Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells

Food and Chemical Toxicology

Volumn 48, Issue 3, 2010, Pages 883-890

  Choi, Hee Sook ^a   Cho, Min Chul ^a   Lee, Hee Gu ^b   Yoon, Do Young ^a  

^a Konkuk University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

A549; Apoptosis; Cell cycle arrest; Indole 3 carbinol; Lung cancer

Indexed keywords

3 INDOLEMETHANOL; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN D1; DNA FRAGMENT; FAS ANTIGEN; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHOPROTEIN; PROTEIN P21; PROTEIN P53; SERINE; WORTMANNIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG CANCER; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANTICARCINOGENIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 8; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; DNA REPAIR; ENZYME ACTIVATION; FAS LIGAND PROTEIN; FLOW CYTOMETRY; GENES, P53; HUMANS; INDICATORS AND REAGENTS; INDOLES; LUNG NEOPLASMS; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 76749161020     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.12.028     Document Type: Article

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