메뉴 건너뛰기




Volumn 30, Issue , 2014, Pages 230-237

Recent advances in natural product discovery

Author keywords

[No Author keywords available]

Indexed keywords

BOTTOM UP APPROACH; GENETIC MANIPULATIONS; GENOMICS; HETEROLOGOUS EXPRESSION; HUMAN THERAPEUTICS; NATURAL PRODUCTS; PHARMACEUTICAL INDUSTRY; SCREENING APPROACHES;

EID: 84908338451     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2014.09.002     Document Type: Review
Times cited : (126)

References (59)
  • 1
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30 years from 1981 to 2010
    • Newman D.J., Cragg G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 2012, 75:311-335.
    • (2012) J Nat Prod , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 2
    • 67650436176 scopus 로고    scopus 로고
    • Drug discovery and natural products: end of an era or an endless frontier?
    • Li J.W., Vederas J.C. Drug discovery and natural products: end of an era or an endless frontier?. Science 2009, 325:161-165.
    • (2009) Science , vol.325 , pp. 161-165
    • Li, J.W.1    Vederas, J.C.2
  • 6
    • 84908328891 scopus 로고    scopus 로고
    • Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery
    • Ramadhar T.R., Beemelmanns C., Currie C.R., Clardy J. Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery. J Antibiot (Tokyo) 2013.
    • (2013) J Antibiot (Tokyo)
    • Ramadhar, T.R.1    Beemelmanns, C.2    Currie, C.R.3    Clardy, J.4
  • 8
    • 84867632542 scopus 로고    scopus 로고
    • Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes
    • Seyedsayamdost M.R., Traxler M.F., Clardy J., Kolter R. Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes. Methods Enzymol 2012, 517:89-109.
    • (2012) Methods Enzymol , vol.517 , pp. 89-109
    • Seyedsayamdost, M.R.1    Traxler, M.F.2    Clardy, J.3    Kolter, R.4
  • 11
    • 84868022653 scopus 로고    scopus 로고
    • Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach
    • Du L., King J.B., Morrow B.H., Shen J.K., Miller A.N., Cichewicz R.H. Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach. J Nat Prod 2012, 75:1819-1823.
    • (2012) J Nat Prod , vol.75 , pp. 1819-1823
    • Du, L.1    King, J.B.2    Morrow, B.H.3    Shen, J.K.4    Miller, A.N.5    Cichewicz, R.H.6
  • 12
    • 84870206740 scopus 로고    scopus 로고
    • Production of cytotoxic glidobactins/luminmycins by Photorhabdus asymbiotica in liquid media and live crickets
    • Theodore C.M., King J.B., You J., Cichewicz R.H. Production of cytotoxic glidobactins/luminmycins by Photorhabdus asymbiotica in liquid media and live crickets. J Nat Prod 2012, 75:2007-2011.
    • (2012) J Nat Prod , vol.75 , pp. 2007-2011
    • Theodore, C.M.1    King, J.B.2    You, J.3    Cichewicz, R.H.4
  • 14
    • 84871959363 scopus 로고    scopus 로고
    • Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen
    • Graupner K., Scherlach K., Bretschneider T., Lackner G., Roth M., Gross H., Hertweck C. Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen. Angew Chem Int Ed Engl 2012, 51:13173-13177.
    • (2012) Angew Chem Int Ed Engl , vol.51 , pp. 13173-13177
    • Graupner, K.1    Scherlach, K.2    Bretschneider, T.3    Lackner, G.4    Roth, M.5    Gross, H.6    Hertweck, C.7
  • 20
    • 79959920872 scopus 로고    scopus 로고
    • AntiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
    • Medema M.H., Blin K., Cimermancic P., de Jager V., Zakrzewski P., Fischbach M.A., Weber T., Takano E., Breitling R. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucl Acids Res 2011, 39:W339-W346.
    • (2011) Nucl Acids Res , vol.39 , pp. W339-W346
    • Medema, M.H.1    Blin, K.2    Cimermancic, P.3    de Jager, V.4    Zakrzewski, P.5    Fischbach, M.A.6    Weber, T.7    Takano, E.8    Breitling, R.9
  • 22
    • 84864368726 scopus 로고    scopus 로고
    • Identification and molecular genetic analysis of the cichorine gene cluster in Aspergillus nidulans
    • Sanchez J.F., Entwistle R., Corcoran D., Oakley B.R., Wang C.C. Identification and molecular genetic analysis of the cichorine gene cluster in Aspergillus nidulans. MedChemComm 2012, 3:997-1002.
    • (2012) MedChemComm , vol.3 , pp. 997-1002
    • Sanchez, J.F.1    Entwistle, R.2    Corcoran, D.3    Oakley, B.R.4    Wang, C.C.5
  • 23
    • 84864097219 scopus 로고    scopus 로고
    • Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus
    • Lim F.Y., Hou Y., Chen Y., Oh J.H., Lee I., Bugni T.S., Keller N.P. Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus. Appl Environ Microbiol 2012, 78:4117-4125.
    • (2012) Appl Environ Microbiol , vol.78 , pp. 4117-4125
    • Lim, F.Y.1    Hou, Y.2    Chen, Y.3    Oh, J.H.4    Lee, I.5    Bugni, T.S.6    Keller, N.P.7
  • 24
    • 84867350993 scopus 로고    scopus 로고
    • Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440
    • Cacho R.A., Jiang W., Chooi Y.H., Walsh C.T., Tang Y. Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. J Am Chem Soc 2012, 134:16781-16790.
    • (2012) J Am Chem Soc , vol.134 , pp. 16781-16790
    • Cacho, R.A.1    Jiang, W.2    Chooi, Y.H.3    Walsh, C.T.4    Tang, Y.5
  • 25
    • 84879229261 scopus 로고    scopus 로고
    • Molecular genetic characterization of the biosynthesis cluster of a prenylated isoindolinone alkaloid aspernidine A in Aspergillus nidulans
    • Yaegashi J., Praseuth M.B., Tyan S.W., Sanchez J.F., Entwistle R., Chiang Y.M., Oakley B.R., Wang C.C. Molecular genetic characterization of the biosynthesis cluster of a prenylated isoindolinone alkaloid aspernidine A in Aspergillus nidulans. Org Lett 2013, 15:2862-2865.
    • (2013) Org Lett , vol.15 , pp. 2862-2865
    • Yaegashi, J.1    Praseuth, M.B.2    Tyan, S.W.3    Sanchez, J.F.4    Entwistle, R.5    Chiang, Y.M.6    Oakley, B.R.7    Wang, C.C.8
  • 26
    • 84934439063 scopus 로고    scopus 로고
    • Tools for manipulation of secondary metabolism pathways: rapid promoter replacements and gene deletions in Aspergillus nidulans
    • Oakley C.E., Edgerton-Morgan H., Oakley B.R. Tools for manipulation of secondary metabolism pathways: rapid promoter replacements and gene deletions in Aspergillus nidulans. Methods Mol Biol 2012, 944:143-161.
    • (2012) Methods Mol Biol , vol.944 , pp. 143-161
    • Oakley, C.E.1    Edgerton-Morgan, H.2    Oakley, B.R.3
  • 28
    • 84868515764 scopus 로고    scopus 로고
    • Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species
    • Franke J., Ishida K., Hertweck C. Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species. Angew Chem Int Ed Engl 2012, 51:11611-11615.
    • (2012) Angew Chem Int Ed Engl , vol.51 , pp. 11611-11615
    • Franke, J.1    Ishida, K.2    Hertweck, C.3
  • 29
    • 84867577748 scopus 로고    scopus 로고
    • Molecular genetic analysis reveals that a nonribosomal peptide synthetase-like (NRPS-like) gene in Aspergillus nidulans is responsible for microperfuranone biosynthesis
    • Yeh H.H., Chiang Y.M., Entwistle R., Ahuja M., Lee K.H., Bruno K.S., Wu T.K., Oakley B.R., Wang C.C. Molecular genetic analysis reveals that a nonribosomal peptide synthetase-like (NRPS-like) gene in Aspergillus nidulans is responsible for microperfuranone biosynthesis. Appl Microbiol Biotechnol 2012, 96:739-748.
    • (2012) Appl Microbiol Biotechnol , vol.96 , pp. 739-748
    • Yeh, H.H.1    Chiang, Y.M.2    Entwistle, R.3    Ahuja, M.4    Lee, K.H.5    Bruno, K.S.6    Wu, T.K.7    Oakley, B.R.8    Wang, C.C.9
  • 30
    • 77954303579 scopus 로고    scopus 로고
    • Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol
    • Chou W.K., Fanizza I., Uchiyama T., Komatsu M., Ikeda H., Cane D.E. Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol. J Am Chem Soc 2010, 132:8850-8851.
    • (2010) J Am Chem Soc , vol.132 , pp. 8850-8851
    • Chou, W.K.1    Fanizza, I.2    Uchiyama, T.3    Komatsu, M.4    Ikeda, H.5    Cane, D.E.6
  • 33
    • 84887855441 scopus 로고    scopus 로고
    • Discovery of cryptic polyketide metabolites from Dermatophytes using heterologous expression in Aspergillus nidulans
    • Yin W.B., Chooi Y.H., Smith A.R., Cacho R.A., Hu Y.C., White T.C., Tang Y. Discovery of cryptic polyketide metabolites from Dermatophytes using heterologous expression in Aspergillus nidulans. ACS Synth Biol 2013, 2:629-634.
    • (2013) ACS Synth Biol , vol.2 , pp. 629-634
    • Yin, W.B.1    Chooi, Y.H.2    Smith, A.R.3    Cacho, R.A.4    Hu, Y.C.5    White, T.C.6    Tang, Y.7
  • 34
    • 84895075667 scopus 로고    scopus 로고
    • Strategies for mining fungal natural products
    • Wiemann P., Keller N.P. Strategies for mining fungal natural products. J Ind Microbiol Biotechnol 2014, 41:301-313.
    • (2014) J Ind Microbiol Biotechnol , vol.41 , pp. 301-313
    • Wiemann, P.1    Keller, N.P.2
  • 35
    • 84872175341 scopus 로고    scopus 로고
    • Engineering fungal secondary metabolism: a roadmap to novel compounds
    • Scharf D.H., Brakhage A.A. Engineering fungal secondary metabolism: a roadmap to novel compounds. J Biotechnol 2013, 163:179-183.
    • (2013) J Biotechnol , vol.163 , pp. 179-183
    • Scharf, D.H.1    Brakhage, A.A.2
  • 36
    • 84860784197 scopus 로고    scopus 로고
    • Direct cloning of large genomic sequences
    • Cobb R.E., Zhao H. Direct cloning of large genomic sequences. Nat Biotechnol 2012, 30:405-406.
    • (2012) Nat Biotechnol , vol.30 , pp. 405-406
    • Cobb, R.E.1    Zhao, H.2
  • 37
    • 84867645703 scopus 로고    scopus 로고
    • DNA assembler: A synthetic biology tool for characterizing and engineering natural product gene clusters
    • Shao Z., Zhao H. DNA assembler: a synthetic biology tool for characterizing and engineering natural product gene clusters. Methods Enzymol 2012, 517:203-224.
    • (2012) Methods Enzymol , vol.517 , pp. 203-224
    • Shao, Z.1    Zhao, H.2
  • 38
    • 79952642503 scopus 로고    scopus 로고
    • Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler
    • Shao Z., Luo Y., Zhao H. Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler. Mol Biosyst 2011, 7:1056-1059.
    • (2011) Mol Biosyst , vol.7 , pp. 1056-1059
    • Shao, Z.1    Luo, Y.2    Zhao, H.3
  • 39
    • 84887870749 scopus 로고    scopus 로고
    • Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold
    • Shao Z., Rao G., Li C., Abil Z., Luo Y., Zhao H. Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold. ACS Synth Biol 2013, 2:662-669.
    • (2013) ACS Synth Biol , vol.2 , pp. 662-669
    • Shao, Z.1    Rao, G.2    Li, C.3    Abil, Z.4    Luo, Y.5    Zhao, H.6
  • 40
    • 84890086658 scopus 로고    scopus 로고
    • Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster
    • Luo Y., Huang H., Liang J., Wang M., Lu L., Shao Z., Cobb R.E., Zhao H. Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster. Nat Commun 2013, 4:2894.
    • (2013) Nat Commun , vol.4 , pp. 2894
    • Luo, Y.1    Huang, H.2    Liang, J.3    Wang, M.4    Lu, L.5    Shao, Z.6    Cobb, R.E.7    Zhao, H.8
  • 42
    • 84859643086 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of polyketides - a perspective
    • Wong F.T., Khosla C. Combinatorial biosynthesis of polyketides - a perspective. Curr Opin Chem Biol 2012, 16:117-123.
    • (2012) Curr Opin Chem Biol , vol.16 , pp. 117-123
    • Wong, F.T.1    Khosla, C.2
  • 43
    • 84885028788 scopus 로고    scopus 로고
    • Deoxysugar pathway interchange for erythromycin analogues heterologously produced through Escherichia coli
    • Jiang M., Zhang H., Park S.H., Li Y., Pfeifer B.A. Deoxysugar pathway interchange for erythromycin analogues heterologously produced through Escherichia coli. Metab Eng 2013, 20C:92-100.
    • (2013) Metab Eng , vol.20 C , pp. 92-100
    • Jiang, M.1    Zhang, H.2    Park, S.H.3    Li, Y.4    Pfeifer, B.A.5
  • 44
    • 84864275239 scopus 로고    scopus 로고
    • Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket
    • Harvey C.J., Puglisi J.D., Pande V.S., Cane D.E., Khosla C. Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket. J Am Chem Soc 2012, 134:12259-12265.
    • (2012) J Am Chem Soc , vol.134 , pp. 12259-12265
    • Harvey, C.J.1    Puglisi, J.D.2    Pande, V.S.3    Cane, D.E.4    Khosla, C.5
  • 45
    • 84865515585 scopus 로고    scopus 로고
    • Synthetic biological approaches to natural product biosynthesis
    • Winter J.M., Tang Y. Synthetic biological approaches to natural product biosynthesis. Curr Opin Biotechnol 2012, 23:736-743.
    • (2012) Curr Opin Biotechnol , vol.23 , pp. 736-743
    • Winter, J.M.1    Tang, Y.2
  • 46
    • 84869884770 scopus 로고    scopus 로고
    • Bioengineering natural product biosynthetic pathways for therapeutic applications
    • Wu M.C., Law B., Wilkinson B., Micklefield J. Bioengineering natural product biosynthetic pathways for therapeutic applications. Curr Opin Biotechnol 2012, 23:931-940.
    • (2012) Curr Opin Biotechnol , vol.23 , pp. 931-940
    • Wu, M.C.1    Law, B.2    Wilkinson, B.3    Micklefield, J.4
  • 48
    • 84873941080 scopus 로고    scopus 로고
    • Engineering fungal nonreducing polyketide synthase by heterologous expression and domain swapping
    • Yeh H.H., Chang S.L., Chiang Y.M., Bruno K.S., Oakley B.R., Wu T.K., Wang C.C. Engineering fungal nonreducing polyketide synthase by heterologous expression and domain swapping. Org Lett 2013, 15:756-759.
    • (2013) Org Lett , vol.15 , pp. 756-759
    • Yeh, H.H.1    Chang, S.L.2    Chiang, Y.M.3    Bruno, K.S.4    Oakley, B.R.5    Wu, T.K.6    Wang, C.C.7
  • 49
    • 84883484875 scopus 로고    scopus 로고
    • Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways
    • Walker M.C., Thuronyi B.W., Charkoudian L.K., Lowry B., Khosla C., Chang M.C. Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways. Science 2013, 341:1089-1094.
    • (2013) Science , vol.341 , pp. 1089-1094
    • Walker, M.C.1    Thuronyi, B.W.2    Charkoudian, L.K.3    Lowry, B.4    Khosla, C.5    Chang, M.C.6
  • 51
    • 84908351030 scopus 로고    scopus 로고
    • Epigenetic regulation of secondary metabolite biosynthetic genes in fungi
    • Springer, Netherlands, G. Witzany (Ed.)
    • Cichewicz R. Epigenetic regulation of secondary metabolite biosynthetic genes in fungi. Biocommunication of fungi 2012, 57-69. Springer, Netherlands. G. Witzany (Ed.).
    • (2012) Biocommunication of fungi , pp. 57-69
    • Cichewicz, R.1
  • 52
    • 84888004195 scopus 로고    scopus 로고
    • Cloning and sequencing of the chaetocin biosynthetic gene cluster
    • Gerken T., Walsh C.T. Cloning and sequencing of the chaetocin biosynthetic gene cluster. ChemBioChem 2013, 14:2256-2258.
    • (2013) ChemBioChem , vol.14 , pp. 2256-2258
    • Gerken, T.1    Walsh, C.T.2
  • 53
    • 84893493312 scopus 로고    scopus 로고
    • DNA assembly techniques for next-generation combinatorial biosynthesis of natural products
    • Cobb R.E., Ning J.C., Zhao H. DNA assembly techniques for next-generation combinatorial biosynthesis of natural products. J Ind Microbiol Biotechnol 2014, 41:469-477.
    • (2014) J Ind Microbiol Biotechnol , vol.41 , pp. 469-477
    • Cobb, R.E.1    Ning, J.C.2    Zhao, H.3
  • 55
    • 84881252814 scopus 로고    scopus 로고
    • Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology
    • Peck S.C., van der Donk W.A. Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology. Curr Opin Chem Biol 2013, 17:580-588.
    • (2013) Curr Opin Chem Biol , vol.17 , pp. 580-588
    • Peck, S.C.1    van der Donk, W.A.2
  • 58
    • 84891882533 scopus 로고    scopus 로고
    • New natural products as new leads for antibacterial drug discovery
    • Brown D.G., Lister T., May-Dracka T.L. New natural products as new leads for antibacterial drug discovery. Bioorg Med Chem Lett 2014, 24:413-418.
    • (2014) Bioorg Med Chem Lett , vol.24 , pp. 413-418
    • Brown, D.G.1    Lister, T.2    May-Dracka, T.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.