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Volumn 23, Issue 3, 2012, Pages 99-107

Interleukin-6, its role in fibrosing conditions

Author keywords

Fibrosis; Interleukin 6; Interleukin 6 signalling; Systemic sclerosis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MESSENGER RNA;

EID: 84861712626     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2012.04.003     Document Type: Short Survey
Times cited : (72)

References (84)
  • 1
    • 0036694589 scopus 로고    scopus 로고
    • IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    • Ishihara K., Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine and Growth Factor Reviews 2002, 13:357-368.
    • (2002) Cytokine and Growth Factor Reviews , vol.13 , pp. 357-368
    • Ishihara, K.1    Hirano, T.2
  • 2
    • 0033959608 scopus 로고    scopus 로고
    • Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy
    • Nishimoto N., Sasai M., Shima Y. Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy. Blood 2000, 95:56-61.
    • (2000) Blood , vol.95 , pp. 56-61
    • Nishimoto, N.1    Sasai, M.2    Shima, Y.3
  • 3
    • 0032536542 scopus 로고    scopus 로고
    • Interleukin 6 is required for the development of collagen-induced arthritis
    • Alonzi T., Fattori E., Lazzaro D. Interleukin 6 is required for the development of collagen-induced arthritis. Journal of Experimental Medicine 1998, 187:461-468.
    • (1998) Journal of Experimental Medicine , vol.187 , pp. 461-468
    • Alonzi, T.1    Fattori, E.2    Lazzaro, D.3
  • 4
    • 0032534730 scopus 로고    scopus 로고
    • IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells
    • Samoilova E.B., Horton J.L., Hilliard B., Liu T.-S.T., Chen Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. Journal of Immunology 1998, 161:6480-6486.
    • (1998) Journal of Immunology , vol.161 , pp. 6480-6486
    • Samoilova, E.B.1    Horton, J.L.2    Hilliard, B.3    Liu, T.-S.T.4    Chen, Y.5
  • 5
    • 0024269961 scopus 로고
    • Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis
    • Hirano T., Matsuda T., Turner M. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. European Journal of Immunology 1988, 18:1797-1802.
    • (1988) European Journal of Immunology , vol.18 , pp. 1797-1802
    • Hirano, T.1    Matsuda, T.2    Turner, M.3
  • 6
    • 0038341934 scopus 로고    scopus 로고
    • Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice
    • Lin Z.-Q., Kondo T., Ishida Y., Takayasu T., Mukaida N. Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice. Journal of Leukocyte Biology 2003, 73:713-721.
    • (2003) Journal of Leukocyte Biology , vol.73 , pp. 713-721
    • Lin, Z.-Q.1    Kondo, T.2    Ishida, Y.3    Takayasu, T.4    Mukaida, N.5
  • 7
    • 0033664369 scopus 로고    scopus 로고
    • Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice
    • Gallucci R.M., Simeonova P.P., Matheson J.M. Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice. The FASEB Journal 2000, 14:2525-2531.
    • (2000) The FASEB Journal , vol.14 , pp. 2525-2531
    • Gallucci, R.M.1    Simeonova, P.P.2    Matheson, J.M.3
  • 8
    • 0019495308 scopus 로고
    • T cell-replacing factor-(TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF
    • Muraguchi A., Kishimoto T., Miki Y. T cell-replacing factor-(TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF. Journal of Immunology 1981, 127:412-416.
    • (1981) Journal of Immunology , vol.127 , pp. 412-416
    • Muraguchi, A.1    Kishimoto, T.2    Miki, Y.3
  • 9
    • 0020046865 scopus 로고
    • Human helper T cell factor(s) (ThF). II. Induction of IgG production in B lymphoblastoid cell lines and identification of T cell-replacing factor-(TRF) like factor(s)
    • Teranishi T., Hirano T., Arima N., Onoue K. Human helper T cell factor(s) (ThF). II. Induction of IgG production in B lymphoblastoid cell lines and identification of T cell-replacing factor-(TRF) like factor(s). Journal of Immunology 1982, 128:1903-1908.
    • (1982) Journal of Immunology , vol.128 , pp. 1903-1908
    • Teranishi, T.1    Hirano, T.2    Arima, N.3    Onoue, K.4
  • 10
    • 0022499547 scopus 로고
    • Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    • Hirano T., Yasukawa K., Harada H. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986, 324:73-76.
    • (1986) Nature , vol.324 , pp. 73-76
    • Hirano, T.1    Yasukawa, K.2    Harada, H.3
  • 12
    • 0026682873 scopus 로고
    • Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo
    • Saito M., Yoshida K., Hibi M., Taga T., Kishimoto T. Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. Journal of Immunology 1992, 148:4066-4071.
    • (1992) Journal of Immunology , vol.148 , pp. 4066-4071
    • Saito, M.1    Yoshida, K.2    Hibi, M.3    Taga, T.4    Kishimoto, T.5
  • 13
    • 9044222888 scopus 로고    scopus 로고
    • Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders
    • Yoshida K., Taga T., Saito M. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proceedings of the National Academy of Sciences of the United States of America 1996, 93:407-411.
    • (1996) Proceedings of the National Academy of Sciences of the United States of America , vol.93 , pp. 407-411
    • Yoshida, K.1    Taga, T.2    Saito, M.3
  • 14
    • 18244383058 scopus 로고    scopus 로고
    • The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis
    • Jenkins B.J., Roberts A.W., Najdovska M., Grail D., Ernst M. The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis. Blood 2005, 105:3512-3520.
    • (2005) Blood , vol.105 , pp. 3512-3520
    • Jenkins, B.J.1    Roberts, A.W.2    Najdovska, M.3    Grail, D.4    Ernst, M.5
  • 16
    • 0028328436 scopus 로고
    • Impaired immune and acute-phase responses in interleukin-6-deficient mice
    • Kopf M., Baumann H., Freer G. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 1994, 368:339-342.
    • (1994) Nature , vol.368 , pp. 339-342
    • Kopf, M.1    Baumann, H.2    Freer, G.3
  • 17
    • 0027484249 scopus 로고
    • Disruption of the CNTF gene results in motor neuron degeneration
    • Masu Y., Wolf E., Holtmann B., Sendtner M., Brem G., Thoenen H. Disruption of the CNTF gene results in motor neuron degeneration. Nature 1993, 365:27-32.
    • (1993) Nature , vol.365 , pp. 27-32
    • Masu, Y.1    Wolf, E.2    Holtmann, B.3    Sendtner, M.4    Brem, G.5    Thoenen, H.6
  • 18
    • 0026768292 scopus 로고
    • Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
    • Stewart C.L., Kaspar P., Brunet L.J. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 1992, 359:76-79.
    • (1992) Nature , vol.359 , pp. 76-79
    • Stewart, C.L.1    Kaspar, P.2    Brunet, L.J.3
  • 19
    • 0027233526 scopus 로고
    • Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation
    • Escary J.-L., Perreau J., Dumenil D., Ezine S., Brulet P. Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature 1993, 363:361-364.
    • (1993) Nature , vol.363 , pp. 361-364
    • Escary, J.-L.1    Perreau, J.2    Dumenil, D.3    Ezine, S.4    Brulet, P.5
  • 20
    • 0032539008 scopus 로고    scopus 로고
    • Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects
    • Betz U.A.K., Bloch W., van den Broek M. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. Journal of Experimental Medicine 1998, 188:1955-1965.
    • (1998) Journal of Experimental Medicine , vol.188 , pp. 1955-1965
    • Betz, U.A.K.1    Bloch, W.2    van den Broek, M.3
  • 21
    • 0028281794 scopus 로고
    • Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
    • Stahl N., Boulton T., Farruggella T. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. Science 1994, 263:92-95.
    • (1994) Science , vol.263 , pp. 92-95
    • Stahl, N.1    Boulton, T.2    Farruggella, T.3
  • 22
    • 0141866756 scopus 로고    scopus 로고
    • Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
    • Matthews V., Schuster B., Schütze S. Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). Journal of Biological Chemistry 2003, 278:38829-38839.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 38829-38839
    • Matthews, V.1    Schuster, B.2    Schütze, S.3
  • 23
    • 80052358980 scopus 로고    scopus 로고
    • Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
    • Jones S.A., Scheller J., Rose-John S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Journal of Clinical Investigation 2011, 121:3375-3383.
    • (2011) Journal of Clinical Investigation , vol.121 , pp. 3375-3383
    • Jones, S.A.1    Scheller, J.2    Rose-John, S.3
  • 24
    • 0037053394 scopus 로고    scopus 로고
    • Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts
    • Vermes C., Jacobs J.J., Zhang J., Firneisz G., Roebuck K.A., Glant T.T. Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts. Journal of Biological Chemistry 2002, 277:16879-16887.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 16879-16887
    • Vermes, C.1    Jacobs, J.J.2    Zhang, J.3    Firneisz, G.4    Roebuck, K.A.5    Glant, T.T.6
  • 26
    • 0028087834 scopus 로고
    • Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism
    • Horiuchi S., Koyanagiu Y., Zhouu Y. Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism. European Journal of Immunology 1994, 24:1945-1948.
    • (1994) European Journal of Immunology , vol.24 , pp. 1945-1948
    • Horiuchi, S.1    Koyanagiu, Y.2    Zhouu, Y.3
  • 27
    • 79955456934 scopus 로고    scopus 로고
    • Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding
    • Garbers C., Jänner N., Chalaris A. Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding. Journal of Biological Chemistry 2011, 286:14804-14811.
    • (2011) Journal of Biological Chemistry , vol.286 , pp. 14804-14811
    • Garbers, C.1    Jänner, N.2    Chalaris, A.3
  • 29
    • 34548856204 scopus 로고    scopus 로고
    • Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
    • Chalaris A., Rabe B., Paliga K. Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood 2007, 110:1748-1755.
    • (2007) Blood , vol.110 , pp. 1748-1755
    • Chalaris, A.1    Rabe, B.2    Paliga, K.3
  • 30
    • 69949140396 scopus 로고    scopus 로고
    • The microvascular endothelium in scleroderma
    • Kahaleh B. The microvascular endothelium in scleroderma. Rheumatology (Oxford) 2008, 47:v14-v15.
    • (2008) Rheumatology (Oxford) , vol.47
    • Kahaleh, B.1
  • 31
    • 0035160256 scopus 로고    scopus 로고
    • Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
    • Jostock T., Müllberg J., Özbek S. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. European Journal of Biochemistry 2001, 268:160-167.
    • (2001) European Journal of Biochemistry , vol.268 , pp. 160-167
    • Jostock, T.1    Müllberg, J.2    Özbek, S.3
  • 32
    • 11144357767 scopus 로고    scopus 로고
    • Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms
    • McLoughlin R.M., Hurst S.M., Nowell M.A. Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. Journal of Immunology 2004, 172:5676-5683.
    • (2004) Journal of Immunology , vol.172 , pp. 5676-5683
    • McLoughlin, R.M.1    Hurst, S.M.2    Nowell, M.A.3
  • 33
    • 59849091830 scopus 로고    scopus 로고
    • Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis
    • Nowell M.A., Williams A.S., Carty S.A. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Journal of Immunology 2009, 182:613-622.
    • (2009) Journal of Immunology , vol.182 , pp. 613-622
    • Nowell, M.A.1    Williams, A.S.2    Carty, S.A.3
  • 34
    • 0030755934 scopus 로고    scopus 로고
    • Structure and function of a new STAT-induced STAT inhibitor
    • Naka T., Narazaki M., Hirata M. Structure and function of a new STAT-induced STAT inhibitor. Nature 1997, 387:924-929.
    • (1997) Nature , vol.387 , pp. 924-929
    • Naka, T.1    Narazaki, M.2    Hirata, M.3
  • 35
    • 0037938816 scopus 로고    scopus 로고
    • SOCS3 negatively regulates IL-6 signaling in vivo
    • Croker B.A., Krebs D.L., Zhang J.-G. SOCS3 negatively regulates IL-6 signaling in vivo. Nature Immunology 2003, 4:540-545.
    • (2003) Nature Immunology , vol.4 , pp. 540-545
    • Croker, B.A.1    Krebs, D.L.2    Zhang, J.-G.3
  • 36
    • 0038614944 scopus 로고    scopus 로고
    • SOCS3 regulates the plasticity of gp130 signaling
    • Lang R., Pauleau A.-L., Parganas E. SOCS3 regulates the plasticity of gp130 signaling. Nature Immunology 2003, 4:546-550.
    • (2003) Nature Immunology , vol.4 , pp. 546-550
    • Lang, R.1    Pauleau, A.-L.2    Parganas, E.3
  • 37
    • 84855469919 scopus 로고    scopus 로고
    • IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3
    • Croker B.A., Kiu H., Pellegrini M. IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3. Immunology and Cell Biology 2012, 90:124-129.
    • (2012) Immunology and Cell Biology , vol.90 , pp. 124-129
    • Croker, B.A.1    Kiu, H.2    Pellegrini, M.3
  • 38
    • 33646146734 scopus 로고    scopus 로고
    • Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-[beta]1 production
    • Ogata H., Chinen T., Yoshida T. Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-[beta]1 production. Oncogene 2006, 25:2520-2530.
    • (2006) Oncogene , vol.25 , pp. 2520-2530
    • Ogata, H.1    Chinen, T.2    Yoshida, T.3
  • 39
    • 79959813763 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling inhibit tubular epithelial cell-myofibroblast transdifferentiation
    • Liu Q., Liu S., Shi Y. Suppressors of cytokine signaling inhibit tubular epithelial cell-myofibroblast transdifferentiation. American Journal of Nephrology 2011, 34:142-151.
    • (2011) American Journal of Nephrology , vol.34 , pp. 142-151
    • Liu, Q.1    Liu, S.2    Shi, Y.3
  • 41
    • 0028242234 scopus 로고
    • The role of interleukin-6 in mucosal IgA antibody responses in vivo
    • Ramsay A., Husband A., Ramshaw I. The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science 1994, 264:561-563.
    • (1994) Science , vol.264 , pp. 561-563
    • Ramsay, A.1    Husband, A.2    Ramshaw, I.3
  • 42
    • 0032986491 scopus 로고    scopus 로고
    • CD4+ T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice
    • Baker P.J., Dixon M., Evans R.T., Dufour L., Johnson E., Roopenian D.C. CD4+ T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infection and Immunity 1999, 67:2804-2809.
    • (1999) Infection and Immunity , vol.67 , pp. 2804-2809
    • Baker, P.J.1    Dixon, M.2    Evans, R.T.3    Dufour, L.4    Johnson, E.5    Roopenian, D.C.6
  • 43
    • 0029846756 scopus 로고    scopus 로고
    • Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
    • Cressman D.E., Greenbaum L.E., DeAngelis R.A. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996, 274:1379-1383.
    • (1996) Science , vol.274 , pp. 1379-1383
    • Cressman, D.E.1    Greenbaum, L.E.2    DeAngelis, R.A.3
  • 44
    • 0032831637 scopus 로고    scopus 로고
    • Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice
    • Natsume M., Tsuji H., Harada A. Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice. Journal of Leukocyte Biology 1999, 66:601-608.
    • (1999) Journal of Leukocyte Biology , vol.66 , pp. 601-608
    • Natsume, M.1    Tsuji, H.2    Harada, A.3
  • 45
    • 0034464010 scopus 로고    scopus 로고
    • Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration
    • Peters M., Blinn G., Jostock T. Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration. Gastroenterology 2000, 119:1663-1671.
    • (2000) Gastroenterology , vol.119 , pp. 1663-1671
    • Peters, M.1    Blinn, G.2    Jostock, T.3
  • 46
    • 3042635767 scopus 로고    scopus 로고
    • The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis
    • Wang X.-P., Schunck M., Kallen K.-J. The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis. Journal of Investigative Dermatology 2003, 123:124-131.
    • (2003) Journal of Investigative Dermatology , vol.123 , pp. 124-131
    • Wang, X.-P.1    Schunck, M.2    Kallen, K.-J.3
  • 47
    • 0030934532 scopus 로고    scopus 로고
    • Wound healing-aiming for perfect skin regeneration
    • Martin P. Wound healing-aiming for perfect skin regeneration. Science 1997, 276:75-81.
    • (1997) Science , vol.276 , pp. 75-81
    • Martin, P.1
  • 48
    • 32844464795 scopus 로고    scopus 로고
    • IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice
    • Gallucci R.M., Lee E.G., Tomasek J.J. IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice. Journal of Investigative Dermatology 2006, 126:561-568.
    • (2006) Journal of Investigative Dermatology , vol.126 , pp. 561-568
    • Gallucci, R.M.1    Lee, E.G.2    Tomasek, J.J.3
  • 49
    • 0026601232 scopus 로고
    • Interleukin-1, interleukin-2, interleukin-4, interleukin-6, tumor necrosis factor α, and interferon-γ levels in sera from patients with scleroderma
    • Needleman B.W., Wigley F.M., Stair R.W. Interleukin-1, interleukin-2, interleukin-4, interleukin-6, tumor necrosis factor α, and interferon-γ levels in sera from patients with scleroderma. Arthritis and Rheumatism 1992, 35:67-72.
    • (1992) Arthritis and Rheumatism , vol.35 , pp. 67-72
    • Needleman, B.W.1    Wigley, F.M.2    Stair, R.W.3
  • 50
    • 0032746822 scopus 로고    scopus 로고
    • Enhanced production of interleukin-6 (IL-6), oncostatin M and soluble IL-6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis
    • Hasegawa M., Sato S., Ihn H., Takehara K. Enhanced production of interleukin-6 (IL-6), oncostatin M and soluble IL-6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis. Rheumatology (Oxford) 1999, 38:612-617.
    • (1999) Rheumatology (Oxford) , vol.38 , pp. 612-617
    • Hasegawa, M.1    Sato, S.2    Ihn, H.3    Takehara, K.4
  • 51
    • 80155206307 scopus 로고    scopus 로고
    • Immunization with DNA topoisomerase I and Freund's complete adjuvant induces skin and lung fibrosis and autoimmunity via interleukin-6 signaling
    • Yoshizaki A., Yanaba K., Ogawa A., Asano Y., Kadono T., Sato S. Immunization with DNA topoisomerase I and Freund's complete adjuvant induces skin and lung fibrosis and autoimmunity via interleukin-6 signaling. Arthritis and Rheumatism 2011, 63:3575-3585.
    • (2011) Arthritis and Rheumatism , vol.63 , pp. 3575-3585
    • Yoshizaki, A.1    Yanaba, K.2    Ogawa, A.3    Asano, Y.4    Kadono, T.5    Sato, S.6
  • 52
    • 47249089967 scopus 로고    scopus 로고
    • Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells
    • Briso E.M., Dienz O., Rincon M. Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells. Journal of Immunology 2008, 180:7102-7106.
    • (2008) Journal of Immunology , vol.180 , pp. 7102-7106
    • Briso, E.M.1    Dienz, O.2    Rincon, M.3
  • 53
    • 77949881389 scopus 로고    scopus 로고
    • Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells
    • Jones G.W., McLoughlin R.M., Hammond V.J. Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. Journal of Immunology 2010, 184:2130-2139.
    • (2010) Journal of Immunology , vol.184 , pp. 2130-2139
    • Jones, G.W.1    McLoughlin, R.M.2    Hammond, V.J.3
  • 54
    • 0033121274 scopus 로고    scopus 로고
    • Endogenous IL-1 alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A
    • Kawaguchi Y., Hara M., Wright T.M. Endogenous IL-1 alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A. Journal of Clinical Investigation 1999, 103:1253-1260.
    • (1999) Journal of Clinical Investigation , vol.103 , pp. 1253-1260
    • Kawaguchi, Y.1    Hara, M.2    Wright, T.M.3
  • 55
    • 0032577453 scopus 로고    scopus 로고
    • Interleukin (IL)-6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity
    • Silacci P., Dayer J.-M., Desgeorges A., Peter R., Manueddu C., Guerne P.-A. Interleukin (IL)-6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity. Journal of Biological Chemistry 1998, 273:13625-13629.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 13625-13629
    • Silacci, P.1    Dayer, J.-M.2    Desgeorges, A.3    Peter, R.4    Manueddu, C.5    Guerne, P.-A.6
  • 56
    • 24644463283 scopus 로고    scopus 로고
    • Importance of plasma matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinase (TIMP) in development of fibrosis in agnogenic myeloid metaplasia
    • Wang J.C. Importance of plasma matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinase (TIMP) in development of fibrosis in agnogenic myeloid metaplasia. Leukemia and Lymphoma 2005, 46:1261-1268.
    • (2005) Leukemia and Lymphoma , vol.46 , pp. 1261-1268
    • Wang, J.C.1
  • 57
    • 84858021399 scopus 로고    scopus 로고
    • Enhanced secretion of TIMP-1 by human hypertrophic scar keratinocytes could contribute to fibrosis
    • Simon F., Bergeron D., Larochelle S. Enhanced secretion of TIMP-1 by human hypertrophic scar keratinocytes could contribute to fibrosis. Burns 2012, 38:421-427.
    • (2012) Burns , vol.38 , pp. 421-427
    • Simon, F.1    Bergeron, D.2    Larochelle, S.3
  • 58
    • 0035026949 scopus 로고    scopus 로고
    • Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression
    • Ramos C., Montaño M., Garci{dotless}óa-Alvarez J. Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression. American Journal of Respiratory Cell and Molecular Biology 2001, 24:591-598.
    • (2001) American Journal of Respiratory Cell and Molecular Biology , vol.24 , pp. 591-598
    • Ramos, C.1    Montaño, M.2    Garcióa-Alvarez, J.3
  • 59
    • 0033830350 scopus 로고    scopus 로고
    • TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?
    • Selman M., Ruiz V., Cabrera S. TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?. American Journal of Physics 2000, 279:L562-L574.
    • (2000) American Journal of Physics , vol.279
    • Selman, M.1    Ruiz, V.2    Cabrera, S.3
  • 60
    • 0036800192 scopus 로고    scopus 로고
    • Metalloproteinase inhibitors: biological actions and therapeutic opportunities
    • Baker A.H., Edwards D.R., Murphy G. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. Journal of Cell Science 2002, 115:3719-3727.
    • (2002) Journal of Cell Science , vol.115 , pp. 3719-3727
    • Baker, A.H.1    Edwards, D.R.2    Murphy, G.3
  • 61
    • 0036171194 scopus 로고    scopus 로고
    • Oncostatin M stimulates tissue inhibitor of metalloproteinase-1 via a MEK-sensitive mechanism in human myofibroblasts
    • Sohara N., Trojanowska M., Reuben A. Oncostatin M stimulates tissue inhibitor of metalloproteinase-1 via a MEK-sensitive mechanism in human myofibroblasts. Journal of Hepatology 2002, 36:191-199.
    • (2002) Journal of Hepatology , vol.36 , pp. 191-199
    • Sohara, N.1    Trojanowska, M.2    Reuben, A.3
  • 62
    • 0027375872 scopus 로고
    • The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells
    • Shingu M., Nagai Y., Isayama T., Naono T., Nobunaga M. The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells. Clinical and Experimental Immunology 1993, 94:145-149.
    • (1993) Clinical and Experimental Immunology , vol.94 , pp. 145-149
    • Shingu, M.1    Nagai, Y.2    Isayama, T.3    Naono, T.4    Nobunaga, M.5
  • 63
    • 34248171876 scopus 로고    scopus 로고
    • TIMP-1 mediates the inhibitory effect of interleukin-6 on the proliferation of a hepatocarcinoma cell line in a STAT3-dependent manner
    • Guo S.-Y., Shen X., Yang J. TIMP-1 mediates the inhibitory effect of interleukin-6 on the proliferation of a hepatocarcinoma cell line in a STAT3-dependent manner. Brazilian Journal of Medical and Biological Research 2007, 40:621-631.
    • (2007) Brazilian Journal of Medical and Biological Research , vol.40 , pp. 621-631
    • Guo, S.-Y.1    Shen, X.2    Yang, J.3
  • 64
    • 0035968289 scopus 로고    scopus 로고
    • JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells
    • Smart D.E., Vincent K.J., Arthur M.J.P. JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells. Journal of Biological Chemistry 2001, 276:24414-24421.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 24414-24421
    • Smart, D.E.1    Vincent, K.J.2    Arthur, M.J.P.3
  • 65
    • 33845650187 scopus 로고    scopus 로고
    • JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation
    • Smart D.E., Green K., Oakley F. JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation. Hepatology 2006, 44:1432-1440.
    • (2006) Hepatology , vol.44 , pp. 1432-1440
    • Smart, D.E.1    Green, K.2    Oakley, F.3
  • 66
    • 0035438384 scopus 로고    scopus 로고
    • Interferon-γ and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation
    • Cavet J., Dickinson A.M., Norden J., Taylor P.R.A., Jackson G.H., Middleton P.G. Interferon-γ and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation. Blood 2001, 98:1594-1600.
    • (2001) Blood , vol.98 , pp. 1594-1600
    • Cavet, J.1    Dickinson, A.M.2    Norden, J.3    Taylor, P.R.A.4    Jackson, G.H.5    Middleton, P.G.6
  • 67
    • 68249160054 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease
    • Chen X., Das R., Komorowski R. Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease. Blood 2009, 114:891-900.
    • (2009) Blood , vol.114 , pp. 891-900
    • Chen, X.1    Das, R.2    Komorowski, R.3
  • 68
    • 79953024119 scopus 로고    scopus 로고
    • Blockade of IL-6-signaling inhibits the pathogenesis of CD4+ T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen
    • Noguchi D., Wakita D., Ohkuri T. Blockade of IL-6-signaling inhibits the pathogenesis of CD4+ T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen. Immunology Letters 2011, 136:146-155.
    • (2011) Immunology Letters , vol.136 , pp. 146-155
    • Noguchi, D.1    Wakita, D.2    Ohkuri, T.3
  • 69
    • 78751469023 scopus 로고    scopus 로고
    • Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation
    • Tawara I., Koyama M., Liu C. Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation. Clinical Cancer Research 2011, 17:77-88.
    • (2011) Clinical Cancer Research , vol.17 , pp. 77-88
    • Tawara, I.1    Koyama, M.2    Liu, C.3
  • 71
    • 83655184758 scopus 로고    scopus 로고
    • Interleukin 6 underlies angiotensin II-Induced hypertension and chronic renal damage
    • Zhang W., Wang W., Yu H. Interleukin 6 underlies angiotensin II-Induced hypertension and chronic renal damage. Hypertension 2012, 59:136-144.
    • (2012) Hypertension , vol.59 , pp. 136-144
    • Zhang, W.1    Wang, W.2    Yu, H.3
  • 72
    • 0037781942 scopus 로고    scopus 로고
    • STAT proteins mediate angiotensin II-induced production of TIMP-1 in human proximal tubular epithelial cells
    • Chen X., Wang J., Zhou F., Wang X., Feng Z. STAT proteins mediate angiotensin II-induced production of TIMP-1 in human proximal tubular epithelial cells. Kidney International 2003, 64:459-467.
    • (2003) Kidney International , vol.64 , pp. 459-467
    • Chen, X.1    Wang, J.2    Zhou, F.3    Wang, X.4    Feng, Z.5
  • 73
    • 77954730368 scopus 로고    scopus 로고
    • A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy
    • Pang M., Ma L., Gong R. A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney International 2010, 78:257-268.
    • (2010) Kidney International , vol.78 , pp. 257-268
    • Pang, M.1    Ma, L.2    Gong, R.3
  • 74
    • 63149096121 scopus 로고    scopus 로고
    • Cytokine profiling and Stat3 phosphorylation in epithelial-mesenchymal interactions between keloid keratinocytes and fibroblasts
    • Lim C.P., Phan T.T., Lim I.J., Cao X. Cytokine profiling and Stat3 phosphorylation in epithelial-mesenchymal interactions between keloid keratinocytes and fibroblasts. Journal of Investigative Dermatology 2008, 129:851-861.
    • (2008) Journal of Investigative Dermatology , vol.129 , pp. 851-861
    • Lim, C.P.1    Phan, T.T.2    Lim, I.J.3    Cao, X.4
  • 75
    • 77955500182 scopus 로고    scopus 로고
    • Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats
    • Meléndez G.C., McLarty J.L., Levick S.P., Du Y., Janicki J.S., Brower G.L. Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats. Hypertension 2010, 56:225-231.
    • (2010) Hypertension , vol.56 , pp. 225-231
    • Meléndez, G.C.1    McLarty, J.L.2    Levick, S.P.3    Du, Y.4    Janicki, J.S.5    Brower, G.L.6
  • 76
    • 84856076539 scopus 로고    scopus 로고
    • Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart
    • Mir S.A., Chatterjee A., Mitra A., Pathak K., Mahata S.K., Sarkar S. Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart. Journal of Biological Chemistry 2012, 287:2666-2677.
    • (2012) Journal of Biological Chemistry , vol.287 , pp. 2666-2677
    • Mir, S.A.1    Chatterjee, A.2    Mitra, A.3    Pathak, K.4    Mahata, S.K.5    Sarkar, S.6
  • 77
    • 0033829671 scopus 로고    scopus 로고
    • Increased levels of interleukin-6 are associated with lymphocytosis in bronchoalveolar lavage fluids of idiopathic nonspecific interstitial pneumonia
    • Park C.S., Chung S.W., Ki S.Y. Increased levels of interleukin-6 are associated with lymphocytosis in bronchoalveolar lavage fluids of idiopathic nonspecific interstitial pneumonia. American Journal of Respiratory and Critical Care Medicine 2000, 162:1162-1168.
    • (2000) American Journal of Respiratory and Critical Care Medicine , vol.162 , pp. 1162-1168
    • Park, C.S.1    Chung, S.W.2    Ki, S.Y.3
  • 78
    • 79960740114 scopus 로고    scopus 로고
    • Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury
    • Pedroza M., Schneider D.J., Karmouty-Quintana H. Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury. PLoS ONE 2011, 6:e22667.
    • (2011) PLoS ONE , vol.6
    • Pedroza, M.1    Schneider, D.J.2    Karmouty-Quintana, H.3
  • 79
    • 77953645116 scopus 로고    scopus 로고
    • Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor
    • McFarland-Mancini M.M., Funk H.M., Paluch A.M. Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. Journal of Immunology 2010, 184:7219-7228.
    • (2010) Journal of Immunology , vol.184 , pp. 7219-7228
    • McFarland-Mancini, M.M.1    Funk, H.M.2    Paluch, A.M.3
  • 80
    • 72549108357 scopus 로고    scopus 로고
    • Tumor necrosis factor-α processing inhibitor-1 inhibits skin fibrosis in a bleomycin-induced murine model of scleroderma
    • Terao M., Murota H., Kitaba S., Katayama I. Tumor necrosis factor-α processing inhibitor-1 inhibits skin fibrosis in a bleomycin-induced murine model of scleroderma. Experimental Dermatology 2010, 19:38-43.
    • (2010) Experimental Dermatology , vol.19 , pp. 38-43
    • Terao, M.1    Murota, H.2    Kitaba, S.3    Katayama, I.4
  • 81
    • 78049421175 scopus 로고    scopus 로고
    • The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab
    • Shima Y., Kuwahara Y., Murota H. The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab. Rheumatology (Oxford) 2010, 49:2408-2412.
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 2408-2412
    • Shima, Y.1    Kuwahara, Y.2    Murota, H.3
  • 82
    • 83455230778 scopus 로고    scopus 로고
    • Blockade of interleukin-6 receptor alleviates disease in mouse model of scleroderma
    • Kitaba S., Murota H., Terao M. Blockade of interleukin-6 receptor alleviates disease in mouse model of scleroderma. American Journal of Pathology 2012, 180:165-176.
    • (2012) American Journal of Pathology , vol.180 , pp. 165-176
    • Kitaba, S.1    Murota, H.2    Terao, M.3
  • 83
    • 0025734094 scopus 로고
    • Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA)
    • Lotz M., Guerne P.A. Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA). Journal of Biological Chemistry 1991, 266:2017-2020.
    • (1991) Journal of Biological Chemistry , vol.266 , pp. 2017-2020
    • Lotz, M.1    Guerne, P.A.2
  • 84
    • 0033198793 scopus 로고    scopus 로고
    • Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
    • Sano S., Itami S., Takeda K. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO Journal 1999, 18:4657-4668.
    • (1999) EMBO Journal , vol.18 , pp. 4657-4668
    • Sano, S.1    Itami, S.2    Takeda, K.3


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