Increased accumulation of extracellular thrombospondin-2 due to low degradation activity stimulates type i collagen expression in scleroderma fibroblasts

American Journal of Pathology

Volumn 180, Issue 2, 2012, Pages 703-714

  Kajihara, Ikko ^a   Jinnin, Masatoshi ^a   Yamane, Keitaro ^a   Makino, Takamitsu ^a   Honda, Noritoshi ^a   Igata, Toshikatsu ^a   Masuguchi, Shinichi ^a   Fukushima, Satoshi ^a   Okamoto, Yoshinobu ^b   Hasegawa, Minoru ^b   Fujimoto, Manabu ^b   Ihn, Hironobu ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; MESSENGER RNA; MICRORNA; MICRORNA 7; THROMBOSPONDIN 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL LYSATE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SCLERODERMA; SYSTEMIC SCLEROSIS; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CASE-CONTROL STUDIES; CELLS, CULTURED; COLLAGEN TYPE I; DOWN-REGULATION; EXTRACELLULAR MATRIX; FEMALE; FIBROBLASTS; HUMANS; MALE; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MICE; MICE, INBRED C57BL; MICRORNAS; MIDDLE AGED; RNA, MESSENGER; RNA, SMALL INTERFERING; SCLERODERMA, SYSTEMIC; SKIN; THROMBOSPONDINS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION; YOUNG ADULT;

EID: 84856013803     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.10.030     Document Type: Article

References (52)

1. J.H. Korn Immunologic aspects of scleroderma Curr Opin Rheumatol 1 1989 479 484
2. C. Mauch, T. Kreig Fibroblast-matrix interactions and their role in the pathogenesis of fibrosis Rheum Dis Clin North Am 16 1990 93 107
3. C. Mauch, E. Kozlowska, B. Eckes, T. Krieg Altered regulation of collagen metabolism in scleroderma fibroblasts grown within three-dimensional collagen gels Exp Dermatol 1 1992 185 190
4. A. Jelaska, M. Arakawa, G. Broketa, J.H. Korn Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts Arthritis Rheum 39 1996 1338 1346
5. J. Massagu The transforming growth factor-beta family Annu Rev Cell Biol 6 1990 597 641
6. E.C. LeRoy, E.A. Smith, M.B. Kahaleh, M. Trojanowska, R.M. Silver A strategy for determining the pathogenesis of systemic sclerosis Is transforming growth factor beta the answer? Arthritis Rheum 32 1989 817 825
7. E.C. LeRoy Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast J Clin Invest 54 1974 880 889
8. S.A. Jimenez, G. Feldman, R.I. Bashey, R. Bienkowski, J. Rosenbloom Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts Biochem J 237 1986 837 843
9. P. Bornstein, E.H. Sage Thrombospondins Methods Enzymol 245 1994 62 85
10. R.F. Macko, A.C. Gelber, B.A. Young, M.H. Lowitt, B. White, F.M. Wigley, S.E. Goldblum Increased circulating concentrations of the counteradhesive proteins SPARC and thrombospondin-1 in systemic sclerosis (scleroderma) Relationship to platelet and endothelial cell activation J Rheumatol 29 2002 2565 2570
11. Y. Mimura, H. Ihn, M. Jinnin, Y. Asano, K. Yamane, K. Tamaki Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-beta signaling in cultured scleroderma fibroblasts Am J Pathol 166 2005 1451 1463
12. R. Hesselstrand, A. Kassner, D. Heinegrd, T. Saxne COMP: a candidate molecule in the pathogenesis of systemic sclerosis with a potential as a disease marker Ann Rheum Dis 67 2008 1242 1248
13. G. Farina, R. Lemaire, J.H. Korn, R.L. Widom Cartilage oligomeric matrix protein is overexpressed by scleroderma dermal fibroblasts Matrix Biol 25 2006 213 222
14. P. Bornstein, A. Agah, T.R. Kyriakides The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury [Erratum appeared in Int J Biochem Cell Biol 2005, 37:239240] Int J Biochem Cell Biol 36 2004 1115 1125
15. Z. Yang, T.R. Kyriakides, P. Bornstein Matricellular proteins as modulators of cell-matrix interactions: adhesive defect in thrombospondin 2-null fibroblasts is a consequence of increased levels of matrix metalloproteinase-2 Mol Biol Cell 11 2000 3353 3364
16. L.C. Armstrong, B. Bjrkblom, K.D. Hankenson, A.W. Siadak, C.E. Stiles, P. Bornstein Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism Mol Biol Cell 13 2002 1893 1905
17. E.C. LeRoy, C. Black, R. Fleischmajer, S. Jablonska, T. Krieg, T.A. Medsger, N. Rowell, F. Wollheim Scleroderma (systemic sclerosis): classification, subsets and pathogenesis J Rheumatol 15 1988 202 205
18. M. Jinnin, T. Makino, I. Kajihara, N. Honda, K. Makino, A. Ogata, H. Ihn Serum levels of soluble vascular endothelial growth factor receptor-2 in patients with systemic sclerosis Br J Dermatol 162 2010 751 758
19. H. Ihn, E.C. LeRoy, M. Trojanowska Oncostatin M stimulates transcription of the human alpha2(I) collagen gene via the Sp1/Sp3-binding site J Biol Chem 272 1997 24666 24672
20. T. Makino, M. Jinnin, F.C. Muchemwa, S. Fukushima, H. Kogushi-Nishi, C. Moriya, T. Igata, A. Fujisawa, T. Johno, H. Ihn Basic fibroblast growth factor stimulates the proliferation of human dermal fibroblasts via the ERK1/2 and JNK pathways Br J Dermatol 162 2010 717 723
21. T. Igata, M. Jinnin, T. Makino, C. Moriya, F.C. Muchemwa, T. Ishihara, H. Ihn Up-regulated type I collagen expression by the inhibition of Rac1 signaling pathway in human dermal fibroblasts Biochem Biophys Res Commun 393 2010 101 105
22. J.A. Handy, N.K. Saxena, P. Fu, S. Lin, J.E. Mells, N.A. Gupta, F.A. Anania Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3) [Erratum appeared in J Cell Biochem 2011 Feb;112(2):734] J Cell Biochem 110 2010 1195 1207
23. N. Higashi-Kuwata, M. Jinnin, T. Makino, S. Fukushima, Y. Inoue, F.C. Muchemwa, Y. Yonemura, Y. Komohara, M. Takeya, H. Mitsuya, H. Ihn Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis Arthritis Res Ther 12 2010 R128
24. T. Yamamoto, S. Takagawa, I. Katayama, K. Yamazaki, Y. Hamazaki, H. Shinkai, K. Nishioka Animal model of sclerotic skin I: local injections of bleomycin induce sclerotic skin mimicking scleroderma J Invest Dermatol 112 1999 456 462
25. C. Tanaka, M. Fujimoto, Y. Hamaguchi, S. Sato, K. Takehara, M. Hasegawa Inducible costimulator ligand regulates bleomycin-induced lung and skin fibrosis in a mouse model independently of the inducible costimulator/inducible costimulator ligand pathway Arthritis Rheum 62 2010 1723 1732
26. C.D. Pacheco, R. Kunkel, A.P. Lieberman Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects Hum Mol Genet 16 2007 1495 1503
27. X. Su, L. Ao, N. Zou, Y. Song, X. Yang, G.Y. Cai, D.A. Fullerton, X. Meng Post-transcriptional regulation of TNF-induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells: an obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27 Biochim Biophys Acta 1783 2008 1623 1631
28. H. Yan, A.J. Choi, B.H. Lee, A.H. Ting Identification and functional analysis of epigenetically silenced microRNAs in colorectal cancer cells PLoS One 6 2011 e20628
29. T. Nakashima, M. Jinnin, T. Etoh, S. Fukushima, S. Masuguchi, K. Maruo, Y. Inoue, T. Ishihara, H. Ihn Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy PLoS One 5 2010 e14334
30. M. Jinnin, H. Ihn, Y. Asano, K. Yamane, M. Trojanowska, K. Tamaki Platelet derived growth factor induced tenascin-C transcription is phosphoinositide 3-kinase/Akt-dependent and mediated by Ets family transcription factors J Cell Physiol 206 2006 718 727
31. A. Albini, R. Benelli, D.M. Noonan, C. Brigati The "chemoinvasion assay": a tool to study tumor and endothelial cell invasion of basement membranes Int J Dev Biol 48 2004 563 571
32. M.M. Martin, J.A. Buckenberger, J. Jiang, G.E. Malana, G.J. Nuovo, M. Chotani, D.S. Feldman, T.D. Schmittgen, T.S. Elton The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding J Biol Chem 282 2007 24262 24269
33. G.J. Nuovo In situ detection of precursor and mature microRNAs in paraffin embedded, formalin fixed tissues and cell preparations Methods 44 2008 39 46
34. K. Kuroda, H. Shinkai Gene expression of types I and III collagen, decorin, matrix metalloproteinases and tissue inhibitors of metalloproteinases in skin fibroblasts from patients with systemic sclerosis Arch Dermatol Res 289 1997 567 572
35. A. Prudova, U. auf dem Keller, G.S. Butler, C.M. Overall Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics Mol Cell Proteomics 9 2010 894 911
36. B.P. Lewis, C.B. Burge, D.P. Bartel Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 120 2005 15 20
37. B. Maurer, J. Stanczyk, A. Jngel, A. Akhmetshina, M. Trenkmann, M. Brock, O. Kowal-Bielecka, R.E. Gay, B.A. Michel, J.H. Distler, S. Gay, O. Distler MicroRNA-29, a key regulator of collagen expression in systemic sclerosis Arthritis Rheum 62 2010 1733 1743
38. G. Liu, A. Friggeri, Y. Yang, J. Milosevic, Q. Ding, V.J. Thannickal, N. Kaminski, E. Abraham miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis J Exp Med 207 2010 1589 1597
39. S.K. Venugopal, J. Jiang, T.H. Kim, Y. Li, S.S. Wang, N.J. Torok, J. Wu, M.A. Zern Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation Am J Physiol Gastrointest Liver Physiol 298 2010 G101 G106
40. M. Kato, J. Zhang, M. Wang, L. Lanting, H. Yuan, J.J. Rossi, R. Natarajan MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors Proc Natl Acad Sci USA 104 2007 3432 3437
41. Y. Chen, X. Shi-wen, M. Eastwood, C.M. Black, C.P. Denton, A. Leask, D.J. Abraham Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts Arthritis Rheum 54 2006 1309 1316
42. A.M. Holmes, M. Ponticos, X. Shi-Wen, C.P. Denton, D.J. Abraham Elevated CCN2 expression in scleroderma: a putative role for the TGFβ accessory receptors TGFβRIII and endoglin J Cell Commun Signal 5 2011 173 177
43. I. Ellis, A.M. Grey, A.M. Schor, S.L. Schor Antagonistic effects of TGF-beta 1 and MSF on fibroblast migration and hyaluronic acid synthesis Possible implications for dermal wound healing J Cell Sci 102 1992 447 456
44. A. Kuehbacher, C. Urbich, S. Dimmeler Targeting microRNA expression to regulate angiogenesis Trends Pharmacol Sci 29 2008 12 15
45. Y. Chen, D.H. Gorski Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5 Blood 111 2008 1217 1226
46. V. Furer, J.D. Greenberg, M. Attur, S.B. Abramson, M.H. Pillinger The role of microRNA in rheumatoid arthritis and other autoimmune diseases Clin Immunol 136 2010 1 15
47. L.F. Lu, A. Liston MicroRNA in the immune system, microRNA as an immune system Immunology 127 2009 291 298
48. J. Davidson-Moncada, F.N. Papavasiliou, W. Tam MicroRNAs of the immune system: roles in inflammation and cancer Ann N Y Acad Sci 1183 2010 183 194
49. A. Leask, D.J. Abraham, D.R. Finlay, A. Holmes, D. Pennington, X. Shi-Wen, Y. Chen, K. Venstrom, X. Dou, M. Ponticos, C. Black, C. Bernabeu, J.K. Jackman, P.R. Findell, M.K. Connolly Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts [Erratum appeared in Arthritis Rheum 2002, 46:2830] Arthritis Rheum 46 2002 1857 1865
50. S. Schultz-Cherry, H. Chen, D.F. Mosher, T.M. Misenheimer, H.C. Krutzsch, D.D. Roberts, J.E. Murphy-Ullrich Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1 J Biol Chem 270 1995 7304 7310
51. T.R. Kyriakides, Y.H. Zhu, L.T. Smith, S.D. Bain, Z. Yang, M.T. Lin, K.G. Danielson, R.V. Iozzo, M. LaMarca, C.E. McKinney, E.I. Ginns, P. Bornstein Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis J Cell Biol 140 1998 419 430
52. M. Streit, L. Riccardi, P. Velasco, L.F. Brown, T. Hawighorst, P. Bornstein, M. Detmar Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis Proc Natl Acad Sci USA 96 1999 14888 14893