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Volumn 10, Issue 10, 2014, Pages

Uncovering Enhancer Functions Using the α-Globin Locus

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; POLYCOMB GROUP PROTEIN; RNA; RNA POLYMERASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR NF E2; RNA POLYMERASE II;

EID: 84908333065     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004668     Document Type: Article
Times cited : (29)

References (113)
  • 1
    • 0028851523 scopus 로고
    • Hematopoiesis: how does it happen
    • Orkin SH, (1995) Hematopoiesis: how does it happen? Curr Opin Cell Biol 7: 870–877.
    • (1995) Curr Opin Cell Biol , vol.7 , pp. 870-877
    • Orkin, S.H.1
  • 2
    • 0032986213 scopus 로고    scopus 로고
    • A novel method of cell separation based on dual parameter immunomagnetic cell selection
    • Partington KM, Jenkinson EJ, Anderson G, (1999) A novel method of cell separation based on dual parameter immunomagnetic cell selection. J Immunol Methods 223: 195–205.
    • (1999) J Immunol Methods , vol.223 , pp. 195-205
    • Partington, K.M.1    Jenkinson, E.J.2    Anderson, G.3
  • 3
    • 0017095301 scopus 로고
    • Studies on column fractionation of immune cells. VI. Separation of thymus-derived lymphocytes by means of protein beads coated with antigen-antibody complexes
    • Eckert R, Mix E, von Broen B, (1976) Studies on column fractionation of immune cells. VI. Separation of thymus-derived lymphocytes by means of protein beads coated with antigen-antibody complexes. Acta Biol Med Ger 35: 663–671.
    • (1976) Acta Biol Med Ger , vol.35 , pp. 663-671
    • Eckert, R.1    Mix, E.2    Von Broen, B.3
  • 4
    • 84908315446 scopus 로고    scopus 로고
    • The Molecular Basis of Normal Erythroid/Megakaryocyte Development and Mechanisms of Epigenetic/Transcriptional Deregulation Leading to Erythroleukemia and Thalassaemia
    • Vernimmen D (2014) The Molecular Basis of Normal Erythroid/Megakaryocyte Development and Mechanisms of Epigenetic/Transcriptional Deregulation Leading to Erythroleukemia and Thalassaemia. In: Bonifer C, Cockerill PN, editors. Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development Epigenetics and Human Health. Heidelberg: Springer. pp. 247–266.
    • (2014) Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development Epigenetics and Human Health , pp. 247-266
    • Vernimmen, D.1
  • 5
    • 3543038232 scopus 로고    scopus 로고
    • Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2
    • Anguita E, Hughes J, Heyworth C, Blobel GA, Wood WG, et al. (2004) Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J 23: 2841–2852.
    • (2004) EMBO J , vol.23 , pp. 2841-2852
    • Anguita, E.1    Hughes, J.2    Heyworth, C.3    Blobel, G.A.4    Wood, W.G.5
  • 6
    • 5444255213 scopus 로고    scopus 로고
    • The active spatial organization of the beta-globin locus requires the transcription factor EKLF
    • Drissen R, Palstra RJ, Gillemans N, Splinter E, Grosveld F, et al. (2004) The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev 18: 2485–2490.
    • (2004) Genes Dev , vol.18 , pp. 2485-2490
    • Drissen, R.1    Palstra, R.J.2    Gillemans, N.3    Splinter, E.4    Grosveld, F.5
  • 7
    • 34247272882 scopus 로고    scopus 로고
    • Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression
    • Vernimmen D, De Gobbi M, Sloane-Stanley JA, Wood WG, Higgs DR, (2007) Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression. EMBO J 26: 2041–2051.
    • (2007) EMBO J , vol.26 , pp. 2041-2051
    • Vernimmen, D.1    De Gobbi, M.2    Sloane-Stanley, J.A.3    Wood, W.G.4    Higgs, D.R.5
  • 8
    • 0020959462 scopus 로고
    • Simian virus 40 early- and late-region promoter functions are enhanced by the 72-base-pair repeat inserted at distant locations and inverted orientations
    • Fromm M, Berg P, (1983) Simian virus 40 early- and late-region promoter functions are enhanced by the 72-base-pair repeat inserted at distant locations and inverted orientations. Mol Cell Biol 3: 991–999.
    • (1983) Mol Cell Biol , vol.3 , pp. 991-999
    • Fromm, M.1    Berg, P.2
  • 9
    • 0019769520 scopus 로고
    • The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants
    • Moreau P, Hen R, Wasylyk B, Everett R, Gaub MP, et al. (1981) The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants. Nucleic Acids Res 9: 6047–6068.
    • (1981) Nucleic Acids Res , vol.9 , pp. 6047-6068
    • Moreau, P.1    Hen, R.2    Wasylyk, B.3    Everett, R.4    Gaub, M.P.5
  • 10
    • 0019811465 scopus 로고
    • Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences
    • Banerji J, Rusconi S, Schaffner W, (1981) Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences. Cell 27: 299–308.
    • (1981) Cell , vol.27 , pp. 299-308
    • Banerji, J.1    Rusconi, S.2    Schaffner, W.3
  • 11
    • 0019196221 scopus 로고
    • Spacer DNA sequences upstream of the T-A-T-A-A-A-T-A sequence are essential for promotion of H2A histone gene transcription in vivo
    • Grosschedl R, Birnstiel ML, (1980) Spacer DNA sequences upstream of the T-A-T-A-A-A-T-A sequence are essential for promotion of H2A histone gene transcription in vivo. Proc Natl Acad Sci U S A 77: 7102–7106.
    • (1980) Proc Natl Acad Sci U S A , vol.77 , pp. 7102-7106
    • Grosschedl, R.1    Birnstiel, M.L.2
  • 12
    • 0037442825 scopus 로고    scopus 로고
    • Identification of HTF (HER2 transcription factor) as an AP-2 (activator protein-2) transcription factor and contribution of the HTF binding site to ERBB2 gene overexpression
    • Vernimmen D, Begon D, Salvador C, Gofflot S, Grooteclaes M, et al. (2003) Identification of HTF (HER2 transcription factor) as an AP-2 (activator protein-2) transcription factor and contribution of the HTF binding site to ERBB2 gene overexpression. Biochem J 370: 323–329.
    • (2003) Biochem J , vol.370 , pp. 323-329
    • Vernimmen, D.1    Begon, D.2    Salvador, C.3    Gofflot, S.4    Grooteclaes, M.5
  • 13
    • 84888015137 scopus 로고    scopus 로고
    • Super-enhancers in the control of cell identity and disease
    • Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-Andre V, et al. (2013) Super-enhancers in the control of cell identity and disease. Cell 155: 934–947.
    • (2013) Cell , vol.155 , pp. 934-947
    • Hnisz, D.1    Abraham, B.J.2    Lee, T.I.3    Lau, A.4    Saint-Andre, V.5
  • 14
    • 0035957953 scopus 로고    scopus 로고
    • CREB-binding protein and p300 in transcriptional regulation
    • Vo N, Goodman RH, (2001) CREB-binding protein and p300 in transcriptional regulation. J Biol Chem 276: 13505–13508.
    • (2001) J Biol Chem , vol.276 , pp. 13505-13508
    • Vo, N.1    Goodman, R.H.2
  • 15
    • 0032498230 scopus 로고    scopus 로고
    • The enhanceosome and transcriptional synergy
    • Carey M, (1998) The enhanceosome and transcriptional synergy. Cell 92: 5–8.
    • (1998) Cell , vol.92 , pp. 5-8
    • Carey, M.1
  • 17
    • 84890717859 scopus 로고    scopus 로고
    • Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
    • Shi J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, et al. (2013) Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev 27: 2648–2662.
    • (2013) Genes Dev , vol.27 , pp. 2648-2662
    • Shi, J.1    Whyte, W.A.2    Zepeda-Mendoza, C.J.3    Milazzo, J.P.4    Shen, C.5
  • 18
    • 58149463874 scopus 로고    scopus 로고
    • Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription
    • Amano T, Sagai T, Tanabe H, Mizushina Y, Nakazawa H, et al. (2009) Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription. Dev Cell 16: 47–57.
    • (2009) Dev Cell , vol.16 , pp. 47-57
    • Amano, T.1    Sagai, T.2    Tanabe, H.3    Mizushina, Y.4    Nakazawa, H.5
  • 19
    • 22244458301 scopus 로고    scopus 로고
    • Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences
    • Hughes JR, Cheng JF, Ventress N, Prabhakar S, Clark K, et al. (2005) Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences. Proc Natl Acad Sci U S A 102: 9830–9835.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9830-9835
    • Hughes, J.R.1    Cheng, J.F.2    Ventress, N.3    Prabhakar, S.4    Clark, K.5
  • 20
    • 23744509914 scopus 로고    scopus 로고
    • A newly discovered human alpha-globin gene
    • Goh SH, Lee YT, Bhanu NV, Cam MC, Desper R, et al. (2005) A newly discovered human alpha-globin gene. Blood 106: 1466–1472.
    • (2005) Blood , vol.106 , pp. 1466-1472
    • Goh, S.H.1    Lee, Y.T.2    Bhanu, N.V.3    Cam, M.C.4    Desper, R.5
  • 21
    • 84866124484 scopus 로고    scopus 로고
    • The molecular basis of alpha-thalassemia
    • Higgs DR, (2013) The molecular basis of alpha-thalassemia. Cold Spring Harb Perspect Med 3: a011718.
    • (2013) Cold Spring Harb Perspect Med , vol.3 , pp. a011718
    • Higgs, D.R.1
  • 22
    • 0021014396 scopus 로고
    • Beta-globin gene inactivation by DNA translocation in gamma beta-thalassaemia
    • Kioussis D, Vanin E, deLange T, Flavell RA, Grosveld FG, (1983) Beta-globin gene inactivation by DNA translocation in gamma beta-thalassaemia. Nature 306: 662–666.
    • (1983) Nature , vol.306 , pp. 662-666
    • Kioussis, D.1    Vanin, E.2    Delange, T.3    Flavell, R.A.4    Grosveld, F.G.5
  • 23
    • 0023663887 scopus 로고
    • Position-independent, high-level expression of the human beta-globin gene in transgenic mice
    • Grosveld F, van Assendelft GB, Greaves DR, Kollias G, (1987) Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell 51: 975–985.
    • (1987) Cell , vol.51 , pp. 975-985
    • Grosveld, F.1    Van Assendelft, G.B.2    Greaves, D.R.3    Kollias, G.4
  • 24
    • 0025365383 scopus 로고
    • Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster
    • Hatton CS, Wilkie AO, Drysdale HC, Wood WG, Vickers MA, et al. (1990) Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster. Blood 76: 221–227.
    • (1990) Blood , vol.76 , pp. 221-227
    • Hatton, C.S.1    Wilkie, A.O.2    Drysdale, H.C.3    Wood, W.G.4    Vickers, M.A.5
  • 25
    • 79951559441 scopus 로고    scopus 로고
    • Gene test review. Alpha-thalassemia
    • Galanello R, Cao A, (2011) Gene test review. Alpha-thalassemia. Genet Med 13: 83–88.
    • (2011) Genet Med , vol.13 , pp. 83-88
    • Galanello, R.1    Cao, A.2
  • 26
    • 39049083467 scopus 로고    scopus 로고
    • Long-range regulation of alpha-globin gene expression
    • Higgs DR, Vernimmen D, Wood B, (2008) Long-range regulation of alpha-globin gene expression. Adv Genet 61: 143–173.
    • (2008) Adv Genet , vol.61 , pp. 143-173
    • Higgs, D.R.1    Vernimmen, D.2    Wood, B.3
  • 27
    • 0029130729 scopus 로고
    • Targeted inactivation of the major positive regulatory element (HS-40) of the human alpha-globin gene locus
    • Bernet A, Sabatier S, Picketts DJ, Ouazana R, Morle F, et al. (1995) Targeted inactivation of the major positive regulatory element (HS-40) of the human alpha-globin gene locus. Blood 86: 1202–1211.
    • (1995) Blood , vol.86 , pp. 1202-1211
    • Bernet, A.1    Sabatier, S.2    Picketts, D.J.3    Ouazana, R.4    Morle, F.5
  • 28
    • 0024993211 scopus 로고
    • A major positive regulatory region located far upstream of the human alpha-globin gene locus
    • Higgs DR, Wood WG, Jarman AP, Sharpe J, Lida J, et al. (1990) A major positive regulatory region located far upstream of the human alpha-globin gene locus. Genes Dev 4: 1588–1601.
    • (1990) Genes Dev , vol.4 , pp. 1588-1601
    • Higgs, D.R.1    Wood, W.G.2    Jarman, A.P.3    Sharpe, J.4    Lida, J.5
  • 29
    • 84861222154 scopus 로고    scopus 로고
    • Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR
    • Ganis JJ, Hsia N, Trompouki E, de Jong JL, DiBiase A, et al. (2012) Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR. Dev Biol 366: 185–194.
    • (2012) Dev Biol , vol.366 , pp. 185-194
    • Ganis, J.J.1    Hsia, N.2    Trompouki, E.3    De Jong, J.L.4    Dibiase, A.5
  • 30
    • 0038107364 scopus 로고    scopus 로고
    • Functional and comparative analysis of globin loci in pufferfish and humans
    • Gillemans N, McMorrow T, Tewari R, Wai AW, Burgtorf C, et al. (2003) Functional and comparative analysis of globin loci in pufferfish and humans. Blood 101: 2842–2849.
    • (2003) Blood , vol.101 , pp. 2842-2849
    • Gillemans, N.1    McMorrow, T.2    Tewari, R.3    Wai, A.W.4    Burgtorf, C.5
  • 31
    • 0032052216 scopus 로고    scopus 로고
    • Hemoglobins from bacteria to man: evolution of different patterns of gene expression
    • Hardison R, (1998) Hemoglobins from bacteria to man: evolution of different patterns of gene expression. J Exp Biol 201: 1099–1117.
    • (1998) J Exp Biol , vol.201 , pp. 1099-1117
    • Hardison, R.1
  • 32
    • 0025734604 scopus 로고
    • Characterization of the major regulatory element upstream of the human alpha-globin gene cluster
    • Jarman AP, Wood WG, Sharpe JA, Gourdon G, Ayyub H, et al. (1991) Characterization of the major regulatory element upstream of the human alpha-globin gene cluster. Mol Cell Biol 11: 4679–4689.
    • (1991) Mol Cell Biol , vol.11 , pp. 4679-4689
    • Jarman, A.P.1    Wood, W.G.2    Sharpe, J.A.3    Gourdon, G.4    Ayyub, H.5
  • 34
    • 0027283593 scopus 로고
    • Role of upstream DNase I hypersensitive sites in the regulation of human alpha globin gene expression
    • Sharpe JA, Summerhill RJ, Vyas P, Gourdon G, Higgs DR, et al. (1993) Role of upstream DNase I hypersensitive sites in the regulation of human alpha globin gene expression. Blood 82: 1666–1671.
    • (1993) Blood , vol.82 , pp. 1666-1671
    • Sharpe, J.A.1    Summerhill, R.J.2    Vyas, P.3    Gourdon, G.4    Higgs, D.R.5
  • 36
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, et al. (2006) A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125: 315–326.
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3    Kamal, M.4    Huebert, D.J.5
  • 37
    • 78149485776 scopus 로고    scopus 로고
    • Interpretation of developmental signaling at chromatin: the Polycomb perspective
    • Sawarkar R, Paro R, (2010) Interpretation of developmental signaling at chromatin: the Polycomb perspective. Dev Cell 19: 651–661.
    • (2010) Dev Cell , vol.19 , pp. 651-661
    • Sawarkar, R.1    Paro, R.2
  • 38
    • 77956202054 scopus 로고    scopus 로고
    • Polycomb group proteins set the stage for early lineage commitment
    • Surface LE, Thornton SR, Boyer LA, (2010) Polycomb group proteins set the stage for early lineage commitment. Cell Stem Cell 7: 288–298.
    • (2010) Cell Stem Cell , vol.7 , pp. 288-298
    • Surface, L.E.1    Thornton, S.R.2    Boyer, L.A.3
  • 39
    • 34547624303 scopus 로고    scopus 로고
    • Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    • Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, et al. (2007) Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448: 553–560.
    • (2007) Nature , vol.448 , pp. 553-560
    • Mikkelsen, T.S.1    Ku, M.2    Jaffe, D.B.3    Issac, B.4    Lieberman, E.5
  • 40
    • 84878292464 scopus 로고    scopus 로고
    • ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection
    • Long HK, Blackledge NP, Klose RJ, (2013) ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Biochem Soc Trans 41: 727–740.
    • (2013) Biochem Soc Trans , vol.41 , pp. 727-740
    • Long, H.K.1    Blackledge, N.P.2    Klose, R.J.3
  • 41
    • 84864752375 scopus 로고    scopus 로고
    • Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells
    • Clouaire T, Webb S, Skene P, Illingworth R, Kerr A, et al. (2012) Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells. Genes Dev 26: 1714–1728.
    • (2012) Genes Dev , vol.26 , pp. 1714-1728
    • Clouaire, T.1    Webb, S.2    Skene, P.3    Illingworth, R.4    Kerr, A.5
  • 43
    • 84857190178 scopus 로고    scopus 로고
    • An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment
    • Lynch MD, Smith AJ, De Gobbi M, Flenley M, Hughes JR, et al. (2011) An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment. EMBO J 31: 317–329.
    • (2011) EMBO J , vol.31 , pp. 317-329
    • Lynch, M.D.1    Smith, A.J.2    De Gobbi, M.3    Flenley, M.4    Hughes, J.R.5
  • 44
    • 77951116072 scopus 로고    scopus 로고
    • CpG islands influence chromatin structure via the CpG-binding protein Cfp1
    • Thomson JP, Skene PJ, Selfridge J, Clouaire T, Guy J, et al. (2010) CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature 464: 1082–1086.
    • (2010) Nature , vol.464 , pp. 1082-1086
    • Thomson, J.P.1    Skene, P.J.2    Selfridge, J.3    Clouaire, T.4    Guy, J.5
  • 45
    • 70349952171 scopus 로고    scopus 로고
    • Role of the polycomb protein EED in the propagation of repressive histone marks
    • Margueron R, Justin N, Ohno K, Sharpe ML, Son J, et al. (2009) Role of the polycomb protein EED in the propagation of repressive histone marks. Nature 461: 762–767.
    • (2009) Nature , vol.461 , pp. 762-767
    • Margueron, R.1    Justin, N.2    Ohno, K.3    Sharpe, M.L.4    Son, J.5
  • 46
    • 84867073340 scopus 로고    scopus 로고
    • Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage
    • Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, et al. (2012) Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell 151: 206–220.
    • (2012) Cell , vol.151 , pp. 206-220
    • Wamstad, J.A.1    Alexander, J.M.2    Truty, R.M.3    Shrikumar, A.4    Li, F.5
  • 47
    • 55749106396 scopus 로고    scopus 로고
    • The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells
    • Garrick D, De Gobbi M, Samara V, Rugless M, Holland M, et al. (2008) The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells. Blood 112: 3889–3899.
    • (2008) Blood , vol.112 , pp. 3889-3899
    • Garrick, D.1    De Gobbi, M.2    Samara, V.3    Rugless, M.4    Holland, M.5
  • 49
    • 84879260661 scopus 로고    scopus 로고
    • A double take on bivalent promoters
    • Voigt P, Tee WW, Reinberg D, (2013) A double take on bivalent promoters. Genes Dev 27: 1318–1338.
    • (2013) Genes Dev , vol.27 , pp. 1318-1338
    • Voigt, P.1    Tee, W.W.2    Reinberg, D.3
  • 50
    • 33644934033 scopus 로고    scopus 로고
    • Recruitment of transcription complexes to the beta-globin locus control region and transcription of hypersensitive site 3 prior to erythroid differentiation of murine embryonic stem cells
    • Levings PP, Zhou Z, Vieira KF, Crusselle-Davis VJ, Bungert J, (2006) Recruitment of transcription complexes to the beta-globin locus control region and transcription of hypersensitive site 3 prior to erythroid differentiation of murine embryonic stem cells. FEBS J 273: 746–755.
    • (2006) FEBS J , vol.273 , pp. 746-755
    • Levings, P.P.1    Zhou, Z.2    Vieira, K.F.3    Crusselle-Davis, V.J.4    Bungert, J.5
  • 51
    • 14044259362 scopus 로고    scopus 로고
    • Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage
    • Szutorisz H, Canzonetta C, Georgiou A, Chow CM, Tora L, et al. (2005) Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage. Mol Cell Biol 25: 1804–1820.
    • (2005) Mol Cell Biol , vol.25 , pp. 1804-1820
    • Szutorisz, H.1    Canzonetta, C.2    Georgiou, A.3    Chow, C.M.4    Tora, L.5
  • 52
    • 0022632467 scopus 로고
    • Self-renewal and differentiation of interleukin-3-dependent multipotent stem cells are modulated by stromal cells and serum factors
    • Spooncer E, Heyworth CM, Dunn A, Dexter TM, (1986) Self-renewal and differentiation of interleukin-3-dependent multipotent stem cells are modulated by stromal cells and serum factors. Differentiation 31: 111–118.
    • (1986) Differentiation , vol.31 , pp. 111-118
    • Spooncer, E.1    Heyworth, C.M.2    Dunn, A.3    Dexter, T.M.4
  • 53
    • 0041806587 scopus 로고    scopus 로고
    • GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling
    • Grass JA, Boyer ME, Pal S, Wu J, Weiss MJ, et al. (2003) GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A 100: 8811–8816.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8811-8816
    • Grass, J.A.1    Boyer, M.E.2    Pal, S.3    Wu, J.4    Weiss, M.J.5
  • 54
    • 0023137324 scopus 로고
    • Induction of transformed cells to terminal differentiation and the modulation of gene expression
    • Marks PA, Sheffery M, Rifkind RA, (1987) Induction of transformed cells to terminal differentiation and the modulation of gene expression. Cancer Res 47: 659–666.
    • (1987) Cancer Res , vol.47 , pp. 659-666
    • Marks, P.A.1    Sheffery, M.2    Rifkind, R.A.3
  • 55
    • 0037428397 scopus 로고    scopus 로고
    • The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y
    • Romier C, Cocchiarella F, Mantovani R, Moras D, (2003) The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. J Biol Chem 278: 1336–1345.
    • (2003) J Biol Chem , vol.278 , pp. 1336-1345
    • Romier, C.1    Cocchiarella, F.2    Mantovani, R.3    Moras, D.4
  • 56
    • 56649097577 scopus 로고    scopus 로고
    • NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations
    • Gatta R, Mantovani R, (2008) NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations. Nucleic Acids Res 36: 6592–6607.
    • (2008) Nucleic Acids Res , vol.36 , pp. 6592-6607
    • Gatta, R.1    Mantovani, R.2
  • 57
    • 84901329530 scopus 로고    scopus 로고
    • Differential regulation of the alpha-globin locus by Kruppel-like factor 3 in erythroid and non-erythroid cells
    • Funnell AP, Vernimmen D, Lim WF, Mak KS, Wienert B, et al. (2014) Differential regulation of the alpha-globin locus by Kruppel-like factor 3 in erythroid and non-erythroid cells. BMC Mol Biol 15: 8.
    • (2014) BMC Mol Biol , vol.15 , pp. 8
    • Funnell, A.P.1    Vernimmen, D.2    Lim, W.F.3    Mak, K.S.4    Wienert, B.5
  • 58
    • 76049106672 scopus 로고    scopus 로고
    • Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition
    • Lower KM, Hughes JR, De Gobbi M, Henderson S, Viprakasit V, et al. (2009) Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition. Proc Natl Acad Sci U S A 106: 21771–21776.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 21771-21776
    • Lower, K.M.1    Hughes, J.R.2    De Gobbi, M.3    Henderson, S.4    Viprakasit, V.5
  • 60
    • 79961022267 scopus 로고    scopus 로고
    • Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters
    • Koch F, Fenouil R, Gut M, Cauchy P, Albert TK, et al. (2011) Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters. Nat Struct Mol Biol 18: 956–963.
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 956-963
    • Koch, F.1    Fenouil, R.2    Gut, M.3    Cauchy, P.4    Albert, T.K.5
  • 61
    • 77952367798 scopus 로고    scopus 로고
    • Widespread transcription at neuronal activity-regulated enhancers
    • Kim TK, Hemberg M, Gray JM, Costa AM, Bear DM, et al. (2010) Widespread transcription at neuronal activity-regulated enhancers. Nature 465: 182–187.
    • (2010) Nature , vol.465 , pp. 182-187
    • Kim, T.K.1    Hemberg, M.2    Gray, J.M.3    Costa, A.M.4    Bear, D.M.5
  • 62
    • 77952908743 scopus 로고    scopus 로고
    • A large fraction of extragenic RNA pol II transcription sites overlap enhancers
    • De Santa F, Barozzi I, Mietton F, Ghisletti S, Polletti S, et al. (2010) A large fraction of extragenic RNA pol II transcription sites overlap enhancers. PLoS Biol 8: e1000384.
    • (2010) PLoS Biol , vol.8 , pp. e1000384
    • De Santa, F.1    Barozzi, I.2    Mietton, F.3    Ghisletti, S.4    Polletti, S.5
  • 63
    • 33847334699 scopus 로고    scopus 로고
    • Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
    • Heintzman ND, Stuart RK, Hon G, Fu Y, Ching CW, et al. (2007) Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet 39: 311–318.
    • (2007) Nat Genet , vol.39 , pp. 311-318
    • Heintzman, N.D.1    Stuart, R.K.2    Hon, G.3    Fu, Y.4    Ching, C.W.5
  • 64
    • 0018130949 scopus 로고
    • Human alpha-globin gene expression following chromosomal dependent gene transfer into mouse erythroleukemia cells
    • Deisseroth A, Hendrick D, (1978) Human alpha-globin gene expression following chromosomal dependent gene transfer into mouse erythroleukemia cells. Cell 15: 55–63.
    • (1978) Cell , vol.15 , pp. 55-63
    • Deisseroth, A.1    Hendrick, D.2
  • 65
    • 0016680786 scopus 로고
    • Hemoglobin synthesis in somatic cell hybrids: globin gene expression in hybrids between mouse erythroleukemia and human marrow cells or fibroblasts
    • Deisseroth A, Burk R, Picciano D, Anderson WF, Nienhuis A, et al. (1975) Hemoglobin synthesis in somatic cell hybrids: globin gene expression in hybrids between mouse erythroleukemia and human marrow cells or fibroblasts. Proc Natl Acad Sci U S A 72: 1102–1106.
    • (1975) Proc Natl Acad Sci U S A , vol.72 , pp. 1102-1106
    • Deisseroth, A.1    Burk, R.2    Picciano, D.3    Anderson, W.F.4    Nienhuis, A.5
  • 66
    • 0029013420 scopus 로고
    • Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments
    • Craddock CF, Vyas P, Sharpe JA, Ayyub H, Wood WG, et al. (1995) Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments. EMBO J 14: 1718–1726.
    • (1995) EMBO J , vol.14 , pp. 1718-1726
    • Craddock, C.F.1    Vyas, P.2    Sharpe, J.A.3    Ayyub, H.4    Wood, W.G.5
  • 67
    • 0041689973 scopus 로고    scopus 로고
    • Highly restricted localization of RNA polymerase II within a locus control region of a tissue-specific chromatin domain
    • Johnson KD, Grass JA, Park C, Im H, Choi K, et al. (2003) Highly restricted localization of RNA polymerase II within a locus control region of a tissue-specific chromatin domain. Mol Cell Biol 23: 6484–6493.
    • (2003) Mol Cell Biol , vol.23 , pp. 6484-6493
    • Johnson, K.D.1    Grass, J.A.2    Park, C.3    Im, H.4    Choi, K.5
  • 68
    • 84861402632 scopus 로고    scopus 로고
    • An RNA-independent linkage of noncoding transcription to long-range enhancer function
    • Yoo EJ, Cooke NE, Liebhaber SA, (2012) An RNA-independent linkage of noncoding transcription to long-range enhancer function. Mol Cell Biol 32: 2020–2029.
    • (2012) Mol Cell Biol , vol.32 , pp. 2020-2029
    • Yoo, E.J.1    Cooke, N.E.2    Liebhaber, S.A.3
  • 69
    • 33846011896 scopus 로고    scopus 로고
    • Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence
    • Wallace HA, Marques-Kranc F, Richardson M, Luna-Crespo F, Sharpe JA, et al. (2007) Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell 128: 197–209.
    • (2007) Cell , vol.128 , pp. 197-209
    • Wallace, H.A.1    Marques-Kranc, F.2    Richardson, M.3    Luna-Crespo, F.4    Sharpe, J.A.5
  • 71
    • 76049125820 scopus 로고    scopus 로고
    • Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40)
    • Vernimmen D, Marques-Kranc F, Sharpe JA, Sloane-Stanley JA, Wood WG, et al. (2009) Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40). Blood 114: 4253–4260.
    • (2009) Blood , vol.114 , pp. 4253-4260
    • Vernimmen, D.1    Marques-Kranc, F.2    Sharpe, J.A.3    Sloane-Stanley, J.A.4    Wood, W.G.5
  • 72
    • 39049120185 scopus 로고    scopus 로고
    • Tissue-specific histone modification and transcription factor binding in alpha globin gene expression
    • De Gobbi M, Anguita E, Hughes J, Sloane-Stanley JA, Sharpe JA, et al. (2007) Tissue-specific histone modification and transcription factor binding in alpha globin gene expression. Blood 110: 4503–4510.
    • (2007) Blood , vol.110 , pp. 4503-4510
    • De Gobbi, M.1    Anguita, E.2    Hughes, J.3    Sloane-Stanley, J.A.4    Sharpe, J.A.5
  • 74
    • 0037447160 scopus 로고    scopus 로고
    • The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation
    • Sawado T, Halow J, Bender MA, Groudine M, (2003) The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation. Genes Dev 17: 1009–1018.
    • (2003) Genes Dev , vol.17 , pp. 1009-1018
    • Sawado, T.1    Halow, J.2    Bender, M.A.3    Groudine, M.4
  • 75
    • 77957694828 scopus 로고    scopus 로고
    • Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation
    • Song SH, Kim A, Ragoczy T, Bender MA, Groudine M, et al. (2010) Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation. Blood 116: 2356–2364.
    • (2010) Blood , vol.116 , pp. 2356-2364
    • Song, S.H.1    Kim, A.2    Ragoczy, T.3    Bender, M.A.4    Groudine, M.5
  • 76
    • 84905593782 scopus 로고    scopus 로고
    • Enhancer loops appear stable during development and are associated with paused polymerase
    • Ghavi-Helm Y, Klein FA, Pakozdi T, Ciglar L, Noordermeer D, et al. (2014) Enhancer loops appear stable during development and are associated with paused polymerase. Nature 512: 96–100.
    • (2014) Nature , vol.512 , pp. 96-100
    • Ghavi-Helm, Y.1    Klein, F.A.2    Pakozdi, T.3    Ciglar, L.4    Noordermeer, D.5
  • 77
    • 84860323219 scopus 로고    scopus 로고
    • The hypersensitive sites of the murine beta-globin locus control region act independently to affect nuclear localization and transcriptional elongation
    • Bender MA, Ragoczy T, Lee J, Byron R, Telling A, et al. (2012) The hypersensitive sites of the murine beta-globin locus control region act independently to affect nuclear localization and transcriptional elongation. Blood 119: 3820–3827.
    • (2012) Blood , vol.119 , pp. 3820-3827
    • Bender, M.A.1    Ragoczy, T.2    Lee, J.3    Byron, R.4    Telling, A.5
  • 78
    • 84857051019 scopus 로고    scopus 로고
    • Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development
    • Stadhouders R, Thongjuea S, Andrieu-Soler C, Palstra RJ, Bryne JC, et al. (2012) Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development. EMBO J 31: 986–999.
    • (2012) EMBO J , vol.31 , pp. 986-999
    • Stadhouders, R.1    Thongjuea, S.2    Andrieu-Soler, C.3    Palstra, R.J.4    Bryne, J.C.5
  • 79
    • 84876222028 scopus 로고    scopus 로고
    • Selective inhibition of tumor oncogenes by disruption of super-enhancers
    • Loven J, Hoke HA, Lin CY, Lau A, Orlando DA, et al. (2013) Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell 153: 320–334.
    • (2013) Cell , vol.153 , pp. 320-334
    • Loven, J.1    Hoke, H.A.2    Lin, C.Y.3    Lau, A.4    Orlando, D.A.5
  • 80
    • 80051564877 scopus 로고    scopus 로고
    • Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions
    • Zentner GE, Tesar PJ, Scacheri PC, (2011) Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions. Genome Res 21: 1273–1283.
    • (2011) Genome Res , vol.21 , pp. 1273-1283
    • Zentner, G.E.1    Tesar, P.J.2    Scacheri, P.C.3
  • 81
    • 33746423865 scopus 로고    scopus 로고
    • Locus control region transcription plays an active role in long-range gene activation
    • Ho Y, Elefant F, Liebhaber SA, Cooke NE, (2006) Locus control region transcription plays an active role in long-range gene activation. Mol Cell 23: 365–375.
    • (2006) Mol Cell , vol.23 , pp. 365-375
    • Ho, Y.1    Elefant, F.2    Liebhaber, S.A.3    Cooke, N.E.4
  • 82
    • 0036187459 scopus 로고    scopus 로고
    • A defined locus control region determinant links chromatin domain acetylation with long-range gene activation
    • Ho Y, Elefant F, Cooke N, Liebhaber S, (2002) A defined locus control region determinant links chromatin domain acetylation with long-range gene activation. Mol Cell 9: 291–302.
    • (2002) Mol Cell , vol.9 , pp. 291-302
    • Ho, Y.1    Elefant, F.2    Cooke, N.3    Liebhaber, S.4
  • 83
    • 34547195831 scopus 로고    scopus 로고
    • The locus control region activates serpin gene expression through recruitment of liver-specific transcription factors and RNA polymerase II
    • Zhao H, Friedman RD, Fournier RE, (2007) The locus control region activates serpin gene expression through recruitment of liver-specific transcription factors and RNA polymerase II. Mol Cell Biol 27: 5286–5295.
    • (2007) Mol Cell Biol , vol.27 , pp. 5286-5295
    • Zhao, H.1    Friedman, R.D.2    Fournier, R.E.3
  • 84
    • 0036924095 scopus 로고    scopus 로고
    • Promoter activation by enhancer-dependent and -independent loading of activator and coactivator complexes
    • Spicuglia S, Kumar S, Yeh JH, Vachez E, Chasson L, et al. (2002) Promoter activation by enhancer-dependent and -independent loading of activator and coactivator complexes. Mol Cell 10: 1479–1487.
    • (2002) Mol Cell , vol.10 , pp. 1479-1487
    • Spicuglia, S.1    Kumar, S.2    Yeh, J.H.3    Vachez, E.4    Chasson, L.5
  • 85
    • 0033602445 scopus 로고    scopus 로고
    • Effects of altered gene order or orientation of the locus control region on human beta-globin gene expression in mice
    • Tanimoto K, Liu Q, Bungert J, Engel JD, (1999) Effects of altered gene order or orientation of the locus control region on human beta-globin gene expression in mice. Nature 398: 344–348.
    • (1999) Nature , vol.398 , pp. 344-348
    • Tanimoto, K.1    Liu, Q.2    Bungert, J.3    Engel, J.D.4
  • 86
    • 0032479079 scopus 로고    scopus 로고
    • Going the distance: a current view of enhancer action
    • Blackwood EM, Kadonaga JT, (1998) Going the distance: a current view of enhancer action. Science 281: 60–63.
    • (1998) Science , vol.281 , pp. 60-63
    • Blackwood, E.M.1    Kadonaga, J.T.2
  • 87
    • 34548708489 scopus 로고    scopus 로고
    • A facilitated tracking and transcription mechanism of long-range enhancer function
    • Zhu X, Ling J, Zhang L, Pi W, Wu M, et al. (2007) A facilitated tracking and transcription mechanism of long-range enhancer function. Nucleic Acids Res 35: 5532–5544.
    • (2007) Nucleic Acids Res , vol.35 , pp. 5532-5544
    • Zhu, X.1    Ling, J.2    Zhang, L.3    Pi, W.4    Wu, M.5
  • 88
    • 0036923739 scopus 로고    scopus 로고
    • Dynamics of enhancer-promoter communication during differentiation-induced gene activation
    • Hatzis P, Talianidis I, (2002) Dynamics of enhancer-promoter communication during differentiation-induced gene activation. Mol Cell 10: 1467–1477.
    • (2002) Mol Cell , vol.10 , pp. 1467-1477
    • Hatzis, P.1    Talianidis, I.2
  • 89
    • 24044540381 scopus 로고    scopus 로고
    • Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking
    • Wang Q, Carroll JS, Brown M, (2005) Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Mol Cell 19: 631–642.
    • (2005) Mol Cell , vol.19 , pp. 631-642
    • Wang, Q.1    Carroll, J.S.2    Brown, M.3
  • 90
    • 80052942443 scopus 로고    scopus 로고
    • Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
    • Tan M, Luo H, Lee S, Jin F, Yang JS, et al. (2011) Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 146: 1016–1028.
    • (2011) Cell , vol.146 , pp. 1016-1028
    • Tan, M.1    Luo, H.2    Lee, S.3    Jin, F.4    Yang, J.S.5
  • 91
    • 27544466462 scopus 로고    scopus 로고
    • The role of enhancers as centres for general transcription factor recruitment
    • Szutorisz H, Dillon N, Tora L, (2005) The role of enhancers as centres for general transcription factor recruitment. Trends Biochem Sci 30: 593–599.
    • (2005) Trends Biochem Sci , vol.30 , pp. 593-599
    • Szutorisz, H.1    Dillon, N.2    Tora, L.3
  • 92
    • 78650731391 scopus 로고    scopus 로고
    • Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1
    • Stumpf M, Yue X, Schmitz S, Luche H, Reddy JK, et al. (2010) Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1. Proc Natl Acad Sci U S A 107: 21541–21546.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 21541-21546
    • Stumpf, M.1    Yue, X.2    Schmitz, S.3    Luche, H.4    Reddy, J.K.5
  • 93
    • 0024509622 scopus 로고
    • A review of the molecular genetics of the human alpha-globin gene cluster
    • Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, et al. (1989) A review of the molecular genetics of the human alpha-globin gene cluster. Blood 73: 1081–1104.
    • (1989) Blood , vol.73 , pp. 1081-1104
    • Higgs, D.R.1    Vickers, M.A.2    Wilkie, A.O.3    Pretorius, I.M.4    Jarman, A.P.5
  • 94
    • 0028349217 scopus 로고
    • Expression gradient in sheep alpha alpha and alpha alpha alpha globin gene haplotypes: mRNA levels
    • Vestri R, Pieragostini E, Ristaldi MS, (1994) Expression gradient in sheep alpha alpha and alpha alpha alpha globin gene haplotypes: mRNA levels. Blood 83: 2317–2322.
    • (1994) Blood , vol.83 , pp. 2317-2322
    • Vestri, R.1    Pieragostini, E.2    Ristaldi, M.S.3
  • 96
    • 9644302474 scopus 로고    scopus 로고
    • Recruitment of transcription complexes to the beta-globin gene locus in vivo and in vitro
    • Vieira KF, Levings PP, Hill MA, Crusselle VJ, Kang SH, et al. (2004) Recruitment of transcription complexes to the beta-globin gene locus in vivo and in vitro. J Biol Chem 279: 50350–50357.
    • (2004) J Biol Chem , vol.279 , pp. 50350-50357
    • Vieira, K.F.1    Levings, P.P.2    Hill, M.A.3    Crusselle, V.J.4    Kang, S.H.5
  • 98
    • 67649766870 scopus 로고    scopus 로고
    • Transcription factories: gene expression in unions
    • Sutherland H, Bickmore WA, (2009) Transcription factories: gene expression in unions? Nat Rev Genet 10: 457–466.
    • (2009) Nat Rev Genet , vol.10 , pp. 457-466
    • Sutherland, H.1    Bickmore, W.A.2
  • 99
    • 84876216563 scopus 로고    scopus 로고
    • Master transcription factors and mediator establish super-enhancers at key cell identity genes
    • Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, et al. (2013) Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 153: 307–319.
    • (2013) Cell , vol.153 , pp. 307-319
    • Whyte, W.A.1    Orlando, D.A.2    Hnisz, D.3    Abraham, B.J.4    Lin, C.Y.5
  • 100
    • 84893928513 scopus 로고    scopus 로고
    • Transcription in the context of the 3D nucleus
    • Wendt KS, Grosveld FG, (2014) Transcription in the context of the 3D nucleus. Curr Opin Genet Dev 25: 62–67.
    • (2014) Curr Opin Genet Dev , vol.25 , pp. 62-67
    • Wendt, K.S.1    Grosveld, F.G.2
  • 101
    • 67349255210 scopus 로고    scopus 로고
    • CpG islands–‘a rough guide’
    • Illingworth RS, Bird AP, (2009) CpG islands–‘a rough guide’. FEBS Lett 583: 1713–1720.
    • (2009) FEBS Lett , vol.583 , pp. 1713-1720
    • Illingworth, R.S.1    Bird, A.P.2
  • 102
    • 77952415942 scopus 로고    scopus 로고
    • Memories of lost enhancers
    • Sen R, Grosschedl R, (2010) Memories of lost enhancers. Genes Dev 24: 973–979.
    • (2010) Genes Dev , vol.24 , pp. 973-979
    • Sen, R.1    Grosschedl, R.2
  • 103
    • 84862622207 scopus 로고    scopus 로고
    • The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation
    • Chen S, Ma J, Wu F, Xiong LJ, Ma H, et al. (2012) The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation. Genes Dev 26: 1364–1375.
    • (2012) Genes Dev , vol.26 , pp. 1364-1375
    • Chen, S.1    Ma, J.2    Wu, F.3    Xiong, L.J.4    Ma, H.5
  • 104
    • 84900414095 scopus 로고    scopus 로고
    • The Histone Lysine Demethylase JMJD3/KDM6B Is Recruited to p53 Bound Promoters and Enhancer Elements in a p53 Dependent Manner
    • Williams K, Christensen J, Rappsilber J, Nielsen AL, Johansen JV, et al. (2014) The Histone Lysine Demethylase JMJD3/KDM6B Is Recruited to p53 Bound Promoters and Enhancer Elements in a p53 Dependent Manner. PLoS ONE 9: e96545.
    • (2014) PLoS ONE , vol.9 , pp. e96545
    • Williams, K.1    Christensen, J.2    Rappsilber, J.3    Nielsen, A.L.4    Johansen, J.V.5
  • 105
    • 83255188897 scopus 로고    scopus 로고
    • Polycomb-repressed genes have permissive enhancers that initiate reprogramming
    • Taberlay PC, Kelly TK, Liu CC, You JS, De Carvalho DD, et al. (2011) Polycomb-repressed genes have permissive enhancers that initiate reprogramming. Cell 147: 1283–1294.
    • (2011) Cell , vol.147 , pp. 1283-1294
    • Taberlay, P.C.1    Kelly, T.K.2    Liu, C.C.3    You, J.S.4    De Carvalho, D.D.5
  • 106
    • 84892392571 scopus 로고    scopus 로고
    • Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer
    • Kondo T, Isono K, Kondo K, Endo TA, Itohara S, et al. (2014) Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer. Dev Cell 28: 94–101.
    • (2014) Dev Cell , vol.28 , pp. 94-101
    • Kondo, T.1    Isono, K.2    Kondo, K.3    Endo, T.A.4    Itohara, S.5
  • 107
    • 77951428293 scopus 로고    scopus 로고
    • UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis
    • Seenundun S, Rampalli S, Liu QC, Aziz A, Palii C, et al. (2010) UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis. EMBO J 29: 1401–1411.
    • (2010) EMBO J , vol.29 , pp. 1401-1411
    • Seenundun, S.1    Rampalli, S.2    Liu, Q.C.3    Aziz, A.4    Palii, C.5
  • 108
    • 84872522528 scopus 로고    scopus 로고
    • Latent enhancers activated by stimulation in differentiated cells
    • Ostuni R, Piccolo V, Barozzi I, Polletti S, Termanini A, et al. (2013) Latent enhancers activated by stimulation in differentiated cells. Cell 152: 157–171.
    • (2013) Cell , vol.152 , pp. 157-171
    • Ostuni, R.1    Piccolo, V.2    Barozzi, I.3    Polletti, S.4    Termanini, A.5
  • 109
    • 84863869789 scopus 로고    scopus 로고
    • Human limb abnormalities caused by disruption of hedgehog signaling
    • Anderson E, Peluso S, Lettice LA, Hill RE, (2012) Human limb abnormalities caused by disruption of hedgehog signaling. Trends Genet 28: 364–373.
    • (2012) Trends Genet , vol.28 , pp. 364-373
    • Anderson, E.1    Peluso, S.2    Lettice, L.A.3    Hill, R.E.4
  • 110
    • 77957203411 scopus 로고    scopus 로고
    • Homozygous deletion of the major alpha-globin regulatory element (MCS-R2) responsible for a severe case of hemoglobin H disease
    • Sollaino MC, Paglietti ME, Loi D, Congiu R, Podda R, et al. (2010) Homozygous deletion of the major alpha-globin regulatory element (MCS-R2) responsible for a severe case of hemoglobin H disease. Blood 116: 2193–2194.
    • (2010) Blood , vol.116 , pp. 2193-2194
    • Sollaino, M.C.1    Paglietti, M.E.2    Loi, D.3    Congiu, R.4    Podda, R.5
  • 111
    • 77955267950 scopus 로고    scopus 로고
    • Novel large deletions in the human alpha-globin gene cluster: Clarifying the HS-40 long-range regulatory role in the native chromosome environment
    • Coelho A, Picanco I, Seuanes F, Seixas MT, Faustino P, (2010) Novel large deletions in the human alpha-globin gene cluster: Clarifying the HS-40 long-range regulatory role in the native chromosome environment. Blood Cells Mol Dis 45: 147–153.
    • (2010) Blood Cells Mol Dis , vol.45 , pp. 147-153
    • Coelho, A.1    Picanco, I.2    Seuanes, F.3    Seixas, M.T.4    Faustino, P.5
  • 113
    • 84880506815 scopus 로고    scopus 로고
    • Analysis of sequence variation underlying tissue-specific transcription factor binding and gene expression
    • Lower KM, De Gobbi M, Hughes JR, Derry CJ, Ayyub H, et al. (2013) Analysis of sequence variation underlying tissue-specific transcription factor binding and gene expression. Hum Mutat 34: 1140–1148.
    • (2013) Hum Mutat , vol.34 , pp. 1140-1148
    • Lower, K.M.1    De Gobbi, M.2    Hughes, J.R.3    Derry, C.J.4    Ayyub, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.