Oxidative stress-dependent activation of the eIF2α-ATFr unfolded protein response branch by skin sensitizer 1-fluoro-2,4-dinitrobenzene modulates dendritic-like cell maturation and inflammatory status in a biphasic manner

Free Radical Biology and Medicine

Volumn 77, Issue , 2014, Pages 217-229

  Luís, Andreia ^a   Martins, João Demétrio ^b,c   Silva, Ana ^b   Ferreira, Isabel ^b   Cruz, Maria Teresa ^b,c   Neves, Bruno Miguel ^a,b  

^a UNIVERSITY OF AVEIRO   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Allergic contact dermatitis; ATF4; Autophagy; Dendritic cell maturation; ER stress; ROS

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; ACTIVATING TRANSCRIPTION FACTOR 4; CD86 ANTIGEN; CHAPERONE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUCOSE REGULATED PROTEIN 78; HEME OXYGENASE 1; INITIATION FACTOR 2ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 8; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; THYMOCYTE ANTIBODY; TRANSCRIPTION FACTOR NRF2; ATF4 PROTEIN, HUMAN; HEAT SHOCK PROTEIN; INITIATION FACTOR 2; MOLECULAR CHAPERONE GRP78;

ARTICLE; AUTOPHAGY; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL PROTECTION; DENDRITIC CELL; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOBIOLOGY; INFLAMMATORY CELL; INFLAMMATORY DISEASE; INTRACELLULAR SIGNALING; LYSOSOME MEMBRANE; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SKIN SENSITIZATION; TRANSIENT EXPRESSION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; WESTERN BLOTTING; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; INTRACELLULAR MEMBRANE; LANGERHANS CELL; LYSOSOME; METABOLISM; PHYSIOLOGY; TRANSCRIPTION INITIATION;

ACTIVATING TRANSCRIPTION FACTOR 4; AUTOPHAGY; CELL LINE; CELL SURVIVAL; DINITROFLUOROBENZENE; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; HEAT-SHOCK PROTEINS; HUMANS; INTRACELLULAR MEMBRANES; LANGERHANS CELLS; LYSOSOMES; TRANSCRIPTIONAL ACTIVATION; UNFOLDED PROTEIN RESPONSE;

EID: 84908387127     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.09.008     Document Type: Article

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