메뉴 건너뛰기




Volumn 13, Issue 1, 2014, Pages

Mitochondrial dysfunction in obesity: Potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome

Author keywords

Co enzyme Q10; Inflammation; Metabolic syndrome; Obesity; Oxidative stress

Indexed keywords

PLACEBO; UBIDECARENONE;

EID: 84908143345     PISSN: None     EISSN: 22516581     Source Type: Journal    
DOI: 10.1186/2251-6581-13-60     Document Type: Review
Times cited : (67)

References (146)
  • 1
    • 67650333178 scopus 로고    scopus 로고
    • A comprehensive definition for metabolic syndrome
    • 2675814, 19407331
    • Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech 2009, 2:231-237. 10.1242/dmm.001180, 2675814, 19407331.
    • (2009) Dis Model Mech , vol.2 , pp. 231-237
    • Huang, P.L.1
  • 2
    • 67349091737 scopus 로고    scopus 로고
    • Oxidative stress and metabolic syndrome
    • 19281826
    • Roberts CK, Sindhu KK. Oxidative stress and metabolic syndrome. Life Sci 2009, 84:705-712. 10.1016/j.lfs.2009.02.026, 19281826.
    • (2009) Life Sci , vol.84 , pp. 705-712
    • Roberts, C.K.1    Sindhu, K.K.2
  • 3
    • 72649106550 scopus 로고    scopus 로고
    • A novel component of the metabolic syndrome: the oxidative stress
    • 19747805
    • Hopps E, Noto D, Caimi G, Averna MR. A novel component of the metabolic syndrome: the oxidative stress. Nutr Metab Cardiovasc Dis 2010, 20:72-77. 10.1016/j.numecd.2009.06.002, 19747805.
    • (2010) Nutr Metab Cardiovasc Dis , vol.20 , pp. 72-77
    • Hopps, E.1    Noto, D.2    Caimi, G.3    Averna, M.R.4
  • 4
    • 77954859197 scopus 로고    scopus 로고
    • The role of mitochondria in the pathogenesis of type 2 diabetes
    • Patti M-E, Corvera S. The role of mitochondria in the pathogenesis of type 2 diabetes. Endocrine Rev 2010, 31:364-395.
    • (2010) Endocrine Rev , vol.31 , pp. 364-395
    • Patti, M.-E.1    Corvera, S.2
  • 5
    • 0028587742 scopus 로고
    • Tumor necrosis factor alpha: a key component of the obesity-diabetes link
    • Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 1994, 43:1271-1278.
    • (1994) Diabetes , vol.43 , pp. 1271-1278
    • Hotamisligil, G.S.1    Spiegelman, B.M.2
  • 6
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • 296995, 14679176
    • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003, 112:1796-1808. 10.1172/JCI200319246, 296995, 14679176.
    • (2003) J Clin Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3    Rosenbaum, M.4    Leibel, R.L.5    Ferrante, A.W.6
  • 7
    • 18244372432 scopus 로고    scopus 로고
    • Mechanisms of insulin resistance in humans and possible links with inflammation
    • 15824195
    • Savage DB, Petersen KF, Shulman GI. Mechanisms of insulin resistance in humans and possible links with inflammation. Hypertension 2005, 45:828-833. 10.1161/01.HYP.0000163475.04421.e4, 15824195.
    • (2005) Hypertension , vol.45 , pp. 828-833
    • Savage, D.B.1    Petersen, K.F.2    Shulman, G.I.3
  • 8
    • 34147125312 scopus 로고    scopus 로고
    • Defective mitochondrial biogenesis
    • 17395885
    • Nisoli E, Clementi E, Carruba MO, Moncada S. Defective mitochondrial biogenesis. Circ Res 2007, 100:795-806. 10.1161/01.RES.0000259591.97107.6c, 17395885.
    • (2007) Circ Res , vol.100 , pp. 795-806
    • Nisoli, E.1    Clementi, E.2    Carruba, M.O.3    Moncada, S.4
  • 11
    • 77954560505 scopus 로고    scopus 로고
    • Clinical aspects of coenzyme Q-10; in relationship with its bioenergetic and antioxidant properties
    • Netherlands: Springer, Gvozdjakova A
    • Littarru GP, Tiano L. Clinical aspects of coenzyme Q-10; in relationship with its bioenergetic and antioxidant properties. Mitochondrial Medicine 2008, 303-321. Netherlands: Springer, Gvozdjakova A.
    • (2008) Mitochondrial Medicine , pp. 303-321
    • Littarru, G.P.1    Tiano, L.2
  • 12
    • 77949562391 scopus 로고    scopus 로고
    • Coenzyme Q10 contents in foods and fortification strategies
    • 20301015
    • Pravst I, Žmitek K, Žmitek J. Coenzyme Q10 contents in foods and fortification strategies. Crit Rev Food Sci Nutr 2010, 50:269-280. 10.1080/10408390902773037, 20301015.
    • (2010) Crit Rev Food Sci Nutr , vol.50 , pp. 269-280
    • Pravst, I.1    Žmitek, K.2    Žmitek, J.3
  • 13
    • 0030867199 scopus 로고    scopus 로고
    • Coenzyme Q10 in the diet-daily intake and relative bioavailability
    • Weber C, Bysted A, Hølmer G. Coenzyme Q10 in the diet-daily intake and relative bioavailability. Mol Aspects Med 1997, 18(Supplement 1):251-254.
    • (1997) Mol Aspects Med , vol.18 , pp. 251-254
    • Weber, C.1    Bysted, A.2    Hølmer, G.3
  • 14
    • 0025195880 scopus 로고
    • Co-enzyme Q10: a new drug for cardiovascular disease
    • 2202752
    • Greenberg S, Frishman WH. Co-enzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol 1990, 30:596-608. 10.1002/j.1552-4604.1990.tb01862.x, 2202752.
    • (1990) J Clin Pharmacol , vol.30 , pp. 596-608
    • Greenberg, S.1    Frishman, W.H.2
  • 15
    • 33645099245 scopus 로고    scopus 로고
    • Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics
    • 16551570
    • Bhagavan HN, Chopra RK. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res 2006, 40:445-453. 10.1080/10715760600617843, 16551570.
    • (2006) Free Radic Res , vol.40 , pp. 445-453
    • Bhagavan, H.N.1    Chopra, R.K.2
  • 16
    • 0026636509 scopus 로고
    • Distribution and redox state of ubiquinones in rat and human tissues
    • 1586151
    • Aberg F, Appelkvist EL, Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. Arch Biochem Biophys 1992, 295:230-234. 10.1016/0003-9861(92)90511-T, 1586151.
    • (1992) Arch Biochem Biophys , vol.295 , pp. 230-234
    • Aberg, F.1    Appelkvist, E.L.2    Dallner, G.3    Ernster, L.4
  • 17
    • 0025176546 scopus 로고
    • Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy
    • 2305693
    • Langsjoen PH, Langsjoen PH, Folkers K. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1990, 65:521-523. 10.1016/0002-9149(90)90824-K, 2305693.
    • (1990) Am J Cardiol , vol.65 , pp. 521-523
    • Langsjoen, P.H.1    Langsjoen, P.H.2    Folkers, K.3
  • 19
    • 0032470151 scopus 로고    scopus 로고
    • Coenzyme Q10 in cardiovascular disease with emphasis on heart failure and myocardial ischaemia
    • Langsjoen PH, Langsjoen AM. Coenzyme Q10 in cardiovascular disease with emphasis on heart failure and myocardial ischaemia. Asia Pacific Heart J 1998, 7:160-168.
    • (1998) Asia Pacific Heart J , vol.7 , pp. 160-168
    • Langsjoen, P.H.1    Langsjoen, A.M.2
  • 20
    • 0033796008 scopus 로고    scopus 로고
    • Regulation of ubiquinone metabolism
    • 11035257
    • Dallner G, Sindelar PJ. Regulation of ubiquinone metabolism. Free Radic Biol Med 2000, 29:285-294. 10.1016/S0891-5849(00)00307-5, 11035257.
    • (2000) Free Radic Biol Med , vol.29 , pp. 285-294
    • Dallner, G.1    Sindelar, P.J.2
  • 21
    • 24944584210 scopus 로고    scopus 로고
    • Mitochondrial dysfunction induces triglyceride accumulation in 3 T3-L1 cells: role of fatty acid beta-oxidation and glucose
    • 15741651
    • Vankoningsloo S, Piens M, Lecocq C, Gilson A, De Pauw A, Renard P, Demazy C, Houbion A, Raes M, Arnould T. Mitochondrial dysfunction induces triglyceride accumulation in 3 T3-L1 cells: role of fatty acid beta-oxidation and glucose. J Lipid Res 2005, 46:1133-1149. 10.1194/jlr.M400464-JLR200, 15741651.
    • (2005) J Lipid Res , vol.46 , pp. 1133-1149
    • Vankoningsloo, S.1    Piens, M.2    Lecocq, C.3    Gilson, A.4    De Pauw, A.5    Renard, P.6    Demazy, C.7    Houbion, A.8    Raes, M.9    Arnould, T.10
  • 23
    • 44649151707 scopus 로고    scopus 로고
    • The PPAR trio: regulators of myocardial energy metabolism in health and disease
    • 18462747
    • Madrazo JA, Kelly DP. The PPAR trio: regulators of myocardial energy metabolism in health and disease. J Mol Cell Cardiol 2008, 44:968-975. 10.1016/j.yjmcc.2008.03.021, 18462747.
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 968-975
    • Madrazo, J.A.1    Kelly, D.P.2
  • 24
    • 15044339157 scopus 로고    scopus 로고
    • Role of the PPAR family of nuclear receptors in the regulation of metabolic and cardiovascular homeostasis: new approaches to therapy
    • 15780828
    • Chinetti-Gbaguidi G, Fruchart J-C, Staels B. Role of the PPAR family of nuclear receptors in the regulation of metabolic and cardiovascular homeostasis: new approaches to therapy. Curr Opin Pharmacol 2005, 5:177-183. 10.1016/j.coph.2004.11.004, 15780828.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 177-183
    • Chinetti-Gbaguidi, G.1    Fruchart, J.-C.2    Staels, B.3
  • 25
    • 77449139468 scopus 로고    scopus 로고
    • PGC-1α activation as a therapeutic approach in mitochondrial disease
    • 19859975
    • Wenz T. PGC-1α activation as a therapeutic approach in mitochondrial disease. Iubmb Life 2009, 61:1051-1062. 10.1002/iub.261, 19859975.
    • (2009) Iubmb Life , vol.61 , pp. 1051-1062
    • Wenz, T.1
  • 26
    • 49649128985 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and healthy aging
    • 2562606, 18662766
    • López-Lluch G, Irusta PM, Navas P, de Cabo R. Mitochondrial biogenesis and healthy aging. Exp Gerontol 2008, 43:813-819. 10.1016/j.exger.2008.06.014, 2562606, 18662766.
    • (2008) Exp Gerontol , vol.43 , pp. 813-819
    • López-Lluch, G.1    Irusta, P.M.2    Navas, P.3    de Cabo, R.4
  • 27
    • 0037322888 scopus 로고    scopus 로고
    • Exercise induces transient transcriptional activation of the PGC-1α gene in human skeletal muscle
    • 2342594, 12563009
    • Pilegaard H, Saltin B, Neufer PD. Exercise induces transient transcriptional activation of the PGC-1α gene in human skeletal muscle. J Physiol 2003, 546:851-858. 10.1113/jphysiol.2002.034850, 2342594, 12563009.
    • (2003) J Physiol , vol.546 , pp. 851-858
    • Pilegaard, H.1    Saltin, B.2    Neufer, P.D.3
  • 28
    • 77954909425 scopus 로고    scopus 로고
    • PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity
    • 2928513, 20371735
    • Lira VA, Benton CR, Yan Z, Bonen A. PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab 2010, 299:E145-E161. 2928513, 20371735.
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , pp. E145-E161
    • Lira, V.A.1    Benton, C.R.2    Yan, Z.3    Bonen, A.4
  • 29
    • 31344433403 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity
    • 16424281
    • Corton JC, Brown-Borg HM. Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity. J Gerontol A Biol Sci Med Sci 2005, 60:1494-1509. 10.1093/gerona/60.12.1494, 16424281.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 1494-1509
    • Corton, J.C.1    Brown-Borg, H.M.2
  • 30
    • 42049114658 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components
    • 18211970
    • Bastin J, Aubey F, Rötig A, Munnich A, Djouadi F. Activation of peroxisome proliferator-activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components. J Clin Endocrinol Metab 2008, 93:1433-1441. 10.1210/jc.2007-1701, 18211970.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1433-1441
    • Bastin, J.1    Aubey, F.2    Rötig, A.3    Munnich, A.4    Djouadi, F.5
  • 33
    • 0141610413 scopus 로고
    • Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy
    • 286916, 2928337
    • Ogasahara S, Engel AG, Frens D, Mack D. Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy. Proc Natl Acad Sci 1989, 86:2379-2382. 10.1073/pnas.86.7.2379, 286916, 2928337.
    • (1989) Proc Natl Acad Sci , vol.86 , pp. 2379-2382
    • Ogasahara, S.1    Engel, A.G.2    Frens, D.3    Mack, D.4
  • 34
    • 4143093775 scopus 로고    scopus 로고
    • Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults
    • 15313151
    • Miles MV, Horn PS, Tang PH, Morrison JA, Miles L, DeGrauw T, Pesce AJ. Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults. Clin Chim Acta 2004, 347:139-144. 10.1016/j.cccn.2004.04.003, 15313151.
    • (2004) Clin Chim Acta , vol.347 , pp. 139-144
    • Miles, M.V.1    Horn, P.S.2    Tang, P.H.3    Morrison, J.A.4    Miles, L.5    DeGrauw, T.6    Pesce, A.J.7
  • 35
    • 4744359658 scopus 로고    scopus 로고
    • Comparison of coenzyme Q10 plasma levels in obese and normal weight children
    • 15469864
    • Menke T, Niklowitz P, de Sousa G, Reinehr T, Andler W. Comparison of coenzyme Q10 plasma levels in obese and normal weight children. Clin Chim Acta 2004, 349:121-127. 10.1016/j.cccn.2004.06.015, 15469864.
    • (2004) Clin Chim Acta , vol.349 , pp. 121-127
    • Menke, T.1    Niklowitz, P.2    de Sousa, G.3    Reinehr, T.4    Andler, W.5
  • 36
    • 7944229937 scopus 로고    scopus 로고
    • Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the 'recoupling hypothesis'
    • 15256611
    • Chew GT, Watts GF. Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the 'recoupling hypothesis'. QJM 2004, 97:537-548. 10.1093/qjmed/hch089, 15256611.
    • (2004) QJM , vol.97 , pp. 537-548
    • Chew, G.T.1    Watts, G.F.2
  • 37
    • 0030607116 scopus 로고    scopus 로고
    • Plasma ubiquinol/cholesterol ratios in patients with hyperlipidaemia, those with diabetes mellitus and in patients requiring dialysis
    • 8879843
    • McDonnell MG, Archbold GPR. Plasma ubiquinol/cholesterol ratios in patients with hyperlipidaemia, those with diabetes mellitus and in patients requiring dialysis. Clin Chim Acta 1996, 253:117-126. 10.1016/0009-8981(96)06357-7, 8879843.
    • (1996) Clin Chim Acta , vol.253 , pp. 117-126
    • McDonnell, M.G.1    Archbold, G.P.R.2
  • 38
    • 33751233521 scopus 로고    scopus 로고
    • Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q10
    • 17116186
    • Lim SC, Tan HH, Goh SK, Subramaniam T, Sum CF, Tan IK, Lee BL, Ong CN. Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q10. Diabetic Med 2006, 23:1344-1349. 10.1111/j.1464-5491.2006.01996.x, 17116186.
    • (2006) Diabetic Med , vol.23 , pp. 1344-1349
    • Lim, S.C.1    Tan, H.H.2    Goh, S.K.3    Subramaniam, T.4    Sum, C.F.5    Tan, I.K.6    Lee, B.L.7    Ong, C.N.8
  • 39
    • 67649534542 scopus 로고    scopus 로고
    • Malondialdehyde and coenzyme Q10 in platelets and serum in type 2 diabetes mellitus: correlation with glycemic control
    • 210, 19530339
    • El-ghoroury EA, Raslan HM, Badawy EA, El-Saaid GS, Agybi MH, Siam I, Salem SI. Malondialdehyde and coenzyme Q10 in platelets and serum in type 2 diabetes mellitus: correlation with glycemic control. Blood Coagul Fibrinolysis 2009, 20:248-251. 210, 10.1097/MBC.0b013e3283254549, 19530339.
    • (2009) Blood Coagul Fibrinolysis , vol.20 , pp. 248-251
    • El-ghoroury, E.A.1    Raslan, H.M.2    Badawy, E.A.3    El-Saaid, G.S.4    Agybi, M.H.5    Siam, I.6    Salem, S.I.7
  • 40
    • 56649118739 scopus 로고    scopus 로고
    • Antioxidant level and redox status of coenzyme Q10 in the plasma and blood cells of children with diabetes mellitus type 1
    • 18694454
    • Menke T, Niklowitz P, Wiesel T, Andler W. Antioxidant level and redox status of coenzyme Q10 in the plasma and blood cells of children with diabetes mellitus type 1. Pediatr Diabetes 2008, 9:540-545. 10.1111/j.1399-5448.2008.00389.x, 18694454.
    • (2008) Pediatr Diabetes , vol.9 , pp. 540-545
    • Menke, T.1    Niklowitz, P.2    Wiesel, T.3    Andler, W.4
  • 41
    • 7944221535 scopus 로고    scopus 로고
    • Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction
    • 15541254
    • Silver MA, Langsjoen PH, Szabo S, Patil H, Zelinger A. Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction. Am J Cardiol 2004, 94:1306-1310. 10.1016/j.amjcard.2004.07.121, 15541254.
    • (2004) Am J Cardiol , vol.94 , pp. 1306-1310
    • Silver, M.A.1    Langsjoen, P.H.2    Szabo, S.3    Patil, H.4    Zelinger, A.5
  • 44
    • 27644465314 scopus 로고    scopus 로고
    • Statin-associated myopathy with normal creatine kinase levels. Case report from a Norwegian family
    • 16218940
    • Troseid M, Henriksen OA, Lindal S. Statin-associated myopathy with normal creatine kinase levels. Case report from a Norwegian family. APMIS 2005, 113:635-637. 10.1111/j.1600-0463.2005.apm_270.x, 16218940.
    • (2005) APMIS , vol.113 , pp. 635-637
    • Troseid, M.1    Henriksen, O.A.2    Lindal, S.3
  • 46
    • 34247639532 scopus 로고    scopus 로고
    • Effect of coenzyme q10 on myopathic symptoms in patients treated with statins
    • 17493470
    • Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme q10 on myopathic symptoms in patients treated with statins. Am J Cardiol 2007, 99:1409-1412. 10.1016/j.amjcard.2006.12.063, 17493470.
    • (2007) Am J Cardiol , vol.99 , pp. 1409-1412
    • Caso, G.1    Kelly, P.2    McNurlan, M.A.3    Lawson, W.E.4
  • 47
    • 0022021457 scopus 로고
    • Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10
    • 397155, 3856239
    • Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci 1985, 82:901-904. 10.1073/pnas.82.3.901, 397155, 3856239.
    • (1985) Proc Natl Acad Sci , vol.82 , pp. 901-904
    • Folkers, K.1    Vadhanavikit, S.2    Mortensen, S.A.3
  • 50
    • 0015436711 scopus 로고
    • Vitamin E and free radical peroxidation of lipids
    • 4572176
    • Tappel AL. Vitamin E and free radical peroxidation of lipids. Ann N Y Acad Sci 1972, 203:12-28. 10.1111/j.1749-6632.1972.tb27851.x, 4572176.
    • (1972) Ann N Y Acad Sci , vol.203 , pp. 12-28
    • Tappel, A.L.1
  • 51
    • 0025979077 scopus 로고
    • Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol
    • 51081, 2000375
    • Stocker R, Bowry VW, Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci 1991, 88:1646-1650. 10.1073/pnas.88.5.1646, 51081, 2000375.
    • (1991) Proc Natl Acad Sci , vol.88 , pp. 1646-1650
    • Stocker, R.1    Bowry, V.W.2    Frei, B.3
  • 53
    • 34248161002 scopus 로고    scopus 로고
    • Coenzyme Q, oxidative stress and aging
    • 1978491, 17482528
    • Sohal RS, Forster MJ. Coenzyme Q, oxidative stress and aging. Mitochondrion 2007, 7(Suppl):S103-S111. 1978491, 17482528.
    • (2007) Mitochondrion , vol.7 , pp. S103-S111
    • Sohal, R.S.1    Forster, M.J.2
  • 54
    • 77953034200 scopus 로고    scopus 로고
    • Chain-breaking antioxidant activity of reduced forms of mitochondria-targeted quinones, a novel type of geroprotectors
    • 2830047, 20195487
    • Roginsky VA, Tashlitsky VN, Skulachev VP. Chain-breaking antioxidant activity of reduced forms of mitochondria-targeted quinones, a novel type of geroprotectors. Aging 2009, 1:481-489. 2830047, 20195487.
    • (2009) Aging , vol.1 , pp. 481-489
    • Roginsky, V.A.1    Tashlitsky, V.N.2    Skulachev, V.P.3
  • 55
    • 56249128541 scopus 로고    scopus 로고
    • Mechanism of the neuroprotective role of coenzyme Q10 with or without L-dopa in rotenone-induced parkinsonism
    • Abdin AA, Hamouda HE. Mechanism of the neuroprotective role of coenzyme Q10 with or without L-dopa in rotenone-induced parkinsonism. Neuropharmacol 2008, 55:1340-1346.
    • (2008) Neuropharmacol , vol.55 , pp. 1340-1346
    • Abdin, A.A.1    Hamouda, H.E.2
  • 56
    • 0033216635 scopus 로고    scopus 로고
    • Coenzyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes
    • 10569635
    • Tomasetti M, Littarru GP, Stocker R, Alleva R. Coenzyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes. Free Radic Biol Med 1999, 27:1027-1032. 10.1016/S0891-5849(99)00132-X, 10569635.
    • (1999) Free Radic Biol Med , vol.27 , pp. 1027-1032
    • Tomasetti, M.1    Littarru, G.P.2    Stocker, R.3    Alleva, R.4
  • 57
    • 0035378494 scopus 로고    scopus 로고
    • In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage
    • Tomasetti M, Alleva R, Borghi B, Collins AR. In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage. FASEB J 2001, 15:1425-1427.
    • (2001) FASEB J , vol.15 , pp. 1425-1427
    • Tomasetti, M.1    Alleva, R.2    Borghi, B.3    Collins, A.R.4
  • 58
    • 29944435940 scopus 로고    scopus 로고
    • Effect of coenzyme Q10 on catalase activity and other antioxidant parameters in streptozotocin-induced diabetic rats
    • 16388100
    • Modi K, Santani DD, Goyal RK, Bhatt PA. Effect of coenzyme Q10 on catalase activity and other antioxidant parameters in streptozotocin-induced diabetic rats. Biol Trace Elem Res 2006, 109:25-34. 10.1385/BTER:109:1:025, 16388100.
    • (2006) Biol Trace Elem Res , vol.109 , pp. 25-34
    • Modi, K.1    Santani, D.D.2    Goyal, R.K.3    Bhatt, P.A.4
  • 59
    • 84855221555 scopus 로고    scopus 로고
    • Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity
    • 22222558
    • Fouad AA, Jresat I. Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity. Environ Toxicol Pharmacol 2012, 33:158-167. 10.1016/j.etap.2011.12.011, 22222558.
    • (2012) Environ Toxicol Pharmacol , vol.33 , pp. 158-167
    • Fouad, A.A.1    Jresat, I.2
  • 60
    • 84856482639 scopus 로고    scopus 로고
    • Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease
    • 21996047
    • Lee B-J, Huang Y-C, Chen S-J, Lin P-T. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition 2012, 28:250-255. 10.1016/j.nut.2011.06.004, 21996047.
    • (2012) Nutrition , vol.28 , pp. 250-255
    • Lee, B.-J.1    Huang, Y.-C.2    Chen, S.-J.3    Lin, P.-T.4
  • 61
    • 0030031771 scopus 로고    scopus 로고
    • Coexpression of heat-shock protein 60 and intercellular-adhesion molecule-1 is related to increased adhesion of monocytes and T cells to aortic endothelium of rats in response to endotoxin
    • Seitz CS, Kleindienst R, Xu Q, Wick G. Coexpression of heat-shock protein 60 and intercellular-adhesion molecule-1 is related to increased adhesion of monocytes and T cells to aortic endothelium of rats in response to endotoxin. Lab Invest 1996, 74:241-252.
    • (1996) Lab Invest , vol.74 , pp. 241-252
    • Seitz, C.S.1    Kleindienst, R.2    Xu, Q.3    Wick, G.4
  • 63
    • 18244370762 scopus 로고    scopus 로고
    • Inflammation, stress, and diabetes
    • 1087185, 15864338
    • Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 2005, 115:1111-1119. 10.1172/JCI200525102, 1087185, 15864338.
    • (2005) J Clin Invest , vol.115 , pp. 1111-1119
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 64
    • 33845542363 scopus 로고    scopus 로고
    • Weight gain induced by high-fat feeding involves increased liver oxidative stress
    • 16899792
    • Milagro FI, Campion J, Martinez JA. Weight gain induced by high-fat feeding involves increased liver oxidative stress. Obesity 2006, 14:1118-1123. 10.1038/oby.2006.128, 16899792.
    • (2006) Obesity , vol.14 , pp. 1118-1123
    • Milagro, F.I.1    Campion, J.2    Martinez, J.A.3
  • 65
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterol 2007, 132:2169-2180.
    • (2007) Gastroenterol , vol.132 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 66
    • 34548400409 scopus 로고    scopus 로고
    • Inflammation and obesity: stamping out insulin resistance?
    • 17646847
    • Abedini A, Shoelson SE. Inflammation and obesity: stamping out insulin resistance?. Immunol Cell Biol 2007, 85:399-400. 10.1038/sj.icb.7100107, 17646847.
    • (2007) Immunol Cell Biol , vol.85 , pp. 399-400
    • Abedini, A.1    Shoelson, S.E.2
  • 68
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • 1440292, 15685173
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 2005, 11:183-190. 10.1038/nm1166, 1440292, 15685173.
    • (2005) Nat Med , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 70
    • 69549105884 scopus 로고    scopus 로고
    • Abdominal adiposity is associated with elevated C-reactive protein independent of BMI in healthy nonobese people
    • 2732149, 19587368
    • Lapice E, Maione S, Patti L, Cipriano P, Rivellese AA, Riccardi G, Vaccaro O. Abdominal adiposity is associated with elevated C-reactive protein independent of BMI in healthy nonobese people. Diabetes Care 2009, 32:1734-1736. 10.2337/dc09-0176, 2732149, 19587368.
    • (2009) Diabetes Care , vol.32 , pp. 1734-1736
    • Lapice, E.1    Maione, S.2    Patti, L.3    Cipriano, P.4    Rivellese, A.A.5    Riccardi, G.6    Vaccaro, O.7
  • 71
    • 70350565467 scopus 로고    scopus 로고
    • Neutrophil activation in morbid obesity, chronic activation of acute inflammation
    • 19390527
    • Nijhuis J, Rensen SS, Slaats Y, van Dielen FM, Buurman WA, Greve JW. Neutrophil activation in morbid obesity, chronic activation of acute inflammation. Obesity 2009, 17:2014-2018. 10.1038/oby.2009.113, 19390527.
    • (2009) Obesity , vol.17 , pp. 2014-2018
    • Nijhuis, J.1    Rensen, S.S.2    Slaats, Y.3    van Dielen, F.M.4    Buurman, W.A.5    Greve, J.W.6
  • 72
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • 7678183
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91. 10.1126/science.7678183, 7678183.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 73
    • 0033073540 scopus 로고    scopus 로고
    • The role of TNF alpha in adipocyte metabolism
    • 10355025
    • Sethi JK, Hotamisligil GS. The role of TNF alpha in adipocyte metabolism. Semin Cell Dev Biol 1999, 10:19-29. 10.1006/scdb.1998.0273, 10355025.
    • (1999) Semin Cell Dev Biol , vol.10 , pp. 19-29
    • Sethi, J.K.1    Hotamisligil, G.S.2
  • 74
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • 295872, 7738205
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995, 95:2409-2415. 10.1172/JCI117936, 295872, 7738205.
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 75
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
    • 295809, 7738178
    • Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 1995, 95:2111-2119. 10.1172/JCI117899, 295809, 7738178.
    • (1995) J Clin Invest , vol.95 , pp. 2111-2119
    • Kern, P.A.1    Saghizadeh, M.2    Ong, J.M.3    Bosch, R.J.4    Deem, R.5    Simsolo, R.B.6
  • 76
    • 79953030266 scopus 로고    scopus 로고
    • The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids
    • 21310207
    • El-Moselhy MA, Taye A, Sharkawi SS, El-Sisi SFI, Ahmed AF. The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids. Food Chem Toxicol 2011, 49:1129-1140. 10.1016/j.fct.2011.02.004, 21310207.
    • (2011) Food Chem Toxicol , vol.49 , pp. 1129-1140
    • El-Moselhy, M.A.1    Taye, A.2    Sharkawi, S.S.3    El-Sisi, S.F.I.4    Ahmed, A.F.5
  • 78
    • 84863911000 scopus 로고    scopus 로고
    • Cholesterol-lowering drugs inhibit lectin-like oxidized low-density lipoprotein-1 receptor function by membrane raft disruption
    • 22570368
    • Matarazzo S, Quitadamo MC, Mango R, Ciccone S, Novelli G, Biocca S. Cholesterol-lowering drugs inhibit lectin-like oxidized low-density lipoprotein-1 receptor function by membrane raft disruption. Mol Pharmacol 2012, 82:246-254. 10.1124/mol.112.078915, 22570368.
    • (2012) Mol Pharmacol , vol.82 , pp. 246-254
    • Matarazzo, S.1    Quitadamo, M.C.2    Mango, R.3    Ciccone, S.4    Novelli, G.5    Biocca, S.6
  • 80
    • 84860459972 scopus 로고    scopus 로고
    • Effects of adiposity on plasma lipid response to reductions in dietary saturated fatty acids and cholesterol
    • 3090171, 22332058
    • Flock MR, Green MH, Kris-Etherton PM. Effects of adiposity on plasma lipid response to reductions in dietary saturated fatty acids and cholesterol. Advances in Nutrition 2011, 2:261-274. 10.3945/an.111.000422, 3090171, 22332058.
    • (2011) Advances in Nutrition , vol.2 , pp. 261-274
    • Flock, M.R.1    Green, M.H.2    Kris-Etherton, P.M.3
  • 81
    • 0030857878 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor knockout mice exhibit exaggerated microvascular responses to inflammatory stimuli
    • Henninger DD, Gerritsen ME, Granger DN. Low-density lipoprotein receptor knockout mice exhibit exaggerated microvascular responses to inflammatory stimuli. Cir Res 1997, 81:274-281.
    • (1997) Cir Res , vol.81 , pp. 274-281
    • Henninger, D.D.1    Gerritsen, M.E.2    Granger, D.N.3
  • 82
    • 0041924007 scopus 로고    scopus 로고
    • Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol
    • 1868257, 12937162
    • Zabalawi M, Bhat S, Loughlin T, Thomas MJ, Alexander E, Cline M, Bullock B, Willingham M, Sorci-Thomas MG. Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol. Am J Pathol 2003, 163:1201-1213. 10.1016/S0002-9440(10)63480-3, 1868257, 12937162.
    • (2003) Am J Pathol , vol.163 , pp. 1201-1213
    • Zabalawi, M.1    Bhat, S.2    Loughlin, T.3    Thomas, M.J.4    Alexander, E.5    Cline, M.6    Bullock, B.7    Willingham, M.8    Sorci-Thomas, M.G.9
  • 83
    • 0033864582 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
    • 380255, 10953027
    • Li AC, Brown KK, Silvestre MJ, Willson TM, Palinski W, Glass CK. Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J Clin Invest 2000, 106:523-531. 10.1172/JCI10370, 380255, 10953027.
    • (2000) J Clin Invest , vol.106 , pp. 523-531
    • Li, A.C.1    Brown, K.K.2    Silvestre, M.J.3    Willson, T.M.4    Palinski, W.5    Glass, C.K.6
  • 84
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-[gamma] is a negative regulator of macrophage activation
    • 9422508
    • Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-[gamma] is a negative regulator of macrophage activation. Nature 1998, 391:79-82. 10.1038/34178, 9422508.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 86
    • 60849106971 scopus 로고    scopus 로고
    • In vitro effects of the reduced form of coenzyme Q10 on secretion levels of TNF-α and chemokines in response to LPS in the human monocytic cell line THP-1
    • Schmelzer C, Lorenz G, Rimbach G, Döring F. In vitro effects of the reduced form of coenzyme Q10 on secretion levels of TNF-α and chemokines in response to LPS in the human monocytic cell line THP-1. J Nutr Biochem 2009, 44:62-66.
    • (2009) J Nutr Biochem , vol.44 , pp. 62-66
    • Schmelzer, C.1    Lorenz, G.2    Rimbach, G.3    Döring, F.4
  • 87
    • 57349102400 scopus 로고    scopus 로고
    • Influence of Coenzyme Q10 on release of pro-inflammatory chemokines in the human monocytic cell line THP-1
    • 18997284
    • Schmelzer C, Lorenz G, Rimbach G, Döring F. Influence of Coenzyme Q10 on release of pro-inflammatory chemokines in the human monocytic cell line THP-1. BioFactors 2007, 31:211-217. 10.1002/biof.5520310308, 18997284.
    • (2007) BioFactors , vol.31 , pp. 211-217
    • Schmelzer, C.1    Lorenz, G.2    Rimbach, G.3    Döring, F.4
  • 90
    • 84857871990 scopus 로고    scopus 로고
    • Ubiquinol affects the expression of genes involved in PPARalpha signalling and lipid metabolism without changes in methylation of CpG promoter islands in the liver of mice
    • 3303474, 22448092
    • Schmelzer C, Kitano M, Hosoe K, Doring F. Ubiquinol affects the expression of genes involved in PPARalpha signalling and lipid metabolism without changes in methylation of CpG promoter islands in the liver of mice. J Clin Biochem Nutr 2012, 50:119-126. 10.3164/jcbn.11-19, 3303474, 22448092.
    • (2012) J Clin Biochem Nutr , vol.50 , pp. 119-126
    • Schmelzer, C.1    Kitano, M.2    Hosoe, K.3    Doring, F.4
  • 91
    • 77954171665 scopus 로고    scopus 로고
    • Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-α gene expression signature in SAMP1 mice
    • Schmelzer C, Kubo H, Mori M, Sawashita J, Kitano M, Hosoe K, Boomgaarden I, Döring F, Higuchi K. Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-α gene expression signature in SAMP1 mice. Mol Nutr Food Res 2010, 54:805-815.
    • (2010) Mol Nutr Food Res , vol.54 , pp. 805-815
    • Schmelzer, C.1    Kubo, H.2    Mori, M.3    Sawashita, J.4    Kitano, M.5    Hosoe, K.6    Boomgaarden, I.7    Döring, F.8    Higuchi, K.9
  • 92
    • 46449129625 scopus 로고    scopus 로고
    • Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome
    • 18544898
    • Kunitomo M, Yamaguchi Y, Kagota S, Otsubo K. Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome. J Pharmacol Sci 2008, 107:128-137. 10.1254/jphs.FP0072365, 18544898.
    • (2008) J Pharmacol Sci , vol.107 , pp. 128-137
    • Kunitomo, M.1    Yamaguchi, Y.2    Kagota, S.3    Otsubo, K.4
  • 93
    • 84857805203 scopus 로고    scopus 로고
    • Effects of coenzyme Q10 and alpha-lipoic acid supplementation in fructose fed rats
    • full_text, 3303477, 22448096
    • Ozdogan S, Kaman D, Simsek BC. Effects of coenzyme Q10 and alpha-lipoic acid supplementation in fructose fed rats. J Clin Biochem Nutr 2012, 50:145-151. full_text, 3303477, 22448096.
    • (2012) J Clin Biochem Nutr , vol.50 , pp. 145-151
    • Ozdogan, S.1    Kaman, D.2    Simsek, B.C.3
  • 94
    • 65949119758 scopus 로고    scopus 로고
    • Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients
    • 2671099, 19228872
    • Hamilton SJ, Chew GT, Watts GF. Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes Care 2009, 32:810-812. 10.2337/dc08-1736, 2671099, 19228872.
    • (2009) Diabetes Care , vol.32 , pp. 810-812
    • Hamilton, S.J.1    Chew, G.T.2    Watts, G.F.3
  • 96
    • 34548721636 scopus 로고    scopus 로고
    • Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study
    • 17644511
    • Tiano L, Belardinelli R, Carnevali P, Principi F, Seddaiu G, Littarru GP. Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study. Eur Heart J 2007, 28:2249-2255. 10.1093/eurheartj/ehm267, 17644511.
    • (2007) Eur Heart J , vol.28 , pp. 2249-2255
    • Tiano, L.1    Belardinelli, R.2    Carnevali, P.3    Principi, F.4    Seddaiu, G.5    Littarru, G.P.6
  • 97
    • 0016135162 scopus 로고
    • Reduction by coenzyme Q10 of hypertension induced by deoxycorticosterone and saline in rats
    • Yamagami T, Iwamoto Y, Folkers K, Blomqvist CG. Reduction by coenzyme Q10 of hypertension induced by deoxycorticosterone and saline in rats. Int J Vitam Nutr Res 1974, 44:487-496.
    • (1974) Int J Vitam Nutr Res , vol.44 , pp. 487-496
    • Yamagami, T.1    Iwamoto, Y.2    Folkers, K.3    Blomqvist, C.G.4
  • 98
    • 0016137070 scopus 로고
    • Deficiency of coenzyme Q10 in hypertensive rats and reduction of deficiency by treatment with coenzyme Q10
    • 4836275
    • Iwamoto Y, Yamagami T, Folkers K, Blomqvist CG. Deficiency of coenzyme Q10 in hypertensive rats and reduction of deficiency by treatment with coenzyme Q10. Biochem Biophys Res Commun 1974, 58:743-748. 10.1016/S0006-291X(74)80480-8, 4836275.
    • (1974) Biochem Biophys Res Commun , vol.58 , pp. 743-748
    • Iwamoto, Y.1    Yamagami, T.2    Folkers, K.3    Blomqvist, C.G.4
  • 99
    • 38049161857 scopus 로고    scopus 로고
    • Effects of decylubiquinone (coenzyme Q10 analog) supplementation on SHRSP
    • 18198397
    • Murad LB, Guimaraes MR, Vianna LM. Effects of decylubiquinone (coenzyme Q10 analog) supplementation on SHRSP. BioFactors 2007, 30:13-18. 10.1002/biof.5520300102, 18198397.
    • (2007) BioFactors , vol.30 , pp. 13-18
    • Murad, L.B.1    Guimaraes, M.R.2    Vianna, L.M.3
  • 101
    • 84856035599 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled crossover study of coenzyme q10 therapy in hypertensive patients with the metabolic syndrome
    • 22113168
    • Young JM, Florkowski CM, Molyneux SL, McEwan RG, Frampton CM, Nicholls MG, Scott RS, George PM. A randomized, double-blind, placebo-controlled crossover study of coenzyme q10 therapy in hypertensive patients with the metabolic syndrome. Am J Hypertens 2012, 25:261-270. 10.1038/ajh.2011.209, 22113168.
    • (2012) Am J Hypertens , vol.25 , pp. 261-270
    • Young, J.M.1    Florkowski, C.M.2    Molyneux, S.L.3    McEwan, R.G.4    Frampton, C.M.5    Nicholls, M.G.6    Scott, R.S.7    George, P.M.8
  • 104
    • 0031829432 scopus 로고    scopus 로고
    • Control of arterial tone after long-term coenzyme Q10 supplementation in senescent rats
    • 1565529, 9723964
    • Lonnrot K, Porsti I, Alho H, Wu X, Hervonen A, Tolvanen JP. Control of arterial tone after long-term coenzyme Q10 supplementation in senescent rats. Br J Pharmacol 1998, 124:1500-1506. 10.1038/sj.bjp.0701970, 1565529, 9723964.
    • (1998) Br J Pharmacol , vol.124 , pp. 1500-1506
    • Lonnrot, K.1    Porsti, I.2    Alho, H.3    Wu, X.4    Hervonen, A.5    Tolvanen, J.P.6
  • 105
    • 70449529407 scopus 로고    scopus 로고
    • Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome
    • 19638284
    • Kumar A, Kaur H, Devi P, Mohan V. Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Ther 2009, 124:259-268. 10.1016/j.pharmthera.2009.07.003, 19638284.
    • (2009) Pharmacol Ther , vol.124 , pp. 259-268
    • Kumar, A.1    Kaur, H.2    Devi, P.3    Mohan, V.4
  • 106
    • 0031881379 scopus 로고    scopus 로고
    • Heart failure: is there an energy deficit contributing to contractile dysfunction?
    • Vogt AM, Kübler W. Heart failure: is there an energy deficit contributing to contractile dysfunction?. Basic Res Cardiol 1998, 93:1-10.
    • (1998) Basic Res Cardiol , vol.93 , pp. 1-10
    • Vogt, A.M.1    Kübler, W.2
  • 108
    • 0025086659 scopus 로고
    • A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10
    • Langsjoen PH, Folkers K. A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10. Int J Tissue React 1990, 12:169-171.
    • (1990) Int J Tissue React , vol.12 , pp. 169-171
    • Langsjoen, P.H.1    Folkers, K.2
  • 109
  • 110
    • 0019381272 scopus 로고
    • A protective effect of coenzyme Q10 on ischemia and reperfusion of the isolated perfused rat heart
    • Ohhara H, Kanaide H, Yoshimura R, Okada M, Nakamura M. A protective effect of coenzyme Q10 on ischemia and reperfusion of the isolated perfused rat heart. J Mol Cell Cardiol 1981, 13:65-74.
    • (1981) J Mol Cell Cardiol , vol.13 , pp. 65-74
    • Ohhara, H.1    Kanaide, H.2    Yoshimura, R.3    Okada, M.4    Nakamura, M.5
  • 111
    • 0028455370 scopus 로고
    • Coenzyme Q10 enhances cardiac functional and metabolic recovery and reduces Ca2+ overload during postischemic reperfusion
    • Hano O, Thompson-Gorman SL, Zweier JL, Lakatta EG. Coenzyme Q10 enhances cardiac functional and metabolic recovery and reduces Ca2+ overload during postischemic reperfusion. Am J Physiol 1994, 266:H2174-H2181.
    • (1994) Am J Physiol , vol.266 , pp. H2174-H2181
    • Hano, O.1    Thompson-Gorman, S.L.2    Zweier, J.L.3    Lakatta, E.G.4
  • 112
    • 0033032252 scopus 로고    scopus 로고
    • Bioenergetic effect of liposomal coenzyme Q10 on myocardial ischemia reperfusion injury
    • 10416045
    • Niibori K, Wroblewski KP, Yokoyama H, Crestanello JA, Whitman GJ. Bioenergetic effect of liposomal coenzyme Q10 on myocardial ischemia reperfusion injury. BioFactors 1999, 9:307-313. 10.1002/biof.5520090228, 10416045.
    • (1999) BioFactors , vol.9 , pp. 307-313
    • Niibori, K.1    Wroblewski, K.P.2    Yokoyama, H.3    Crestanello, J.A.4    Whitman, G.J.5
  • 114
    • 0021288630 scopus 로고
    • Effect of coenzyme Q10 on the survival time and lipid peroxidation of adriamycin (doxorubicin) treated mice
    • Shinozawa S, Etowo K, Araki Y, Oda T. Effect of coenzyme Q10 on the survival time and lipid peroxidation of adriamycin (doxorubicin) treated mice. Acta Med Okayama 1984, 38:57-63.
    • (1984) Acta Med Okayama , vol.38 , pp. 57-63
    • Shinozawa, S.1    Etowo, K.2    Araki, Y.3    Oda, T.4
  • 115
    • 0033812251 scopus 로고    scopus 로고
    • Deficit of coenzyme Q in heart and liver mitochondria of rats with streptozotocin-induced diabetes
    • Kucharska J, Braunova Z, Ulicna O, Zlatos L, Gvozdjakova A. Deficit of coenzyme Q in heart and liver mitochondria of rats with streptozotocin-induced diabetes. Physiol Res 2000, 49:411-418.
    • (2000) Physiol Res , vol.49 , pp. 411-418
    • Kucharska, J.1    Braunova, Z.2    Ulicna, O.3    Zlatos, L.4    Gvozdjakova, A.5
  • 116
    • 0032588765 scopus 로고    scopus 로고
    • Coenzyme Q10 depletion and mitochondrial energy disturbances in rejection development in patients after heart transplantation
    • 10416044
    • Gvozdjakova A, Kucharska J, Mizera S, Braunova Z, Schreinerova Z, Schramekova E, Pechan I, Fabian J. Coenzyme Q10 depletion and mitochondrial energy disturbances in rejection development in patients after heart transplantation. BioFactors 1999, 9:301-306. 10.1002/biof.5520090227, 10416044.
    • (1999) BioFactors , vol.9 , pp. 301-306
    • Gvozdjakova, A.1    Kucharska, J.2    Mizera, S.3    Braunova, Z.4    Schreinerova, Z.5    Schramekova, E.6    Pechan, I.7    Fabian, J.8
  • 117
    • 0032588774 scopus 로고    scopus 로고
    • The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus
    • 10416046
    • Eriksson JG, Forsen TJ, Mortensen SA, Rohde M. The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus. BioFactors 1999, 9:315-318. 10.1002/biof.5520090229, 10416046.
    • (1999) BioFactors , vol.9 , pp. 315-318
    • Eriksson, J.G.1    Forsen, T.J.2    Mortensen, S.A.3    Rohde, M.4
  • 118
    • 0032757898 scopus 로고    scopus 로고
    • Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with Type 1 diabetes mellitus
    • 10220205
    • Henriksen JE, Andersen CB, Hother-Nielsen O, Vaag A, Mortensen SA, Beck-Nielsen H. Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with Type 1 diabetes mellitus. Diabet Med 1999, 16:312-318. 10.1046/j.1464-5491.1999.00064.x, 10220205.
    • (1999) Diabet Med , vol.16 , pp. 312-318
    • Henriksen, J.E.1    Andersen, C.B.2    Hother-Nielsen, O.3    Vaag, A.4    Mortensen, S.A.5    Beck-Nielsen, H.6
  • 119
    • 38349117774 scopus 로고    scopus 로고
    • Supplementation of coenzyme Q10 and α-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats
    • 19083397
    • Sena CM, Nunes E, Gomes A, Santos MS, Proença T, Martins MI, Seiça RM. Supplementation of coenzyme Q10 and α-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats. Nutr Res 2008, 28:113-121. 10.1016/j.nutres.2007.12.005, 19083397.
    • (2008) Nutr Res , vol.28 , pp. 113-121
    • Sena, C.M.1    Nunes, E.2    Gomes, A.3    Santos, M.S.4    Proença, T.5    Martins, M.I.6    Seiça, R.M.7
  • 120
    • 0036851863 scopus 로고    scopus 로고
    • The liver X receptor gene team: potential new players in atherosclerosis
    • 12411951
    • Repa JJ, Mangelsdorf DJ. The liver X receptor gene team: potential new players in atherosclerosis. Nat Med 2002, 8:1243-1248. 10.1038/nm1102-1243, 12411951.
    • (2002) Nat Med , vol.8 , pp. 1243-1248
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 122
    • 0037324340 scopus 로고    scopus 로고
    • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    • 12524534
    • Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 2003, 9:213-219. 10.1038/nm820, 12524534.
    • (2003) Nat Med , vol.9 , pp. 213-219
    • Joseph, S.B.1    Castrillo, A.2    Laffitte, B.A.3    Mangelsdorf, D.J.4    Tontonoz, P.5
  • 123
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
    • 9630215
    • Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, Mangelsdorf DJ. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 1998, 93:693-704. 10.1016/S0092-8674(00)81432-4, 9630215.
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.M.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 125
    • 79952018447 scopus 로고    scopus 로고
    • The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice
    • 21086475
    • Schmelzer C, Okun JG, Haas D, Higuchi K, Sawashita J, Mori M, Doring F. The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice. Iubmb Life 2010, 62:812-818. 10.1002/iub.388, 21086475.
    • (2010) Iubmb Life , vol.62 , pp. 812-818
    • Schmelzer, C.1    Okun, J.G.2    Haas, D.3    Higuchi, K.4    Sawashita, J.5    Mori, M.6    Doring, F.7
  • 127
    • 33746095409 scopus 로고    scopus 로고
    • Life-long supplementation with a low dosage of coenzyme Q10 in the rat: effects on antioxidant status and DNA damage
    • 16873932
    • Quiles JL, Ochoa JJ, Battino M, Gutierrez-Rios P, Nepomuceno EA, Frias ML, Huertas JR, Mataix J. Life-long supplementation with a low dosage of coenzyme Q10 in the rat: effects on antioxidant status and DNA damage. BioFactors 2005, 25:73-86. 10.1002/biof.5520250109, 16873932.
    • (2005) BioFactors , vol.25 , pp. 73-86
    • Quiles, J.L.1    Ochoa, J.J.2    Battino, M.3    Gutierrez-Rios, P.4    Nepomuceno, E.A.5    Frias, M.L.6    Huertas, J.R.7    Mataix, J.8
  • 128
    • 0842348226 scopus 로고    scopus 로고
    • Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet
    • 15036411
    • Quiles JL, Ochoa JJ, Huertas JR, Mataix J. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet. Exp Gerontol 2004, 39:189-194. 10.1016/j.exger.2003.10.002, 15036411.
    • (2004) Exp Gerontol , vol.39 , pp. 189-194
    • Quiles, J.L.1    Ochoa, J.J.2    Huertas, J.R.3    Mataix, J.4
  • 129
    • 70349761355 scopus 로고    scopus 로고
    • Induction of non-alcoholic fatty liver disease and insulin resistance by feeding a high-fat diet in rats: does coenzyme Q monomethyl ether have a modulatory effect?
    • 19592219
    • Safwat GM, Pisano S, D'Amore E, Borioni G, Napolitano M, Kamal AA, Ballanti P, Botham KM, Bravo E. Induction of non-alcoholic fatty liver disease and insulin resistance by feeding a high-fat diet in rats: does coenzyme Q monomethyl ether have a modulatory effect?. Nutrition 2009, 25:1157-1168. 10.1016/j.nut.2009.02.009, 19592219.
    • (2009) Nutrition , vol.25 , pp. 1157-1168
    • Safwat, G.M.1    Pisano, S.2    D'Amore, E.3    Borioni, G.4    Napolitano, M.5    Kamal, A.A.6    Ballanti, P.7    Botham, K.M.8    Bravo, E.9
  • 130
    • 33847665561 scopus 로고    scopus 로고
    • Protective role of melatonin and coenzyme Q10 in ochratoxin A toxicity in rat liver and kidney
    • 17365150
    • Sutken E, Aral E, Ozdemir F, Uslu S, Alatas O, Colak O. Protective role of melatonin and coenzyme Q10 in ochratoxin A toxicity in rat liver and kidney. Int J Toxicol 2007, 26:81-87. 10.1080/10915810601122893, 17365150.
    • (2007) Int J Toxicol , vol.26 , pp. 81-87
    • Sutken, E.1    Aral, E.2    Ozdemir, F.3    Uslu, S.4    Alatas, O.5    Colak, O.6
  • 131
    • 24644463306 scopus 로고    scopus 로고
    • Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet
    • 16125350
    • Bello RI, Gomez-Diaz C, Buron MI, Alcain FJ, Navas P, Villalba JM. Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet. Exp Gerontol 2005, 40:694-706. 10.1016/j.exger.2005.07.003, 16125350.
    • (2005) Exp Gerontol , vol.40 , pp. 694-706
    • Bello, R.I.1    Gomez-Diaz, C.2    Buron, M.I.3    Alcain, F.J.4    Navas, P.5    Villalba, J.M.6
  • 133
    • 81455138113 scopus 로고    scopus 로고
    • Correlation between vitamin A, E, coenzyme Q-10 and degree of insulin resistance in obese and non-obese subjects
    • 3208010, 22128213
    • Mehmetoglu I, Yerlikaya FH, Kurban S. Correlation between vitamin A, E, coenzyme Q-10 and degree of insulin resistance in obese and non-obese subjects. J Clin Biochem Nutr 2011, 49:159-163. 10.3164/jcbn.11-08, 3208010, 22128213.
    • (2011) J Clin Biochem Nutr , vol.49 , pp. 159-163
    • Mehmetoglu, I.1    Yerlikaya, F.H.2    Kurban, S.3
  • 136
    • 0343986284 scopus 로고    scopus 로고
    • Drug delivery to mitochondria: the key to mitochondrial medicine
    • 10699318
    • Murphy MP, Smith RA. Drug delivery to mitochondria: the key to mitochondrial medicine. Adv Drug Deliv Rev 2000, 41:235-250. 10.1016/S0169-409X(99)00069-1, 10699318.
    • (2000) Adv Drug Deliv Rev , vol.41 , pp. 235-250
    • Murphy, M.P.1    Smith, R.A.2
  • 137
    • 21744450416 scopus 로고    scopus 로고
    • Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury
    • 15985532
    • Adlam VJ, Harrison JC, Porteous CM, James AM, Smith RA, Murphy MP, Sammut IA. Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. FASEB J 2005, 19:1088-1095. 10.1096/fj.05-3718com, 15985532.
    • (2005) FASEB J , vol.19 , pp. 1088-1095
    • Adlam, V.J.1    Harrison, J.C.2    Porteous, C.M.3    James, A.M.4    Smith, R.A.5    Murphy, M.P.6    Sammut, I.A.7
  • 138
    • 56049120778 scopus 로고    scopus 로고
    • The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis
    • 18845241
    • Lowes DA, Thottakam BM, Webster NR, Murphy MP, Galley HF. The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radic Biol Med 2008, 45:1559-1565. 10.1016/j.freeradbiomed.2008.09.003, 18845241.
    • (2008) Free Radic Biol Med , vol.45 , pp. 1559-1565
    • Lowes, D.A.1    Thottakam, B.M.2    Webster, N.R.3    Murphy, M.P.4    Galley, H.F.5
  • 143
    • 62549161327 scopus 로고    scopus 로고
    • Pharmacokinetic properties and metabolism of idebenone
    • Kutz K, Drewe J, Vankan P. Pharmacokinetic properties and metabolism of idebenone. J Neurol 2009, 256(Suppl 1):31-35.
    • (2009) J Neurol , vol.256 , pp. 31-35
    • Kutz, K.1    Drewe, J.2    Vankan, P.3
  • 144
    • 0022400051 scopus 로고
    • Effects of idebenone (CV-2619) and its metabolites on respiratory activity and lipid peroxidation in brain mitochondria from rats and dogs
    • 2871147
    • Sugiyama Y, Fujita T, Matsumoto M, Okamoto K, Imada I. Effects of idebenone (CV-2619) and its metabolites on respiratory activity and lipid peroxidation in brain mitochondria from rats and dogs. J Pharmacobiodyn 1985, 8:1006-1017. 10.1248/bpb1978.8.1006, 2871147.
    • (1985) J Pharmacobiodyn , vol.8 , pp. 1006-1017
    • Sugiyama, Y.1    Fujita, T.2    Matsumoto, M.3    Okamoto, K.4    Imada, I.5
  • 145
    • 0024563876 scopus 로고
    • Inhibition of lipid peroxidation by idebenone in brain mitochondria in the presence of succinate
    • 2764644
    • Suno M, Nagaoka A. Inhibition of lipid peroxidation by idebenone in brain mitochondria in the presence of succinate. Arch Gerontol Geriatr 1989, 8:291-297. 10.1016/0167-4943(89)90010-1, 2764644.
    • (1989) Arch Gerontol Geriatr , vol.8 , pp. 291-297
    • Suno, M.1    Nagaoka, A.2
  • 146
    • 0024556068 scopus 로고
    • Effects of idebenone on lipid peroxidation and hemolysis in erythrocytes of stroke-prone spontaneously hypertensive rats
    • 2764645
    • Suno M, Shibota M, Nagaoka A. Effects of idebenone on lipid peroxidation and hemolysis in erythrocytes of stroke-prone spontaneously hypertensive rats. Arch Gerontol Geriatr 1989, 8:307-311. 10.1016/0167-4943(89)90012-5, 2764645.
    • (1989) Arch Gerontol Geriatr , vol.8 , pp. 307-311
    • Suno, M.1    Shibota, M.2    Nagaoka, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.