A flavonoid isolated from Streptomyces sp. (ERINLG-4) induces apoptosis in human lung cancer A549 cells through p53 and cytochrome c release caspase dependant pathway

Chemico-Biological Interactions

Volumn 224, Issue , 2014, Pages 24-35

  Balachandran, C ^a   Sangeetha, B ^b   Duraipandiyan, V ^a,c   Raj, M Karunai ^d   Ignacimuthu, S ^a   Al Dhabi, N A ^c   Balakrishna, K ^a   Parthasarathy, K ^d   Arulmozhi, N M ^d   Arasu, M Valan ^c  

^a LOYOLA COLLEGE   (India)

^b Advinus Therapeutics Private Limited Bangalore   (India)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d Orchid Chemicals and Pharmaceuticals Ltd   (India)

Author keywords

Caspases; Cytochrome c; Molecular docking; p53; Streptomyces sp.

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; FLAVONOID; PROTEIN BCL 2; PROTEIN P53; QUERCETIN 3 O BETA RHAMNOPYRANOSYL (1-6) BETA GLUCOPYRANOSIDE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CASPASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BACTERIAL STRAIN; CANCER CELL; CELL PROLIFERATION; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME RELEASE; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; LUNG CANCER; MITOCHONDRION; MOLECULAR DOCKING; NUCLEOTIDE SEQUENCE; PROTEIN CLEAVAGE; SOIL MICROFLORA; STREPTOMYCES; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; ISOLATION AND PURIFICATION; LUNG TUMOR; METABOLISM; PATHOLOGY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; VERO CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVONOIDS; HUMANS; LUNG NEOPLASMS; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53; VERO CELLS;

EID: 84908282521     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.09.019     Document Type: Article

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