A High-Throughput screen identifies a new natural product with Broad-Spectrum antibacterial activity

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Ymele Leki, Patrick ^a   Cao, Shugeng ^b   Sharp, Jared ^a   Lambert, Kathleen G ^a   McAdam, Alexander J ^a   Husson, Robert N ^a   Tamayo, Giselle ^c   Clardy, Jon ^b   Watnick, Paula I ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSIDAD DE COSTA RICA   (Costa Rica)

Author keywords

[No Author keywords available]

Indexed keywords

2 (HYDROXYMETHYL) 3 PROPYL BENZOQUINONE; 5 HYDROXY 4 (HYDROXYMETHYL) 2 METHYL 2,3 DIHYDROBENZOFURAN; AMPICILLIN; ANTIBIOTIC AGENT; COTRIMOXAZOLE; ETHAMBUTOL; FUNGAL EXTRACT; ISONIAZID; LEVOFLOXACIN; MIRANDAMYCIN; NATURAL PRODUCT; PYRAZINAMIDE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BIOLOGICAL PRODUCT;

ACCURACY; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; ENDOPHYTE; ESCHERICHIA COLI; FERMENTATION MEDIUM; HIGH THROUGHPUT SCREENING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PH MEASUREMENT; PREDICTION; PROCESS DEVELOPMENT; PSEUDOMONAS AERUGINOSA; SENSITIVITY AND SPECIFICITY; VALIDATION PROCESS; VIBRIO CHOLERAE; BACTERIUM; CHEMISTRY; DRUG EFFECT; ECOSYSTEM; FUNGUS; ISOLATION AND PURIFICATION; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; PH; STANDARD;

ANTI-BACTERIAL AGENTS; BACTERIA; BIOLOGICAL AGENTS; COLORIMETRY; ECOSYSTEM; FUNGI; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROGEN-ION CONCENTRATION; MICROBIAL SENSITIVITY TESTS;

EID: 84857132826     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031307     Document Type: Article

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