Advanced tracers in PET imaging of cardiovascular disease

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Li, Yesen ^a,b   Zhang, Wei ^c,d   Wu, Hua ^a   Liu, Gang ^b  

^a THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^b XIAMEN UNIVERSITY   (China)

^c SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^d AFFILIATED HOSPITAL OF NORTH SICHUAN MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; TRACER; CONTRAST MEDIUM; RADIOISOTOPE;

ANGIOGENESIS; CARDIAC IMAGING; CARDIOVASCULAR DISEASE; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST; HEART MUSCLE BLOOD FLOW; HEART MUSCLE METABOLISM; HEART MUSCLE PERFUSION; HUMAN; IMAGE ANALYSIS; IMAGE QUALITY; MOLECULAR IMAGING; MYOCARDIAL PERFUSION IMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MEDICINE; POSITRON EMISSION TOMOGRAPHY; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYMPATHETIC NERVE; CARDIOVASCULAR DISEASES; PATHOLOGY; PROCEDURES;

CARDIOVASCULAR DISEASES; CONTRAST MEDIA; DIAGNOSTIC IMAGING; HUMANS; POSITRON-EMISSION TOMOGRAPHY; RADIOISOTOPES;

EID: 84908337134     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/504532     Document Type: Review

References (122)

1. Oxenham H., Sharpe N., Cardiovascular aging and heart failure. European Journal of Heart Failure 2003 5 4 427 434 10.1016/S1388-9842(03)00011-4 2-s2.0-0042969401
2. Gaemperli O., Kaufmann P. A., PET and PET/CT in cardiovascular disease. Annals of the New York Academy of Sciences 2011 1228 1 109 136 10.1111/j.1749-6632.2011.06030.x 2-s2.0-79959806287
3. Schwaiger M., Ziegler S. I., Nekolla S. G., PET/CT challenge for the non-invasive diagnosis of coronary artery disease. European Journal of Radiology 2010 73 3 494 503 10.1016/j.ejrad.2009.12.025 2-s2.0-77949490328
4. Massoud T. F., Gambhir S. S., Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes and Development 2003 17 5 545 580 10.1101/gad.1047403 2-s2.0-0037338436
5. Dobrucki L. W., Sinusas A. J., PET and SPECT in cardiovascular molecular imaging. Nature Reviews Cardiology 2010 7 1 38 47 10.1038/nrcardio.2009.201 2-s2.0-76849098682
6. Jang B., Park S., Kang S. H., Kim J. K., Kim S. K., Kim I. H., Choi Y., Gold nanorods for target selective SPECT/CT imaging and photothermal therapy in vivo. Quantitative Imaging in Medicine and Surgery 2012 2 1 11
7. Klocke F. J., Baird M. G., Lorell B. H., ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging-executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to Revise the 1995 Guidelines for the Clinical Use of Cardiac Radionuclide Imaging). Journal of the American College of Cardiology 2003 42 7 1318 1333 10.1016/j.jacc.2003.08.011
8. Ter Pogossian M. M., Phelps M. E., Hoffman E. J., Mullan N. A., A positron emission transaxial tomograph for nuclear imaging (PETT). Radiology 1975 114 1 89 98 10.1148/114.1.89 2-s2.0-0016441373
9. Slart R. H. J. A., Bax J. J., van Veldhuisen D. J., van der Wall E. E., Dierckx R. A. J. O., Jager P. L., Imaging techniques in nuclear cardiology for the assessment of myocardial viability. International Journal of Cardiovascular Imaging 2006 22 1 63 80 10.1007/s10554-005-7514-8 2-s2.0-33644855976
10. Ametamey S. M., Honer M., Schubiger P. A., Molecular imaging with PET. Chemical Reviews 2008 108 5 1501 1516 10.1021/cr0782426 2-s2.0-44849112165
11. Kherlopian A. R., Song T., Duan Q., Neimark M. A., Po M. J., Gohagan J. K., Laine A. F., A review of imaging techniques for systems biology. BMC Systems Biology 2008 2, article 74 10.1186/1752-0509-2-74 2-s2.0-51949110868
12. Dorbala S., Di Carli M. F., Beanlands R. S., Merhige M. E., Williams B. A., Veledar E., Chow B. J. W., Min J. K., Pencina M. J., Berman D. S., Shaw L. J., Prognostic value of stress myocardial perfusion positron emission tomography: results from a multicenter observational registry. Journal of the American College of Cardiology 2013 61 2 176 184 10.1016/j.jacc.2012.09.043 2-s2.0-84871924800
13. Kobylecka M., Maczewska J., Fronczewska-Wieniawska K., Mazurek T., Płazińska M. T., Królicki L., Myocardial viability assessment in 18FDG PET/CT study (18FDG PET myocardial viability assessment). Nuclear Medicine Review 2012 15 1 52 60 10.5603/NMR.2012.0010 2-s2.0-84865006398
14. Underwood S. R., de Bondt P., Flotats A., Marcasa C., Pinto F., Schaefer W., Verberne H. J., The current and future status of nuclear cardiology: a consensus report. European Heart Journal Cardiovascular Imaging 2014 10.1093/ehjci/jeu060
15. Danad I., Raijmakers P. G., Knaapen P., Diagnosing coronary artery disease with hybrid PET/CT: it takes two to tango. Journal of Nuclear Cardiology 2013 20 5 874 890 10.1007/s12350-013-9753-8 2-s2.0-84879855153
16. Flotats A., Knuuti J., Gutberlet M., Marcassa C., Bengel F. M., Kaufmann P. A., Rees M. R., Hesse B., Hybrid cardiac imaging: SPECT/CT and PET/CT. A joint position statement by the European Association of Nuclear Medicine (EANM), the European Society of Cardiac Radiology (ESCR) and the European Council of Nuclear Cardiology (ECNC). European Journal of Nuclear Medicine and Molecular Imaging 2011 38 1 201 212 10.1007/s00259-010-1586-y 2-s2.0-79551578904
17. Ratib O., Nkoulou R., Potential applications of PET/MR imaging in cardiology. Journal of Nuclear Medicine 2014 55 40S 46S
18. Sogbein O. O., Pelletier-Galarneau M., Schindler T. H., Wei L., Wells R. G., Ruddy T. D., New SPECT and PET radiopharmaceuticals for imaging cardiovascular disease. BioMed Research International 2014 2014 25 942960 10.1155/2014/942960
19. Rahmim A., Zaidi H., PET versus SPECT: strengths, limitations and challenges. Nuclear Medicine Communications 2008 29 3 193 207 10.1097/MNM.0b013e3282f3a515 2-s2.0-41849104653
20. Thomas G. S., Maddahi J., The technetium shortage. Journal of Nuclear Cardiology 2010 17 6 993 998 10.1007/s12350-010-9281-8 2-s2.0-78651314450
21. Pichler B. J., Wehrl H. F., Judenhofer M. S., Latest advances in molecular imaging instrumentation. Journal of Nuclear Medicine 2008 49 supplement 2 5S 23S 10.2967/jnumed.108.045880 2-s2.0-46749154311
22. Patton J., Sandler M., Berman D., D-SPECT: a new solid state camera for high speed molecular imaging. The Journal of Nuclear Medicine 2006 47 supplement 1 189
23. Koepfli P., Hany T. F., Wyss C. A., Namdar M., Burger C., Konstantinidis A. V., Berthold T., Von Schulthess G. K., Kaufmann P. A., CT attenuation correction for myocardial perfusion quantification using a PET/CT hybrid scanner. Journal of Nuclear Medicine 2004 45 4 537 542 2-s2.0-2542458613
24. Anagnostopoulos C., Georgakopoulos A., Pianou N., Nekolla S. G., Assessment of myocardial perfusion and viability by positron emission tomography. International Journal of Cardiology 2013 167 5 1737 1749 10.1016/j.ijcard.2012.12.009 2-s2.0-84883284221
25. Filho J. L. G. C., de Souza Leão Lima R., de Souza MacHado Neto L., Kayat Bittencourt L., Domingues R. C., Da Fonseca L. M. B., PET/CT and vascular disease: current concepts. European Journal of Radiology 2011 80 1 60 67 10.1016/j.ejrad.2010.12.102 2-s2.0-80052735751
26. Knešaurek K., Machac J., Ho Kim J., Comparison of 2D, 3D high dose and 3D low dose gated myocardial 82Rb PET imaging. BMC Nuclear Medicine 2007 7, article 4 10.1186/1471-2385-7-4 2-s2.0-37249060819
27. Knešaurek K., Machac J., Krynyckyi B. R., Almeida O. D., Comparison of 2-dimensional and 3-dimensional 82Rb myocardial perfusion PET imaging. Journal of Nuclear Medicine 2003 44 8 1350 1356 2-s2.0-0141557956
28. Sánchez-Crespo A., Andreo P., Larsson S. A., Positron flight in human tissues and its influence on PET image spatial resolution. European Journal of Nuclear Medicine and Molecular Imaging 2004 31 1 44 51 10.1007/s00259-003-1330-y 2-s2.0-1642430605
29. Kaufmann P. A., Gnecchi-Ruscone T., Yap J. T., Rimoldi O., Camici P. G., Assessment of the reproducibility of baseline and hyperemic myocardial blood flow measurements with 15O-labeled water and PET. Journal of Nuclear Medicine 1999 40 11 1848 1856 2-s2.0-0032716443
30. Glover D. K., Gropler R. J., Journey to find the ideal PET flow tracer for clinical use: are we there yet? Journal of Nuclear Cardiology 2007 14 6 765 768 10.1016/j.nuclcard.2007.09.019 2-s2.0-36049023088
31. Iida H., Kanno I., Takahashi A., Miura S., Murakami M., Takahashi K., Ono Y., Shishido F., Inugami A., Tomura N., Higano S., Fujita H., Sasaki H., Nakamichi H., Mizusawa S., Kondo Y., Uemura K., Measurement of absolute myocardial blood flow with H215O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect. Circulation 1988 78 1 104 115 10.1161/01.CIR.78.1.104 2-s2.0-0023693417
32. 15O]water techniques. Circulation 1996 93 11 2000 2006 10.1161/01.CIR.93.11.2000 2-s2.0-0030006446
33. Katoh C., Morita K., Shiga T., Kubo N., Nakada K., Tamaki N., Improvement of algorithm for quantification of regional myocardial blood flow using15O-water with PET. Journal of Nuclear Medicine 2004 45 11 1908 1916 2-s2.0-16544376567
34. 2O and a clinical PET/CT scanner. European Journal of Nuclear Medicine and Molecular Imaging 2011 38 5 930 939 10.1007/s00259-011-1730-3 2-s2.0-79953695928
35. Adachi I., Gaemperli O., Valenta I., Schepis T., Siegrist P. T., Treyer V., Burger C., Morita K., Kaufmann P. A., Assessment of myocardial perfusion by dynamic O-15-labeled water PET imaging: validation of a new fast factor analysis. Journal of Nuclear Cardiology 2007 14 5 698 705 10.1016/j.nuclcard.2007.05.012 2-s2.0-34548425084
36. Di Carli M. F., Dorbala S., Meserve J., El Fakhri G., Sitek A., Moore S. C., Clinical myocardial perfusion PET/CT. Journal of Nuclear Medicine 2007 48 5 783 793 10.2967/jnumed.106.032789 2-s2.0-34250656647
37. 2O PET/CT scan. Journal of Nuclear Medicine 2011 52 5 745 749 10.2967/jnumed.110.085431 2-s2.0-79955753204
38. Bateman T. M., Heller G. V., McGhie A. I., Friedman J. D., Case J. A., Bryngelson J. R., Hertenstein G. K., Moutray K. L., Reid K., Cullom S. J., Diagnostic accuracy of rest/stress ECG-gated Rb-82 myocardial perfusion PET: comparison with ECG-gated Tc-99m sestamibi SPECT. Journal of Nuclear Cardiology 2006 13 1 24 33 10.1016/j.nuclcard.2005.12.004 2-s2.0-32044472882
39. Go R. T., Marwick T. H., MacIntyre W. J., Saha G. B., Neumann D. R., Underwood D. A., Simpfendorfer C. C., A prospective comparison of rubidium-82 PET and thallium-201 SPECT myocardial perfusion imaging utilizing a single dipyridamole stress in the diagnosis of coronary artery disease. Journal of Nuclear Medicine 1990 31 12 1899 1905 2-s2.0-0025605314
40. Kim J., Bravo P. E., Gholamrezanezhad A., Sohn S., Rafique A., Travis A., MacHac J., Coronary artery and thoracic aorta calcification is inversely related to coronary flow reserve as measured by 82Rb PET/CT in intermediate risk patients. Journal of Nuclear Cardiology 2013 20 3 375 384 10.1007/s12350-013-9675-5 2-s2.0-84878020171
41. Heller G. V., Calnon D., Dorbala S., Recent advances in cardiac PET and PET/CT myocardial perfusion imaging. Journal of Nuclear Cardiology 2009 16 6 962 969 10.1007/s12350-009-9142-5 2-s2.0-72249109592
42. Senthamizhchelvan S., Bravo P. E., Esaias C., Lodge M. A., Merrill J., Hobbs R. F., Sgouros G., Bengel F. M., Human biodistribution and radiation dosimetry of82Rb. Journal of Nuclear Medicine 2010 51 10 1592 1599 10.2967/jnumed.110.077669 2-s2.0-78349255152
43. Arumugam P., Tout D., Tonge C., Myocardial perfusion scintigraphy using rubidium-82 positron emission tomography. British Medical Bulletin 2013 107 87 100 10.1093/bmb/ldt026
44. Lautamäki R., George R. T., Kitagawa K., Higuchi T., Merrill J., Voicu C., Dipaula A., Nekolla S. G., Lima J. A. C., Lardo A. C., Bengel F. M., Rubidium-82 PET-CT for quantitative assessment of myocardial blood flow: validation in a canine model of coronary artery stenosis. European Journal of Nuclear Medicine and Molecular Imaging 2009 36 4 576 586 10.1007/s00259-008-0972-1 2-s2.0-62149148841
45. Goldstein R. A., Mullani N. A., Marani S. K., Fisher D. J., Gould K. L., O'Brien H. A. Jr., Myocardial perfusion with rubidium-82. II. Effects of metabolic and pharmacologic interventions. Journal of Nuclear Medicine 1983 24 10 907 915 2-s2.0-0021043561
46. Krivokapich J., Huang S. C., Phelps M. E., MacDonald N. S., Shine K. I., Dependence of 13NH3 myocardial extraction and clearance on flow and metabolism. The American Journal of Physiology 1982 242 4 H536 H542 2-s2.0-0020122928
47. Schelbert H. R., Phelps M. E., Huang S. C., MacDonald N. S., Hansen H., Selin C., Kuhl D. E., N-13 ammonia as an indicator of myocardial blood flow. Circulation 1981 63 6 1259 1272 10.1161/01.CIR.63.6.1259 2-s2.0-0019450543
48. 13N-ammonia and PET: comparison of tracer models. Journal of Nuclear Medicine 1999 40 6 1045 1055 2-s2.0-0033037072
49. Herzog B. A., Husmann L., Valenta I., Gaemperli O., Siegrist P. T., Tay F. M., Burkhard N., Wyss C. A., Kaufmann P. A., Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve. Journal of the American College of Cardiology 2009 54 2 150 156 10.1016/j.jacc.2009.02.069 2-s2.0-67649385766
50. Fiechter M., Gebhard C., Ghadri J. R., Fuchs T. A., Pazhenkottil A. P., Nkoulou R. N., Herzog B. A., Altorfer U., Gaemperli O., Kaufmann P. A., Myocardial perfusion imaging with 13N-Ammonia PET is a strong predictor for outcome. International Journal of Cardiology 2013 167 3 1023 1026 10.1016/j.ijcard.2012.03.076 2-s2.0-84880924929
51. Alexánderson E., Jácome R., Jiménez-Santos M., Ochoa J. M., Romero E., Cabral M. A. P., Ricalde A., Iñarra F., Meave A., Alexánderson G., Evaluation of the endothelial function in hypertensive patients with 13N-ammonia PET. Journal of Nuclear Cardiology 2012 19 5 979 986 10.1007/s12350-012-9584-z 2-s2.0-84868213908
52. Fiechter M., Ghadri J. R., Gebhard C., Fuchs T. A., Pazhenkottil A. P., Nkoulou R. N., Herzog B. A., Wyss C. A., Gaemperli O., Kaufmann P. A., Diagnostic value of13N-ammonia myocardial perfusion PET: added value of myocardial flow reserve. Journal of Nuclear Medicine 2012 53 8 1230 1234 10.2967/jnumed.111.101840 2-s2.0-84864767807
53. 13N-ammonia uptake in myocardial single cells indicating potential limitations in its applicability as a marker of myocardial blood flow. Circulation 1985 71 2 387 393 10.1161/01.CIR.71.2.387 2-s2.0-0021893820
54. Yalamanchili P., Wexler E., Hayes M., Yu M., Bozek J., Kagan M., Radeke H. S., Azure M., Purohit A., Casebier D. S., Robinson S. P., Mechanism of uptake and retention of F-18 BMS-747158-02 in cardiomyocytes: a novel PET myocardial imaging agent. Journal of Nuclear Cardiology 2007 14 6 782 788 10.1016/j.nuclcard.2007.07.009 2-s2.0-36048952709
55. Schuler F., Casida J. E., The insecticide target in the PSST subunit of complex I. Pest Management Science 2001 57 10 932 940 10.1002/ps.364 2-s2.0-0034765787
56. Huisman M. C., Higuchi T., Reder S., Nekolla S. G., Poethko T., Wester H., Ziegler S. I., Casebier D. S., Robinson S. P., Schwaiger M., Initial characterization of an 18F-labeled myocardial perfusion tracer. Journal of Nuclear Medicine 2008 49 4 630 636 10.2967/jnumed.107.044727 2-s2.0-42049114255
57. Maddahi J., Properties of an ideal PET perfusion tracer: new PET tracer cases and data. Journal of Nuclear Cardiology 2012 19 supplement 1 S30 S37 10.1007/s12350-011-9491-8 2-s2.0-84861491722
58. Higuchi T., Nekolla S. G., Huisman M. M., Reder S., Poethko T., Yu M., Wester H., Casebier D. S., Robinson S. P., Botnar R. M., Schwaiger M., A new 18F-labeled myocardial PET tracer: myocardial uptake after permanent and transient coronary occlusion in rats. Journal of Nuclear Medicine 2008 49 10 1715 1722 10.2967/jnumed.108.053967 2-s2.0-53749103013
59. 18F-labeled tracer for myocardial perfusion PET: dosimetry, biodistribution, safety, and imaging characteristics after a single injection at rest. Journal of Nuclear Medicine 2011 52 9 1490 1498 10.2967/jnumed.111.092528 2-s2.0-80052639367
60. Berman D. S., Maddahi J., Tamarappoo B. K., Czernin J., Taillefer R., Udelson J. E., Gibson C. M., Devine M., Lazewatsky J., Bhat G., Washburn D., Phase II safety and clinical comparison with single-photon emission computed tomography myocardial perfusion imaging for detection of coronary artery disease: flurpiridaz F 18 positron emission tomography. Journal of the American College of Cardiology 2013 61 4 469 477 10.1016/j.jacc.2012.11.022 2-s2.0-84872688085
61. 18F-labeled mitochondrial complex I inhibitors as PET myocardial perfusion imaging agents in rats, rabbits, and primates. European Journal of Nuclear Medicine and Molecular Imaging 2009 36 1 63 72 10.1007/s00259-008-0909-8 2-s2.0-57249115914
62. 18F]FP2OP as myocardial perfusion imaging agent for positron emission tomography. Bioorganic and Medicinal Chemistry 2010 18 3 1312 1320 10.1016/j.bmc.2009.12.022 2-s2.0-75149125191
63. 18F-fluorobenzyl triphenyl phosphonium in dog myocardium. Journal of Nuclear Medicine 2006 47 8 1359 1366 2-s2.0-33749060656
64. 18F]Fluorophenyl)triphenylphosphonium ion. A potential myocardial blood flow agent for PET. Molecular Imaging and Biology 2011 13 3 511 517 10.1007/s11307-010-0349-2 2-s2.0-79956211678
65. Tadamura E., Tamaki N., Okazawa H., Fujibayashi Y., Kudoh T., Yonekura Y., Magata Y., Nohara R., Sasayama S., Konishi J., Generator-produced copper-62-PTSM as a myocardial PET perfusion tracer compared with nitrogen-13-ammonia. Journal of Nuclear Medicine 1996 37 5 729 735 2-s2.0-0030139832
66. Schinkel A. F. L., Valkema R., Geleijnse M. L., Sijbrands E. J., Poldermans D., Single-photon emission computed tomography for assessment of myocardial viability. EuroIntervention 2010 6 supplement G G115 G122 2-s2.0-77957083463
67. Shabana A., El-Menyar A., Myocardial viability: what we knew and what is new. Cardiology Research and Practice 2012 1 1 607486 10.1155/2012/607486 2-s2.0-84866979768
68. Iida H., Rhodes C. G., Araujo L. I., Yamamoto Y., De Suva R., Maseri A., Jones T., Noninvasive quantification of regional myocardial metabolic rate for oxygen by use of 15O2 inhalation and positron emission tomography: theory, error analysis, and application in humans. Circulation 1996 94 4 792 807 10.1161/01.CIR.94.4.792 2-s2.0-0029757173
69. 2 inhalation and positron emission tomography: experimental validation. Circulation 1996 94 4 808 816 10.1161/01.CIR.94.4.808 2-s2.0-0029737631
70. Grassi I., Nanni C., Allegri V., Morigi J. J., Montini G. C., Castellucci P., Fanti S., The clinical use of PET with (11)C-acetate. American Journal of Nuclear Medicine and Molecular Imaging 2012 2 33 47
71. Brown M., Marshall D. R., Sobel B. E., Bergmann S. R., Delineation of myocardial oxygen utilization with carbon-11-labeled acetate. Circulation 1987 76 3 687 696 10.1161/01.CIR.76.3.687 2-s2.0-0023221917
72. Brown M. A., Myears D. W., Bergmann S. R., Validity of estimates of myocardial oxidative metabolism with carbon-11 acetate and positron emission tomography desite altered patterns of substrate utilization. Journal of Nuclear Medicine 1989 30 2 187 193 2-s2.0-0024557820
73. 11C]acetate for measuring myocardial blood flow: studies in normal subjects and patients with hypertrophic cardiomyopathy. Journal of Nuclear Cardiology 2010 17 2 264 275 10.1007/s12350-009-9181-y 2-s2.0-77953321358
74. 11C]Acetate. 2004
75. Stanley W. C., Recchia F. A., Lopaschuk G. D., Myocardial substrate metabolism in the normal and failing heart. Physiological Reviews 2005 85 3 1093 1129 10.1152/physrev.00006.2004 2-s2.0-21244492310
76. Bergmann S. R., Imaging of myocardial fatty acid metabolism with PET. Journal of Nuclear Cardiology 2007 14 3 S118 S124 10.1016/j.nuclcard.2007.02.007 2-s2.0-34249712815
77. Bielefeld D. R., Vary T. C., Neely J. R., Inhibition of carnitine palmitoyl-CoA transferase activity and fatty acid oxidation by lactate and oxfenicine in cardiac muscle. Journal of Molecular and Cellular Cardiology 1985 17 6 619 625 2-s2.0-0021836092
78. Bartels G. L., Remme W. J., Scholte H. R., Acute myocardial ischaemia induces cardiac carnitine release in man. European Heart Journal 1997 18 1 84 90 10.1093/oxfordjournals.eurheartj.a015122 2-s2.0-0031055787
79. 11C]-labeled fatty acids. Nuclear Medicine and Biology 2005 32 5 495 503 10.1016/j.nucmedbio.2005.03.003 2-s2.0-20744453864
80. 11C-labeled palmitate. Circulation 1980 61 2 242 255 10.1161/01.CIR.61.2.242 2-s2.0-0018924873
81. Geltman E. M., Metabolic imaging of patients with cardiomyopathy. Circulation 1991 84 3 I265 I272 2-s2.0-0025941589
82. DeGrado T. R., Coenen H. H., Stocklin G., 14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid (FTHA): evaluation in mouse of a new probe of myocardial utilization of long chain fatty acids. Journal of Nuclear Medicine 1991 32 10 1888 1896 2-s2.0-0025944969
83. Taylor M., Wallhaus T. R., Degrado T. R., Russell D. C., Stanko P., Nickles R. J., Stone C. K., An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in patients with congestive heart failure. Journal of Nuclear Medicine 2001 42 1 55 62 2-s2.0-0035136262
84. Renstrom B., Rommelfanger S., Stone C. K., DeGrado T. R., Carlson K. J., Scarbrough E., Nickles R. J., Liedtke A. J., Holden J. E., Comparison of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia. Journal of Nuclear Medicine 1998 39 10 1684 1689 2-s2.0-0031663696
85. DeGrado T. R., Kitapci M. T., Wang S., Ying J., Lopaschuk G. D., Validation of 18F-fluoro-4-thia-palmitate as a PET probe for myocardial fatty acid oxidation: effects of hypoxia and composition of exogenous fatty acids. Journal of Nuclear Medicine 2006 47 1 173 181 2-s2.0-33846937676
86. 18F-fluoro-4-thia- oleate as a PET probe of fatty acid oxidation. The Journal of Nuclear Medicine 2010 51 8 1310 1317 10.2967/jnumed.109.074245 2-s2.0-77956196117
87. Opie L. H., Effects of regional ischemia on metabolism of glucose and fatty acids. Relative rates of aerobic and anaerobic energy production during myocardial infarction and comparison with effects of anoxia. Circulation Research 1976 38 5 52 74 2-s2.0-0017066492
88. Camici P., Ferrannini E., Opie L. H., Myocardial metabolism in ischemic heart disease: basic principles and application to imaging by positron emission tomography. Progress in Cardiovascular Diseases 1989 32 3 217 238 10.1016/0033-0620(89)90027-3 2-s2.0-0024325693
89. Iida H., Ruotsalainen U., Mäki M., Haaparnata M., Bergman J., Voipio-Pulkki L., Nuutila P., Koshino K., Knuuti J., F-18 fluorodeoxyglucose uptake and water-perfusable tissue fraction in assessment of myocardial viability. Annals of Nuclear Medicine 2012 26 8 644 655 10.1007/s12149-012-0631-2 2-s2.0-84868003855
90. 18F-fluorodeoxyglucose positron emission tomography for characterizing and predicting early remodeling in the rat infarct model. International Journal of Cardiovascular Imaging 2012 28 6 1407 1415 10.1007/s10554-011-9983-2 2-s2.0-84870316792
91. Knuuti M. J., Yki-Jarvinen H., Voipio-Pulkki L.-., Maki M., Ruotsalainen U., Harkonen R., Teras M., Haaparanta M., Bergman J., Hartiala J., Wegelius U., Nuutila P., Enhancement of myocardial [fluorine-18]fluorodeoxyglucose uptake by a nicotinic acid derivative. Journal of Nuclear Medicine 1994 35 6 989 998 2-s2.0-0028242736
92. Knuuti M. J., Nuutila P., Ruotsalainen U., Teras M., Saraste M., Harkonen R., Ahonen A., Wegelius U., Haapanen A., Bergman J., Haaparanta M., Voipio-Pulkki L.-., The value of quantitative analysis of glucose utilization in detection of myocardial viability by PET. Journal of Nuclear Medicine 1993 34 12 2068 2075 2-s2.0-0027133543
93. 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. Journal of the American College of Cardiology 2006 48 9 1818 1824 10.1016/j.jacc.2006.05.076 2-s2.0-33750445273
94. Battegay E. J., Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects. Journal of Molecular Medicine 1995 73 7 333 346 2-s2.0-0029121235
95. Carmeliet P., Jain R. K., Molecular mechanisms and clinical applications of angiogenesis. Nature 2011 473 7347 298 307 10.1038/nature10144 2-s2.0-79956328903
96. Schwartz M. A., Schaller M. D., Ginsberg M. H., Integrins: emerging paradigms of signal transduction. Annual Review of Cell and Developmental Biology 1995 11 549 599 10.1146/annurev.cb.11.110195.003001 2-s2.0-0029589660
97. Brooks P. C., Clark R. A. F., Cheresh D. A., Requirement of vascular integrin αv β 3 for angiogenesis. Science 1994 264 5158 569 571 10.1126/science.7512751 2-s2.0-0028362876
98. Cai W., Chen X., Multimodality imaging of vascular endothelial growth factor and vascular endothelial growth factor receptor expression. Frontiers in Bioscience 2007 12 11 4267 4279 10.2741/2386 2-s2.0-34347209035
99. Tateishi U., Oka T., Inoue T., Radiolabeled RGD peptides as integrin alpha(v)beta3-targeted PET tracers. Current Medicinal Chemistry 2012 19 20 3301 3309 10.2174/092986712801215937 2-s2.0-84863743045
100. Stacy M. R., Maxfield M. W., Sinusas A. J., Targeted molecular imaging of angiogenesis in PET and SPECT: a review. Yale Journal of Biology and Medicine 2012 85 1 75 86 2-s2.0-84859359084
101. Rodriguez-Porcel M., Cai W., Gheysens O., Willmann J. K., Chen K., Wang H., Chen I. Y., He L., Wu J. C., Li Z., Mohamedali K. A., Kim S., Rosenblum M. G., Chen X., Gambhir S. S., Imaging of VEGF receptor in a rat myocardial infarction model using PET. Journal of Nuclear Medicine 2008 49 4 667 673 10.2967/jnumed.107.040576 2-s2.0-42049103246
102. Wagner B., Anton M., Nekolla S. G., Reder S., Henke J., Seidl S., Hegenloh R., Miyagawa M., Haubner R., Schwaiger M., Bengel F. M., Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography. Journal of the American College of Cardiology 2006 48 10 2107 2115 10.1016/j.jacc.2006.08.029 2-s2.0-33750940935
103. 18F-AlF-NOTA-PRGD2. European Journal of Nuclear Medicine and Molecular Imaging 2012 39 4 683 692 10.1007/s00259-011-2052-1 2-s2.0-84862776698
104. Makowski M. R., Ebersberger U., Nekolla S., Schwaiger M., In vivo molecular imaging of angiogenesis, targeting α v β 3 integrin expression, in a patient after acute myocardial infarction. European Heart Journal 2008 29 18 2201 10.1093/eurheartj/ehn129 2-s2.0-52449122280
105. 18F]Galacto-RGD. PLoS Medicine 2005 2, article e70 10.1371/journal.pmed.0020070 2-s2.0-18244376347
106. Almutairi A., Rossin R., Shokeen M., Hagooly A., Ananth A., Capoccia B., Guillaudeu S., Abendschein D., Anderson C. J., Welch M. J., Fréchet J. M. J., Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis. Proceedings of the National Academy of Sciences of the United States of America 2009 106 3 685 690 10.1073/pnas.0811757106 2-s2.0-58849120616
107. Hori M., Sasayama S., Kitabatake A., Toyo-Oka T., Handa S., Yokoyama M., Matsuzaki M., Takeshita A., Origasa H., Matsui K., Hosoda S., Low-dose carvedilol improves left ventricular function and reduces cardiovascular hospitalization in Japanese patients with chronic heart failure: the Multicenter Carvedilol Heart Failure Dose Assessment (MUCHA) trial. American Heart Journal 2004 147 2 324 330 10.1016/j.ahj.2003.07.023 2-s2.0-10744226812
108. 11C]CGP12388. European Journal of Nuclear Medicine and Molecular Imaging 2005 32 4 443 447 10.1007/s00259-004-1701-z 2-s2.0-17944382949
109. 11C-CGP12177 PET predicts improvement of cardiac function after carvedilol treatment in patients with idiopathic dilated cardiomyopathy. Journal of Nuclear Medicine 2009 50 2 220 225 10.2967/jnumed.108.056341 2-s2.0-59249087440
110. Goldstein D. S., Brush J. E. Jr., Eisenhofer G., Stull R., Esler M., In vivo measurement of neuronal uptake of norepinephrine in the human heart. Circulation 1988 78 1 41 48 10.1161/01.CIR.78.1.41 2-s2.0-0023707487
111. Hasking G. J., Esler M. D., Jennings G. L., Burton D., Johns J. A., Korner P. I., Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation 1986 73 4 615 621 10.1161/01.CIR.73.4.615 2-s2.0-0022492202
112. Li S., Holmes C., Kopin I. J., Goldstein D. S., Aging-related changes in cardiac sympathetic function in humans, assessed by 6-18F-fluorodopamine PET scanning. The Journal of Nuclear Medicine 2003 44 10 1599 1603 2-s2.0-0642341627
113. 18F]Fluorodopamine positron emission tomographic scanning in the assessment of cardiac sympathoneural function-studies in normal humans. Clinical Autonomic Research 1997 7 1 17 29 10.1007/BF02267622 2-s2.0-0030615128
114. Gutterman D. D., Morgan D. A., Miller F. J., Effect of brief myocardial ischemia on sympathetic coronary vasoconstriction. Circulation Research 1992 71 4 960 969 2-s2.0-0026808796
115. Luisi A. J. Jr., Suzuki G., DeKemp R., Haka M. S., Toorongian S. A., Canty J. M. Jr., Fallavollita J. A., Regional 11C-hydroxyephedrine retention in hibernating myocardium: chronic inhomogeneity of sympathetic innervation in the absence of infarction. Journal of Nuclear Medicine 2005 46 8 1368 1374 2-s2.0-25444507126
116. Raffel D. M., Koeppe R. A., Jung Y. W., Gu G., Jang K. S., Sherman P. S., Quesada C. A., Quantification of cardiac sympathetic nerve density with N-11C-guanyl-meta-octopamine and tracer kinetic analysis. Journal of Nuclear Medicine 2013 54 1645 1652
117. Herschman H. R., Molecular Imaging: looking at Problems, Seeing Solutions. Science 2003 302 5645 605 608 10.1126/science.1090585 2-s2.0-0142209343
118. Nensa F., Poeppe T. D., Beiderwellen K., Schelhorn J., Mahabadi A. A., Erbel R., Heusch P., Nassenstein K., Bockisch A., Forsting M., Schlosser T., Hybrid PET/MR imaging of the heart: feasibility and initial results. Radiology 2013 268 2 366 373 10.1148/radiol.13130231 2-s2.0-84880670098
119. Nekolla S. G., Martinez-Moeller A., Saraste A., PET and MRI in cardiac imaging: from validation studies to integrated applications. European Journal of Nuclear Medicine and Molecular Imaging 2009 36 1 121 130 10.1007/s00259-008-0980-1 2-s2.0-60649120728
120. 64Cu-labeled magnetic nanoparticles for multimodal imaging. Bioconjugate Chemistry 2008 19 7 1496 1504 10.1021/bc800108v 2-s2.0-47749089344
121. Lee H., Li Z., Chen K., Hsu A. R., Xu C., Xie J., Sun S., Chen X., PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles. The Journal of Nuclear Medicine 2008 49 8 1371 1379 10.2967/jnumed.108.051243 2-s2.0-48749104610
122. Schindler T., Schelbert H., Dilsizian V., Narula J., Quantitation of myocardial perfusion: absolute blood flow versus relative uptake. Atlas of Nuclear Cardiology 2013 New York, NY, USA Springer 145 194