Model-based prediction of monoclonal antibody retention in ion-exchange chromatography

Journal of Chromatography A

Volumn 1298, Issue , 2013, Pages 17-25

  Guélat, Bertrand ^a   Delegrange, Lydia ^b   Valax, Pascal ^b   Morbidelli, Massimo ^a  

^a ETH ZURICH   (Switzerland)

^b MERCK SERONO S A   (Switzerland)

Author keywords

Adsorption equilibrium; Colloidal model; Ion exchange; Monoclonal antibody variants; Prediction

Indexed keywords

ADSORPTION EQUILIBRIA; ADSORPTION EQUILIBRIUM CONSTANTS; AMINO ACID SEQUENCE; COLLOIDAL MODELS; ION-EXCHANGE CHROMATOGRAPHY; MODEL-BASED PREDICTION; STRUCTURAL DIFFERENCES; STRUCTURAL INFORMATION;

ADSORPTION ISOTHERMS; AMINO ACIDS; CHROMATOGRAPHY; EQUILIBRIUM CONSTANTS; ION EXCHANGE; MONOCLONAL ANTIBODIES; PROTEINS; RESINS;

FORECASTING;

BEVACIZUMAB; HERCETIN; MONOCLONAL ANTIBODY; SODIUM CHLORIDE; TRASTUZUMAB; UNCLASSIFIED DRUG;

ACCURACY; ADSORPTION; AMINO ACID SEQUENCE; ARTICLE; DISSOCIATION; ION EXCHANGE CHROMATOGRAPHY; PH; PHYSICAL MODEL; PREDICTION; PRIORITY JOURNAL; PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CATION EXCHANGE RESINS; CHROMATOGRAPHY, ION EXCHANGE; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; PROTEINS;

EID: 84879184192     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2013.04.048     Document Type: Article

References (26)

1. Carta G., Jungbauer A. Protein Chromatography Process Development and Scale-Up 2010, Wiley-VCH, Weinheim.
2. Müller-Späth T., Aumann L., Ströhlein G., Kornmann H., Valax P., Delegrange L., Charbaut E., Baer G., Lamproye A., Jöhnck M., Schulte M., Morbidelli M. Biotechnol. Bioeng. 2010, 107:974.
3. Mehta A., Tse M.L., Fogle J., Len A., Shrestha R., Fontes N., Lebreton B., Wolk B., van Reis R. Chem. Eng. Prog. 2008, 104:S14.
4. Vlasak J., Ionescu R. Curr. Pharm. Biotechnol. 2008, 9:468.
5. Harris R.J., Kabakoff B., Macchi F.D., Shen F.J., Kwong M., Andya J.D., Shire S.J., Bjork N., Totpal K., Chen A.B. J. Chromatogr. B 2001, 752:233.
6. Weitzhandler M., Farnan D., Horvath J., Rohrer J.S., Slingsby R.W., Avdalovic N., Pohl C. J. Chromatogr. A 1998, 828:365.
7. Muller-Spath T., Krattli M., Aumann L., Strohlein G., Morbidelli M. Biotechnol. Bioeng. 2010, 107:652.
8. Guélat B., Ströhlein G., Lattuada M., Delegrange L., Valax P., Morbidelli M. J. Chromatogr. A 2012, 1253:32.
9. Guiochon G. Fundamentals of Preparative and Nonlinear Chromatography 2006, Elsevier, Amsterdam.
10. Yao Y., Lenhoff A.M. Anal. Chem. 2004, 76:6743.
11. Dismer F., Hubbuch J. J. Chromatogr. A 2010, 1217:1343.
12. M. Salvalaglio, B. Guelat, M. Morbidelli, C. Cavallotti, in preparation.
13. Mazza C.B., Sukumar N., Breneman C.M., Cramer S.M. Anal. Chem. 2001, 73:5457.
14. Chung W.K., Hou Y., Freed A., Holstein M., Makhatadze G.I., Cramer S.N. Biotechnol. Bioeng. 2009, 102:869.
15. Malmquist G., Nilsson U.H., Norrman M., Skarp U., Stromgren M., Carredano E. J. Chromatogr. A 2006, 1115:164.
16. Roth C.M., Unger K.K., Lenhoff A.M. J. Chromatogr. A 1996, 726:45.
17. Ishihara T., Kadoya T., Yoshida H., Tamada T., Yamamoto S. J. Chromatogr. A 2005, 1093:126.
18. Pabst T.M., Carta G. J. Chromatogr. A 2007, 1142:19.
19. DePhillips P., Lenhoff A.M. J. Chromatogr. A 2000, 883:39.
20. Guélat B., Ströhlein G., Lattuada M., Morbidelli M. J. Chromatogr. A 2010, 1217:5610.
21. Roth C.M., Lenhoff A.M. Langmuir 1993, 9:962.
22. Liu H.C., Gaza-Bulseco G., Faldu D., Chumsae C., Sun J. J. Pharm. Sci. 2008, 97:2426.
23. Berg J.M., Tymoczko J.L., Stryer L. Biochemistry 2002, Freeman, New York.
24. Martell A.E., Smith R.M. Critical Stability Constants 1974, Plenum Press, New York.
25. Perrin D.D. International Union of Pure and Applied Chemistry, Commission on Electroanalytical Chemistry, Dissociation Constants of Organic Bases in Aqueous Solution 1965, Butterworths, London.
26. Forrer N., Butte A., Morbidelli M. J. Chromatogr. A 2008, 1214:59.