메뉴 건너뛰기




Volumn 32, Issue 5, 2005, Pages 495-503

Inhibition of carnitine-acyl transferase I by oxfenicine studied in vivo with [11C]-labeled fatty acids

Author keywords

Carnitine; Fatty acid oxidation; Myocardial metabolism; Oxfenicine; PET

Indexed keywords

ACYL COENZYME A; CARBON 11; CARNITINE; CARNITINE PALMITOYLTRANSFERASE; DODECANOIC ACID C 11; FATTY ACID DERIVATIVE; LACTIC ACID; OCTANOIC ACID C 11; OXFENICINE; PALMITIC ACID; PALMITIC ACID C 11; TETRADECANOIC ACID C 11; TRACER; UNCLASSIFIED DRUG;

EID: 20744453864     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2005.03.003     Document Type: Article
Times cited : (9)

References (30)
  • 1
    • 0021836092 scopus 로고
    • Inhibition of carnitine palmitoyl-CoA transferase activity and fatty acid oxidation by lactate and oxfenicine in cardiac muscle
    • D.R. Bielefeld, T.C. Vary, and J.R. Neely Inhibition of carnitine palmitoyl-CoA transferase activity and fatty acid oxidation by lactate and oxfenicine in cardiac muscle J Mol Cell Cardiol 17 1985 619 625
    • (1985) J Mol Cell Cardiol , vol.17 , pp. 619-625
    • Bielefeld, D.R.1    Vary, T.C.2    Neely, J.R.3
  • 2
    • 0024398031 scopus 로고
    • Energy-linked regulation of mitochondrial fatty acid oxidation in the isolated perfused rat heart
    • P.M. Latipaa Energy-linked regulation of mitochondrial fatty acid oxidation in the isolated perfused rat heart J Mol Cell Cardiol 21 1989 765 771
    • (1989) J Mol Cell Cardiol , vol.21 , pp. 765-771
    • Latipaa, P.M.1
  • 3
    • 0027959194 scopus 로고
    • Carnitine-acylcarnitine translocase deficiency: Implications in human pathology
    • S.V. Pande, and M.S. Murthy Carnitine-acylcarnitine translocase deficiency: implications in human pathology Biochim Biophys Acta 1226 3 1994 269 276
    • (1994) Biochim Biophys Acta , vol.1226 , Issue.3 , pp. 269-276
    • Pande, S.V.1    Murthy, M.S.2
  • 4
    • 0023277403 scopus 로고
    • The role of the carnitine system in myocardial fatty acid oxidation: Carnitine deficiency, failing mitochondria and cardiomyopathy
    • H.R. Scholte, I.E. Luyt-Houwen, and M.H. Vaandrager-Verduin The role of the carnitine system in myocardial fatty acid oxidation: carnitine deficiency, failing mitochondria and cardiomyopathy Basic Res Cardiol 82 Suppl 1 1987 63 73
    • (1987) Basic Res Cardiol , vol.82 , Issue.1 SUPPL. , pp. 63-73
    • Scholte, H.R.1    Luyt-Houwen, I.E.2    Vaandrager-Verduin, M.H.3
  • 5
    • 0031884872 scopus 로고    scopus 로고
    • Carnitine deficiency-induced cardiomyopathy
    • D.J. Paulson Carnitine deficiency-induced cardiomyopathy Mol Cell Biochem 180 1-2 1998 33 41
    • (1998) Mol Cell Biochem , vol.180 , Issue.1-2 , pp. 33-41
    • Paulson, D.J.1
  • 6
    • 0018611877 scopus 로고
    • Role of carnitine in fatty acid metabolism of normal and ischemic myocardium
    • L.H. Opie Role of carnitine in fatty acid metabolism of normal and ischemic myocardium Am Heart J 97 1979 375 388
    • (1979) Am Heart J , vol.97 , pp. 375-388
    • Opie, L.H.1
  • 7
    • 0035021014 scopus 로고    scopus 로고
    • Influence of l-carnitine and its derivatives on myocardial metabolism and function in ischemic heart disease and during cardiopulmonary bypass
    • R. Lango, R.T. Smolenski, M. Narkiewics, J. Suchorzewska, and W. Lysiac-Szydlowska Influence of l-carnitine and its derivatives on myocardial metabolism and function in ischemic heart disease and during cardiopulmonary bypass Cardiovasc Res 51 2001 21 29
    • (2001) Cardiovasc Res , vol.51 , pp. 21-29
    • Lango, R.1    Smolenski, R.T.2    Narkiewics, M.3    Suchorzewska, J.4    Lysiac-Szydlowska, W.5
  • 8
    • 0030860259 scopus 로고    scopus 로고
    • Alterations in fatty acid oxidation during reperfusion of the heart after myocardial ischemia
    • G.D. Lopaschuk Alterations in fatty acid oxidation during reperfusion of the heart after myocardial ischemia Am J Cardiol 80 1997 11A 16A
    • (1997) Am J Cardiol , vol.80
    • Lopaschuk, G.D.1
  • 9
    • 0028009239 scopus 로고
    • Cellular uncoupling induced by accumulation of long-chain acylcarnitine during ischemia
    • K.A. Yamada, J. McHowat, G.X. Yan, K. Donahue, J. Peirick, and A.G. Kleber Cellular uncoupling induced by accumulation of long-chain acylcarnitine during ischemia Circ Res 74 1994 83 95
    • (1994) Circ Res , vol.74 , pp. 83-95
    • Yamada, K.A.1    McHowat, J.2    Yan, G.X.3    Donahue, K.4    Peirick, J.5    Kleber, A.G.6
  • 10
    • 0031055787 scopus 로고    scopus 로고
    • Acute myocardial ischemia induces cardiac carnitine release in man
    • G.L. Bartels, W.J. Remme, and H.R. Scholte Acute myocardial ischemia induces cardiac carnitine release in man Eur Heart J 18 1997 84 90
    • (1997) Eur Heart J , vol.18 , pp. 84-90
    • Bartels, G.L.1    Remme, W.J.2    Scholte, H.R.3
  • 11
    • 0022490156 scopus 로고
    • Fatty acid metabolism in hearts containing elevated levels of CoA
    • G.D. Lopaschuk, C.A. Hansen, and J.R. Neely Fatty acid metabolism in hearts containing elevated levels of CoA Am J Physiol 250 1986 H351 H359
    • (1986) Am J Physiol , vol.250
    • Lopaschuk, G.D.1    Hansen, C.A.2    Neely, J.R.3
  • 12
    • 0036084877 scopus 로고    scopus 로고
    • Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin
    • J.Y. Kong, and S.W. Rabkin Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin Am J Physiol 282 2002 H717 H725
    • (2002) Am J Physiol , vol.282
    • Kong, J.Y.1    Rabkin, S.W.2
  • 13
    • 0018841814 scopus 로고
    • External assessment of myocardial metabolism with carbon-11-labeled palmitate in vivo
    • R.A. Goldstein, M.S. Klein, M.J. Welch, and B.E. Sobel External assessment of myocardial metabolism with carbon-11-labeled palmitate in vivo J Nucl Med 21 1980 342 348
    • (1980) J Nucl Med , vol.21 , pp. 342-348
    • Goldstein, R.A.1    Klein, M.S.2    Welch, M.J.3    Sobel, B.E.4
  • 14
    • 0020432934 scopus 로고
    • C-11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron computed tomography. I: Kinetics of C-11 palmitic acid in normal myocardium
    • H.R. Schön, H.R. Schelbert, G. Robinsson, A. Najafi, S.-C. Huang, and H. Hansen C-11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron computed tomography. I: Kinetics of C-11 palmitic acid in normal myocardium Am Heart J 103 1982 532 547
    • (1982) Am Heart J , vol.103 , pp. 532-547
    • Schön, H.R.1    Schelbert, H.R.2    Robinsson, G.3    Najafi, A.4    Huang, S.-C.5    Hansen, H.6
  • 15
    • 0029840737 scopus 로고    scopus 로고
    • Quantitation of myocardial fatty acid metabolism using PET
    • S.R. Bergmann, C.J. Weinheimer, J. Markham, and P. Merrero Quantitation of myocardial fatty acid metabolism using PET J Nucl Med 37 1996 1723 1730
    • (1996) J Nucl Med , vol.37 , pp. 1723-1730
    • Bergmann, S.R.1    Weinheimer, C.J.2    Markham, J.3    Merrero, P.4
  • 16
    • 0021864482 scopus 로고
    • Two mechanisms produce tissue-specific inhibition of fatty acid oxidation by oxfenicine
    • T.P. Stephens, A.J. Higgins, G.A. Cook, and R.A. Harris Two mechanisms produce tissue-specific inhibition of fatty acid oxidation by oxfenicine Biochem J 227 2 1985 651 660
    • (1985) Biochem J , vol.227 , Issue.2 , pp. 651-660
    • Stephens, T.P.1    Higgins, A.J.2    Cook, G.A.3    Harris, R.A.4
  • 17
    • 0021024932 scopus 로고
    • Carnitine - Metabolism and functions
    • J. Bremer Carnitine - metabolism and functions Physiol Rev 63 1983 1420 1479
    • (1983) Physiol Rev , vol.63 , pp. 1420-1479
    • Bremer, J.1
  • 19
    • 0022389649 scopus 로고
    • Graphical evaluation of blood-to-brain transfer constants from multiple time uptake data: Generalizations
    • C.S. Patlak, and R.G. Blasberg Graphical evaluation of blood-to-brain transfer constants from multiple time uptake data: generalizations J Cereb Blood Flow Metab 5 1985 584 590
    • (1985) J Cereb Blood Flow Metab , vol.5 , pp. 584-590
    • Patlak, C.S.1    Blasberg, R.G.2
  • 20
    • 0026055469 scopus 로고
    • Distribution of carbon flux within fatty acid utilization during myocardial ischemia and reperfusion
    • S.H. Nellis, A.J. Liedtke, and B. Renstrom Distribution of carbon flux within fatty acid utilization during myocardial ischemia and reperfusion Circ Res 69 1991 779 790
    • (1991) Circ Res , vol.69 , pp. 779-790
    • Nellis, S.H.1    Liedtke, A.J.2    Renstrom, B.3
  • 21
    • 0021817798 scopus 로고
    • Efflux of metabolized an nonmetabolized fatty acid from canine myocardium. Implications for quantifying myocardial metabolism tomographically
    • K.A.A. Fox, D.R. Abendschein, H.D. Ambos, B.E. Sobel, and S.R. Bergmann Efflux of metabolized an nonmetabolized fatty acid from canine myocardium. Implications for quantifying myocardial metabolism tomographically Circ Res 57 1985 232 243
    • (1985) Circ Res , vol.57 , pp. 232-243
    • Fox, K.A.A.1    Abendschein, D.R.2    Ambos, H.D.3    Sobel, B.E.4    Bergmann, S.R.5
  • 24
    • 0015351536 scopus 로고
    • 14C]acetate into lipid in the perfused rat heart
    • 14C]acetate into lipid in the perfused rat heart J Mol Cell Cardiol 4 1972 213 228
    • (1972) J Mol Cell Cardiol , vol.4 , pp. 213-228
    • Gloster, J.1    Harris, P.2
  • 25
    • 20744447367 scopus 로고
    • Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart
    • P.J. Randle, P.J. England, and R.M. Denton Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart Circ Res 63 1988 628 634
    • (1988) Circ Res , vol.63 , pp. 628-634
    • Randle, P.J.1    England, P.J.2    Denton, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.