Noninvasive quantification of regional myocardial metabolic rate for oxygen by use of 15O2 inhalation and positron emission tomography: Theory, error analysis, and application in humans

Circulation

Volumn 94, Issue 4, 1996, Pages 792-807

  Iida, Hidehiro ^a,b   Rhodes, Christopher G ^a   Araujo, Luis I ^a   Yamamoto, Yusuke ^a   De Suva, Ranil ^a   Maseri, Attilio ^a   Jones, Terry ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b RESEARCH INSTITUTE FOR BRAIN AND BLOOD VESSELS AKITA   (Japan)

Author keywords

blood flow; myocardium; oxygen; tomography

Indexed keywords

CARBON MONOXIDE; METHANE; OXYGEN 15;

ADULT; ANALYTICAL ERROR; ARTICLE; COMPARTMENT MODEL; HEART MUSCLE BLOOD FLOW; HEART MUSCLE OXYGEN CONSUMPTION; HUMAN; HUMAN EXPERIMENT; LUNG VOLUME; MALE; METABOLIC RATE; NORMAL HUMAN; OXYGEN BREATHING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

EID: 0029757173     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.94.4.792     Document Type: Article

References (48)

1. Pike VW, Eakins MN, Allan RM, Selwyn AP. Preparation of [1-11C]acetate: an agent for the study of myocardial metabolism by positron emission tomography. Int J Appl Radiat Isot. 1982;33: 505-512.
2. Brown MA, Marshall DR, Sobel BE, Bergmann SR. Delineation of myocardial oxygen utilization with carbon-11-labeled acetate. Circulation. 1987;76:687-696.
3. Brown MA, Myears DW, Bergmann SR. Noninvasive assessment of canine myocardial oxidative metabolism with carbon-11 acetate and positron emission tomography. J Am Coll Cardiol. 1988;12:1054-1063.
4. Buxton DB, Schwaiger M, Nguyen A, Phelps ME, Schelbert HR. Radiolabeled acetate as a tracer of myocardial tricarboxylic acid cycle flux. Circ Res. 1988;63:628-634.
5. Buxton DB, Nienaber CA, Luxen A, Ratib O, Hansen H, Phelps ME, Schelbert HR. Noninvasive quantification of regional oxygen consumption in vivo with [1-11C] acetate and dynamic positron emission tomography. Circulation. 1989;79:134-142.
6. Armbrecht JJ, Buxton DB, Brunken RC, Phelps ME, Scheiben HR. Regional myocardial oxygen consumption determined noninvasively in humans with [1-11-C] acetate and dynamic positron tomography. Circulation. 1989;80:863-872.
7. Brown MA, Myears DW, Bergmann SR. Validity of estimates of myocardial oxidative metabolism with carbon-11 acetate and positron emission tomography despite altered patterns of substrate utilization. J Nucl Med. 1989;30:187-193.
8. 11C]acetate as a tracer for noninvasive assessment of oxidative metabolism with positron emission tomography in normal, ischemic, postischemic, and hyperemic canine myocardium. Circulation. 1990;81:1594-1605.
9. Jones T, Chesler DA, Ter-Pogossian MM. The continuous inhalation of oxygen-15 for assessing regional oxygen extraction in the brain of man. Br J Radiol. 1976;49:339-343.
10. 2. J Nucl Med. 1978; 19:48-53.
11. Frackowiak RS, Lenzi GL, Jones T, Heather JD. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using O-15 and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr. 1980;4:727-736.
12. Lammertsma AA, Jones T. Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain, 1: description of the method. J Cereb Blood Flow Metab. 1983;3:416-424.
13. Mintun MA, Raichle ME, Martin WRW, Herscovitch P. Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography. J Nucl Med. 1984;25:177-187.
14. 2 inhalation and dynamic positron emission tomography. J Cereb Blood Flow Metab. 1987;7:403-414.
15. Holden JE, Eriksson L, Roland PE, Stone-Elander S, Widen L, Kesselberg M. Direct comparison of single-scan autoradiographic with multiplescan least-squares fitting approaches to PET CMRO2 estimation. J Cereb Blood Flow Metab. 1988;8:671-680.
16. Huang S-C, Feng D-G, Phelps ME. Model dependency and estimation reliability in measurement of cerebral oxygen utilization rate with oxygen-15 and dynamic positron emission tomography. J Cereb Blood Flow Metab. 1986;6:105-119.
17. Wisenberg G, Schelbert HR, Hoffman EJ. Phelps ME, Robinson GD, Selin CE, Child J, Skorton D, Kuhl DE. In vivo quantitation of regional myocardial blood flow by positron-emission computed tomography. Circulation. 1981;63:1248-1258.
18. Henze E, Huang SC, Ratib O, Hoffman E, Phelps ME, Schelbert HR. Measurement of regional tissue and blood radiotracer concentrations from serial tomographic images of the heart. J Nucl Med. 1983; 24:987-996.
19. 15O and dynamic positronemission tomography: strategy for quantification in relation to the partial-volume effect. Circulation. 1988;78:104-115.
20. 2 inhalation and positron emission tomography. Circulation. 1996;94:808-816.
21. Hoffman EJ, Huang S-C, Phelps ME. Quantitation in positron emission computed tomography, 1: effect of object size. J Comput Assist Tomogr. 1979;3:299-308.
22. Araujo LI, Lammertsma A, Rhodes CG, MacFalls EO, Iida H, Rechavia E, Galassi A, de Suva R, Jones T, Maseri A. Noninvasive quantification of regional myocardial blood flow in normal volunteers and patients with coronary artery disease using oxygen-15 labeled water and positron emission tomography. Circulation. 1991;83:875-885.
23. Iida H, Rhodes CG, Kanno I, Jones T, de Silva R, Araujo LI. Use of the left ventricular time-activity curve as a noninvasive input function in dynamic oxygen-15-water positron emission tomography. J Nucl Med. 1992;33:1669-1677.
24. Iida H, Jones T, Miura S. Modeling approach to eliminate the need to separate arterial plasma in oxygen-15 inhalation positron emission tomography. J Nucl Med. 1993;34:1333-1340.
25. Brudin LH, Rhodes CG, Valind SO, Wollmer P, Hughes JMB. Regional Jung density and blood volume in nonsmoking and smoking subjects measured by PET. J Appl Physiol. 1987;63:1324-1334.
26. Valind SO, Rhodes CG, Brudin LH, Jones T. Measurement of regional ventilation pulmonary gas volume: theory and error analysis with special reference to positron emission tomography. J Nucl Med. 1991;32:1937-1944.
27. 15O autoradiography and positron emission tomography, with respect to the dispersion of the input function. J Cereb Blood Flow Metab. 1986;6:536-545.
28. Spinks TJ, Jones T, Gilardi MC, Heather JD. Physical performance of the latest generation of commercial positron scanner. IEEE Trans Nucl Sci. 1988;35:721-725.
29. Spinks TJ, Araujo LI, Rhodes CG, Hutton BF. Physical aspects of cardiac scanning with a block detector positron tomography. J Comput Assist Tomogr. 1991;15:893-904.
30. Robb RA. A software system for interactive and quantitative analysis of biomedical images. In: Höhne KH, Fuchs H, Pizer SM, eds. 3-D Imaging in Medicine. NATO ASI Series, 1990, Vol F 60:333-361.
31. Iida H, Rhodes CG, de Silva R, Yamamoto Y, Jones T, Araujo LI, Maseri A, Jones T. Myocardial tissue fraction: correction for partial volume effects and measure of tissue viability. J Nucl Med. 1991; 32:2169-2175.
32. Rhodes CG, Wollmer P, Fazio F, Jones T. Quantitative measurement of regional extravascular lung density using positron emission and transmission tomography. J Comput Assist Tomogr. 1981;5:783-791.
33. Crystal GJ, Downey HF, Bashour AFA. Small vessel and total coronary blood volume during intracoronary adenosine. Am J Physiol. 1981;241:H194-H201.
34. O'Keefe DD, Huffman JIE, Cheitlin R, O'Neill MJ, Allard JR, Shapkin E. Coronary blood flow in experimental canine left ventricular hypertrophy. Circ Res. 1978;43:43-51.
35. Yipintsoi T, Bassingthwaite JB. Circulatory transport of iodoantipyrine and water in the isolated dog heart. Circ Res. 1970;27: 461-467.
36. Iida H, Kanno I, Miura S, Murakami M, Takahashi K, Uemura K. A determination of the regional brain/blood partition coefficient of water using dynamic positron emission tomography. J Cereb Blood Flow Metab. 1989;9:874-885.
37. Brachfeld N, Bozer J, Gorlin R. Action of nitroglycerin on the coronary circulation in normal and in mild cardiac subjects. Circulation. 1959;19:697-704.
38. Leight L, DeFazio V, Talmers FN, Regan TJ, Hellmens HK. Coronary blood flow, myocardial oxygen consumption and myocardial metabolism in normal and hyperthyroid human subjects. Circulation. 1956;14:90-99.
39. Messer JV, Wagman RJ, Levine HJ, Neill WA, Krasnow N, Gorlin R. Patterns of human myocardial oxygen extraction during rest and exercise. J Clin Invest. 1962;41:725-735.
40. Bing RJ, Hammond MM, Handelsman JC, Powers SR, Spencer FC, Eckenhoff JE, Goodale WT, Hafkenschiel HJ, Kety SS. Measurement of coronary blood flow, oxygen consumption and efficiency of leftventricle in man. Am Heart J. 1949;38:1-11.
41. Regan TJ, Binak K, Gordon S, DeFazio V, Hellems HK. Myocardial blood flow and oxygen consumption during postprandial lipemia and heparin-induced lipolysis. Circulation. 1961;23:55-63.
42. 2 inhalation and positron emission tomography: experimental validation. Circulation. 1996;94:808-816.
43. 2 and positron emission tomography. Circulation. 1991;84(suppl II):II-47. Abstract.
44. Bol A, Melin J, Bahija E, Vogelaers D, Iida H. Assessment of myocardial oxygen reserve with PET: comparison with Pick oxygen consumption. Circulation. 1991;84(suppl II):Il-425. Abstract.
45. 2. J Nucl Med. 1991;32 (suppl):988. Abstract.
46. 15-hemoglobin. Circ Res. 1978;42:511-518.
47. Wise RJS, Bernardi S, Frackowiak RSJ, Legg NJ, Jones T. Serial observations on the pathophysiology of acute stroke. Brain. 1983; 106:197-222.
48. Brudin LH, Rhodes CG, Valind SO, Jones T, Hughes JMB. Interrelationships between regional blood flow, blood volume, and ventilation in supine humans. J Appl Physiol. 1994;76:1205-1210.