Targeted molecular imaging of angiogenesis in PET and SPECT: A review

Yale Journal of Biology and Medicine

Volumn 85, Issue 1, 2012, Pages 75-86

  Stacy, Mitchel R ^a   Maxfield, Mark W ^a   Sinusas, Albert J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; CT; Hind limb ischemia; Molecular imaging; Myocardial ischemia; PET; SPECT

Indexed keywords

MARACICLATIDE; MARACICLATIDE TC 99M; RADIOPHARMACEUTICAL AGENT; RP 748; RP 748 IN 111; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR; VITRONECTIN RECEPTOR;

ANGIOGENESIS; CARDIOVASCULAR DISEASE; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; GENE THERAPY; HUMAN; LIMB ISCHEMIA; MEDICAL LITERATURE; MOLECULAR IMAGING; MOLECULAR INTERACTION; MOLECULAR PROBE; NANOPROBE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVIEW; RISK BENEFIT ANALYSIS; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TARGETED MOLECULAR IMAGING; TUMOR VASCULARIZATION;

HUMANS; INTEGRINS; MOLECULAR IMAGING; NEOVASCULARIZATION, PATHOLOGIC; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84859359084     PISSN: 00440086     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (67)

1. Dobrucki LW, de Muinck E, Lindner J, Sinusas AJ. Approaches to multimodality imaging of angiogenesis. J Nucl Med. 2010;51(Suppl 1):66S-79S.
2. Dobrucki LW, Sinusas AJ. PET and SPECT in cardiovascular molecular imaging. Nature reviews. Cardiology. 2010;7(1):38-47.
3. Sinusas AJ, Thomas JD, Mills G. The future of molecular imaging. JACC Cardiovasc Imaging. 2011;4(7):799-806.
4. Morrison AR, Sinusas AJ. Advances in radionuclide imaging in myocardial biology. J Nucl Med. 2010;17(1):116-34.
5. Dobrucki LW, Sinusas AJ. Molecular imaging. A new approach to nuclear cardiology. Q J Nucl Med Mol Imaging. 2005;49(1):106-115.
6. Dobrucki LW, Sinusas AJ. Molecular cardiovascular imaging. Curr Cardiol Rep. 2005;7(2):130-5.
7. Dobrucki LW, Sinusas AJ. Cardiovascular molecular imaging. Semin Nucl Med. 2005;35(1):73-81.
8. Dobrucki LW, Sinusas AJ. Imaging angiogenesis. Curr Opin Biotechnol. 2007;18:90-6.
9. Dobrucki LW, Dione DP, Kalinowski L, Dione D, Mendizabal M, Yu J, et al. Serial noninvasive targeted imaging of peripheral angiogenesis: validation and application of a semiautomated quantitative approach. J Nucl Med. 2009;50(8):1356-63.
10. Razavian M, Marfatia R, Mongue-Din H, Tavakoli S, Sinusas AJ, Zhang J, et al. Integrin-Targeted Imaging of Inflammation in Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2011;31(12):2820-6.
11. Inubushi M. Positron-Emission Tomography Reporter Gene Expression Imaging in Rat Myocardium. Circulation. 2002;107(2):326-32.
12. Lindsey ML, Escobar GP, Dobrucki LW, Goshorn DK, Bouges S, Mingoia JT, et al. Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction. Am J Physiol Heart Circ Physiol. 2006;290(1):H232-H239.
13. Rodriguez-Porcel M, Cai W, Gheysens O, Willmann JK, Chen K, Wang H, et al. Imaging of VEGF receptor in a rat myocardial infarction model using PET. J Nucl Med. 2008;49(4):667-73.
14. Sinusas AJ. Imaging of angiogenesis. J Nucl Cardiol. 2004;11:617-33.
15. Seaman ME, Contino G, Bardeesy N, Kelly KA. Molecular imaging agents: impact on diagnosis and therapeutics in oncology. Expert Rev Mol Med. 2010;12:e20.
16. Mitsos S, Katsanos K, Koletsis E, Kagadis GC, Anastasiou N, Diamantopoulos A, et al. Therapeutic angiogenesis for myocardial ischemia revisited: basic biological concepts and focus on latest clinical trials. Angiogenesis. 2012;15(1):1-22.
17. Fam NP, Verma S, Kutryk M, Stewart DJ. Clinician guide to angiogenesis. Circulation. 2003;108(21):2613-8.
18. Simons M. Angiogenesis: where do we stand now? Circulation. 2005;111(12):1556-66.
19. Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature. 2011;473(7347):298-307.
20. Bruce D, Tan PH. Vascular endothelial growth factor receptors and the therapeutic targeting of angiogenesis in cancer: where do we go from here? Cell Commun Adhes. 2011;18(5):85-103.
21. Sipkins DA, Cheresh DA, Kazemi MR, Nevin LM, Bednarski MD, Li KC. Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med. 1998;4(5):623-6.
22. Streeter J, Gessner R, Tsuruta J, Feingold S, Dayton P. Assessment of molecular imaging of angiogenesis with three-dimensional ultrasongraphy. Mol Imaging. 2011;10(6):460-8.
23. Willmann JK, Chen K, Wang H, Paulmurugan R, Rollins M, Cai W, et al. Monitoring of the biological response to murine hindlimb ischemia with 64Cu-labeled vascular endothelial growth factor-121 positron emission tomography. Circulation. 2008;117(7):915-22.
24. Hua J, Dobrucki LW, Sadeghi MM, Zhang J, Bourke BN, Cavaliere P, et al. Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia. Circulation. 2005;111(24):3255-60.
25. Buschmann IR, Voskui M, van Royen N, Hoefer IE, Scheffler K, Grundmann S, et al. Invasive and non-invasive evaluation of spontaneous arteriogenesis in a novel porcine model for peripheral arterial obstructive disease. Atherosclerosis. 2003;167(1):33-43.
26. Kalinowski L, Dobrucki LW, Meoli D, Dione D, Sadeghi MM, Madri J, et al. Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. J Appl Physiol. 2008;104(5):1504-12.
27. Dobrucki L, Meoli D, Hu J, Sadeghi M, Sinusas A. Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury. J Physiol Pharmacol. 2009;60(Suppl 4):117-23.
28. Meoli D, Sadeghi M, Krassilnikova S, Bourke B, Giordano F, Dione D, et al. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest. 2004;113(12):1684-91.
29. Dobrucki L, Tsutsumi Y, Kalinowski L, Dean J, Gavin M, Sen S, et al. Analysis of angiogenesis induced by local IGF-1 expression after myocardial infarction using microSPECT-CT imaging. J Mol Cell Cardiol. 2010;48(6):1071-9.
30. Schaper W. Collateral circulation: past and present. Basic Res Cardiol. 2009;104(1):5-21.
31. Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 1992;359(6398):843-5.
32. Brogi E, Schatteman G, Wu T, Kim EA, Varticovski L, Keyt B, et al. Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression. J Clin Invest. 1996;97(2):469-76.
33. Banai S, Jaklitsch MT, Shou M, Lazarous DF, Scheinowitz M, Biro S, et al. Angiogenic-in-duced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation. 1994;89(5):2183-9.
34. Li J, Brown LF, Hibberd MG, Grossman JD, Morgan JP, Simons M. VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. Am J Physiol. 1996;270(5 Pt 2):H1803-11.
35. Dufraine J, Funahashi Y, Kitajewski J. Notch signaling regulates tumor angiogenesis by diverse mechanisms. Oncogene. 2008;27(38):5132-7.
36. Schwartz MA, Schaller MD, Ginsberg MH. Integrins: emerging paradigms of signal transduction. Ann Rev Cell Dev Biol. 1995;11:549-99.
37. Brooks PC, Clark RAF, Cheresh DA. Requirement of Vascular Integrin alpha v beta 3 for Angiogenesis. Science. 1994;264:569-71.
38. Lake Tahoe invitation meeting 2002 J Nucl Cardiol. 2003;10:223-57.
39. Haubner R, Beer AJ, Wang H, Chen X. Positron emission tomography tracers for imaging angiogenesis. Eur J Nucl Med Mol Imaging. 2010;37(Suppl 1):S86-S103.
40. Tallheden T, Nannmark U, Lorentzon M, Rakotonirainy O, Soussi B, Waagstein F, et al. In vivo MR imaging of magnetically labeled human embryonic stem cells. Life Sci. 2006;79(10):999-1006.
41. van Laake LW, Passier R, Monshouwer-Kloots J, Nederhoff MG, Ward-van Oostwaard D, Field LJ, et al. Monitoring of cell therapy and assessment of cardiac function using magnetic resonance imaging in a mouse model of myocardial infarction. Nat Protoc. 2007;2(10):2551-67.
42. Lappalainen RS, Narkilahti S, Huhtala T, Liimatainen T, Suuronen T, Narvanen A, et al. The SPECT imaging shows the accumulation of neural progenitor cells into internal organs after systemic administration in middle cerebral artery occlusion rats. Neurosci Lett. 2008;440(3):246-50.
43. Cao F, Li Z, Lee A, Liu Z, Chen K, Wang H, et al. Noninvasive de novo imaging of human embryonic stem cell-derived teratoma formation. Cancer Res. 2009;69(7):2709-13.
44. Cai W, Chen X. Multimodality molecular imaging of tumor angiogenesis. J Nucl Med. 2008;49(Suppl 2):113S-128S.
45. Cai W, Niu G, Chen X. Imaging of integrins as biomarkers for tumor angiogenesis. Curr Pharm Des. 2008;14(28):2943-73.
46. Miller JC, Pien HH, Sahani D, Sorensen AG, Thrall JH. Imaging angiogenesis: applications and potential for drug development. J Natl Cancer Inst. 2005;97(3):172-87.
47. Winter PM, Caruthers SD, Kassner A, Harris TD, Chinen LK, Allen JS, et al. Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging. Cancer Res. 2003;63(18):5838-43.
48. Schmieder AH, Winter PM, Caruthers SD, Harris TD, Williams TA, Allen JS, et al. Molecular MR imaging of melanoma angiogenesis with alphanubeta3-targeted paramagnetic nanoparticles. Magn Reson Med. 2005;53(3):621-7.
49. Beer AJ, Schwaiger M. Imaging of integrin alphavbeta3 expression. Cancer Metastasis Rev. 2008;27(4):631-44.
50. Indrevoll B, Kindberg GM, Solbakken M, Bjurgert E, Johansen JH, Karlsen H, et al. NC-100717: a versatile RGD peptide scaffold for angiogenesis imaging. Bioorg Med Chem Lett. 2006;16(24):6190-3.
51. Makowski MR, Ebersberger U, Nekolla S, Schwaiger M. In vivo molecular imaging of angiogenesis, targeting alphavbeta3 integrin expression, in a patient after acute myocardial infarction. Eur Heart J. 2008;29(18):2201.
52. Li S, Dobrucki LW, Sinusas AJ, Liu YH. A new method for SPECT quantification of targeted radiotracers uptake in the myocardium. Med Image Comput Comput Assist Interv. 2005;8(Pt 2):684-91.
53. Lu E, Wagner WR, Schellenberger U, Abraham JA, Klibanov AL, Woulfe SR, et al. Targeted in vivo labeling of receptors for vascular endothelial growth factor: approach to identification of ischemic tissue. Circulation. 2003;108(1):97-103.
54. Collingridge DR, Carroll VA, Glaser M, Aboagye EO, Osman S, Hutchinson OC, et al. The Development of [(124)I] Iodinated-VG76e: A Novel Tracer for Imaging Vascular Endothelial Growth Factor in Vivo Using Positron Emission Tomography 1. Cancer Res. 2002;62(20):5912-9.
55. Li S, Peck-Radosavljevic M, Koller E, Koller F, Kaserer K, Kreil A, et al. Characterization of (123)I-vascular endothelial growth factorbinding sites expressed on human tumour cells: possible implication for tumour scintigraphy. Int J Cancer. 2001;91(6):789-96.
56. Wang T, Mancuso JJ, Kazmi SM, Dwelle J, Sapozhnikova V, Willsey B, et al. Combined two-photon luminescence microscopy and OCT for macrophage detection in the hypercholesterolemic rabbit aorta using plasmonic gold nanorose. Lasers Surg Med. 2012;44(1):49-59.
57. Owens DE 3rd, Peppas NA. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J. Pharm. 2006;307(1):93-102.
58. Cai W, Chen K, Mohamedali KA, Cao Q, Gambhir SS, Rosenblum MG, et al. PET of Vascular Endothelial Growth Factor Receptor Expression. J Nucl Med. 2006;47(12):2048-56.
59. Backer MV, Levashova Z, Patel V, Jehning BT, Claffey K, Blankenberg FG, et al. Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes. Nat Med. 2007;13(4):504-9.
60. Levashova Z, Backer M, Backer JM, Blankenberg FG. Imaging vascular endothelial growth factor (VEGF) receptors in turpentine-induced sterile thigh abscesses with radiolabeled single-chain VEGF. J Nucl Med. 2009;50(12):2058-63.
61. Bengel FM, Anton M, Richter T, Simoes MV, Haubner R, Henke J, et al. Noninvasive imaging of transgene expression by use of positron emission tomography in a pig model of myocardial gene transfer. Circulation. 2003;108(17):2127-33.
62. Wu JC. Molecular Imaging of the Kinetics of Vascular Endothelial Growth Factor Gene Expression in Ischemic Myocardium. Circulation. 2004;110(6):685-91.
63. Wu JC. Positron Emission Tomography Imaging of Cardiac Reporter Gene Expression in Living Rats. Circulation. 2002;106(2):180-3.
64. Bach-Gansmo T, Danielsson R, Saracco A, Wilczek B, Bogsrud T, Fangberget A, et al. Integrin receptor imaging of breast cancer: a proof-of-concept study to evaluate 99mTc-NC100692. J Nucl Med. 2006;47(9):1434-9.
65. Edwards D, Jones P, Haramis H, Battle M, Lear R, Barnett DJ, et al. 99mTc-NC100692--a tracer for imaging vitronectin receptors associated with angiogenesis: a preclinical investigation. Nucl Med Biol. 2008;35(3):365-75.
66. Jaffer F, Libby P, Weissleder R. Molecular imaging of cardiovascular disease. Circulation. 2007;116(9):1052-61.
67. Almutairi A, Rossin R, Shokeen M, Hagooly A, Ananth A, Capoccia B, et al. Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis. Proc Natl Acad Sci USA. 2009;106(3):685-90.