Regulation of ubiquinone metabolism

Free Radical Biology and Medicine

Volumn 29, Issue 3-4, 2000, Pages 285-294

  Dallner, Gustav ^a   Sindelar, Pavel J ^a,b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Antioxidants; Free radicals; Mevalonate pathway; Oxidative stress; Peroxisome proliferators; Ubiquinone; Tocopherol

Indexed keywords

FREE RADICAL; PEROXISOME PROLIFERATOR; UBIQUINONE;

ANTIOXIDANT ACTIVITY; HUMAN; LIPID METABOLISM; LIPID PEROXIDATION; METABOLIC REGULATION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW;

MAMMALIA;

EID: 0033796008     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00307-5     Document Type: Article

References (62)

1. Ernster L. Ubiquinone redox coenzyme, hydrogen carrier, antioxidant . Folkers K., Yamamura Y. Biomedical and clinical aspects of coenzyme Q. vol. 4:1984;3-13 Elsevier, Amsterdam.
2. Ernster L. Lipid peroxidation in biological membranes mechanisms and implications . Yagi K. Active oxygens, lipid peroxides, and antioxidants. 1993;1-38 CRC Press, Boca Raton.
3. Grünler J., Ericsson J., Dallner G. Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone, and prenylated proteins. Biochim. Biophys. Acta. 1212:1994;259-277.
4. Olson R.E., Rudney H. Biosynthesis of ubiquinone. Vitam. Horm. 40:1983;1-43.
5. Teclebrhan H., Olsson J., Swiezewska E., Dallner G. Biosynthesis of the side chain of ubiquinone transprenyltransferase in rat liver microsomes . J. Biol. Chem. 268:1993;23081-23086.
6. Poulter C.D., Rilling H.C. Prenyl transferases and isomerases. Porter J.W., Spurgeon S.L. Biosynthesis of isoprenoid compounds. 1981;161-224 John Wiley, New York.
7. Åberg F., Appelkvist E.L., Dallner G., Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. Arch. Biochem. Biophys. 295:1992;230-234.
8. Runquist M., Parmryd I., Thelin A., Chojnacki T., Dallner G. Distribution of branch-point prenyltransferases in regions of bovine brain. J. Neurochem. 65:1995;2299-2306.
9. Yamamoto T., Shimizu S.I., Sugawara H., Momose K., Rudney H. Identification of regulatory sites in the biosynthesis of ubiquinone in the perfused rat heart. Arch. Biochem. Biophys. 269:1989;86-92.
10. Trumpower B.L., Houser R.M., Olson R.E. Studies on ubiquinone. Demonstration of the total biosynthesis of ubiquinone-9 in rat liver mitochondria. J. Biol. Chem. 249:1974;3041-3048.
11. Nambudiri A.M.D., Brockman D., Alam S.S., Rudney H. Alternate routes for ubiquinone biosynthesis in rats. Biochem. Biophys. Res. Commun. 76:1977;282-288.
12. Thelin A., Schedin S., Dallner G. Half-life of ubiquinone-9 in rat tissues. FEBS Lett. 313:1992;118-120.
13. Andersson M., Elmberger P.G., Edlund C., Kristensson K., Dallner G. Rates of cholesterol, ubiquinone, dolichol, and dolichyl-P biosynthesis in rat brain slices. FEBS Lett. 269:1990;15-18.
14. Elmberger P.G., Kalen A., Brunk U., Dallner G. Discharge of newly synthesized dolichol, dolichyl phosphate, and ubiquinone with lipoproteins to rat liver perfusate and to the bile. Lipids. 24:1989;919-930.
15. Imada I., Watanabe M., Matsumoto N., Morimoto H. Metabolism of ubiquinone-7. Biochemistry. 9:1970;2870-2878.
16. Nakamura T., Ohno T., Hamamura K., Sato T. Metabolism of coenzyme Q10 biliary and urinary excretion study in guinea pigs . Biofactors. 9:1999;111-119.
17. Littarru G.P., Battino M., Folkers K. Clinical aspects of coenzyme Q improvment of cellular bioenergetics or antioxidant protection? Cadenas E., Packer L. Handbook of antioxidants. 1996;203-239 Marcel Dekker, New York.
18. Beal M.F. Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases. Biofactors. 9:1999;261-266.
19. Ramasarma T. Metabolism of coenzyme Q. Lenaz G. Coenzyme Q. 1985;131-142 John Wiley, Chichester.
20. Zhang Y., Åberg F., Appelkvist E.L., Dallner G., Ernster L. Uptake of dietary coenzyme Q supplement is limited in rats. J. Nutr. 125:1995;446-453.
21. Kishi T., Okamoto T., Kanamori N., Yamagami T., Kishi H., Okada A., Folkers K. Estimation of plasma levels of coenzyme Q10 and relationship to oral dosage. Folkers K., Yamamura Y. Biomedical and clinical aspects of coenzyme Q. vol. 3:1981;67-78 Elsevier, Amsterdam.
22. Turunen M., Appelkvist E.L., Sindelar P., Dallner G. Blood concentration of coenzyme Q10 increases in rat when esterified forms are administered. J. Nutr. 129:1999;2113-2118.
23. Ulrich E.L., Girvin M.E., Cramer W.A., Markley J.L. Location and mobility of ubiquinones of different chain lengths in artificial membrane vesicles. Biochemistry. 24:1985;2501-2508.
24. Lenaz G., Fato R., Di Bernardo S., Jarreta D., Costa A., Genova M.L., Parenti Castelli G. Localization and mobility of coenzyme Q in lipid bilayers and membranes. Biofactors. 9:1999;87-93.
25. Valtersson C., van Duyn G., Verkleij A.J., Chojnacki T., de Kruijff B., Dallner G. The influence of dolichol, dolichol esters, and dolichyl phosphate on phospholipid polymorphism and fluidity in model membranes. J. Biol. Chem. 260:1985;2742-2751.
26. Kalen A., Norling B., Appelkvist E.L., Dallner G. Ubiquinone biosynthesis by the microsomal fraction from rat liver. Biochim. Biophys. Acta. 926:1987;70-78.
27. Tollbom, Ö.; Valtersson, C.; Chojnacki, T.; Dallner, G. Esterification of dolichol in rat liver. J. Biol. Chem. 263:1347-1352; 1988.
28. Löw P., Peterson E., Edlund C., Brunk U., Appelkvist E.L. Nonmembrane associated dolichol in rat liver. Lipids. 27:1992;1-9.
29. Åberg F., Zhang Y., Teclebrhan H., Appelkvist E.L., Dallner G. Increases in tissue levels of ubiquinone in association with peroxisome proliferation. Chem. Biol. Interact. 99:1996;205-218.
30. Ernster L., Dallner G. Biochemical, physiological, and medical aspects of ubiquinone function. Biochim. Biophys. Acta. 1271:1995;195-204.
31. Elmberger P.G., Kalen A., Appelkvist E.L., Dallner G. In vitro and in vivo synthesis of dolichol and other main mevalonate products in various organs of the rat. Eur. J. Biochem. 168:1987;1-11.
32. Brown M.S., Goldstein J.L. Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. J. Lipid Res. 21:1980;505-517.
33. Elmberger P.G., Kalen A., Lund E., Reihner E., Eriksson M., Berglund L., Angelin B., Dallner G. Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia. J. Lipid Res. 32:1991;935-940.
34. Bargossi A.M., Grossi G., Fiorella P.L., Gaddi A., Di Giulio R., Battino M. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Molec. Aspects Med. 15:1994;187-193.
35. Löw P., Andersson M., Edlund C., Dallner G. Effects of mevinolin treatment on tissue dolichol and ubiquinone levels in the rat. Biochim. Biophys. Acta. 1165:1992;102-109.
36. Thelin A., Peterson E., Hutson J.L., McCarthy A.D., Ericsson J., Dallner G. Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids. Biochim. Biophys. Acta. 1215:1994;245-249.
37. Keller R.K. Squalene synthase inhibition alters metabolism of nonsterols in rat liver. Biochim. Biophys. Acta. 1303:1996;169-179.
38. Åberg F., Zhang Y., Appelkvist E.L., Dallner G. Effect of clofibrate, phthalates, and probucol on ubiquinone levels. Chem. Biol. Interact. 91:1994;1-14.
39. Turunen M., Sindelar P., Dallner G. Induction of endogenous coenzyme Q biosynthesis by administration of peroxisomal inducers. Biofactors. 9:1999;131-139.
40. Turunen M., Dallner G. Elevation of ubiquinone content by peroxisomal inducers in rat liver during aging. Chem. Biol. Interact. 116:1998;79-91.
41. Lakshmanan M.R., Cama H.R., Joshi V.C., Ramasarma T. Metabolism of ubiquinone in relation to vitamin A status in the rat. Biochim. Biophys. Acta. 170:1968;392-398.
42. Blumberg, B.; Evans, R. M. Orphan nuclear receptors - new ligands and new possibilities. Genes Devel 12:3249-3155; 1998.
43. Aithal H.N., Joshi V.C., Ramasarma T. Effect of cold exposure on the metabolism of ubiquinone in the rat. Biochim. Biophys. Acta. 162:1968;66-72.
44. Pedersen S., Tata J.R., Ernster L. Ubiquinone (coenzyme Q) and the regulation of basal metabolic rate by thyroid hormones. Biochim. Biophys. Acta. 69:1963;407-409.
45. Kagan V.E., Nohl H., Quinn P.J. Coenzyme Q its role in scavenging and generation of radicals in membranes . Cadenas E., Packer L. Handbook of antioxidants. 1996;157-201 Marcel Dekker, New York.
46. Zhang Y., Turunen M., Appelkvist E.L. Restricted uptake of dietary coenzyme Q is in contrast to the unrestricted uptake of α-tocopherol into rat tissues and cells. J. Nutr. 126:1996;2089-2097.
47. Åberg F., Appelkvist E.L., Bröijersen A., Eriksson M., Angelin B., Hjemdahl P., Dallner G. Gemfibrozil-induced decrease in serum ubiquinone and α- and γ-tocopherol levels in men with combined hyperlipidemia. Eur. J. Clin. Invest. 28:1998;235-242.
48. Shi H., Noguchi N., Niki E. Dynamics of antioxidant action of ubiquinol a reappraisal . Biofactors. 9:1999;141-148.
49. Lenaz G., Esposti M.D. Physical properties of ubiquinones in model systems and membranes. Lenaz G. Coenzyme Q. 1985;83-105 John Wiley, Chichester.
50. Forsmark-Andree P., Lee C.P., Dallner G., Ernster L. Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles. Free Radic. Biol. Med. 22:1997;391-400.
51. Kalen A., Appelkvist E.L., Dallner G. Age-related changes in the lipid composition of rat and human tissues. Lipids. 24:1989;579-584.
52. Söderberg M., Edlund C., Kristensson K., Dallner G. Lipid compositions of different regions of the human brain during aging. J. Neurochem. 54:1990;415-423.
53. Zhang Y., Appelkvist E.L., Kristensson K., Dallner G. The lipid compositions of different regions of rat brain during development and aging. Neurobiol. Aging. 17:1996;869-875.
54. Lass A., Kwong L., Sohal R.S. Mitochondrial coenzyme Q content and aging. Biofactors. 9:1999;199-205.
55. Olsson J.M., Eriksson L.C., Dallner G. Lipid composition of intracellular membranes isolated from rat liver nodules in Wistar rats. Cancer Res. 51:1991;3774-3780.
56. Olsson J.M., Schedin S., Techlebrhan H., Eriksson L.C., Dallner G. Enzymes of the mevalonate pathway in rat liver nodules induced by 2-acetylaminofluorene treatment. Carcinogenesis. 16:1995;599-605.
57. Eggens I., Elmberger P.G., Löw P. Polyisoprenoid, cholesterol, and ubiquinone levels in human hepatocellular carcinomas. Br. J. Exp. Path. 70:1989;83-92.
58. Söderberg M., Edlund C., Alafuzoff I., Kristensson K., Dallner G. Lipid composition in different regions of the rat brain in Alzheimer's disease/senile dementia of Alzheimer's type. J. Neurochem. 59:1992;1646-1653.
59. Guan Z.Z., Söderberg M., Sindelar P., Prusiner S.B., Kristensson K., Dallner G. Lipid composition in scrapie-infected mouse brain prion infection increases the levels of dolichyl phosphate and ubiquinone . J. Neurochem. 66:1996;277-285.
60. Halliwell B., Gutteridge J.M.C. Free radicals in biology and medicine. 1999;1-936 Oxford University Press, Oxford.
61. Beal M.F., Matthews R.T. Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases. Molec. Aspects Med. 18:1997;169-179.
62. Rötig, A.; Appelkvist, E. L.; Geromel, V.; Chretien, D.; Kadhom, N.; Edery, P.; Lebideau, M.; Dallner, G.; Munnich, A.; Ernster, L.; Rustin, P. Quinone-responsive multiple respiratory chain dysfunction due widespread coenzyeme Q10 deficiency. Lancet, in press.