The role of the polycomb complex in silencing ά-globin gene expression in nonerythroid cells

Blood

Volumn 112, Issue 9, 2008, Pages 3889-3899

  Garrick, David ^a   De Gobbi, Marco ^a   Samara, Vasiliki ^a   Rugless, Michelle ^a   Holland, Michelle ^a   Ayyub, Helena ^a   Lower, Karen ^a   Sloane Stanley, Jackie ^a   Gray, Nicki ^a   Koch, Christoph ^b   Dunham, Ian ^b   Higgs, Douglas R ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; HISTONE DEACETYLASE; POLYCOMB GROUP PROTEIN; SMALL INTERFERING RNA; DNA BINDING PROTEIN; EZH2 PROTEIN, HUMAN; GLOBIN; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CELL DIFFERENTIATION; CHROMATIN; CPG ISLAND; ERYTHROID CELL; GENE CONTROL; GENE EXPRESSION; GENE SILENCING; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; CELL CULTURE; CELL LINE; DRUG ANTAGONISM; EMBRYONIC STEM CELL; GENETICS; HELA CELL; METABOLISM; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; RNA INTERFERENCE;

BASE SEQUENCE; CELL LINE; CELLS, CULTURED; DNA-BINDING PROTEINS; EMBRYONIC STEM CELLS; GENE SILENCING; GLOBINS; HELA CELLS; HISTONE DEACETYLASES; HUMANS; PLURIPOTENT STEM CELLS; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS;

EID: 55749106396     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-06-161901     Document Type: Article

References (33)

1. Higgs DR, Vernimmen D, De Gobbi M, et al. How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation. Biochem Soc Symp. 2006;(73):11-22.
2. Flint J, Thomas K, Micklem G, et al. The relationship between chromosome structure and function at a human telomeric region. Nat Genet. 1997;15:252-257.
3. Smith ZE, Higgs DR. The pattern of replication at a human telomeric region (16p13.3): its relationship to chromosome structure and gene expression. Hum Mol Genet. 1999;8:1373-1386.
4. Anguita E, Johnson CA, Wood WG, Turner BM, Higgs DR. Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster. Proc Natl Acad Sci U S A. 2001;98:12114-12119.
5. Brown KE, Amoils S, Horn JM, et al. Expression of alpha- and beta-globin genes occurs within different nuclear domains in haemopoietic cells. Nat Cell Biol. 2001;3:602-606.
6. Higgs DR, Sharpe JA, Wood WG. Understanding alpha globin gene expression: a step towards effective gene therapy. Semin Hematol. 1998;35:93-104.
7. van der Ploeg LH, Flavell RA. DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues. Cell. 1980;19:947-958.
8. Ruefli AA, Ausserlechner MJ, Bernhard D, et al. The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proc Natl Acad Sci U S A. 2001;98:10833-10838.
9. Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. EZH2 is downstream of the pRBE2F pathway, essential for proliferation and amplified in cancer. EMBO J. 2003;22:5323-5335.
10. Garrick D, Samara V, McDowell TL, et al. A conserved truncated isoform of the ATR-X syndrome protein lacking the SWI/SNF-homology domain. Gene. 2004;326:23-34.
11. De Gobbi M, Viprakasit V, Hughes JR, et al. A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. Science. 2006;312:1215-1217.
12. Jenuwein T, Allis CD. Translating the histone code. Science. 2001;293:1074-1080.
13. De Gobbi M, Anguita E, Hughes J, et al. Tissuespecific histone modification and transcription factor binding in alpha globin gene expression. Blood. 2007;110:4503-4510.
14. Peters AH, Kubicek S, Mechtler K, et al. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell. 2003;12:1577-1589.
15. Rice JC, Briggs SD, Ueberheide B, et al. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell. 2003;12:1591-1598.
16. Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. Embo J. 2004;23:4061-4071.
17. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 2002;16:2893-2905.
18. Min J, Zhang Y, Xu RM. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev. 2003;17:1823-1828.
19. Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer. 2006;6:846-856.
20. Vire' E, Brenner C, Deplus R, et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature. 2006;439:871-874.
21. van der Vlag J, Otte AP. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat Genet. 1999;23:474-478.
22. Barbour VM, Tufarelli C, Sharpe JA, et al. alphathalassemia resulting from a negative chromosomal position effect. Blood. 2000;96:800-807.
23. Yagi M, Gelinas R, Elder JT, et al. Chromatin structure and developmental expression of the human alpha-globin cluster. Mol Cell Biol. 1986;6:1108-1116.
24. Lee TI, Jenner RG, Boyer LA, et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 2006;125:301-313.
25. Boyer LA, Plath K, Zeitlinger J, et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature. 2006;441:349-353.
26. Caretti G, Di Padova M, Micales B, Lyons GE, Sartorelli V. The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev. 2004;18:2627-2638.
27. Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 2006;20:1123-1136.
28. Chen X, Hiller M, Sancak Y, Fuller MT. Tissuespecific TAFs counteract Polycomb to turn on terminal differentiation. Science. 2005;310:869-872.
29. Chen H, Tu SW, Hsieh JT. Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer. J Biol Chem. 2005;280:22437-22444.
30. Mimori K, Ogawa K, Okamoto M, Sudo T, Inoue H, Mori M. Clinical significance of enhancer of zeste homolog 2 expression in colorectal cancer cases. Eur J Surg Oncol. 2005;31:376-380.
31. Hughes JR, Cheng JF, Ventress N, et al. Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences. Proc Natl Acad Sci U S A. 2005;102:9830-9835.
32. Roh TY, Cuddapah S, Cui K, Zhao K. The genomic landscape of histone modifications in human T cells. Proc Natl Acad Sci U S A. 2006;103:15782-15787.
33. Tanay A, O'Donnell AH, Damelin M, Bestor TH. Hyperconserved CpG domains underlie Polycomb-binding sites. Proc Natl Acad Sci U S A. 2007;104:5521-5526.