Evaluation of (4-[18F]Fluorophenyl)triphenylphosphonium ion. A potential myocardial blood flow agent for PET

Molecular Imaging and Biology

Volumn 13, Issue 3, 2011, Pages 511-517

  Shoup, Timothy M ^a   Elmaleh, David R ^a   Brownell, Anna Liisa ^a   Zhu, Aijun ^a   Guerrero, J Luis ^a   Fischman, Alan J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

18F; Mitochondrial damage, membrane potential; Myocardial perfusion agent; Positron emission tomography; Tetraphenylphosphonium

Indexed keywords

(4 FLUOROPHENYL)TRIPHENYLPHOSPHONIUM F 18; AMMONIA N 13; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; ORGANOPHOSPHORUS COMPOUND; PHOSPHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; DRUG ACCUMULATION; DRUG DISTRIBUTION; HEART; HEART MUSCLE BLOOD FLOW; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LIVER; LUNG; MALE; MICRO-POSITRON EMISSION TOMOGRAPHY; NONHUMAN; PLASMA CLEARANCE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RABBIT; RADIATION DOSE DISTRIBUTION; RADIOACTIVITY; RAT; ANIMAL; CORONARY ARTERY BLOOD FLOW; INTRAVENOUS DRUG ADMINISTRATION; PERFUSION; PHYSIOLOGY; SCINTISCANNING; SPRAGUE DAWLEY RAT; TIME; TISSUE DISTRIBUTION;

ORYCTOLAGUS CUNICULUS; RATTUS;

ANIMALS; CORONARY CIRCULATION; HEART; INJECTIONS, INTRAVENOUS; MALE; ORGANOPHOSPHORUS COMPOUNDS; PERFUSION; PHOSPHINES; POSITRON-EMISSION TOMOGRAPHY; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 79956211678     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-010-0349-2     Document Type: Article

References (26)

1. H Jadvar HW Strauss GM Segall 1999 SPECT and PET in the evaluation of coronary artery disease Radiographics 19 915 926 10464799 1:STN:280: DyaK1MzpsVSltw%3D%3D
2. RJ Gibbons 2000 Imaging techniques: myocardial perfusion imaging Heart 83 355 360 10677421 10.1136/heart.83.3.355 1:STN:280:DC%2BD3c7ksVWrug%3D%3D
3. GA Beller BL Zaret 2000 Contributions of nuclear cardiology to diagnosis and prognosis of patients with coronary artery disease Circulation 101 1465 1478 10736294 1:STN:280:DC%2BD3c3gt1WksA%3D%3D (Pubitemid 30169872)
4. NK Sabharwal A Lahiri 2003 Role of myocardial perfusion imaging for risk stratification in suspected or known coronary artery disease Heart 89 1291 1297 14594881 10.1136/heart.89.11.1291 1:STN:280:DC%2BD3srhs1yksQ%3D%3D (Pubitemid 37311087)
5. FYJ Keng 2004 Clinical applications of positron emission tomography in cardiology: a review Ann Acad Med Singapore 33 175 182 15098630 1:STN:280:DC%2BD2c3gtFSjug%3D%3D (Pubitemid 38684852)
6. TM Shoup DR Elmaleh RN Hanson AJ Fischman 2004 Fluorine-18 and iodine-125 labeled tetraphenylphosphonium ions as potential PET and SPECT imaging agents for tumors [abstract] J Nucl Med 45 447
7. LB Chen 1988 Mitochondrial membrane potential in living cells Annu Rev Cell Biol 4 155 181 3058159 10.1146/annurev.cb.04.110188.001103 1:CAS:528:DyaL1MXltlSisA%3D%3D (Pubitemid 19139255)
8. DC Wallace 1999 Mitochondrial diseases in man and mouse Science 283 1482 1488 10066162 10.1126/science.283.5407.1482 1:CAS:528:DyaK1MXhs1ygurk%3D (Pubitemid 29133350)
9. JS Modica-Napolitano JR Aprille 2001 Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells Adv Drug Deliv Rev 49 63 70 11377803 10.1016/S0169-409X(01)00125-9 1:CAS:528:DC%2BD3MXjslSmtLk%3D (Pubitemid 32493800)
10. RD Rieke CK White CM Milliren 1976 Electrochemical and electron paramagnetic resonance studies of a series of ammonium and phosphonium compounds J Am Chem Soc 98 6872 6877 10.1021/ja00438a018 1:CAS:528:DyaE28XlvFajtLc%3D
11. IC Summerhayes TJ Lampidis SD Bernal, et al. 1982 Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells Proc Natl Acad Sci USA 79 5292 5296 6752944 10.1073/pnas.79.17.5292 1:CAS:528:DyaL38XlsVWiu7Y%3D (Pubitemid 12002199)
12. N Kamo M Muratsugu R Hongoh Y Kobatake 1979 Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state J Membr Biol 49 105 121 490631 10.1007/BF01868720 1:CAS:528:DyaE1MXlvVyjtrg%3D (Pubitemid 10221193)
13. KF LaNoue T Strzelecki D Strzelecka C Koch 1986 Regulation of the uncoupling protein in brown adipose tissue J Biol Chem 261 298 305 3941078 1:CAS:528:DyaL28Xks1WlsA%3D%3D (Pubitemid 16102883)
14. JC Smith 1990 Potential-sensitive molecular probes in membranes of bioenergetic relevance Biochim Biophys Acta 1016 1 28 2178682 10.1016/0005-2728(90)90002-L 1:CAS:528:DyaK3cXhslCqt7s%3D SPECT imaging agents for tumors [abstract]. J Nucl Med. 2004;45:447 (Pubitemid 20091974)
15. B Wan C Doumen J Duszynski G Salama KF LaNoue 1993 A method of determining electrical potential gradient across mitochondrial membrane in perfused rat hearts Am J Physiol Heart Circ Physiol 265 H445 H452 1:CAS:528:DyaK3sXmsVCrsL4%3D
16. A Labajova A Vojtiskova P Krivakova J Kofranek Z Drahota J Houstek 2006 Evaluation of mitochondrial membrane potential using a computerized device with a tetraphenylphosphonium-selective electrode Anal Biochem 353 37 42 16643832 10.1016/j.ab.2006.03.032 1:CAS:528:DC%2BD28Xks1Wls7o%3D (Pubitemid 43668942)
17. DA Berkich G Salama KF LaNoue 2003 Mitochondrial membrane potentials in ischemic hearts Arch Biochem Biophys 420 279 286 14654067 10.1016/j.abb.2003.09. 021 1:CAS:528:DC%2BD3sXptl2qsbw%3D (Pubitemid 37491112)
18. ADT Costa KD Garlid IC West, et al. 2005 Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria Circ Res 97 329 336 16037573 10.1161/01.RES.0000178451.08719.5b 1:CAS:528:DC%2BD2MXntlSiur8%3D (Pubitemid 41216137)
19. PJ Oliveira AP Rolo VA Sardao, et al. 2004 Advantages in the use of carvedilol versus propranolol for the protection of cardiac mitochondrial function J Portuguese Soc Cardiol 23 1291 1298 (Pubitemid 39647760)
20. P Monteíro AI Duarte LM Gonçalves LA Providência 2005 Valsartan improves mitochondrial function in hearts submitted to acute ischemia Eur J Pharmacol 518 158 164 16055115 10.1016/j.ejphar.2005.06.013 (Pubitemid 41133640)
21. 18F]fluorobenzyl triarylphosphonium ions J Labelled Comp Radiopharm 47 469 476 10.1002/jlcr.835 1:CAS:528:DC%2BD2cXmvVKnsrs%3D (Pubitemid 39062538)
22. 201Tl J Nucl Med 45 1950 1959 15534068 1:CAS:528:DC%2BD2cXhtVKnurrJ (Pubitemid 47618456)
23. 99mTc-sestamibi J Nucl Med 42 272 281 11216526 1:CAS:528:DC%2BD3MXhtlKmtrk%3D (Pubitemid 32150518)
24. 18F-Labeled Myocardial Perfusion Tracer J Nucl Med 49 4 630 636 18344426 10.2967/jnumed.107.044727 (Pubitemid 351520612)
25. P Yalamanchili E Wexler M Hayes M Yu J Bozek M Kagan HS Radeke M Azure A Purohit DS Casebier, et al. 2007 Mechanism of uptake and retention of F-18 BMS-747158-02 in cardiomyocytes: a novel PET myocardial imaging agent J Nucl Cardiol 14 6 782 788 18022104 10.1016/j.nuclcard.2007.07.009 (Pubitemid 350082573)
26. M Yu MT Guaraldi J Bozek M Kagan M Azure H Radeke M Cdebaca SP Robinson 2009 Effects of food intake and anesthetic on cardiac imaging and uptake of BMS747158-02 in comparison with FDG J Nucl Cardiol 16 5 689 690 10.1007/s12350-009-9088-7