Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling

Molecular Metabolism

Volumn 3, Issue 7, 2014, Pages 754-769

  Schugar, Rebecca C ^a   Moll, Ashley R ^a   Andre d'Avignon D ^b   Weinheimer, Carla J ^a   Kovacs, Attila ^a   Crawford, Peter A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

Mitochondrial metabolism; Myocardial ketone body metabolism; Nuclear magnetic resonance (NMR) measurement of substrate metabolism; Oxidative stress; Ventricular remodeling

Indexed keywords

3 OXOACID COENZYME A TRANSFERASE; GLYCOGEN; MYOSIN HEAVY CHAIN ALPHA; NICOTINAMIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL CELL; AORTA CONSTRICTION; ARTICLE; BIOENERGY; CONTROLLED STUDY; DECARBOXYLATION; ECHOCARDIOGRAPHY; ENERGY METABOLISM; ENZYME ACTIVITY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GLUCOSE METABOLISM; GLYCOLYSIS; HEART AFTERLOAD; HEART EJECTION FRACTION; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE OVERLOAD; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART PERFUSION; HEART RATE; HEART VENTRICLE REMODELING; HEMODYNAMICS; HISTOPATHOLOGY; IMMUNOBLOTTING; ISOLATED HEART; KETOACIDOSIS; KETOGENESIS; KETOGENIC DIET; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; MYOFILAMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PERINATAL PERIOD; PROTEIN ACETYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; SYSTOLE; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84908143721     PISSN: None     EISSN: 22128778     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.07.010     Document Type: Article

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