 12368405
    • (2002) J Nutr , vol.132 , pp. 3123-3129
    • Elango, R.1    Pencharz, P.B.2    Ball, R.O.3
  • 42
    • 34147166505 scopus 로고    scopus 로고
    • Skeletal muscle atrophy, a link between depression of protein synthesis and increase in degradation
    • 1:CAS:528:DC%2BD2sXitlSrs7Y%3D 17213191
    • HL Eley MJ Tisdale 2007 Skeletal muscle atrophy, a link between depression of protein synthesis and increase in degradation J Biol Chem 282 7087 7097 1:CAS:528:DC%2BD2sXitlSrs7Y%3D 17213191
    • (2007) J Biol Chem , vol.282 , pp. 7087-7097
    • Eley, H.L.1    Tisdale, M.J.2
  • 44
    • 0026909816 scopus 로고
    • The Sir David Cuthbertson Medal Lecture 1991. The mechanisms and treatment of weight loss in cancer
    • 1:CAS:528:DyaK3sXhvVyksL4%3D 1438334
    • KC Fearon 1992 The Sir David Cuthbertson Medal Lecture 1991. The mechanisms and treatment of weight loss in cancer Proc Nutr Soc 51 251 265 1:CAS:528:DyaK3sXhvVyksL4%3D 1438334
    • (1992) Proc Nutr Soc , vol.51 , pp. 251-265
    • Fearon, K.C.1
  • 45
    • 20344386484 scopus 로고    scopus 로고
    • Branched-chain amino acids and brain function
    • 1:CAS:528:DC%2BD2MXltFaitbc%3D 15930466
    • JD Fernstrom 2005 Branched-chain amino acids and brain function J Nutr 135 1539S 1546S 1:CAS:528:DC%2BD2MXltFaitbc%3D 15930466
    • (2005) J Nutr , vol.135
    • Fernstrom, J.D.1
  • 46
    • 0031002537 scopus 로고    scopus 로고
    • Resistance exercise maintains skeletal muscle protein synthesis during bed rest
    • 1:STN:280:DyaK2s3ivV2ksg%3D%3D 9074967
    • AA Ferrando KD Tipton MM Bamman RR Wolfe 1997 Resistance exercise maintains skeletal muscle protein synthesis during bed rest J Appl Physiol 82 807 810 1:STN:280:DyaK2s3ivV2ksg%3D%3D 9074967
    • (1997) J Appl Physiol , vol.82 , pp. 807-810
    • Ferrando, A.A.1    Tipton, K.D.2    Bamman, M.M.3    Wolfe, R.R.4
  • 47
    • 77950599009 scopus 로고    scopus 로고
    • Augmentation of insulin secretion by leucine supplementation in malnourished rats: Possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway
    • 1:CAS:528:DC%2BC3cXkvFCgtbY%3D 19913855
    • E Filiputti A Rafacho EP Araújo LR Silveira A Trevisan TM Batista R Curi LA Velloso I Quesada AC Boschero EM Carneiro 2010 Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway Metabolism 59 635 644 1:CAS:528:DC%2BC3cXkvFCgtbY%3D 19913855
    • (2010) Metabolism , vol.59 , pp. 635-644
    • Filiputti, E.1    Rafacho, A.2    Araújo, E.P.3    Silveira, L.R.4    Trevisan, A.5    Batista, T.M.6    Curi, R.7    Velloso, L.A.8    Quesada, I.9    Boschero, A.C.10    Carneiro, E.M.11
  • 48
    • 31544458910 scopus 로고    scopus 로고
    • Amino acids and muscle loss with aging
    • 1:CAS:528:DC%2BD28XivFSitA%3D%3D 16365098
    • S Fujita E Volpi 2006 Amino acids and muscle loss with aging J Nutr 136 277S 280S 1:CAS:528:DC%2BD28XivFSitA%3D%3D 16365098
    • (2006) J Nutr , vol.136
    • Fujita, S.1    Volpi, E.2
  • 49
    • 0023196951 scopus 로고
    • Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man
    • 1:CAS:528:DyaL2sXkslWhsLo%3D 3298320
    • RA Gelfand EJ Barrett 1987 Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man J Clin Invest 80 1 6 1:CAS:528:DyaL2sXkslWhsLo%3D 3298320
    • (1987) J Clin Invest , vol.80 , pp. 1-6
    • Gelfand, R.A.1    Barrett, E.J.2
  • 51
    • 57649232182 scopus 로고    scopus 로고
    • Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion
    • 1:CAS:528:DC%2BD1MXptVKnsg%3D%3D 18955382
    • EI Glover SM Phillips BR Oates JE Tang MA Tarnopolsky A Selby K Smith MJ Rennie 2008 Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion J Physiol 586 6049 6061 1:CAS:528:DC%2BD1MXptVKnsg%3D%3D 18955382
    • (2008) J Physiol , vol.586 , pp. 6049-6061
    • Glover, E.I.1    Phillips, S.M.2    Oates, B.R.3    Tang, J.E.4    Tarnopolsky, M.A.5    Selby, A.6    Smith, K.7    Rennie, M.J.8
  • 52
    • 77954752950 scopus 로고    scopus 로고
    • Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy
    • 1:CAS:528:DC%2BC3cXksV2htrY%3D 20383222
    • EI Glover N Yasuda MA Tarnopolsky A Abadi SM Phillips 2010 Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy Appl Physiol Nutr Metab 35 125 133 1:CAS:528:DC%2BC3cXksV2htrY%3D 20383222
    • (2010) Appl Physiol Nutr Metab , vol.35 , pp. 125-133
    • Glover, E.I.1    Yasuda, N.2    Tarnopolsky, M.A.3    Abadi, A.4    Phillips, S.M.5
  • 53
    • 0242659264 scopus 로고    scopus 로고
    • A leucine-supplemented diet improved protein content of skeletal muscle in young tumor-bearing rats
    • 1:CAS:528:DC%2BD3sXps1altr8%3D 14576914
    • MC Gomes-Marcondes G Ventrucci MT Toledo L Cury JC Cooper 2003 A leucine-supplemented diet improved protein content of skeletal muscle in young tumor-bearing rats Braz J Med Biol Res 36 1589 1594 1:CAS:528: DC%2BD3sXps1altr8%3D 14576914
    • (2003) Braz J Med Biol Res , vol.36 , pp. 1589-1594
    • Gomes-Marcondes, M.C.1    Ventrucci, G.2    Toledo, M.T.3    Cury, L.4    Cooper, J.C.5
  • 54
    • 78751593666 scopus 로고
    • Effect of amino acid supplements on growth and fat deposition in the livers of rats fed polished rice
    • 1:CAS:528:DyaG2MXnvVOqsw%3D%3D 14392501
    • AE Harper ME Winje DA Benton CA Elvehjem 1955 Effect of amino acid supplements on growth and fat deposition in the livers of rats fed polished rice J Nutr 56 187 198 1:CAS:528:DyaG2MXnvVOqsw%3D%3D 14392501
    • (1955) J Nutr , vol.56 , pp. 187-198
    • Harper, A.E.1    Winje, M.E.2    Benton, D.A.3    Elvehjem, C.A.4
  • 55
    • 0021197124 scopus 로고
    • Branched-chain amino acid metabolism
    • 1:CAS:528:DyaL2cXlsVymtbc%3D 6380539
    • AE Harper RH Miller KP Block 1984 Branched-chain amino acid metabolism Annu Rev Nutr 4 409 454 1:CAS:528:DyaL2cXlsVymtbc%3D 6380539
    • (1984) Annu Rev Nutr , vol.4 , pp. 409-454
    • Harper, A.E.1    Miller, R.H.2    Block, K.P.3
  • 56
    • 0035887283 scopus 로고    scopus 로고
    • Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans
    • 1:CAS:528:DC%2BD3MXovVygsrg%3D 11600695
    • P Hespel B Op't Eijnde M Van Leemputte B Urso PL Greenhaff V Labarque S Dymarkowski P Van Hecke EA Richter 2001 Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans J Physiol 536 625 633 1:CAS:528: DC%2BD3MXovVygsrg%3D 11600695
    • (2001) J Physiol , vol.536 , pp. 625-633
    • Hespel, P.1    Op'T Eijnde, B.2    Van Leemputte, M.3    Urso, B.4    Greenhaff, P.L.5    Labarque, V.6    Dymarkowski, S.7    Van Hecke, P.8    Richter, E.A.9
  • 57
    • 0343133874 scopus 로고    scopus 로고
    • Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans
    • 1:CAS:528:DC%2BD3cXislKrtbs%3D 10747199
    • T Hortobagyi L Dempsey D Fraser D Zheng G Hamilton J Lambert L Dohm 2000 Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans J Physiol 524 Pt 1 293 304 1:CAS:528:DC%2BD3cXislKrtbs%3D 10747199
    • (2000) J Physiol , vol.524 , Issue.PART 1 , pp. 293-304
    • Hortobagyi, T.1    Dempsey, L.2    Fraser, D.3    Zheng, D.4    Hamilton, G.5    Lambert, J.6    Dohm, L.7
  • 58
    • 65649152957 scopus 로고    scopus 로고
    • Amino acid transceptors: Gate keepers of nutrient exchange and regulators of nutrient signaling
    • 1:CAS:528:DC%2BD1MXkvVyhtr4%3D 19158318
    • HS Hundal PM Taylor 2009 Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling Am J Physiol Endocrinol Metab 296 E603 E613 1:CAS:528:DC%2BD1MXkvVyhtr4%3D 19158318
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Hundal, H.S.1    Taylor, P.M.2
  • 59
    • 0019288156 scopus 로고
    • Fuel and signal function of 2-keto acids in insulin secretion
    • 1:STN:280:DyaL3M%2Fpt1amtQ%3D%3D 7005062
    • JC Hutton I Atwater WJ Malaisse 1980 Fuel and signal function of 2-keto acids in insulin secretion Horm Metab Res Suppl Suppl 10 31 37 1:STN:280:DyaL3M%2Fpt1amtQ%3D%3D 7005062
    • (1980) Horm Metab Res Suppl , vol.10 , pp. 31-37
    • Hutton, J.C.1    Atwater, I.2    Malaisse, W.J.3
  • 60
    • 75749085802 scopus 로고    scopus 로고
    • Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle
    • 1:CAS:528:DC%2BC3cXisVejtL4%3D 19940100
    • N Iwanaka T Egawa N Satoubu K Karaike X Ma S Masuda T Hayashi 2010 Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle J Appl Physiol 108 274 282 1:CAS:528:DC%2BC3cXisVejtL4%3D 19940100
    • (2010) J Appl Physiol , vol.108 , pp. 274-282
    • Iwanaka, N.1    Egawa, T.2    Satoubu, N.3    Karaike, K.4    Ma, X.5    Masuda, S.6    Hayashi, T.7
  • 61
    • 6944226810 scopus 로고    scopus 로고
    • Disuse atrophy and exercise rehabilitation in humans profoundly affects the expression of genes associated with the regulation of skeletal muscle mass
    • 1:CAS:528:DC%2BD2cXkslWitbg%3D 15084522
    • SW Jones RJ Hill PA Krasney B O'Conner N Peirce PL Greenhaff 2004 Disuse atrophy and exercise rehabilitation in humans profoundly affects the expression of genes associated with the regulation of skeletal muscle mass FASEB J 18 1025 1027 1:CAS:528:DC%2BD2cXkslWitbg%3D 15084522
    • (2004) FASEB J , vol.18 , pp. 1025-1027
    • Jones, S.W.1    Hill, R.J.2    Krasney, P.A.3    O'Conner, B.4    Peirce, N.5    Greenhaff, P.L.6
  • 62
    • 31544482447 scopus 로고    scopus 로고
    • Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids
    • 1:CAS:528:DC%2BD2MXht1ektLbF 16280440
    • CS Katsanos H Kobayashi M Sheffield-Moore A Aarsland RR Wolfe 2005 Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids Am J Clin Nutr 82 1065 1073 1:CAS:528:DC%2BD2MXht1ektLbF 16280440
    • (2005) Am J Clin Nutr , vol.82 , pp. 1065-1073
    • Katsanos, C.S.1    Kobayashi, H.2    Sheffield-Moore, M.3    Aarsland, A.4    Wolfe, R.R.5
  • 63
    • 33745853476 scopus 로고    scopus 로고
    • A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
    • 1:CAS:528:DC%2BD28XovVWgtLw%3D 16507602
    • CS Katsanos H Kobayashi M Sheffield-Moore A Aarsland RR Wolfe 2006 A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly Am J Physiol Endocrinol Metab 291 E381 E387 1:CAS:528:DC%2BD28XovVWgtLw%3D 16507602
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Katsanos, C.S.1    Kobayashi, H.2    Sheffield-Moore, M.3    Aarsland, A.4    Wolfe, R.R.5
  • 64
    • 0037319130 scopus 로고    scopus 로고
    • Ubiquitin-proteasome-dependent muscle proteolysis responds slowly to insulin release and refeeding in starved rats
    • 1:CAS:528:DC%2BD3sXitlSmsbc%3D 12563002
    • AJ Kee L Combaret T Tilignac B Souweine E Aurousseau M Dalle D Taillandier D Attaix 2003 Ubiquitin-proteasome-dependent muscle proteolysis responds slowly to insulin release and refeeding in starved rats J Physiol 546 765 776 1:CAS:528:DC%2BD3sXitlSmsbc%3D 12563002
    • (2003) J Physiol , vol.546 , pp. 765-776
    • Kee, A.J.1    Combaret, L.2    Tilignac, T.3    Souweine, B.4    Aurousseau, E.5    Dalle, M.6    Taillandier, D.7    Attaix, D.8
  • 65
    • 31544435440 scopus 로고    scopus 로고
    • Modulations of muscle protein metabolism by branched-chain amino acids in normal and muscle-atrophying rats
    • 1:CAS:528:DC%2BD28XivFSjtQ%3D%3D 16365089
    • H Kobayashi H Kato Y Hirabayashi H Murakami H Suzuki 2006 Modulations of muscle protein metabolism by branched-chain amino acids in normal and muscle-atrophying rats J Nutr 136 234S 236S 1:CAS:528:DC%2BD28XivFSjtQ%3D%3D 16365089
    • (2006) J Nutr , vol.136
    • Kobayashi, H.1    Kato, H.2    Hirabayashi, Y.3    Murakami, H.4    Suzuki, H.5
  • 66
    • 1842453217 scopus 로고    scopus 로고
    • Fundamentals of resistance training: Progression and exercise prescription
    • 15064596
    • WJ Kraemer NA Ratamess 2004 Fundamentals of resistance training: progression and exercise prescription Med Sci Sports Exerc 36 674 688 15064596
    • (2004) Med Sci Sports Exerc , vol.36 , pp. 674-688
    • Kraemer, W.J.1    Ratamess, N.A.2
  • 68
    • 65649086770 scopus 로고    scopus 로고
    • Muscle proteins during 60-day bedrest in women: Impact of exercise or nutrition
    • 1:CAS:528:DC%2BD1MXkvFent7k%3D 19229964
    • JK Lemoine JM Haus SW Trappe TA Trappe 2009 Muscle proteins during 60-day bedrest in women: impact of exercise or nutrition Muscle Nerve 39 463 471 1:CAS:528:DC%2BD1MXkvFent7k%3D 19229964
    • (2009) Muscle Nerve , vol.39 , pp. 463-471
    • Lemoine, J.K.1    Haus, J.M.2    Trappe, S.W.3    Trappe, T.A.4
  • 69
    • 0027093578 scopus 로고
    • Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle
    • 1:CAS:528:DyaK3sXpsVOnsA%3D%3D 1469091
    • RJ Louard DA Fryburg RA Gelfand EJ Barrett 1992 Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle J Clin Invest 90 2348 2354 1:CAS:528:DyaK3sXpsVOnsA%3D%3D 1469091
    • (1992) J Clin Invest , vol.90 , pp. 2348-2354
    • Louard, R.J.1    Fryburg, D.A.2    Gelfand, R.A.3    Barrett, E.J.4
  • 70
    • 0028920308 scopus 로고
    • Overnight branched-chain amino acid infusion causes sustained suppression of muscle proteolysis
    • 1:CAS:528:DyaK2MXltVeku70%3D 7723664
    • RJ Louard EJ Barrett RA Gelfand 1995 Overnight branched-chain amino acid infusion causes sustained suppression of muscle proteolysis Metabolism 44 424 429 1:CAS:528:DyaK2MXltVeku70%3D 7723664
    • (1995) Metabolism , vol.44 , pp. 424-429
    • Louard, R.J.1    Barrett, E.J.2    Gelfand, R.A.3
  • 71
    • 1642276028 scopus 로고    scopus 로고
    • Experimental demonstration of human weight homeostasis: Implications for understanding obesity
    • 1:CAS:528:DC%2BD2cXisVKhtbw%3D 15005834
    • AE Macias 2004 Experimental demonstration of human weight homeostasis: implications for understanding obesity Br J Nutr 91 479 484 1:CAS:528: DC%2BD2cXisVKhtbw%3D 15005834
    • (2004) Br J Nutr , vol.91 , pp. 479-484
    • MacIas, A.E.1
  • 72
    • 0142062997 scopus 로고    scopus 로고
    • Sarcopenia: Causes, consequences, and preventions
    • 14570858
    • TJ Marcell 2003 Sarcopenia: causes, consequences, and preventions J Gerontol A Biol Sci Med Sci 58 M911 M916 14570858
    • (2003) J Gerontol A Biol Sci Med Sci , vol.58
    • Marcell, T.J.1
  • 73
    • 0025150823 scopus 로고
    • Long-term oral branched-chain amino acid treatment in chronic hepatic encephalopathy. A randomized double-blind casein-controlled trial. The Italian Multicenter Study Group
    • 1:STN:280:DyaK3cznsFyrug%3D%3D 2204661
    • G Marchesini FS Dioguardi GP Bianchi M Zoli G Bellati L Roffi D Martines R Abbiati 1990 Long-term oral branched-chain amino acid treatment in chronic hepatic encephalopathy. A randomized double-blind casein-controlled trial. The Italian Multicenter Study Group J Hepatol 11 92 101 1:STN:280: DyaK3cznsFyrug%3D%3D 2204661
    • (1990) J Hepatol , vol.11 , pp. 92-101
    • Marchesini, G.1    Dioguardi, F.S.2    Bianchi, G.P.3    Zoli, M.4    Bellati, G.5    Roffi, L.6    Martines, D.7    Abbiati, R.8
  • 74
    • 55949123726 scopus 로고    scopus 로고
    • Antioxidant supplementation restores defective leucine stimulation of protein synthesis in skeletal muscle from old rats
    • 1:CAS:528:DC%2BD1cXht1ymtr7P 18936220
    • B Marzani M Balage A Venien T Astruc I Papet D Dardevet L Mosoni 2008 Antioxidant supplementation restores defective leucine stimulation of protein synthesis in skeletal muscle from old rats J Nutr 138 2205 2211 1:CAS:528:DC%2BD1cXht1ymtr7P 18936220
    • (2008) J Nutr , vol.138 , pp. 2205-2211
    • Marzani, B.1    Balage, M.2    Venien, A.3    Astruc, T.4    Papet, I.5    Dardevet, D.6    Mosoni, L.7
  • 75
    • 0025868638 scopus 로고
    • Leucine-induced amino acid antagonism in rats: Muscle valine metabolism and growth impairment
    • 1:CAS:528:DyaK3MXit1Orsbg%3D 2002401
    • RC May N Piepenbrock RA Kelly WE Mitch 1991 Leucine-induced amino acid antagonism in rats: muscle valine metabolism and growth impairment J Nutr 121 293 301 1:CAS:528:DyaK3MXit1Orsbg%3D 2002401
    • (1991) J Nutr , vol.121 , pp. 293-301
    • May, R.C.1    Piepenbrock, N.2    Kelly, R.A.3    Mitch, W.E.4
  • 76
    • 0036227772 scopus 로고    scopus 로고
    • Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine
    • 1:CAS:528:DC%2BD38XivF2rtL8%3D 11975938
    • PE May A Barber JT D'Olimpio A Hourihane NN Abumrad 2002 Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine Am J Surg 183 471 479 1:CAS:528:DC%2BD38XivF2rtL8%3D 11975938
    • (2002) Am J Surg , vol.183 , pp. 471-479
    • May, P.E.1    Barber, A.2    D'Olimpio, J.T.3    Hourihane, A.4    Abumrad, N.N.5
  • 77
    • 0032706215 scopus 로고    scopus 로고
    • Prospective randomized control study on the effect of branched-chain amino acids in patients with liver resection for hepatocellular carcinoma
    • 1:STN:280:DC%2BD3c%2FhvFCjsg%3D%3D 10553972
    • WC Meng KL Leung RL Ho TW Leung WY Lau 1999 Prospective randomized control study on the effect of branched-chain amino acids in patients with liver resection for hepatocellular carcinoma Aust N Z J Surg 69 811 815 1:STN:280:DC%2BD3c%2FhvFCjsg%3D%3D 10553972
    • (1999) Aust N Z J Surg , vol.69 , pp. 811-815
    • Meng, W.C.1    Leung, K.L.2    Ho, R.L.3    Leung, T.W.4    Lau, W.Y.5
  • 79
    • 0023519957 scopus 로고
    • Leucine, glucose, and energy metabolism after 3 days of fasting in healthy human subjects
    • 1:CAS:528:DyaL1cXjs1KmtA%3D%3D 3661473
    • KS Nair PD Woolf SL Welle DE Matthews 1987 Leucine, glucose, and energy metabolism after 3 days of fasting in healthy human subjects Am J Clin Nutr 46 557 562 1:CAS:528:DyaL1cXjs1KmtA%3D%3D 3661473
    • (1987) Am J Clin Nutr , vol.46 , pp. 557-562
    • Nair, K.S.1    Woolf, P.D.2    Welle, S.L.3    Matthews, D.E.4
  • 80
    • 0026476465 scopus 로고
    • Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans
    • 1:CAS:528:DyaK3sXjs1Cksw%3D%3D 1443126
    • KS Nair RG Schwartz S Welle 1992 Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans Am J Physiol 263 E928 E934 1:CAS:528:DyaK3sXjs1Cksw%3D%3D 1443126
    • (1992) Am J Physiol , vol.263
    • Nair, K.S.1    Schwartz, R.G.2    Welle, S.3
  • 81
    • 24644499561 scopus 로고    scopus 로고
    • Leucine suppresses myofibrillar proteolysis by down-regulating ubiquitin-proteasome pathway in chick skeletal muscles
    • 1:CAS:528:DC%2BD2MXhtVWnsL7F 16153608
    • K Nakashima A Ishida M Yamazaki H Abe 2005 Leucine suppresses myofibrillar proteolysis by down-regulating ubiquitin-proteasome pathway in chick skeletal muscles Biochem Biophys Res Commun 336 660 666 1:CAS:528:DC%2BD2MXhtVWnsL7F 16153608
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 660-666
    • Nakashima, K.1    Ishida, A.2    Yamazaki, M.3    Abe, H.4
  • 82
    • 34248584866 scopus 로고    scopus 로고
    • Amino acid supplementation prevents the loss of appetite for casein in old Lou/Cjall rats
    • 1:CAS:528:DC%2BD2sXlsF2ht78%3D 17376628
    • GN Nguema E Debras J Grizard J Alliot 2007 Amino acid supplementation prevents the loss of appetite for casein in old Lou/Cjall rats Exp Gerontol 42 652 661 1:CAS:528:DC%2BD2sXlsF2ht78%3D 17376628
    • (2007) Exp Gerontol , vol.42 , pp. 652-661
    • Nguema, G.N.1    Debras, E.2    Grizard, J.3    Alliot, J.4
  • 83
    • 32444435321 scopus 로고    scopus 로고
    • Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise
    • 1:CAS:528:DC%2BD28XhtFGhu78%3D 16424142
    • LE Norton DK Layman 2006 Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise J Nutr 136 533S 537S 1:CAS:528:DC%2BD28XhtFGhu78%3D 16424142
    • (2006) J Nutr , vol.136
    • Norton, L.E.1    Layman, D.K.2
  • 84
    • 0021807582 scopus 로고
    • Fasting plasma amino acid levels in cancer patients
    • 1:STN:280:DyaL2M3lsVegtw%3D%3D 3926295
    • JA Norton CM Gorschboth RA Wesley ME Burt MF Brennan 1985 Fasting plasma amino acid levels in cancer patients Cancer 56 1181 1186 1:STN:280: DyaL2M3lsVegtw%3D%3D 3926295
    • (1985) Cancer , vol.56 , pp. 1181-1186
    • Norton, J.A.1    Gorschboth, C.M.2    Wesley, R.A.3    Burt, M.E.4    Brennan, M.F.5
  • 85
    • 58149133630 scopus 로고    scopus 로고
    • Dietary protein recommendations and the prevention of sarcopenia
    • 1:CAS:528:DC%2BD1cXhsVKntLnI 19057193
    • D Paddon-Jones BB Rasmussen 2009 Dietary protein recommendations and the prevention of sarcopenia Curr Opin Clin Nutr Metab Care 12 86 90 1:CAS:528:DC%2BD1cXhsVKntLnI 19057193
    • (2009) Curr Opin Clin Nutr Metab Care , vol.12 , pp. 86-90
    • Paddon-Jones, D.1    Rasmussen, B.B.2
  • 86
    • 4544351389 scopus 로고    scopus 로고
    • Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest
    • 1:CAS:528:DC%2BD2cXnslWhsbc%3D 15356032
    • D Paddon-Jones M Sheffield-Moore RJ Urban AP Sanford A Aarsland RR Wolfe AA Ferrando 2004 Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest J Clin Endocrinol Metab 89 4351 4358 1:CAS:528:DC%2BD2cXnslWhsbc%3D 15356032
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4351-4358
    • Paddon-Jones, D.1    Sheffield-Moore, M.2    Urban, R.J.3    Sanford, A.P.4    Aarsland, A.5    Wolfe, R.R.6    Ferrando, A.A.7
  • 89
    • 43549116363 scopus 로고    scopus 로고
    • Role of dietary protein in the sarcopenia of aging
    • 1:CAS:528:DC%2BD1cXmtFehtr0%3D 18469288
    • D Paddon-Jones KR Short WW Campbell E Volpi RR Wolfe 2008 Role of dietary protein in the sarcopenia of aging Am J Clin Nutr 87 1562S 1566S 1:CAS:528:DC%2BD1cXmtFehtr0%3D 18469288
    • (2008) Am J Clin Nutr , vol.87
    • Paddon-Jones, D.1    Short, K.R.2    Campbell, W.W.3    Volpi, E.4    Wolfe, R.R.5
  • 90
    • 2942700062 scopus 로고    scopus 로고
    • Protein requirements and supplementation in strength sports
    • 1:CAS:528:DC%2BD2cXltVGiur4%3D 15212752
    • SM Phillips 2004 Protein requirements and supplementation in strength sports Nutrition 20 689 695 1:CAS:528:DC%2BD2cXltVGiur4%3D 15212752
    • (2004) Nutrition , vol.20 , pp. 689-695
    • Phillips, S.M.1
  • 91
    • 69749089808 scopus 로고    scopus 로고
    • Alterations of protein turnover underlying disuse atrophy in human skeletal muscle
    • 1:CAS:528:DC%2BD1MXhtFKnur3K 19608931
    • SM Phillips EI Glover MJ Rennie 2009 Alterations of protein turnover underlying disuse atrophy in human skeletal muscle J Appl Physiol 107 645 654 1:CAS:528:DC%2BD1MXhtFKnur3K 19608931
    • (2009) J Appl Physiol , vol.107 , pp. 645-654
    • Phillips, S.M.1    Glover, E.I.2    Rennie, M.J.3
  • 92
    • 1942534222 scopus 로고    scopus 로고
    • Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: A randomized trial
    • 1:CAS:528:DC%2BD2cXktVGmsr4%3D 15043519
    • RT Poon WC Yu ST Fan J Wong 2004 Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial Aliment Pharmacol Ther 19 779 788 1:CAS:528: DC%2BD2cXktVGmsr4%3D 15043519
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 779-788
    • Poon, R.T.1    Yu, W.C.2    Fan, S.T.3    Wong, J.4
  • 93
    • 0014618879 scopus 로고
    • Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels
    • 1:CAS:528:DyaE3cXmtlaqsg%3D%3D 5355340
    • T Pozefsky P Felig JD Tobin JS Soeldner GF Cahill Jr 1969 Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels J Clin Invest 48 2273 2282 1:CAS:528:DyaE3cXmtlaqsg%3D%3D 5355340
    • (1969) J Clin Invest , vol.48 , pp. 2273-2282
    • Pozefsky, T.1    Felig, P.2    Tobin, J.D.3    Soeldner, J.S.4    Cahill Jr., G.F.5
  • 94
    • 34248337464 scopus 로고    scopus 로고
    • Postprandial whole-body protein metabolism after a meat meal is influenced by chewing efficiency in elderly subjects
    • 17490964
    • D Rémond M Machebeuf C Yven C Buffière L Mioche L Mosoni P Patureau Mirand 2007 Postprandial whole-body protein metabolism after a meat meal is influenced by chewing efficiency in elderly subjects Am J Clin Nutr 85 1286 1292 17490964
    • (2007) Am J Clin Nutr , vol.85 , pp. 1286-1292
    • Rémond, D.1    MacHebeuf, M.2    Yven, C.3    Buffière, C.4    Mioche, L.5    Mosoni, L.6    Patureau Mirand, P.7
  • 95
    • 2342529174 scopus 로고    scopus 로고
    • Control of the size of the human muscle mass
    • 1:CAS:528:DC%2BD2cXjt1emtLw%3D 14977422
    • MJ Rennie H Wackerhage EE Spangenburg FW Booth 2004 Control of the size of the human muscle mass Annu Rev Physiol 66 799 828 1:CAS:528: DC%2BD2cXjt1emtLw%3D 14977422
    • (2004) Annu Rev Physiol , vol.66 , pp. 799-828
    • Rennie, M.J.1    Wackerhage, H.2    Spangenburg, E.E.3    Booth, F.W.4
  • 96
    • 0037657447 scopus 로고    scopus 로고
    • The total branched-chain amino acid requirement in young healthy adult men determined by indicator amino acid oxidation by use of L-[1-13C] phenylalanine
    • 1:CAS:528:DC%2BD3sXjs1OqtLw%3D 12730426
    • R Riazi LJ Wykes RO Ball PB Pencharz 2003 The total branched-chain amino acid requirement in young healthy adult men determined by indicator amino acid oxidation by use of L-[1-13C]phenylalanine J Nutr 133 1383 1389 1:CAS:528:DC%2BD3sXjs1OqtLw%3D 12730426
    • (2003) J Nutr , vol.133 , pp. 1383-1389
    • Riazi, R.1    Wykes, L.J.2    Ball, R.O.3    Pencharz, P.B.4
  • 97
    • 5444238912 scopus 로고    scopus 로고
    • Glucocorticoid excess induces a prolonged leucine resistance on muscle protein synthesis in old rats
    • 1:CAS:528:DC%2BD2cXos1eqt78%3D 15489054
    • I Rieu C Sornet J Grizard D Dardevet 2004 Glucocorticoid excess induces a prolonged leucine resistance on muscle protein synthesis in old rats Exp Gerontol 39 1315 1321 1:CAS:528:DC%2BD2cXos1eqt78%3D 15489054
    • (2004) Exp Gerontol , vol.39 , pp. 1315-1321
    • Rieu, I.1    Sornet, C.2    Grizard, J.3    Dardevet, D.4
  • 98
    • 33746876019 scopus 로고    scopus 로고
    • Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia
    • 1:CAS:528:DC%2BD28Xpslaitbc%3D 16777941
    • I Rieu M Balage C Sornet C Giraudet E Pujos J Grizard L Mosoni D Dardevet 2006 Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia J Physiol 575 305 315 1:CAS:528: DC%2BD28Xpslaitbc%3D 16777941
    • (2006) J Physiol , vol.575 , pp. 305-315
    • Rieu, I.1    Balage, M.2    Sornet, C.3    Giraudet, C.4    Pujos, E.5    Grizard, J.6    Mosoni, L.7    Dardevet, D.8
  • 99
    • 33845407735 scopus 로고    scopus 로고
    • Dietary protein, endurance exercise, and human skeletal-muscle protein turnover
    • 1:CAS:528:DC%2BD2sXhslShtLY%3D 17143053
    • NR Rodriguez LM Vislocky PC Gaine 2007 Dietary protein, endurance exercise, and human skeletal-muscle protein turnover Curr Opin Clin Nutr Metab Care 10 40 45 1:CAS:528:DC%2BD2sXhslShtLY%3D 17143053
    • (2007) Curr Opin Clin Nutr Metab Care , vol.10 , pp. 40-45
    • Rodriguez, N.R.1    Vislocky, L.M.2    Gaine, P.C.3
  • 100
    • 66349095750 scopus 로고    scopus 로고
    • Regulatory mechanisms of skeletal muscle protein turnover during exercise
    • 1:CAS:528:DC%2BD1MXlvFOgsLc%3D 19074568
    • AJ Rose EA Richter 2009 Regulatory mechanisms of skeletal muscle protein turnover during exercise J Appl Physiol 106 1702 1711 1:CAS:528: DC%2BD1MXlvFOgsLc%3D 19074568
    • (2009) J Appl Physiol , vol.106 , pp. 1702-1711
    • Rose, A.J.1    Richter, E.A.2
  • 101
    • 0024430754 scopus 로고
    • Summary comments
    • IH Rosenberg 1989 Summary comments Am J Clin Nutr 50 1231 1233
    • (1989) Am J Clin Nutr , vol.50 , pp. 1231-1233
    • Rosenberg, I.H.1
  • 102
    • 84970070866 scopus 로고
    • Conditional neoplasms and subthreshold neoplastic states: A study of the tar tumors of rabbits
    • 1:STN:280:DC%2BC3crjs1KmsA%3D%3D 19871084
    • P Rous JG Kidd 1941 Conditional neoplasms and subthreshold neoplastic states: a study of the tar tumors of rabbits J Exp Med 73 365 390 1:STN:280:DC%2BC3crjs1KmsA%3D%3D 19871084
    • (1941) J Exp Med , vol.73 , pp. 365-390
    • Rous, P.1    Kidd, J.G.2
  • 103
    • 0018319890 scopus 로고
    • Prevention of atrophy by isometric exercise of a casted leg
    • 1:STN:280:DyaL3c%2FltlaqsQ%3D%3D 502534
    • CK Rozier JD Elder M Brown 1979 Prevention of atrophy by isometric exercise of a casted leg J Sports Med Phys Fitness 19 191 194 1:STN:280:DyaL3c%2FltlaqsQ%3D%3D 502534
    • (1979) J Sports Med Phys Fitness , vol.19 , pp. 191-194
    • Rozier, C.K.1    Elder, J.D.2    Brown, M.3
  • 104
    • 0002830618 scopus 로고
    • Studies on the toxicity and antagonism of amino acids for weanling rats
    • 1:CAS:528:DyaF3sXksFShtLw%3D 13746747
    • HE Sauberlich 1961 Studies on the toxicity and antagonism of amino acids for weanling rats J Nutr 75 61 72 1:CAS:528:DyaF3sXksFShtLw%3D 13746747
    • (1961) J Nutr , vol.75 , pp. 61-72
    • Sauberlich, H.E.1
  • 106
    • 0031967119 scopus 로고    scopus 로고
    • Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets
    • 1:CAS:528:DyaK1cXhs1Wls7s%3D 9482771
    • B Stoll J Henry PJ Reeds H Yu F Jahoor DG Burrin 1998 Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets J Nutr 128 606 614 1:CAS:528:DyaK1cXhs1Wls7s%3D 9482771
    • (1998) J Nutr , vol.128 , pp. 606-614
    • Stoll, B.1    Henry, J.2    Reeds, P.J.3    Yu, H.4    Jahoor, F.5    Burrin, D.G.6
  • 108
    • 0022602879 scopus 로고
    • Improved protein kinetics and albumin synthesis by branched chain amino acid-enriched total parenteral nutrition in cancer cachexia. A prospective randomized crossover trial
    • 1:STN:280:DyaL283hslKlsw%3D%3D 3085914
    • JA Tayek BR Bistrian DJ Hehir R Martin LL Moldawer GL Blackburn 1986 Improved protein kinetics and albumin synthesis by branched chain amino acid-enriched total parenteral nutrition in cancer cachexia. A prospective randomized crossover trial Cancer 58 147 157 1:STN:280:DyaL283hslKlsw%3D%3D 3085914
    • (1986) Cancer , vol.58 , pp. 147-157
    • Tayek, J.A.1    Bistrian, B.R.2    Hehir, D.J.3    Martin, R.4    Moldawer, L.L.5    Blackburn, G.L.6
  • 110
    • 0023194462 scopus 로고
    • Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition
    • 1:CAS:528:DyaL2sXitFWlt7o%3D 3549777
    • P Tessari S Inchiostro G Biolo R Trevisan G Fantin MC Marescotti E Iori A Tiengo G Crepaldi 1987 Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition J Clin Invest 79 1062 1069 1:CAS:528:DyaL2sXitFWlt7o%3D 3549777
    • (1987) J Clin Invest , vol.79 , pp. 1062-1069
    • Tessari, P.1    Inchiostro, S.2    Biolo, G.3    Trevisan, R.4    Fantin, G.5    Marescotti, M.C.6    Iori, E.7    Tiengo, A.8    Crepaldi, G.9
  • 111
    • 0024457063 scopus 로고
    • Protein metabolism and beta-myosin heavy-chain mRNA in unweighted soleus muscle
    • 1:CAS:528:DyaL1MXlsFWntbc%3D 2764153
    • DB Thomason RB Biggs FW Booth 1989 Protein metabolism and beta-myosin heavy-chain mRNA in unweighted soleus muscle Am J Physiol 257 R300 R305 1:CAS:528:DyaL1MXlsFWntbc%3D 2764153
    • (1989) Am J Physiol , vol.257
    • Thomason, D.B.1    Biggs, R.B.2    Booth, F.W.3
  • 112
    • 43749088342 scopus 로고    scopus 로고
    • Aging and sarcopenia
    • 1:STN:280:DC%2BD2sjls1Whuw%3D%3D 18094505
    • DD Thompson 2007 Aging and sarcopenia J Musculoskelet Neuronal Interact 7 344 345 1:STN:280:DC%2BD2sjls1Whuw%3D%3D 18094505
    • (2007) J Musculoskelet Neuronal Interact , vol.7 , pp. 344-345
    • Thompson, D.D.1
  • 113
    • 66149138401 scopus 로고    scopus 로고
    • Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein
    • 1:CAS:528:DC%2BD1MXksVyiu70%3D 19370045
    • KD Tipton TA Elliott AA Ferrando AA Aarsland RR Wolfe 2009 Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein Appl Physiol Nutr Metab 34 151 161 1:CAS:528:DC%2BD1MXksVyiu70%3D 19370045
    • (2009) Appl Physiol Nutr Metab , vol.34 , pp. 151-161
    • Tipton, K.D.1    Elliott, T.A.2    Ferrando, A.A.3    Aarsland, A.A.4    Wolfe, R.R.5
  • 114
    • 33645620516 scopus 로고    scopus 로고
    • The influence of 5 weeks of ULLS and resistance exercise on vastus lateralis and soleus myosin heavy chain distribution
    • 1:STN:280:DC%2BD2c7ht1entA%3D%3D 15002514
    • TA Trappe JA Carrithers A Ekberg J Trieschmann PA Tesch 2002 The influence of 5 weeks of ULLS and resistance exercise on vastus lateralis and soleus myosin heavy chain distribution J Gravit Physiol 9 P127 P128 1:STN:280:DC%2BD2c7ht1entA%3D%3D 15002514
    • (2002) J Gravit Physiol , vol.9
    • Trappe, T.A.1    Carrithers, J.A.2    Ekberg, A.3    Trieschmann, J.4    Tesch, P.A.5
  • 115
    • 34548594086 scopus 로고    scopus 로고
    • Influence of concurrent exercise or nutrition countermeasures on thigh and calf muscle size and function during 60 days of bed rest in women
    • 1:CAS:528:DC%2BD2sXhtFKmt7vM
    • TA Trappe NA Burd ES Louis GA Lee SW Trappe 2007 Influence of concurrent exercise or nutrition countermeasures on thigh and calf muscle size and function during 60 days of bed rest in women Acta Physiol (Oxf) 191 147 159 1:CAS:528:DC%2BD2sXhtFKmt7vM
    • (2007) Acta Physiol (Oxf) , vol.191 , pp. 147-159
    • Trappe, T.A.1    Burd, N.A.2    Louis, E.S.3    Lee, G.A.4    Trappe, S.W.5
  • 116
    • 40449097564 scopus 로고    scopus 로고
    • Human soleus single muscle fiber function with exercise or nutrition countermeasures during 60 days of bed rest
    • 1:CAS:528:DC%2BD1cXjsFylsro%3D 18094071
    • S Trappe A Creer K Minchev D Slivka E Louis N Luden T Trappe 2008 Human soleus single muscle fiber function with exercise or nutrition countermeasures during 60 days of bed rest Am J Physiol Regul Integr Comp Physiol 294 R939 R947 1:CAS:528:DC%2BD1cXjsFylsro%3D 18094071
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.294
    • Trappe, S.1    Creer, A.2    Minchev, K.3    Slivka, D.4    Louis, E.5    Luden, N.6    Trappe, T.7
  • 117
    • 24144446404 scopus 로고    scopus 로고
    • Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
    • 1:CAS:528:DC%2BD2MXhtVSjs7vP 16123357
    • F Tremblay M Krebs L Dombrowski A Brehm E Bernroider E Roth P Nowotny W Waldhäusl A Marette M Roden 2005 Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability Diabetes 54 2674 2684 1:CAS:528:DC%2BD2MXhtVSjs7vP 16123357
    • (2005) Diabetes , vol.54 , pp. 2674-2684
    • Tremblay, F.1    Krebs, M.2    Dombrowski, L.3    Brehm, A.4    Bernroider, E.5    Roth, E.6    Nowotny, P.7    Waldhäusl, W.8    Marette, A.9    Roden, M.10
  • 119
    • 0027240637 scopus 로고
    • Functional and morphological adaptations following four weeks of knee immobilization
    • 1:STN:280:DyaK3sznsVGhtg%3D%3D 8365837
    • JW Veldhuizen FT Verstappen JP Vroemen H Kuipers JM Greep 1993 Functional and morphological adaptations following four weeks of knee immobilization Int J Sports Med 14 283 287 1:STN:280:DyaK3sznsVGhtg%3D%3D 8365837
    • (1993) Int J Sports Med , vol.14 , pp. 283-287
    • Veldhuizen, J.W.1    Verstappen, F.T.2    Vroemen, J.P.3    Kuipers, H.4    Greep, J.M.5
  • 120
    • 65549171522 scopus 로고    scopus 로고
    • Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men
    • 1:CAS:528:DC%2BD1MXlt1Ort7c%3D 19321567
    • S Verhoeven K Vanschoonbeek LB Verdijk R Koopman WK Wodzig P Dendale LJ van Loon 2009 Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men Am J Clin Nutr 89 1468 1475 1:CAS:528:DC%2BD1MXlt1Ort7c%3D 19321567
    • (2009) Am J Clin Nutr , vol.89 , pp. 1468-1475
    • Verhoeven, S.1    Vanschoonbeek, K.2    Verdijk, L.B.3    Koopman, R.4    Wodzig, W.K.5    Dendale, P.6    Van Loon, L.J.7
  • 122
    • 0030666932 scopus 로고    scopus 로고
    • Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes
    • 1:CAS:528:DyaK2sXnt1Sku7k%3D 9357801
    • SJ Wigmore KC Fearon JP Maingay PB Lai JA Ross 1997 Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes Am J Physiol 273 E720 E726 1:CAS:528:DyaK2sXnt1Sku7k%3D 9357801
    • (1997) Am J Physiol , vol.273
    • Wigmore, S.J.1    Fearon, K.C.2    Maingay, J.P.3    Lai, P.B.4    Ross, J.A.5
  • 123
    • 0034893972 scopus 로고    scopus 로고
    • Nutritional support in critically ill patients with cancer
    • 1:CAS:528:DC%2BD3MXmsl2hurY%3D 11525056
    • PW Wong A Enriquez R Barrera 2001 Nutritional support in critically ill patients with cancer Crit Care Clin 17 743 767 1:CAS:528:DC%2BD3MXmsl2hurY%3D 11525056
    • (2001) Crit Care Clin , vol.17 , pp. 743-767
    • Wong, P.W.1    Enriquez, A.2    Barrera, R.3
  • 124
    • 24044552980 scopus 로고    scopus 로고
    • Sex-based differences in skeletal muscle function and morphology with short-term limb immobilization
    • 15860685
    • N Yasuda EI Glover SM Phillips RJ Isfort MA Tarnopolsky 2005 Sex-based differences in skeletal muscle function and morphology with short-term limb immobilization J Appl Physiol 99 1085 1092 15860685
    • (2005) J Appl Physiol , vol.99 , pp. 1085-1092
    • Yasuda, N.1    Glover, E.I.2    Phillips, S.M.3    Isfort, R.J.4    Tarnopolsky, M.A.5
  • 125
    • 48349086611 scopus 로고    scopus 로고
    • Potential antiproteolytic effects of l-leucine: Observations of in vitro and in vivo studies
    • NE Zanchi H Nicastro AH Lancha Jr 2008 Potential antiproteolytic effects of l-leucine: observations of in vitro and in vivo studies Nutr Metab (Lond) 5 20
    • (2008) Nutr Metab (Lond) , vol.5 , pp. 20
    • Zanchi, N.E.1    Nicastro, H.2    Lancha Jr., A.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.