메뉴 건너뛰기




Volumn 19, Issue 20, 2012, Pages 3301-3309

Radiolabeled RGD peptides as integrin alpha(v)beta3-targeted PET tracers

Author keywords

Angiogenesis; Integrin; Integrin alpha(v)beta3; PET; PET CT; Positron emission tomography; Radiolabeled RGD; RGD; RGD peptide; VEGF

Indexed keywords

7 AMINO LYERO GALACTO 2,6 ANHYDRO 7 DEOXYHEPTANAMIDE F 18; ARGINYLGLYCYLASPARTIC ACID; BEVACIZUMAB; CILENGITIDE; ETARACIZUMAB; FLUCICLATIDE F 18; N (2 AMINOETHYL)MALEIMIDE F 18; N [2 (4 FLUOROBENZAMIDO)ETHYL]MALEIMIDE F 18; N SUCCINIMIDYL 4 FLUOROBENZOATE F 18; PACLITAXEL; RADIOPHARMACEUTICAL AGENT; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN; VITRONECTIN RECEPTOR;

EID: 84863743045     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712801215937     Document Type: Review
Times cited : (40)

References (105)
  • 1
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005;307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 2
    • 77957363101 scopus 로고    scopus 로고
    • Integrins as therapeutic targets: Lesions and opportunities
    • Cox D, Brennan M, Moran N. Integrins as therapeutic targets: lesions and opportunities. Nat Rev Drug Discov. 2010;9:804-820.
    • (2010) Nat Rev Drug Discov. , vol.9 , pp. 804-820
    • Cox, D.1    Brennan, M.2    Moran, N.3
  • 5
    • 52549109852 scopus 로고    scopus 로고
    • Imaging of integrin alphavbeta3 expression
    • Beer AJ, Schwaiger M. Imaging of integrin alphavbeta3 expression. Cancer Metastasis Rev. 2008;27:631-644.
    • (2008) Cancer Metastasis Rev. , vol.27 , pp. 631-644
    • Beer, A.J.1    Schwaiger, M.2
  • 7
    • 27944457471 scopus 로고    scopus 로고
    • MicroPET imaging of glioma integrin (alpha)v(beta)3 expression using (64)Cu-labeled tetrameric RGD peptide
    • Wu Y, Zhang X, Xiong Z, Cheng Z, Fisher DR, Liu S, Gambhir SS, Chen X. microPET imaging of glioma integrin (alpha)v(beta)3 expression using (64)Cu-labeled tetrameric RGD peptide. J Nucl Med. 2005;46:1707-1718.
    • (2005) J Nucl Med. , vol.46 , pp. 1707-1718
    • Wu, Y.1    Zhang, X.2    Xiong, Z.3    Cheng, Z.4    Fisher, D.R.5    Liu, S.6    Gambhir, S.S.7    Chen, X.8
  • 9
    • 0036734093 scopus 로고    scopus 로고
    • A reevaluation of integrins as regulators of angiogenesis
    • Hynes RO. A reevaluation of integrins as regulators of angiogenesis. Nat Med. 2002;8:918-921.
    • (2002) Nat Med. , vol.8 , pp. 918-921
    • Hynes, R.O.1
  • 10
    • 63849300752 scopus 로고    scopus 로고
    • Application of RGD-containing peptides as imaging probes for alphavbeta3 expression
    • Dijkgraaf I, Beer AJ, Wester HJ. Application of RGD-containing peptides as imaging probes for alphavbeta3 expression. Front Biosci. 2009;14:887-899.
    • (2009) Front Biosci. , vol.14 , pp. 887-899
    • Dijkgraaf, I.1    Beer, A.J.2    Wester, H.J.3
  • 11
    • 63849238328 scopus 로고    scopus 로고
    • Radiolabeled RGD peptides and peptidomimetics for tumour targeting
    • Haubner R, Decristoforo C. Radiolabeled RGD peptides and peptidomimetics for tumour targeting. Front Biosci. 2009;14:872-886.
    • (2009) Front Biosci. , vol.14 , pp. 872-886
    • Haubner, R.1    Decristoforo, C.2
  • 12
    • 79957760097 scopus 로고    scopus 로고
    • The next generation of positron emission tomography radiopharmaceuticals in oncology
    • Rice SL, Roney CA, Daumar P, Lewis JS. The next generation of positron emission tomography radiopharmaceuticals in oncology. Semin Nucl Med. 2011;41:265-282.
    • (2011) Semin Nucl Med. , vol.41 , pp. 265-282
    • Rice, S.L.1    Roney, C.A.2    Daumar, P.3    Lewis, J.S.4
  • 13
    • 79952741178 scopus 로고    scopus 로고
    • Cilengitide: The first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation
    • Mas-Moruno C, Rechenmacher F, Kessler H. Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation. Anticancer Agents Med Chem. 2010;10:753-768.
    • (2010) Anticancer Agents Med Chem. , vol.10 , pp. 753-768
    • Mas-Moruno, C.1    Rechenmacher, F.2    Kessler, H.3
  • 16
    • 0037103024 scopus 로고    scopus 로고
    • Contrast-enhanced dynamic computed tomography for the evaluation of tumor angiogenesis in patients with lung carcinoma
    • Tateishi U, Kusumoo M, Nishihara H, Nagashima K, Morikawa T, Moriyama N. Contrast-enhanced dynamic computed tomography for the evaluation of tumor angiogenesis in patients with lung carcinoma. Cancer. 2002;95:835-842.
    • (2002) Cancer. , vol.95 , pp. 835-842
    • Tateishi, U.1    Kusumoo, M.2    Nishihara, H.3    Nagashima, K.4    Morikawa, T.5    Moriyama, N.6
  • 17
    • 79952132377 scopus 로고    scopus 로고
    • PET imaging of avß3 expression in cancer patients
    • Beer AJ, Schwaiger M. PET imaging of avß3 expression in cancer patients. Methods Mol Biol. 2011;680:183-200.
    • (2011) Methods Mol Biol. , vol.680 , pp. 183-200
    • Beer, A.J.1    Schwaiger, M.2
  • 20
    • 43749105336 scopus 로고    scopus 로고
    • (68)Ga-labeled multimeric RGD peptides for microPET imaging of integrin alpha(v)beta (3) expression
    • Li ZB, Chen K, Chen X. (68)Ga-labeled multimeric RGD peptides for microPET imaging of integrin alpha(v)beta (3) expression. Eur J Nucl Med Mol Imaging. 2008;35:1100-1108.
    • (2008) Eur J Nucl Med Mol Imaging , vol.35 , pp. 1100-1108
    • Li, Z.B.1    Chen, K.2    Chen, X.3
  • 22
    • 84872204446 scopus 로고    scopus 로고
    • Tumor imaging with a gallium-68 complex of a macrobicyclic cage amine ligand tethered to two integrin-targeting peptides
    • 2011Aug 31. [Epub ahead of print]
    • Donnelly PS, Ma MT, Neels O, Denoyer D, Roselt P, Karas J, Scanlon D, White JM, Hicks R. Tumor imaging with a gallium-68 complex of a macrobicyclic cage amine ligand tethered to two integrin-targeting peptides. Bioconjug Chem. 2011Aug 31. [Epub ahead of print].
    • Bioconjug Chem
    • Donnelly, P.S.1    Ma, M.T.2    Neels, O.3    Denoyer, D.4    Roselt, P.5    Karas, J.6    Scanlon, D.7    White, J.M.8    Hicks, R.9
  • 23
    • 80051700245 scopus 로고    scopus 로고
    • Novel (64)Cu-and (68)Ga-labeled RGD conjugates show improved PET imaging of a(v)ß(3) integrin expression and facile radiosynthesis
    • Dumont RA, Deininger F, Haubner R, Maecke HR, Weber WA, Fani M. Novel (64)Cu-and (68)Ga-labeled RGD conjugates show improved PET imaging of a(v)ß(3) integrin expression and facile radiosynthesis. J Nucl Med. 2011;52:1276-1284.
    • (2011) J Nucl Med. , vol.52 , pp. 1276-1284
    • Dumont, R.A.1    Deininger, F.2    Haubner, R.3    Maecke, H.R.4    Weber, W.A.5    Fani, M.6
  • 24
    • 44149120982 scopus 로고    scopus 로고
    • Preparation of a promising angiogenesis PET imaging agent: 68Ga-labeled c(RGDyK)-isothiocyanatobenzyl-1, 4, 7-triazacyclononane-1, 4, 7-triacetic acid and feasibility studies in mice
    • Jeong JM, Hong MK, Chang YS, Lee YS, Kim YJ, Cheon GJ, Lee DS, Chung JK, Lee MC. Preparation of a promising angiogenesis PET imaging agent: 68Ga-labeled c(RGDyK)-isothiocyanatobenzyl-1, 4, 7-triazacyclononane-1, 4, 7-triacetic acid and feasibility studies in mice. J Nucl Med. 2008;49:830-836.
    • (2008) J Nucl Med. , vol.49 , pp. 830-836
    • Jeong, J.M.1    Hong, M.K.2    Chang, Y.S.3    Lee, Y.S.4    Kim, Y.J.5    Cheon, G.J.6    Lee, D.S.7    Chung, J.K.8    Lee, M.C.9
  • 27
    • 36849012163 scopus 로고    scopus 로고
    • Click chemistry for (18)F-labeling of RGD peptides and microPET imaging of tumor integrin alphavbeta3 expression
    • Li ZB, Wu Z, Chen K, Chin FT, Chen X. Click chemistry for (18)F-labeling of RGD peptides and microPET imaging of tumor integrin alphavbeta3 expression. Bioconjug Chem. 2007;18:1987-1994.
    • (2007) Bioconjug Chem. , vol.18 , pp. 1987-1994
    • Li, Z.B.1    Wu, Z.2    Chen, K.3    Chin, F.T.4    Chen, X.5
  • 28
    • 80955178858 scopus 로고    scopus 로고
    • One-step radiosynthesis of 18F-AlF-NOTA-RGD 2 for tumor angiogenesis PET imaging
    • Liu S, Liu H, Jiang H, Xu Y, Zhang H, Cheng Z. One-step radiosynthesis of 18F-AlF-NOTA-RGD 2 for tumor angiogenesis PET imaging. Eur J Nucl Med Mol Imaging.2011;38:1732-1741.
    • (2011) Eur J Nucl Med Mol Imaging. , vol.38 , pp. 1732-1741
    • Liu, S.1    Liu, H.2    Jiang, H.3    Xu, Y.4    Zhang, H.5    Cheng, Z.6
  • 29
    • 80051795989 scopus 로고    scopus 로고
    • Tetrazine-trans-cyclooctene ligation for the rapid construction of integrin a(v)ß(3) targeted PET tracer based on a cyclic RGD peptide
    • Selvaraj R, Liu S, Hassink M, Huang CW, Yap LP, Park R, Fox JM, Li Z, Conti PS. Tetrazine-trans-cyclooctene ligation for the rapid construction of integrin a(v)ß(3) targeted PET tracer based on a cyclic RGD peptide. Bioorg Med Chem Lett. 2011;21:5011-5014.
    • (2011) Bioorg Med Chem Lett. , vol.21 , pp. 5011-5014
    • Selvaraj, R.1    Liu, S.2    Hassink, M.3    Huang, C.W.4    Yap, L.P.5    Park, R.6    Fox, J.M.7    Li, Z.8    Conti, P.S.9
  • 34
    • 33750420717 scopus 로고    scopus 로고
    • Radiolabeled multimeric cyclic RGD peptides as integrin alphavbeta3 targeted radiotracers for tumor imaging
    • Liu S. Radiolabeled multimeric cyclic RGD peptides as integrin alphavbeta3 targeted radiotracers for tumor imaging. Mol Pharm. 2006;3:472-487.
    • (2006) Mol Pharm. , vol.3 , pp. 472-487
    • Liu, S.1
  • 35
    • 79751488535 scopus 로고    scopus 로고
    • Multimerization of cRGD peptides by click chemistry: Synthetic strategies, chemical limitations, and influence on biological properties
    • Wängler C, Maschauer S, Prante O, Schäfer M, Schirrmacher R, Bartenstein P, Eisenhut M, Wängler B. Multimerization of cRGD peptides by click chemistry: synthetic strategies, chemical limitations, and influence on biological properties. Chembiochem. 2010;11:2168-2181.
    • (2010) Chembiochem. , vol.11 , pp. 2168-2181
    • Wängler, C.1    Maschauer, S.2    Prante, O.3    Schäfer, M.4    Schirrmacher, R.5    Bartenstein, P.6    Eisenhut, M.7    Wängler, B.8
  • 39
    • 34447336118 scopus 로고    scopus 로고
    • (64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression
    • Li ZB, Cai W, Cao Q, Chen K, Wu Z, He L, Chen X. (64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression. J Nucl Med. 2007;48:1162-1171.
    • (2007) J Nucl Med. , vol.48 , pp. 1162-1171
    • Li, Z.B.1    Cai, W.2    Cao, Q.3    Chen, K.4    Wu, Z.5    He, L.6    Chen, X.7
  • 40
    • 34548557001 scopus 로고    scopus 로고
    • 18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2): Synthesis and microPET imaging of alphavbeta3 integrin expression
    • Wu Z, Li ZB, Cai W, He L, Chin FT, Li F, Chen X. 18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2): synthesis and microPET imaging of alphavbeta3 integrin expression. Eur J Nucl Med Mol Imaging. 2007;34:1823-1831.
    • (2007) Eur J Nucl Med Mol Imaging. , vol.34 , pp. 1823-1831
    • Wu, Z.1    Li, Z.B.2    Cai, W.3    He, L.4    Chin, F.T.5    Li, F.6    Chen, X.7
  • 41
    • 34548557001 scopus 로고    scopus 로고
    • (18)F-labeled mini-PEG spacered RGD dimer (18)F-FPRGD2): Synthesis and microPET imaging of alphavbeta 3 integrin expression
    • Wu Z, Li ZB, Cai W, He L, Chin FT, Chen X. (18)F-labeled mini-PEG spacered RGD dimer ((18)F-FPRGD2): synthesis and microPET imaging of alphavbeta 3 integrin expression. Eur J Nucl Med Mol Imaging 2007;34:1823-1931.
    • (2007) Eur J Nucl Med Mol Imaging , vol.34 , pp. 1823-1931
    • Wu, Z.1    Li, Z.B.2    Cai, W.3    He, L.4    Chin, F.T.5    Chen, X.6
  • 42
    • 34548580354 scopus 로고    scopus 로고
    • MicroPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4)
    • Wu Z, Li ZB, Chen K, Cai W, He L, Chin FT, Chen X. MicroPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4). J Nucl Med 2007;48:1536-1544.
    • (2007) J Nucl Med , vol.48 , pp. 1536-1544
    • Wu, Z.1    Li, Z.B.2    Chen, K.3    Cai, W.4    He, L.5    Chin, F.T.6    Chen, X.7
  • 43
    • 4544387211 scopus 로고    scopus 로고
    • MicroPET imaging of breast cancer alphav-integrin expression with 64Cu-labeled dimeric RGD peptides
    • Chen X, Liu S, Hou Y, Tohme M, Park R, Bading JR, Conti PS. MicroPET imaging of breast cancer alphav-integrin expression with 64Cu-labeled dimeric RGD peptides. Mol Imaging Biol 2004;6:350-359.
    • (2004) Mol Imaging Biol , vol.6 , pp. 350-359
    • Chen, X.1    Liu, S.2    Hou, Y.3    Tohme, M.4    Park, R.5    Bading, J.R.6    Conti, P.S.7
  • 44
    • 34447336118 scopus 로고    scopus 로고
    • (64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression
    • Li ZB, Cai W, Cao Q, Chen K, Wu Z, He L, Chen X. (64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression. J Nucl Med. 2007;48:1162-1171.
    • (2007) J Nucl Med. , vol.48 , pp. 1162-1171
    • Li, Z.B.1    Cai, W.2    Cao, Q.3    Chen, K.4    Wu, Z.5    He, L.6    Chen, X.7
  • 45
    • 60549098667 scopus 로고    scopus 로고
    • Dual integrin and gastrin-releasing peptide receptor targeted tumor imaging using 18F-labeled PEGylated RGD-bombesin heterodimer 18F-FB-PEG3-Glu-RGD-BBN
    • Liu Z, Yan Y, Chin FT, Wang F, Chen X. Dual integrin and gastrin-releasing peptide receptor targeted tumor imaging using 18F-labeled PEGylated RGD-bombesin heterodimer 18F-FB-PEG3-Glu-RGD-BBN. J Med Chem. 2009;52:425-432.
    • (2009) J Med Chem. , vol.52 , pp. 425-432
    • Liu, Z.1    Yan, Y.2    Chin, F.T.3    Wang, F.4    Chen, X.5
  • 46
    • 0036095760 scopus 로고    scopus 로고
    • Co-expressed peptide receptors in breast cancer as a molecular basis for in vivo multireceptor tumor imaging
    • Reubi JC, Gugger M, Waser B. Co-expressed peptide receptors in breast cancer as a molecular basis for in vivo multireceptor tumor imaging. Fur J Nucl Med Mol Imaging. 2002;29:855-862.
    • (2002) Fur J Nucl Med Mol Imaging. , vol.29 , pp. 855-862
    • Reubi, J.C.1    Gugger, M.2    Waser, B.3
  • 47
    • 0037907532 scopus 로고    scopus 로고
    • Concomitant expression of several peptide receptors in neuroendocrine tumors: Molecular basis for in vivo multireceptor tumor targeting
    • Reubi JC, Waser B. Concomitant expression of several peptide receptors in neuroendocrine tumors: molecular basis for in vivo multireceptor tumor targeting. Eur J Nucl Med Mol Imaging. 2003;30:781-793.
    • (2003) Eur J Nucl Med Mol Imaging. , vol.30 , pp. 781-793
    • Reubi, J.C.1    Waser, B.2
  • 54
    • 0035821594 scopus 로고    scopus 로고
    • Solid-phase synthesis of a nonpeptide RGD mimeric library: New selective alphavbeta3 integrin antagonists
    • Sulyok GA, Gibson C, Goodman SL, Holzemann G, Wiesner M, Kessler H. Solid-phase synthesis of a nonpeptide RGD mimeric library: new selective alphavbeta3 integrin antagonists J Med Chem. 2001;44:1938-1950.
    • (2001) J Med Chem. , vol.44 , pp. 1938-1950
    • Sulyok, G.A.1    Gibson, C.2    Goodman, S.L.3    Holzemann, G.4    Wiesner, M.5    Kessler, H.6
  • 56
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-76.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 57
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta LG, Chen H, O'Connor SJ, Chisholm V, Meng YG, Krummen L, Winkler M, Ferrara N. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997;57:4593-9.
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3    Chisholm, V.4    Meng, Y.G.5    Krummen, L.6    Winkler, M.7    Ferrara, N.8
  • 60
    • 48149102140 scopus 로고    scopus 로고
    • Evaluation of biodistribution and anti-tumor effect of a dimeric RGD peptide-paclitaxel conjugate in mice with breast cancer
    • Cao Q, Li ZB, Chen K, Wu Z, He L, Neamati N, Chen X. Evaluation of biodistribution and anti-tumor effect of a dimeric RGD peptide-paclitaxel conjugate in mice with breast cancer. Eur J Nucl Med Mol Imaging. 2008;35:1489-1498.
    • (2008) Eur J Nucl Med Mol Imaging. , vol.35 , pp. 1489-1498
    • Cao, Q.1    Li, Z.B.2    Chen, K.3    Wu, Z.4    He, L.5    Neamati, N.6    Chen, X.7
  • 62
    • 85016760511 scopus 로고    scopus 로고
    • First Experience with Clinical-Grade [(18)F]FPP(RGD) (2): An automated multi-step radiosynthesis for clinical PET studies
    • Mar 12. [Epub ahead of print]
    • Chin FT, Shen B, Liu S, Berganos RA, Chang E, Mittra E, Chen X, Gambhir SS. First Experience with Clinical-Grade [(18)F]FPP(RGD) (2): An automated multi-step radiosynthesis for clinical PET studies. Mol Imaging Biol. 2011 Mar 12. [Epub ahead of print].
    • (2011) Mol Imaging Biol.
    • Chin, F.T.1    Shen, B.2    Liu, S.3    Berganos, R.A.4    Chang, E.5    Mittra, E.6    Chen, X.7    Gambhir, S.S.8
  • 67
    • 36849050857 scopus 로고    scopus 로고
    • Synthesis of p-(Di-tert-butyl[18F]fluorosilyl)benzaldehyde ([18F]SiFA-A) with high specific activity by isotopic exchange: A convenient labeling synthon for the 18F-labeling of N-amino-oxy derivatized peptides
    • Schirrmacher E, Wangler B, Crpryk M, Bradtmoller G, Schafer M, Eisenhut M, Jurchat K, Schirrmacher R. Synthesis of p-(Di-tert-butyl[18F]fluorosilyl) benzaldehyde ([18F]SiFA-A) with high specific activity by isotopic exchange: a convenient labeling synthon for the 18F-labeling of N-amino-oxy derivatized peptides. Bioconjug Chem. 2007;18:2085-2089.
    • (2007) Bioconjug Chem. , vol.18 , pp. 2085-2089
    • Schirrmacher, E.1    Wangler, B.2    Crpryk, M.3    Bradtmoller, G.4    Schafer, M.5    Eisenhut, M.6    Jurchat, K.7    Schirrmacher, R.8
  • 68
    • 33846419494 scopus 로고    scopus 로고
    • 3, 4, 6-Tri-O-acetyl-2-deoxy-2-[18F]fluoroglucopyranosyl phenylthiosulfonate: A thiol-reactive agent for the chemoselective 18F-glycosylation of peptides
    • Prante O, Einsiedel J, Haubner R, Gmeiner P, Wester HJ, Kuwert T, Maschauer S. 3, 4, 6-Tri-O-acetyl-2-deoxy-2-[18F]fluoroglucopyranosyl phenylthiosulfonate: a thiol-reactive agent for the chemoselective 18F-glycosylation of peptides. Bioconjug Chem. 2007;18:254-262.
    • (2007) Bioconjug Chem. , vol.18 , pp. 254-262
    • Prante, O.1    Einsiedel, J.2    Haubner, R.3    Gmeiner, P.4    Wester, H.J.5    Kuwert, T.6    Maschauer, S.7
  • 69
    • 33747150885 scopus 로고    scopus 로고
    • A thiol-reactive 18F-labeling agent, N-[2-(4-18F-fluorobenzamido)ethyl] maleimide, and synthesis of RGD peptide-based tracer for PET imaging of alpha v beta 3 integrin expression
    • Cai w, Zhang X, Wu Y, Chen X. A thiol-reactive 18F-labeling agent, N-[2-(4-18F-fluorobenzamido)ethyl]maleimide, and synthesis of RGD peptide-based tracer for PET imaging of alpha v beta 3 integrin expression. J Nucl Med. 2006;47:1172-1180.
    • (2006) J Nucl Med. , vol.47 , pp. 1172-1180
    • Cai, W.1    Zhang, X.2    Wu, Y.3    Chen, X.4
  • 72
    • 37649010525 scopus 로고    scopus 로고
    • Comparison of integrin alphaVbeta3 expression and glucose metabolism in primary and metastatic lesions in cancer patients: A PET study using 18F-galacto-RGD and 18F-FDG
    • Beer AJ, Lorenzen S, Metz S, Herrmann K, Watzlowik P, Wester HJ, Peschel C, Lordick F, Schwaiger M. Comparison of integrin alphaVbeta3 expression and glucose metabolism in primary and metastatic lesions in cancer patients: a PET study using 18F-galacto-RGD and 18F-FDG. J Nucl Med. 2008;49:22-29.
    • (2008) J Nucl Med. , vol.49 , pp. 22-29
    • Beer, A.J.1    Lorenzen, S.2    Metz, S.3    Herrmann, K.4    Watzlowik, P.5    Wester, H.J.6    Peschel, C.7    Lordick, F.8    Schwaiger, M.9
  • 75
    • 36749053493 scopus 로고    scopus 로고
    • [18F]galacto-RGD positron emission tomography for imaging of alphavbeta3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck
    • Beer AJ, Grosu AL, Carlsen J, Kolk A, Sarbia M, Stangier I, Watzlowik P, Wester HJ, Haubner R, Schwaiger M. [18F]galacto-RGD positron emission tomography for imaging of alphavbeta3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck. Clin Cancer Res. 2007;13:6610-6616.
    • (2007) Clin Cancer Res. , vol.13 , pp. 6610-6616
    • Beer, A.J.1    Grosu, A.L.2    Carlsen, J.3    Kolk, A.4    Sarbia, M.5    Stangier, I.6    Watzlowik, P.7    Wester, H.J.8    Haubner, R.9    Schwaiger, M.10
  • 81
    • 33646415036 scopus 로고    scopus 로고
    • Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2
    • Zhang X, Xiong Z, Wu Y, Cai W, Tseng JR, Gambhir SS, Chen X. Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2. J Nucl Med. 2006;47:113-121.
    • (2006) J Nucl Med. , vol.47 , pp. 113-121
    • Zhang, X.1    Xiong, Z.2    Wu, Y.3    Cai, W.4    Tseng, J.R.5    Gambhir, S.S.6    Chen, X.7
  • 84
    • 0842263619 scopus 로고    scopus 로고
    • MicroPET and autoradiographic imaging of breast cancer alpha v-integrin expression using 18F-and 64Cu-labeled RGD peptide
    • Chen X, Park R, Tohme M, Shahinian AH, Bading JR, Conti PS. MicroPET and autoradiographic imaging of breast cancer alpha v-integrin expression using 18F-and 64Cu-labeled RGD peptide. Bioconjug Chem. 2004;15:41-49.
    • (2004) Bioconjug Chem. , vol.15 , pp. 41-49
    • Chen, X.1    Park, R.2    Tohme, M.3    Shahinian, A.H.4    Bading, J.R.5    Conti, P.S.6
  • 86
    • 4544387211 scopus 로고    scopus 로고
    • MicroPET imaging of breast cancer alphav-integrin expression with 64Cu-labeled dimeric RGD peptides
    • Chen X, Liu S, Hou Y, Tohme M, Park R, Bading JR, Conti PS. MicroPET imaging of breast cancer alphav-integrin expression with 64Cu-labeled dimeric RGD peptides. Mol Imaging Biol. 2004;6:350-359.
    • (2004) Mol Imaging Biol. , vol.6 , pp. 350-359
    • Chen, X.1    Liu, S.2    Hou, Y.3    Tohme, M.4    Park, R.5    Bading, J.R.6    Conti, P.S.7
  • 87
    • 27944457471 scopus 로고    scopus 로고
    • MicroPET imaging of glioma integrin {alpha}v{beta}3 expression using 64Cu-labeled dimeric RGD peptide
    • Wu Y, Zhang X, Xiong Z. MicroPET imaging of glioma integrin {alpha}v{beta}3 expression using 64Cu-labeled dimeric RGD peptide. J Nucl Med 2005;46:1707-1718.
    • (2005) J Nucl Med , vol.46 , pp. 1707-1718
    • Wu, Y.1    Zhang, X.2    Xiong, Z.3
  • 88
    • 80051700245 scopus 로고    scopus 로고
    • Novel (64)Cu-and (68)Ga-labeled RGD conjugates show improved PET imaging of a(v)ß(3) integrin expression and facile radiosynthesis
    • Dumont RA, Deininger F, Haubner R, Maecke HR, Weber WA, Fani M. Novel (64)Cu-and (68)Ga-labeled RGD conjugates show improved PET imaging of a(v)ß(3) integrin expression and facile radiosynthesis. J Nucl Med. 2011;52:1276-1284.
    • (2011) J Nucl Med. , vol.52 , pp. 1276-1284
    • Dumont, R.A.1    Deininger, F.2    Haubner, R.3    Maecke, H.R.4    Weber, W.A.5    Fani, M.6
  • 89
    • 79955466439 scopus 로고    scopus 로고
    • Fujibayashi y Noninvasive visualization and quantification of tumor ctVß3 integrin expression using a novel positron emission tomography probe, 64Cu-cyclam-RAFT-c(-RGDfK-)4
    • Jin ZH, Furukawa T, Galibert M, Boturyn D, Coll JL, Fukumura T, Saga T, Dumy P, Fujibayashi Y Noninvasive visualization and quantification of tumor ctVß3 integrin expression using a novel positron emission tomography probe, 64Cu-cyclam-RAFT-c(-RGDfK-)4. Nucl Med Biol. 2011;38:529-540.
    • (2011) Nucl Med Biol. , vol.38 , pp. 529-540
    • Jin, Z.H.1    Furukawa, T.2    Galibert, M.3    Boturyn, D.4    Coll, J.L.5    Fukumura, T.6    Saga, T.7    Dumy, P.8
  • 90
    • 62549139647 scopus 로고    scopus 로고
    • (64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: Comparison of their biological activity
    • Wei L, Ye Y, Wadas TJ, Lewis JS, Welch MJ, Achilefu S, Anderson CJ. (64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity. Nucl Med Biol. 2009;36:277-285.
    • (2009) Nucl Med Biol. , vol.36 , pp. 277-285
    • Wei, L.1    Ye, Y.2    Wadas, T.J.3    Lewis, J.S.4    Welch, M.J.5    Achilefu, S.6    Anderson, C.J.7
  • 91
    • 33750377517 scopus 로고    scopus 로고
    • Vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrinaVß3
    • Cai W, Wu Y, Chen K, Cao Q, Tice DA, Chen X. In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrinaVß3. Cancer Res. 2006;66:9673-9681.
    • (2006) Cancer Res. , vol.66 , pp. 9673-9681
    • Cai, W.1    Wu, Y.2    Chen, K.3    Cao, Q.4    Tice, D.A.5    Chen, X.6
  • 92
    • 84856235199 scopus 로고    scopus 로고
    • Quantification of receptor-ligand binding with [18)F]fluciclatide in metastatic breast cancer patients
    • Sep 3. [Epub ahead of print]
    • Tomasi G, Kenny L, Mauri F, Turkheimer F, Aboagye EO. Quantification of receptor-ligand binding with [(18)F]fluciclatide in metastatic breast cancer patients. Eur J Nucl Med Mol Imaging. 2011 Sep 3. [Epub ahead of print]
    • (2011) Eur J Nucl Med Mol Imaging.
    • Tomasi, G.1    Kenny, L.2    Mauri, F.3    Turkheimer, F.4    Aboagye, E.O.5
  • 93
    • 79952784609 scopus 로고    scopus 로고
    • Monitoring tumor response to antiangiogenic sunitinib therapy with 18F-fluciclatide, an 18F-labeled aVbeta3-integrin and aV beta5-integrin imaging agent
    • Battle MR, Goggi JL, Allen L, Barnett J, Morrison MS. Monitoring tumor response to antiangiogenic sunitinib therapy with 18F-fluciclatide, an 18F-labeled aVbeta3-integrin and aV beta5-integrin imaging agent. J Nucl Med. 2011;52:424-430.
    • (2011) J Nucl Med. , vol.52 , pp. 424-430
    • Battle, M.R.1    Goggi, J.L.2    Allen, L.3    Barnett, J.4    Morrison, M.S.5
  • 95
    • 58249127731 scopus 로고    scopus 로고
    • Use of a novel Arg-Gly-Asp radioligand, 18F-AH111585, to determine changes in tumor vascularity after antitumor therapy
    • Morrison MS, Ricketts SA, Barnett J, Cuthbertson A, Tessier J, Wedge SR. Use of a novel Arg-Gly-Asp radioligand, 18F-AH111585, to determine changes in tumor vascularity after antitumor therapy. J Nucl Med. 2009;50:116-122.
    • (2009) J Nucl Med. , vol.50 , pp. 116-122
    • Morrison, M.S.1    Ricketts, S.A.2    Barnett, J.3    Cuthbertson, A.4    Tessier, J.5    Wedge, S.R.6
  • 96
    • 79959548882 scopus 로고    scopus 로고
    • Pilot study of FPPRGD2 for imaging a(v)ß(3) integrin-how integral are integrins?
    • Choyke PL. Pilot study of FPPRGD2 for imaging a(v)ß(3) integrin-how integral are integrins? Radiology. 2011;260:1-2.
    • (2011) Radiology , vol.260 , pp. 1-2
    • Choyke, P.L.1
  • 99
    • 34548557001 scopus 로고    scopus 로고
    • 18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2): Synthesis and microPET imaging of alphavbeta3 integrin expression
    • Wu Z, Li ZB, Cai W, He L, Chin FT, Li F, Chen X. 18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2): synthesis and microPET imaging of alphavbeta3 integrin expression. Eur J Nucl Med Mol Imaging. 2007;34:1823-1831.
    • (2007) Eur J Nucl Med Mol Imaging. , vol.34 , pp. 1823-1831
    • Wu, Z.1    Li, Z.B.2    Cai, W.3    He, L.4    Chin, F.T.5    Li, F.6    Chen, X.7
  • 100
    • 70349263634 scopus 로고    scopus 로고
    • Noninvasive imaging of tumor integrin expression using (18)F-labeled RGD dimer peptide with PEG (4) linkers
    • Liu Z, Liu S, Wang F, Liu S, Chen X. Noninvasive imaging of tumor integrin expression using (18)F-labeled RGD dimer peptide with PEG (4) linkers. Eur J Nucl Med Mol Imaging. 2009;36:1296-1307.
    • (2009) Eur J Nucl Med Mol Imaging. , vol.36 , pp. 1296-1307
    • Liu, Z.1    Liu, S.2    Wang, F.3    Liu, S.4    Chen, X.5
  • 101
    • 85016760511 scopus 로고    scopus 로고
    • First experience with clinical-grade [(18)F]FPP(RGD) (2): An automated multi-step radiosynthesis for clinical PET studies
    • Mar 12. [Epub ahead of print]
    • Chin FT, Shen B, Liu S, Berganos RA, Chang E, Mittra E, Chen X, Gambhir SS. First experience with clinical-grade [(18)F]FPP(RGD) (2): an automated multi-step radiosynthesis for clinical PET studies. Mol Imaging Biol. 2011 Mar 12. [Epub ahead of print]
    • (2011) Mol Imaging Biol.
    • Chin, F.T.1    Shen, B.2    Liu, S.3    Berganos, R.A.4    Chang, E.5    Mittra, E.6    Chen, X.7    Gambhir, S.S.8
  • 103
    • 34548580354 scopus 로고    scopus 로고
    • Chen X. microPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4)
    • Wu Z, Li ZB, Chen K, Cai W, He L, Chin FT, Li F, Chen X. microPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4). J Nucl Med. 2007;48:1536-1544.
    • (2007) J Nucl Med. , vol.48 , pp. 1536-1544
    • Wu, Z.1    Li, Z.B.2    Chen, K.3    Cai, W.4    He, L.5    Chin, F.T.6    Li, F.7
  • 104
    • 33747150885 scopus 로고    scopus 로고
    • A thiol-reactive 18F-labeling agent, N-[2-(4-18F-fluorobenzamido)ethyl] maleimide, and synthesis of RGD peptide-based tracer for PET imaging of alpha v beta 3 integrin expression
    • Cai W, Zhang X, Wu Y, Chen X. A thiol-reactive 18F-labeling agent, N-[2-(4-18F-fluorobenzamido)ethyl]maleimide, and synthesis of RGD peptide-based tracer for PET imaging of alpha v beta 3 integrin expression. J Nucl Med. 2006;47:1172-1180.
    • (2006) J Nucl Med. , vol.47 , pp. 1172-1180
    • Cai, W.1    Zhang, X.2    Wu, Y.3    Chen, X.4
  • 105
    • 34548007871 scopus 로고    scopus 로고
    • Use of a peptide derived from foot-and-mouth disease virus for the noninvasive imaging of human cancer: Generation and evaluation of 4-[18F]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin alphavbeta6 expression with positron emission tomography
    • Hausner SH, DiCara D, Marik J, Marshall JF, Sutcliffe JL. Use of a peptide derived from foot-and-mouth disease virus for the noninvasive imaging of human cancer: generation and evaluation of 4-[18F]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin alphavbeta6 expression with positron emission tomography. Cancer Res. 2007;67:7833-7840.
    • (2007) Cancer Res. , vol.67 , pp. 7833-7840
    • Hausner, S.H.1    Dicara, D.2    Marik, J.3    Marshall, J.F.4    Sutcliffe, J.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.