Association between C-reactive protein and adiposity in women

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 10, 2009, Pages 3969-3977

  Bochud, Murielle ^b   Marquant, Fabienne ^b   Marques Vidal, Pedro Manuel ^a,b   Vollenweider, Peter ^a   Beckmann, Jacques S ^a   Mooser, Vincent ^c   Paccaud, Fred ^b   Rousson, Valentin ^b  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; LEPTIN;

ADULT; AGED; ARTICLE; BODY MASS; CAUCASIAN; CRP GENE; DIABETOGENESIS; FEMALE; GENE; HUMAN; IMPEDANCE; LEAN BODY WEIGHT; LEPR GENE; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; RANDOMIZATION; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; WAIST CIRCUMFERENCE;

EID: 70349932622     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-2428     Document Type: Article

References (40)

1. Koenig W, Khuseyinova N, Baumert J, Meisinger C 2008 Prospective study of high-sensitivity C-reactive protein as a determinant of mortality: results from the MONICA/KORA Augsburg Cohort Study, 1984-1998. Clin Chem 54:335-342 (Pubitemid 351302620)
2. Strandberg TE, Tilvis RS 2000 C-reactive protein, cardiovascular risk factors, and mortality in a prospective study in the elderly. Arterioscler Thromb Vasc Biol 20:1057-1060 (Pubitemid 30207582)
3. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM 2001 C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:327-334 (Pubitemid 32656163)
4. Han TS, Sattar N, Williams K, Gonzalez-Villalpando C, Lean ME, Haffner SM 2002 Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study. Diabetes Care 25:2016-2021 (Pubitemid 41071061)
5. Laaksonen DE, Niskanen L, Nyyssonen K, Punnonen K, Tuomainen TP, Valkonen VP, Salonen R, Salonen JT 2004 C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men. Diabetologia 47:1403-1410 (Pubitemid 39232426)
6. Onat A, Can G, Hergenc G 2008 Serum C-reactive protein is an independent risk factor predicting cardiometabolic risk. Metabolism 57:207-214
7. Dehghan A, Kardys I, de Maat MP, Uitterlinden AG, Sijbrands EJ, Bootsma AH, Stijnen T, Hofman A, Schram MT, Witteman JC 2007 Genetic variation, C-reactive protein levels, and incidence of diabetes. Diabetes 56:872-878
8. Brunner EJ, Kivimaki M, Witte DR, Lawlor DA, Davey SG, Cooper JA, Miller M, Lowe GD, Rumley A, Casas JP, Shah T, Humphries SE, Hingorani AD, Marmot MG, Timpson NJ, Kumari M 2008 Inflammation, insulin resistance, and diabetes-Mendelian randomization using CRP haplotypes points upstream. PLoS Med 5:e155
9. Ridker PM, Buring JE, Rifai N, Cook NR 2007 Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA 297: 611-619 (Pubitemid 46257283)
10. Zethelius B, Berglund L, Sundstrom J, Ingelsson E, Basu S, Larsson A, Venge P, Arnlov J 2008 Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. N Engl J Med 358:2107-2116 (Pubitemid 351679597)
11. Ridker PM, Wilson PW, Grundy SM 2004 Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? Circulation 109:2818-2825
12. Didelez V, Sheehan N 2007 Mendelian randomization as an instrumental variable approach to causal inference. Stat Methods Med Res 16:309-330 (Pubitemid 47215256)
13. Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih PA, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum JL, Schork NJ, Schmid-Schonbein GW, O'Connor DT 2007 C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/β- adrenergic pathway loci. J Hypertens 25:329-343 (Pubitemid 46071931)
14. Crawford DC, Sanders CL, Qin X, Smith JD, Shephard C, Wong M, Witrak L, Rieder MJ, Nickerson DA 2006 Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey. Circulation 114:2458-2465 (Pubitemid 44901518)
15. Carlson CS, Aldred SF, Lee PK, Tracy RP, Schwartz SM, Rieder M, Liu K, Williams OD, Iribarren C, Lewis EC, Fornage M, Boerwinkle E, Gross M, Jaquish C, Nickerson DA, Myers RM, Siscovick DS, Reiner AP 2005 Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am J Hum Genet 77:64-77 (Pubitemid 40848037)
16. Ridker PM, Pare G, Parker A, Zee RY, Danik JS, Buring JE, Kwiatkowski D, Cook NR, Miletich JP, Chasman DI 2008 Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am J Hum Genet 82:1185-1192
17. Zhang YY, Gottardo L, Mlynarski W, Frazier W, Nolan D, Duffy J, Marescotti MC, Gervino EV, Johnstone MT, Mantzoros CS, Avogaro A, Doria A 2007 Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels. Atherosclerosis 191:121-127 (Pubitemid 46237631)
18. Singh P, Hoffmann M, Wolk R, Shamsuzzaman AS, Somers VK 2007 Leptin induces C-reactive protein expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol 27:e302-e307 (Pubitemid 47312298)
19. Chen K, Li F, Li J, Cai H, Strom S, Bisello A, Kelley DE, Friedman-Einat M, Skibinski GA, McCrory MA, Szalai AJ, Zhao AZ 2006 Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med 12:425-432
20. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P, Guy-Grand B 1998 A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392:398-401 (Pubitemid 28168737)
21. Farooqi IS, Wangensteen T, Collins S, Kimber W, Matarese G, Keogh JM, Lank E, Bottomley B, Lopez-Fernandez J, Ferraz-Amaro I, Dattani MT, Ercan O, Myhre AG, Retterstol L, Stanhope R, Edge JA, McKenzie S, Lessan N, Ghodsi M, De Rosa V, Perna F, Fontana S, Barroso I, Undlien DE, O'Rahilly S 2007 Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med 356:237-247 (Pubitemid 46143227)
22. Mammes O, Aubert R, Betoulle D, Pean F, Herbeth B, Visvikis S, Siest G, Fumeron F 2001 LEPR gene polymorphisms: associations with overweight, fat mass and response to diet in women. Eur J Clin Invest 31:398-404 (Pubitemid 32476959)
23. Romero-Corral A, Sierra-Johnson J, Lopez-Jimenez F, Thomas RJ, Singh P, Hoffmann M, Okcay A, Korinek J, Wolk R, Somers VK 2008 Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population. Nat Clin Pract Cardiovasc Med 5:418-425 (Pubitemid 351935576)
24. Firmann M, Mayor V, Vidal PM, Bochud M, Pecoud A, Hayoz D, Paccaud F, Preisig M, Song KS, Yuan X, Danoff TM, Stirnadel HA, Waterworth D, Mooser V, Waeber G, Vollenweider P 2008 The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovasc Disord 8:6 (Pubitemid 351566647)
25. Stock JH, Wright JH, Yogo M 2002 A survey of weak instruments and weak identification in generalized method of moments. J Bus Econ Statist 4:518-529
26. Timpson NJ, Lawlor DA, Harbord RM, Gaunt TR, Day IN, Palmer LJ, Hattersley AT, Ebrahim S, Lowe GD, Rumley A, Davey Smith G 2005 C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. Lancet 366:1954-1959 (Pubitemid 41713985)
27. Lange LA, Carlson CS, Hindorff LA, Lange EM, Walston J, Durda JP, Cushman M, Bis JC, Zeng D, Lin D, Kuller LH, Nickerson DA, Psaty BM, Tracy RP, Reiner AP 2006 Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. JAMA 296:2703-2711 (Pubitemid 44917547)
28. Wang Y, Kuropatwinski KK, White DW, Hawley TS, Hawley RG, Tartaglia LA, Baumann H 1997 Leptin receptor action in hepatic cells. J Biol Chem 272:16216-16223 (Pubitemid 27276440)
29. Hukshorn CJ, Lindeman JH, Toet KH, Saris WH, Eilers PH, Westerterp-Plantenga MS, Kooistra T 2004 Leptin and the proinflammatory state associated with human obesity. J Clin Endocrinol Metab 89:1773-1778 (Pubitemid 38507933)
30. Viikari LA, Huupponen RK, Viikari JS, Marniemi J, Eklund C, Hurme M, Lehtimaki T, Kivimaki M, Raitakari OT 2007 Relationship between leptin and C-reactive protein in young Finnish adults. J Clin Endocrinol Metab 92:4753-4758 (Pubitemid 350223456)
31. Abdullah SM, Khera A, Leonard D, Das SR, Canham RM, Kamath SA, Vega GL, Grundy SM, McGuire DK, de Lemos JA 2007 Sex differences in the association between leptin and CRP: results from the Dallas Heart Study. Atherosclerosis 195:404-410 (Pubitemid 350087950)
32. Dullaart RP, de Vries R, Dikkeschei LD, Sluiter WJ 2007 Higher plasma leptin largely explains increased C-reactive protein levels in women. Eur J Clin Invest 37:231-233
33. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-141 (Pubitemid 27180337)
34. Jacobsson JA, Danielsson P, Svensson V, Klovins J, Gyllensten U, Marcus C, Schioth HB, Fredriksson R 2008 Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. Biochem Biophys Res Commun 368:476-482
35. Blouin K, Boivin A, Tchernof A 2008 Androgens and body fat distribution. J Steroid Biochem Mol Biol 108:272-280
36. Lawlor DA, Harbord RM, Timpson NJ, Lowe GD, Rumley A, Gaunt TR, Baker I, Yarnell JW, Kivimaki M, Kumari M, Norman PE, Jamrozik K, Hankey GJ, Almeida OP, Flicker L, Warrington N, Marmot MG, Ben-Shlomo Y, Palmer LJ, Day IN, Ebrahim S, Smith GD 2008 The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. PLoS ONE 3:e3011
37. Eiriksdottir G, Smith AV, Aspelund T, Hafsteinsdottir SH, Olafsdottir E, Launer LJ, Harris TB, Gudnason V 2009 The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibility-Reykjavik study. Int J Obes (Lond) 33:267-272
38. Davey Smith G, Ebrahim S 2003 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32:1-22
39. Smith GD, Timpson N, Ebrahim S 2008 Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization. Ann Med 40:524-541
40. Lee CC, You NC, Song Y, Hsu YH, Manson J, Nathan L, Tinker L, Liu S 2009 Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort. Clin Chem 55:351-360