Phase I, first-in-human study of BMS747158, a novel 18F-labeled tracer for myocardial perfusion PET: Dosimetry, biodistribution, safety, and imaging characteristics after a single injection at rest

Journal of Nuclear Medicine

Volumn 52, Issue 9, 2011, Pages 1490-1498

  Maddahi, Jamshid ^a   Czernin, Johannes ^a   Lazewatsky, Joel ^b   Huang, Sung Cheng ^a   Dahlbom, Magnus ^a   Schelbert, Heinrich ^a   Sparks, Richard ^c   Ehlgen, Alexander ^b   Crane, Paul ^b   Zhu, Qi ^b   Devine, Marybeth ^b   Phelps, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b A Subsidiary of Lantheus Holdings   (United States)

^c CDE Dosimetry Services Inc   (United States)

Author keywords

18F labeled BMS747158; Mitochondrial complex 1; Myocardial perfusion imaging

Indexed keywords

FLURPIRIDAZ F 18;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BLOOD; BLOOD PRESSURE; CARDIOTOXICITY; DOSIMETRY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG SAFETY; DRUG TOLERABILITY; ELECTROCARDIOGRAPHY; FEMALE; HEART; HEART PERFUSION; HEART RATE; HUMAN; HUMAN EXPERIMENT; KIDNEY; LABORATORY TEST; MALE; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION ABSORPTION; RADIOCARDIOGRAPHY; SIDE EFFECT; SINGLE DRUG DOSE; URINARY EXCRETION; WHOLE BODY IMAGING;

ADOLESCENT; ADULT; ALGORITHMS; CORONARY CIRCULATION; ELECTROENCEPHALOGRAPHY; FEMALE; FLUORINE RADIOISOTOPES; HEART; HUMANS; MALE; POSITRON-EMISSION TOMOGRAPHY; PYRIDAZINES; RADIOMETRY; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; WHOLE-BODY COUNTING; YOUNG ADULT;

EID: 80052639367     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.092528     Document Type: Article

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