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Volumn 15, Issue 7, 2014, Pages 433-439

Emerging role of epigenetics in systemic sclerosis pathogenesis

Author keywords

[No Author keywords available]

Indexed keywords

BELINOSTAT; ENTINOSTAT; LONG UNTRANSLATED RNA; MICRORNA; PANOBINOSTAT; PIVALOYLOXYMETHYL BUTYRATE; ROMIDEPSIN; TRICHOSTATIN A; VALPROIC ACID; VORINOSTAT;

EID: 84908235099     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2014.44     Document Type: Review
Times cited : (25)

References (66)
  • 1
    • 33847348491 scopus 로고    scopus 로고
    • Systemic sclerosis: A prototypic multisystem fibrotic disorder
    • Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest 2007; 117: 557-567.
    • (2007) J Clin Invest , vol.117 , pp. 557-567
    • Varga, J.1    Abraham, D.2
  • 3
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • Friedman RC, Farh KK-H, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19: 92-105.
    • (2009) Genome Res , vol.19 , pp. 92-105
    • Friedman, R.C.1    Kk-H, F.2    Burge, C.B.3    Bartel, D.P.4
  • 4
    • 0027751663 scopus 로고
    • The C elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75: 843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 6
    • 33744520104 scopus 로고    scopus 로고
    • Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex
    • Han J, Lee Y, Yeom K-H, Nam J-W, Heo I, Rhee J-K et al. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 2006; 125: 887-901.
    • (2006) Cell , vol.125 , pp. 887-901
    • Han, J.1    Lee, Y.2    Yeom, K.-H.3    Nam, J.-W.4    Heo, I.5    Rhee, J.-K.6
  • 7
    • 60149088848 scopus 로고    scopus 로고
    • Origins and mechanisms of miRNAs and siRNAs
    • Carthew RW, Sontheimer EJ. Origins and mechanisms of miRNAs and siRNAs. Cell 2009; 136: 642-655.
    • (2009) Cell , vol.136 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 13
    • 69249202575 scopus 로고    scopus 로고
    • Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: Implication in epithelial-mesenchymal interactions
    • Pottier N, Maurin T, Chevalier B, Puisségur M-P, Lebrigand K, Robbe-Sermesant K et al. Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenchymal interactions. PLoS One 2009; 4: e6718.
    • (2009) PLoS One , vol.4 , pp. e6718
    • Pottier, N.1    Maurin, T.2    Chevalier, B.3    Puisségur, M.-P.4    Lebrigand, K.5    Robbe-Sermesant, K.6
  • 15
    • 84872866349 scopus 로고    scopus 로고
    • The miR-146a rs2910164 C/G polymorphism is associated with telangiectasia in systemic sclerosis
    • Sakoguchi A, Jinnin M, Makino T, Kajihara I, Makino K, Honda N et al. The miR-146a rs2910164 C/G polymorphism is associated with telangiectasia in systemic sclerosis. Clin Exp Dermatol 2013; 38: 99-100.
    • (2013) Clin Exp Dermatol , vol.38 , pp. 99-100
    • Sakoguchi, A.1    Jinnin, M.2    Makino, T.3    Kajihara, I.4    Makino, K.5    Honda, N.6
  • 16
    • 84865322922 scopus 로고    scopus 로고
    • MicroRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma
    • Sing T, Jinnin M, Yamane K, Honda N, Makino K, Kajihara I et al. microRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma. Rheumatology (Oxford) 2012; 51: 1550-1556.
    • (2012) Rheumatology (Oxford) , vol.51 , pp. 1550-1556
    • Sing, T.1    Jinnin, M.2    Yamane, K.3    Honda, N.4    Makino, K.5    Kajihara, I.6
  • 17
    • 84859414443 scopus 로고    scopus 로고
    • TGF-b-mediated downregulation of MicroRNA-196a Contributes to the constitutive upregulated type i collagen expression in scleroderma dermal fibroblasts
    • Honda N, Jinnin M, Kajihara I, Makino T, Makino K, Masuguchi S et al. TGF-b-mediated downregulation of MicroRNA-196a Contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts. J Immunol 2012; 188: 3323-3331.
    • (2012) J Immunol , vol.188 , pp. 3323-3331
    • Honda, N.1    Jinnin, M.2    Kajihara, I.3    Makino, T.4    Makino, K.5    Masuguchi, S.6
  • 18
    • 84856013803 scopus 로고    scopus 로고
    • Increased accumulation of extracellular thrombospondin-2 due to low degradation activity stimulates type i collagen expression in scleroderma fibroblasts
    • Kajihara I, Jinnin M, Yamane K, Makino T, Honda N, Igata T et al. Increased accumulation of extracellular thrombospondin-2 due to low degradation activity stimulates type I collagen expression in scleroderma fibroblasts. Am J Pathol 2012; 180: 703-714.
    • (2012) Am J Pathol , vol.180 , pp. 703-714
    • Kajihara, I.1    Jinnin, M.2    Yamane, K.3    Makino, T.4    Honda, N.5    Igata, T.6
  • 19
    • 40449089184 scopus 로고    scopus 로고
    • Thrombospondins: From structure to therapeutics
    • Carlson CB, Lawler J, Mosher DF. Thrombospondins: from structure to therapeutics. Cell Mol Life Sci 2008; 65: 672-686.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 672-686
    • Carlson, C.B.1    Lawler, J.2    Mosher, D.F.3
  • 20
    • 84872293004 scopus 로고    scopus 로고
    • MicroRNA-7 down-regulation mediates excessive collagen expression in localized scleroderma
    • Etoh M, Jinnin M, Makino K, Yamane K, Nakayama W, Aoi J et al. microRNA-7 down-regulation mediates excessive collagen expression in localized scleroderma. Arch Dermatol Res 2013; 305: 9-15.
    • (2013) Arch Dermatol Res , vol.305 , pp. 9-15
    • Etoh, M.1    Jinnin, M.2    Makino, K.3    Yamane, K.4    Nakayama, W.5    Aoi, J.6
  • 21
    • 84871347177 scopus 로고    scopus 로고
    • MiR-150 down-regulation contributes to the constitutive type i collagen overexpression in scleroderma dermal fibroblasts via the Induction of integrin b3
    • Honda N, Jinnin M, Kira-Etoh T, Makino K, Kajihara I, Makino T et al. miR-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the Induction of integrin b3. Am J Pathol 2013; 182: 206-216.
    • (2013) Am J Pathol , vol.182 , pp. 206-216
    • Honda, N.1    Jinnin, M.2    Kira-Etoh, T.3    Makino, K.4    Kajihara, I.5    Makino, T.6
  • 22
    • 9744251005 scopus 로고    scopus 로고
    • Biochemistry and biology of mammalian DNA methyltransferases
    • Hermann A, Gowher H, Jeltsch A. Biochemistry and biology of mammalian DNA methyltransferases. Cell Mol Life Sci 2004; 61: 2571-2587.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2571-2587
    • Hermann, A.1    Gowher, H.2    Jeltsch, A.3
  • 23
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992; 69: 915-926.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 25
    • 79551655444 scopus 로고    scopus 로고
    • Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation
    • Stanczyk J, Ospelt C, Karouzakis E, Filer A, Raza K, Kolling C et al. Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis Rheum 2011; 63: 373-381.
    • (2011) Arthritis Rheum , vol.63 , pp. 373-381
    • Stanczyk, J.1    Ospelt, C.2    Karouzakis, E.3    Filer, A.4    Raza, K.5    Kolling, C.6
  • 28
    • 84940368260 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies
    • (e-pub ahead of print 8 May 2014 doi:10.1136/annrheumdis-2014-205303)
    • Altorok N, Tsou PS, Coit P, Khanna D, Sawalha AH. Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies. Ann Rheum Dis 2014 (e-pub ahead of print 8 May 2014; doi:10.1136/annrheumdis-2014-205303).
    • (2014) Ann Rheum Dis
    • Altorok, N.1    Tsou, P.S.2    Coit, P.3    Khanna, D.4    Sawalha, A.H.5
  • 29
    • 84873832733 scopus 로고    scopus 로고
    • Tumor necrosis factor co-stimulated T-lymphocytes from patients with systemic sclerosis trigger collagen production in fibroblasts
    • Hügle T, O'Reilly S, Simpson R, Kraaij MD, Bigley V, Collin M et al. Tumor necrosis factor co-stimulated T-lymphocytes from patients with systemic sclerosis trigger collagen production in fibroblasts. Arthritis Rheum 2013; 65: 481-491.
    • (2013) Arthritis Rheum , vol.65 , pp. 481-491
    • Hügle, T.1    O'Reilly, S.2    Simpson, R.3    Kraaij, M.D.4    Bigley, V.5    Collin, M.6
  • 30
    • 70350049103 scopus 로고    scopus 로고
    • Abnormal DNA methylation in CD4\+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis
    • Lei W, Luo Y, Yan K, Zhao S, Li Y, Qiu X et al. Abnormal DNA methylation in CD4\+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. Scand J Rheumatol 2009; 38: 369-374.
    • (2009) Scand J Rheumatol , vol.38 , pp. 369-374
    • Lei, W.1    Luo, Y.2    Yan, K.3    Zhao, S.4    Li, Y.5    Qiu, X.6
  • 31
    • 84858074879 scopus 로고    scopus 로고
    • DNA demethylation of CD40L in CD4\+ T cells from women with systemic sclerosis: A possible explanation for female susceptibility
    • Lian X, Xiao R, Hu X, Kanekura T, Jiang H, Li Y et al. DNA demethylation of CD40L in CD4\+ T cells from women with systemic sclerosis: a possible explanation for female susceptibility. Arthritis Rheum 2012; 64: 2338-2345.
    • (2012) Arthritis Rheum , vol.64 , pp. 2338-2345
    • Lian, X.1    Xiao, R.2    Hu, X.3    Kanekura, T.4    Jiang, H.5    Li, Y.6
  • 32
    • 84862777126 scopus 로고    scopus 로고
    • Demethylation of TNFSF7 contributes to CD70 overexpression in CD4\+ T cells from patients with systemic sclerosis
    • Jiang H, Xiao R, Lian X, Kanekura T, Luo Y, Yin Y et al. Demethylation of TNFSF7 contributes to CD70 overexpression in CD4\+ T cells from patients with systemic sclerosis. Clin Immunol 2012; 143: 39-44.
    • (2012) Clin Immunol , vol.143 , pp. 39-44
    • Jiang, H.1    Xiao, R.2    Lian, X.3    Kanekura, T.4    Luo, Y.5    Yin, Y.6
  • 34
    • 84899914231 scopus 로고    scopus 로고
    • The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis
    • Dees C, Schlottmann I, Funke R, Distler A, Palumbo-Zerr K, Zerr P et al. The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis. Ann Rheum Dis 2014; 73: 1232-1239.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1232-1239
    • Dees, C.1    Schlottmann, I.2    Funke, R.3    Distler, A.4    Palumbo-Zerr, K.5    Zerr, P.6
  • 35
  • 36
    • 33745918328 scopus 로고    scopus 로고
    • Association between enhanced type i collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    • Wang Y, Fan P-S, Kahaleh B. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum 2006; 54: 2271-2279.
    • (2006) Arthritis Rheum , vol.54 , pp. 2271-2279
    • Wang, Y.1    Fan, P.-S.2    Kahaleh, B.3
  • 37
    • 84897879302 scopus 로고    scopus 로고
    • Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype
    • Watson CJ, Collier P, Tea I, Neary R, Watson JA, Robinson C et al. Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype. Hum Mol Genet 2014; 23: 2176-2188.
    • (2014) Hum Mol Genet , vol.23 , pp. 2176-2188
    • Watson, C.J.1    Collier, P.2    Tea, I.3    Neary, R.4    Watson, J.A.5    Robinson, C.6
  • 38
    • 34047210698 scopus 로고    scopus 로고
    • Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents
    • Lin HS, Hu CY, Chan HY, Liew YY, Huang HP, Lepescheux L et al. Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents. Br J Pharmacol 2007; 150: 862-872.
    • (2007) Br J Pharmacol , vol.150 , pp. 862-872
    • Lin, H.S.1    Hu, C.Y.2    Chan, H.Y.3    Liew, Y.Y.4    Huang, H.P.5    Lepescheux, L.6
  • 39
    • 84857233842 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay
    • Grabiec AM, Korchynskyi O, Tak PP, Reedquist KA. Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay. Ann Rheum Dis 2012; 71: 424-431.
    • (2012) Ann Rheum Dis , vol.71 , pp. 424-431
    • Grabiec, A.M.1    Korchynskyi, O.2    Tak, P.P.3    Reedquist, K.A.4
  • 40
    • 18544363755 scopus 로고    scopus 로고
    • Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-b1-induced fibrogenesis in skin fibroblasts
    • Rombouts K, Niki T, Greenwel P, Vandermonde A, Wielant A, Hellemans K et al. Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-b1-induced fibrogenesis in skin fibroblasts. Exp Cell Res 2002; 278: 184-197.
    • (2002) Exp Cell Res , vol.278 , pp. 184-197
    • Rombouts, K.1    Niki, T.2    Greenwel, P.3    Vandermonde, A.4    Wielant, A.5    Hellemans, K.6
  • 41
    • 33846548599 scopus 로고    scopus 로고
    • Trichostatin A blocks TGF-b-induced collagen gene expression in skin fibroblasts: Involvement of Sp1
    • Ghosh AK, Mori Y, Dowling E, Varga J. Trichostatin A blocks TGF-b-induced collagen gene expression in skin fibroblasts: involvement of Sp1. Biochem Biophys Res Commun 2007; 354: 420-426.
    • (2007) Biochem Biophys Res Commun , vol.354 , pp. 420-426
    • Ghosh, A.K.1    Mori, Y.2    Dowling, E.3    Varga, J.4
  • 42
    • 34547758359 scopus 로고    scopus 로고
    • Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis
    • Huber LC, Distler JHW, Moritz F, Hemmatazad H, Hauser T, Michel BA et al. Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis. Arthritis Rheum 2007; 56: 2755-2764.
    • (2007) Arthritis Rheum , vol.56 , pp. 2755-2764
    • Huber, L.C.1    Distler, J.H.W.2    Moritz, F.3    Hemmatazad, H.4    Hauser, T.5    Michel, B.A.6
  • 44
    • 84874432715 scopus 로고    scopus 로고
    • Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis
    • Krämer M, Dees C, Huang J, Schlottmann I, Palumbo-Zerr K, Zerr P et al. Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis. Ann Rheum Dis 2013; 72: 614-620.
    • (2013) Ann Rheum Dis , vol.72 , pp. 614-620
    • Krämer, M.1    Dees, C.2    Huang, J.3    Schlottmann, I.4    Palumbo-Zerr, K.5    Zerr, P.6
  • 45
    • 84892148944 scopus 로고    scopus 로고
    • Identification of novel long noncoding RNAs associated with TGF-beta/Smad3-mediated renal inflammation and fibrosis by RNA sequencing
    • Zhou Q, Chung AC, Huang XR, Dong Y, Yu X, Lan HY. Identification of novel long noncoding RNAs associated with TGF-beta/Smad3-mediated renal inflammation and fibrosis by RNA sequencing. Am J Pathol 2014; 184: 409-417.
    • (2014) Am J Pathol , vol.184 , pp. 409-417
    • Zhou, Q.1    Chung, A.C.2    Huang, X.R.3    Dong, Y.4    Yu, X.5    Lan, H.Y.6
  • 46
    • 84904748043 scopus 로고    scopus 로고
    • Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis
    • e-pub ahead of print 6 April 2014
    • Song X, Cao G, Jing L, Lin S, Wang X, Zhang J et al. Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis. J Cell Mol Med 2014 (e-pub ahead of print 6 April 2014; doi:10.1111/jcmm.12243).
    • (2014) J Cell Mol Med
    • Song, X.1    Cao, G.2    Jing, L.3    Lin, S.4    Wang, X.5    Zhang, J.6
  • 48
    • 84872475091 scopus 로고    scopus 로고
    • Blocking the class i histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-beta and EGFR signaling
    • Liu N, He S, Ma L, Ponnusamy M, Tang J, Tolbert E et al. Blocking the class I histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-beta and EGFR signaling. PLoS ONE 2013; 8: e54001.
    • (2013) PLoS ONE , vol.8 , pp. e54001
    • Liu, N.1    He, S.2    Ma, L.3    Ponnusamy, M.4    Tang, J.5    Tolbert, E.6
  • 49
    • 84868646303 scopus 로고    scopus 로고
    • Multigenerational epigenetic adaptation of the hepatic wound-healing response
    • Zeybel M, Hardy T, Wong YK, Mathers JC, Fox CR, Gackowska A et al. Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nat Med 2012; 18: 1369-1377.
    • (2012) Nat Med , vol.18 , pp. 1369-1377
    • Zeybel, M.1    Hardy, T.2    Wong, Y.K.3    Mathers, J.C.4    Fox, C.R.5    Gackowska, A.6
  • 50
    • 84855471990 scopus 로고    scopus 로고
    • HDAC inhibitors in cancer biology: Emerging mechanisms and clinical applications
    • Khan O, La Thangue NB. HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications. Immunol Cell Biol 2012; 90: 85-94.
    • (2012) Immunol Cell Biol , vol.90 , pp. 85-94
    • Khan, O.1    La Thangue, N.B.2
  • 51
    • 38949096781 scopus 로고    scopus 로고
    • Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
    • Garcia-Manero G, Yang H, Bueso-Ramos C, Ferrajoli A, Cortes J, Wierda WG et al. Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes. Blood 2008; 111: 1060-1066.
    • (2008) Blood , vol.111 , pp. 1060-1066
    • Garcia-Manero, G.1    Yang, H.2    Bueso-Ramos, C.3    Ferrajoli, A.4    Cortes, J.5    Wierda, W.G.6
  • 52
    • 84907689730 scopus 로고    scopus 로고
    • A phase 2 study of belinostat (PXD101) in patients with relapsed or refractory acute myeloid leukemia or patients over the age of 60 with newly diagnosed acute myeloid leukemia: A California cancer consortium study
    • (e-pub ahead of print 24 February 2014)
    • Kirschbaum MH, Foon KA, Frankel P, Ruel C, Pulone B, Tuscano JM et al. A phase 2 study of belinostat (PXD101) in patients with relapsed or refractory acute myeloid leukemia or patients over the age of 60 with newly diagnosed acute myeloid leukemia: a California Cancer Consortium Study. Leuk Lymphoma 2014 (e-pub ahead of print 24 February 2014; doi:10.3109/10428194.2013.877134).
    • (2014) Leuk Lymphoma
    • Kirschbaum, M.H.1    Foon, K.A.2    Frankel, P.3    Ruel, C.4    Pulone, B.5    Tuscano, J.M.6
  • 53
    • 84866758581 scopus 로고    scopus 로고
    • Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: A multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo phase II consortium and the cancer therapeutics research group
    • Yeo W, Chung HC, Chan SL, Wang LZ, Lim R, Picus J et al. Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group. J Clin Oncol 2012; 30: 3361-3367.
    • (2012) J Clin Oncol , vol.30 , pp. 3361-3367
    • Yeo, W.1    Chung, H.C.2    Chan, S.L.3    Wang, L.Z.4    Lim, R.5    Picus, J.6
  • 54
    • 84863615068 scopus 로고    scopus 로고
    • Phase II activity of belinostat (PXD-101), carboplatin, and paclitaxel in women with previously treated ovarian cancer
    • Dizon DS, Damstrup L, Finkler NJ, Lassen U, Celano P, Glasspool R et al. Phase II activity of belinostat (PXD-101), carboplatin, and paclitaxel in women with previously treated ovarian cancer. Int J Gynecol Cancer 2012; 22: 979-986.
    • (2012) Int J Gynecol Cancer , vol.22 , pp. 979-986
    • Dizon, D.S.1    Damstrup, L.2    Finkler, N.J.3    Lassen, U.4    Celano, P.5    Glasspool, R.6
  • 55
    • 84875032119 scopus 로고    scopus 로고
    • A phase i study of panobinostat (LBH589) in patients with primary myelofibrosis (PMF) and post-polycythaemia vera/essential thrombocythaemia myelofibrosis (post-PV/ET MF)
    • Mascarenhas J, Lu M, Li T, Petersen B, Hochman T, Najfeld V et al. A phase I study of panobinostat (LBH589) in patients with primary myelofibrosis (PMF) and post-polycythaemia vera/essential thrombocythaemia myelofibrosis (post-PV/ET MF). Br J Haematol 2013; 161: 68-75.
    • (2013) Br J Haematol , vol.161 , pp. 68-75
    • Mascarenhas, J.1    Lu, M.2    Li, T.3    Petersen, B.4    Hochman, T.5    Najfeld, V.6
  • 56
    • 84880321219 scopus 로고    scopus 로고
    • Phase II trial of panobinostat, an oral pan-deacetylase inhibitor in patients with primary myelofibrosis, post-essential thrombocythaemia, and post-polycythaemia vera myelofibrosis
    • DeAngelo DJ, Mesa RA, Fiskus W, Tefferi A, Paley C, Wadleigh M et al. Phase II trial of panobinostat, an oral pan-deacetylase inhibitor in patients with primary myelofibrosis, post-essential thrombocythaemia, and post-polycythaemia vera myelofibrosis. Br J Haematol 2013; 162: 326-335.
    • (2013) Br J Haematol , vol.162 , pp. 326-335
    • Deangelo, D.J.1    Mesa, R.A.2    Fiskus, W.3    Tefferi, A.4    Paley, C.5    Wadleigh, M.6
  • 57
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodriguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology. Nat Med 2011; 17: 330-339.
    • (2011) Nat Med , vol.17 , pp. 330-339
    • Rodriguez-Paredes, M.1    Esteller, M.2
  • 58
    • 84879834815 scopus 로고    scopus 로고
    • Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor
    • Yardley DA, Ismail-Khan RR, Melichar B, Lichinitser M, Munster PN, Klein PM et al. Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor. J Clin Oncol 2013; 31: 2128-2135.
    • (2013) J Clin Oncol , vol.31 , pp. 2128-2135
    • Yardley, D.A.1    Ismail-Khan, R.R.2    Melichar, B.3    Lichinitser, M.4    Munster, P.N.5    Klein, P.M.6
  • 59
    • 79959306917 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small-cell lung cancer
    • Spigel DR, Burris 3rd HA, Greco FA, Shipley DL, Friedman EK, Waterhouse DM et al. Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small-cell lung cancer. J Clin Oncol 2011; 29: 2582-2589.
    • (2011) J Clin Oncol , vol.29 , pp. 2582-2589
    • Spigel, D.R.1    Burris Iii., H.A.2    Greco, F.A.3    Shipley, D.L.4    Friedman, E.K.5    Waterhouse, D.M.6
  • 60
    • 84855340600 scopus 로고    scopus 로고
    • Phase i study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours
    • Pili R, Salumbides B, Zhao M, Altiok S, Qian D, Zwiebel J et al. Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours. Br J Cancer 2012; 106: 77-84.
    • (2012) Br J Cancer , vol.106 , pp. 77-84
    • Pili, R.1    Salumbides, B.2    Zhao, M.3    Altiok, S.4    Qian, D.5    Zwiebel, J.6
  • 61
    • 84869497592 scopus 로고    scopus 로고
    • Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer
    • Haigentz Jr M, Kim M, Sarta C, Lin J, Keresztes RS, Culliney B et al. Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer. Oral Oncol 2012; 48: 1281-1288.
    • (2012) Oral Oncol , vol.48 , pp. 1281-1288
    • Haigentz, M.1    Kim, M.2    Sarta, C.3    Lin, J.4    Keresztes, R.S.5    Culliney, B.6
  • 62
    • 79959956310 scopus 로고    scopus 로고
    • A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03
    • Iwamoto FM, Lamborn KR, Kuhn JG, Wen PY, Yung WK, Gilbert MR et al. A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03. Neuro Oncol 2011; 13: 509-516.
    • (2011) Neuro Oncol , vol.13 , pp. 509-516
    • Iwamoto, F.M.1    Lamborn, K.R.2    Kuhn, J.G.3    Wen, P.Y.4    Yung, W.K.5    Gilbert, M.R.6
  • 63
    • 84855487228 scopus 로고    scopus 로고
    • Phase 2 clinical trial of 5-azacitidine valproic acid and all-trans retinoic acid in patients with high-risk acute myeloid leukemia or myelodysplastic syndrome
    • Raffoux E, Cras A, Recher C, Boelle PY, de Labarthe A, Turlure P et al. Phase 2 clinical trial of 5-azacitidine, valproic acid, and all-trans retinoic acid in patients with high-risk acute myeloid leukemia or myelodysplastic syndrome. Oncotarget 2010; 1: 34-42.
    • (2010) Oncotarget , vol.1 , pp. 34-42
    • Raffoux, E.1    Cras, A.2    Recher, C.3    Boelle, P.Y.4    De Labarthe, A.5    Turlure, P.6
  • 65
    • 84896031643 scopus 로고    scopus 로고
    • Phase i study of anti-VEGF monoclonal antibody bevacizumab and histone deacetylase inhibitor valproic acid in patients with advanced cancers
    • Wheler JJ, Janku F, Falchook GS, Jackson TL, Fu S, Naing A et al. Phase I study of anti-VEGF monoclonal antibody bevacizumab and histone deacetylase inhibitor valproic acid in patients with advanced cancers. Cancer Chemother Pharmacol 2014; 73: 495-501.
    • (2014) Cancer Chemother Pharmacol , vol.73 , pp. 495-501
    • Wheler, J.J.1    Janku, F.2    Falchook, G.S.3    Jackson, T.L.4    Fu, S.5    Naing, A.6
  • 66
    • 3843151628 scopus 로고    scopus 로고
    • Phase II trial of the histone deacetylase inhibitor pivaloyloxymethyl butyrate (Pivanex, AN-9) in advanced non-small cell lung cancer
    • Reid T, Valone F, Lipera W, Irwin D, Paroly W, Natale R et al. Phase II trial of the histone deacetylase inhibitor pivaloyloxymethyl butyrate (Pivanex, AN-9) in advanced non-small cell lung cancer. Lung Cancer 2004; 45: 381-386.
    • (2004) Lung Cancer , vol.45 , pp. 381-386
    • Reid, T.1    Valone, F.2    Lipera, W.3    Irwin, D.4    Paroly, W.5    Natale, R.6


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