Tissue-specific histone modification and transcription factor binding in α globin gene expression

Blood

Volumn 110, Issue 13, 2007, Pages 4503-4510

  De Gobbi, Marco ^a   Anguita, Eduardo ^a   Hughes, Jim ^a   Sloane Stanley, Jacqueline A ^a   Sharpe, Jacqueline A ^a   Koch, Christoph M ^b   Dunham, Ian ^b   Gibbons, Richard J ^a   Wood, William G ^a   Higgs, Douglas R ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; TRANSCRIPTION FACTOR; GLOBIN; HISTONE;

ACETYLATION; ARTICLE; CELL STRAIN K 562; CONTROLLED STUDY; ERYTHROPOIESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN METHYLATION; PROTEIN MODIFICATION; REGULATORY SEQUENCE; TISSUE SPECIFICITY; ANIMAL; CELL CULTURE; CHROMOSOME 16; CYTOLOGY; ENHANCER REGION; ERYTHROBLAST; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; METABOLISM; METHYLATION; MOUSE; T LYMPHOCYTE; TELOMERE;

ACETYLATION; ANIMALS; CELLS, CULTURED; CHROMOSOMES, HUMAN, PAIR 16; ENHANCER ELEMENTS (GENETICS); ERYTHROBLASTS; GENE EXPRESSION REGULATION; GLOBINS; HISTONES; HUMANS; K562 CELLS; METHYLATION; MICE; PROMOTER REGIONS (GENETICS); T-LYMPHOCYTES; TELOMERE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 39049120185     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-06-097964     Document Type: Article

References (36)

1. Flint J, Tufarelli C, Peden J, et al. Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster. Hum Mol Genet. 2001;10:371-382.
2. Hughes JR, Cheng JF, Ventress N, et al. Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences. Proc Natl Acad Sci U S A. 2005;102:9830-9835.
3. Anguita E, Johnson CA, Wood WG, Turner BM, Higgs DR. Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster. Proc Natl Acad Sci U S A. 2001;98:12114-12119.
4. Anguita E, Hughes J, Heyworth C, Blobel GA, Wood WG, Higgs DR. Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J. 2004;23:2841-2852.
5. Higgs DR, Wood WG, Jarman AP, et al. A major positive regulatory region located far upstream of the human alpha-globin gene locus. Genes Dev. 1990;4:1588-1601.
6. Sharpe JA, Chan-Thomas PS, Lida J, Ayyub H, Wood WG, Higgs DR. Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic mice. EMBO J. 1992;11:4565-4572.
7. Vyas P, Sharpe JA, Watt P, Higgs DR, Wood WG. Regulation of human embryonic globin genes zeta 2 and epsilon in stably transformed mouse erythroleukemia cells. Blood. 1992;80:1832-1837.
8. Sharpe JA, Wells DJ, Whitelaw E, Vyas P, Higgs DR, Wood WG. Analysis of the human alpha-globin gene cluster in transgenic mice. Proc Natl Acad Sci U S A. 1993;90:11262-11266.
9. Higgs DR, Sharpe JA, Wood WG. Understanding alpha globin gene expression: a step towards effective gene therapy. Semin Hematol. 1998;35:93-104.
10. Wallace HA, Marques-Kranc F, Richardson M, et al. Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell. 2007;128:197-209.
11. Pope SH, Fibach E, Sun J, Chin K, Rodgers GP. Two-phase liquid culture system models normal human adult erythropoiesis at the molecular level. Eur J Haematol. 2000;64:292-303.
12. Brown JM, Leach J, Reittie JE, et al. Coregulated human globin genes are frequently in spatial proximity when active. J Cell Biol. 2006;172:177-187.
13. Porcher C, Liao EC, Fujiwara Y, Zon LI, Orkin SH. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development. 1999;126:4603-4615.
14. Visvader JE, Mao X, Fujiwara Y, Hahm K, Orkin SH. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A. 1997;94:13707-13712.
15. Follows GA, Dhami P, Gottgens B, et al. Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites. Genome Res. 2006;16:1310-1319.
16. Wadman IS, Osada H, Grutz GG, et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which include TAL1, E47, GATA-1, and Ldb1/NL1 proteins. EMBO J. 1997;16:3145-3157.
17. Lahlil R, Lecuyer E, Herblot S, Hoang T. SCL assembles a multifactorial complex that determines glycophorin A expression. Mol Cell Biol. 2004;24:1439-1452.
18. Rodriguez P, Bonte E, Krijgsveld J, et al. GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO J. 2005;24:2354-2366.
19. Heintzman ND, Stuart RK, Hon G, et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet. 2007;39:311-318.
20. Boyer LA, Lee TI, Cole MF, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122:947-956.
21. Loh YH, Wu Q, Chew JL, et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet. 2006;38:431-440.
22. Odom DT, Dowell RD, Jacobsen ES, et al. Tissue-specific transcriptional regulation has diverged significantly between human and mouse. Nat Genet. 2007;39:730-732.
23. Anguita E, Sharpe JA, Sloane-Stanley JA, Tufarelli C, Higgs DR, Wood WG. Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype. Blood. 2002;100:3450-3456.
24. Viprakasit V, Harteveld CL, Ayyub H, et al. A novel deletion causing alpha thalassemia clarifies the importance of the major human alpha globin regulatory element. Blood. 2006;107:3811-3812.
25. Johnson KD, Christensen HM, Zhao B, Bresnick EH. Distinct mechanisms control RNA polymerase II recruitment to a tissue-specific locus control region and a downstream promoter. Mol Cell. 2001;8:465-471.
26. Johnson KD, Grass JA, Boyer ME, et al. Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain. Proc Natl Acad Sci U S A. 2002;99:11760-11765.
27. Vernimmen D, De Gobbi M, Sloane-Stanley JA, Wood WG, Higgs DR. Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression. EMBO J. 2007;26:2041-2051.
28. Xiao B, Jing C, Wilson JR, et al. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature. 2003;421:652-656.
29. Guo HB, Guo H. Mechanism of histone methylation catalyzed by protein lysine methyltransferase SET7/9 and origin of product specificity. Proc Natl Acad Sci U S A. 2007;104:8797-8802.
30. Briggs SD, Bryk M, Strahl BD, et al. Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev. 2001;15:3286-3295.
31. Nagy PL, Griesenbeck J, Kornberg RD, Cleary ML. A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A. 2002;99:90-94.
32. Lee JH, Tate CM, You JS, Skalnik DG. Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. J Biol Chem. 2007;282:13419-13429.
33. Martin C, Zhang Y. The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol. 2005;6:838-849.
34. Berger SL. The complex language of chromatin regulation during transcription. Nature. 2007;447:407-412.
35. Ng HH, Robert F, Young RA, Struhl K. Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell. 2003;11:709-719.
36. Guenther MG, Jenner RG, Chevalier B, et al. Global and Hox-specific roles for the MLL1 methyltransferase. Proc Natl Acad Sci U S A. 2005;102:8603-8608.