The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids

Food and Chemical Toxicology

Volumn 49, Issue 5, 2011, Pages 1129-1140

  El Moselhy, Mohamed A ^a   Taye, Ashraf ^a   Sharkawi, Sara Shaaban ^a   El Sisi, Suzan F I ^b   Ahmed, Ahmed Fahmy ^c  

^a Minia University   (Egypt)

^b NATIONAL ORGANIZATION FOR DRUG CONTROL AND RESEARCH NODCAR   (Egypt)

^c Zagazig University   (Egypt)

Author keywords

Curcumin; Free fatty acids; High fat diet; Insulin resistance; TNF ; Type 2 diabetes mellitus

Indexed keywords

ANTIDIABETIC AGENT; CURCUMIN; FATTY ACID; GLUCOSE; INSULIN; ROSIGLITAZONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CURCUMA LONGA; CYTOKINE RESPONSE; DRUG EFFECT; DRUG MECHANISM; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; RAT;

ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; BODY COMPOSITION; CURCUMIN; DIABETES MELLITUS, TYPE 2; DIETARY FATS; FATTY ACIDS, NONESTERIFIED; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; MALE; RATS; RATS, SPRAGUE-DAWLEY; THIAZOLIDINEDIONES; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

CURCUMA LONGA; RATTUS;

EID: 79953030266     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2011.02.004     Document Type: Article

References (79)

1. Ackman R.G., Sipos J.C. Flame ionization detector response for the carbonyl carbon atom in the carboxyl group of fatty acids and esters. J. Chromatogr. 1964, 16:298-305.
2. Adams M., Montague C.T., Prins J.B., Holder J.C., Smith S.A., Sanders L., Digby J.E., Sewter C.P., Lazar M.A., Chatterjee V.K., O'rahilly S. Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation. J. Clin. Invest. 1997, 100(12):3149-3153.
3. Arun N., Nalini N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum. Nutr. 2002, 57(1):41-52.
4. Bainbridge H.W. The reduced sensitivity to insulin of rats and mice fed on a carbohydrate-free, excess-fat diet. J. Physiol. 1925, 60(4):293-300.
5. Beutler B., Cerami A. Cachectin: more than a tumor necrosis factor. N. Engl. J. Med. 1987, 316(7):379-385.
6. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and niddm. Diabetes 1997, 46(1):3-10.
7. Brouet I., Ohshima H. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem. Biophys. Res. Commun. 1995, 206(2):533-540.
8. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001, 414(6865):813-820.
9. Bucolo G., David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin. Chem. 1973, 19(5):476-482.
10. Burstein M., Scholnick H.R., Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J. Lipid Res. 1970, 11(6):583-595.
11. Cai X.J., Lister C.A., Buckingham R.E., Pickavance L., Wilding J., Arch J.R., Wilson S., Williams G. Down-regulation of orexin gene expression by severe obesity in the rats: studies in zucker fatty and zucker diabetic fatty rats and effects of rosiglitazone. Brain Res. Mol. Brain Res. 2000, 77(1):131-137.
12. Clark P.M.S., Hales C.N. Assay of insulin. Textbook of Diabetes 1991, vol. 1:335-347. Blackwell Scientific Publications.
13. Cooke D.W. Diabetes. Encyclopedia of Biological Chemistry 2004, 582-592. Elsevier Inc. J.W. Lane, M.D. Lennarz (Eds.).
14. Davis S. Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas. Goodman and Gilman's the Pharmacological Basis of Therapeutics 2006, 1037-1058. McGraw-Hill, Medical Publishing Division. 11th ed. L.L. Brunton, J.S. Lazo, K.L. Parker (Eds.).
15. Duvoix A., Morceau F., Delhalle S., Schmitz M., Schnekenburger M., Galteau M.M., Dicato M., Diederich M. Induction of apoptosis by curcumin: mediation by glutathione s-transferase p1-1 inhibition. Biochem. Pharmacol. 2003, 66(8):1475-1483.
16. Ejaz A., Wu D., Kwan P., Meydani M. Curcumin inhibits adipogenesis in 3t3-L1 adipocytes and angiogenesis and obesity in C57/Bl mice. J. Nutr. 2009, 139(5):919-925.
17. El-Moselhy M.A., Suzan F.I.E.-S., Rasha A., Salah A.G., Ahmed F.A., Mohamed M.K. The effect of L-Carnitine and bromocriptine on the antihyperglycemic action of bezafibrate in obese rats. J. Egypt. Ger. Soc. Zoo. 2006, 50A:119-136.
18. Folli F., Saad M.J., Backer J.M., Kahn C.R. Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat. J. Biol. Chem. 1992, 267(31):22171-22177.
19. Fonseca V. Effect of thiazolidinediones on body weight in patients with diabetes mellitus. Am. J. Med. 2003, 115:42S-48S. (Suppl 8A).
20. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972, 18(6):499-502.
21. Fujisawa S., Atsumi T., Ishihara M., Kadoma Y. Cytotoxicity, ros-generation activity and radical-scavenging activity of curcumin and related compounds. Anticancer Res. 2004, 24(2B):563-569.
22. Funahashi T., Nakamura T., Shimomura I., Maeda K., Kuriyama H., Takahashi M., Arita Y., Kihara S., Matsuzawa Y. Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. Intern. Med. 1999, 38(2):202-206.
23. Gabriely I., Barzilai N. Surgical removal of visceral adipose tissue: effects on insulin action. Curr. Diab. Rep. 2003, 3(3):201-206.
24. Grundy S.M. Atherogenic dyslipidemia associated with metabolic syndrome and insulin resistance. Clin. Cornerstone. 2006, 8:S21-27. (Suppl 1).
25. Herling A.W., Albus U. Euthanasia of Experimental Animals. Drug Discovery and Evaluation: Pharmacological Assays, second ed 2002, Springer-Verlag, Berlin. H.G. Vogel (Ed.).
26. Hirose H., Kawai T., Yamamoto Y., Taniyama M., Tomita M., Matsubara K., Okazaki Y., Ishii T., Oguma Y., Takei I., Saruta T. Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes. Metabolism 2002, 51(3):314-317.
27. Hong J., Bose M., Ju J., Ryu J.H., Chen X., Sang S., Lee M.J., Yang C.S. Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase a(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis 2004, 25(9):1671-1679.
28. Hotamisligil G.S. Mechanisms of TNF-alpha-induced insulin resistance. Exp. Clin. Endocrinol. Diabetes 1999, 107(2):119-125.
29. Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444(7121):860-867.
30. Hotamisligil G.S., Arner P., Caro J.F., Atkinson R.L., Spiegelman B.M. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 1995, 95(5):2409-2415.
31. Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259(5091):87-91.
32. Jensen M.D., Haymond M.W., Rizza R.A., Cryer P.E., Miles J.M. Influence of body fat distribution on free fatty acid metabolism in obesity. J. Clin. Invest. 1989, 83(4):1168-1173.
33. Jiang C., Ting A.T., Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998, 391(6662):82-86.
34. Kelley D.E., Mokan M., Mandarino L.J. Intracellular defects in glucose metabolism in obese patients with niddm. Diabetes 1992, 41(6):698-706.
35. Kelley D.E., Mokan M., Simoneau J.A., Mandarino L.J. Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J. Clin. Invest. 1993, 92(1):91-98.
36. Kelly I.E., Han T.S., Walsh K., Lean M.E. Effects of a thiazolidinedione compound on body fat and fat distribution of patients with type 2 diabetes. Diabetes Care 1999, 22(2):288-293.
37. Kern P.A., Saghizadeh M., Ong J.M., Bosch R.J., Deem R., Simsolo R.B. The Expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J. Clin. Invest. 1995, 95(5):2111-2119.
38. Kim S., Wanibuchi H., Hamaguchi A., Miura K., Yamanaka S., Iwao H. Angiotensin blockade improves cardiac and renal complications of type ii diabetic rats. Hypertension 1997, 30(5):1054-1061.
39. Kissebah A.H., Peiris A.N. Biology of regional body fat distribution: relationship to non-insulin-dependent diabetes mellitus. Diabetes Metab. Rev. 1989, 5(2):83-109.
40. Koh-Banerjee P., Wang Y., Hu F.B., Spiegelman D., Willett W.C., Rimm E.B. Changes in body weight and body fat distribution as risk factors for clinical diabetes in us men. Am. J. Epidemiol. 2004, 159(12):1150-1159.
41. Kopelman P.G. Obesity as a medical problem. Nature 2000, 404(6778):635-643.
42. Laakso M. Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention. J. Intern. Med. 2001, 249(3):225-235.
43. Lewis G.F., Carpentier A., Adeli K., Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr. Rev. 2002, 23(2):201-229.
44. Lodha R., Bagga A. Traditional Indian systems of medicine. Ann. Acad. Med. Singapore 2000, 29(1):37-41.
45. Long S.D., Pekala P.H. Lipid mediators of insulin resistance. ceramide signalling down-regulates Glut4 gene transcription in 3t3-L1 adipocytes. Biochem. J. 1996, 319(Pt 1):179-184.
46. Moller D.E. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol. Metab. 2000, 11(6):212-217.
47. Naderali E.K., Fatani S., Williams G. Chronic withdrawal of a high-palatable obesity-inducing diet completely reverses metabolic and vascular abnormalities associated with dietary-obesity in the rat. Atherosclerosis 2004, 172(1):63-69.
48. Naderali E.K., Williams G. Prolonged endothelial-dependent and -independent arterial dysfunction induced in the rat by short-term feeding with a high-fat, high-sucrose diet. Atherosclerosis 2003, 166(2):253-259.
49. Nishiyama T., Mae T., Kishida H., Tsukagawa M., Mimaki Y., Kuroda M., Sashida Y., Takahashi K., Kawada T., Nakagawa K., Kitahara M. Curcuminoids and sesquiterpenoids in turmeric (Curcuma Longa L.) suppress an increase in blood glucose level in type 2 diabetic Kk-Ay mice. J. Agric. Food Chem. 2005, 53(4):959-963.
50. Nishizono S., Hayami T., Ikeda I., Imaizumi K. Protection against the diabetogenic effect of feeding tert-butylhydroquinone to rats prior to the administration of streptozotocin. Biosci. Biotechnol. Biochem. 2000, 64(6):1153-1158.
51. Ouwens D.M., Boer C., Fodor M., De Galan P., Heine R.J., Maassen J.A., Diamant M. cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats. Diabetologia 2005, 48(6):1229-1237.
52. Pan M.H., Lin-Shiau S.Y., Lin J.K. Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of Ikappab kinase and Nfkappab activation in macrophages. Biochem. Pharmacol. 2000, 60(11):1665-1676.
53. Pari L., Murugan P. Effect of tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes in streptozotocin induced diabetic rats. J. Basic Clin. Physiol. Pharmacol. 2005, 16(4):257-274.
54. Poitout V., Robertson R.P. Minireview: secondary beta-cell failure in type 2 diabetes - a convergence of glucotoxicity and lipotoxicity. Endocrinology 2002, 143(2):339-342.
55. Rader D.J. Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus. Am. J. Med. 2007, 120(3):S12-S18. (Suppl 1).
56. Randle P.J., Garland P.B., Hales C.N., Newsholme E.A. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963, 1(7285):785-789.
57. Rebrin K., Steil G.M., Mittelman S.D., Bergman R.N. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J. Clin. Invest. 1996, 98(3):741-749.
58. Reddy A.C., Lokesh B.R. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron. Mol. Cell. Biochem. 1994, 137(1):1-8.
59. Roeschlau P., Bernt E., Gruber W. Enzymatic determination of total cholesterol in serum. Z. Klin. Chem. Klin. Biochem. 1974, 12(5):226.
60. Ruan H., Lodish H.F. Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha. Cytokine Growth Factor Rev. 2003, 14(5):447-455.
61. Saltiel A.R., Olefsky J.M. Thiazolidinediones in the treatment of insulin resistance and type ii diabetes. Diabetes 1996, 45(12):1661-1669.
62. Seo K.I., Choi M.S., Jung U.J., Kim H.J., Yeo J., Jeon S.M., Lee M.K. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic Db/Db mice. Mol. Nutr. Food Res. 2008, 52(9):995-1004.
63. Shishodia S., Singh T., Chaturvedi M.M. Modulation of transcription factors by curcumin. Adv. Exp. Med. Biol. 2007, 595:127-148.
64. Shoelson S.E., Lee J., Goldfine A.B. Inflammation and insulin resistance. J. Clin. Invest. 2006, 116(7):1793-1801.
65. Shuldiner A.R., Yang R., Gong D.W. Resistin, obesity and insulin resistance - the emerging role of the adipocyte as an endocrine organ. N. Engl. J. Med. 2001, 345(18):1345-1346.
66. Singh S., Aggarwal B.B. Activation of transcription factor Nf-kappa B is suppressed by curcumin (diferuloylmethane). J. Biol. Chem. 1995, 270(42):24995-25000. (corrected).
67. Sreejayan, Rao M.N. Curcuminoids as potent inhibitors of lipid peroxidation. J. Pharm. Pharmacol. 1994, 46(12):1013-1016.
68. Srinivasan M. Effect of curcumin on blood sugar as seen in a diabetic subject. Indian J. Med. Sci. 1972, 26(4):269-270.
69. Susini C., Lavau M. In-vitro and in-vivo responsiveness of muscle and adipose tissue to insulin in rats rendered obese by a high-fat diet. Diabetes 1978, 27(2):114-120.
70. Toda S., Miyase T., Arichi H., Tanizawa H., Takino Y. Natural Antioxidants. III. Antioxidative Components Isolated from Rhizome of Curcuma Longa L. Chem. Pharm.Bull. (Tokyo) 1985, 33(4):1725-1728.
71. Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J. Clin. Pathol. 1969, 22(2):158-161.
72. Van Herck H., Baumans V., Van Der Craats N.R., Hesp A.P., Meijer G.W., Van Tintelen G., Walvoort H.C., Beynen A.C. Histological changes in the orbital region of rats after orbital puncture. Lab. Anim. 1992, 26(1):53-58.
73. Vauhkonen I., Niskanen L., Vanninen E., Kainulainen S., Uusitupa M., Laakso M. Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands. J. Clin. Invest. 1998, 101(1):86-96.
74. Ventre J., Doebber T., Wu M., Macnaul K., Stevens K., Pasparakis M., Kollias G., Moller D.E. Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice. Diabetes 1997, 46(9):1526-1531.
75. Wallace T.M., Levy J.C., Matthews D.R. Use and abuse of homa modeling. Diabetes Care 2004, 27(6):1487-1495.
76. Weisberg S.P., Leibel R., Tortoriello D.V. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008, 149(7):3549-3558.
77. Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., Mori Y., Ide T., Murakami K., Tsuboyama-Kasaoka N., Ezaki O., Akanuma Y., Gavrilova O., Vinson C., Reitman M.L., Kagechika H., Shudo K., Yoda M., Nakano Y., Tobe K., Nagai R., Kimura S., Tomita M., Froguel P., Kadowaki T. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 2001, 7(8):941-946.
78. Zaragoza-Hermans N., Felber J.P. Studies on the metabolic effects induced in the rat by a high-fat diet. (U-14 C) glucose metabolism in epididymal adipose tissue. Eur. J. Biochem. 1972, 25(1):89-95.
79. Zimmet P., Alberti K.G., Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001, 414(6865):782-787.