Andrographolide prevents high-fat diet-induced obesity in C57BL/6 mice by suppressing the sterol regulatory element-binding protein pathway

Journal of Pharmacology and Experimental Therapeutics

Volumn 351, Issue 2, 2014, Pages 474-483

  Ding, Lili ^a,b   Li, Jinmei ^a,b,e   Song, Baoliang ^c   Xiao, Xu ^c   Huang, Wendong ^d   Zhang, Binfeng ^a,b   Tang, Xiaowen ^a,b   Qi, Meng ^a,b   Yang, Qiming ^a,b   Yang, Qiaoling ^a,b   Yang, Li ^a,b   Wang, Zhengtao ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Center for Standardization of Traditional Chinese Medicines   (China)

^c INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^d CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^e CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGRAPHOLIDE; GLUCOSE; INSULIN; LIPID; MEVINOLIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; DITERPENE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOBESITY EFFECT; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENERGY EXPENDITURE; GENE; GENE TARGETING; GLUCOSE UTILIZATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPID DIET; LIPID METABOLISM; LIPID STORAGE; LIVER; LIVER METABOLISM; MALE; METABOLISM ASSOCIATED GENE; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REPORTER GENE; RESPIRATORY QUOTIENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE METABOLISM; WEIGHT GAIN; WEIGHT REDUCTION; WESTERN BLOTTING; ANIMAL; BLOOD; BROWN ADIPOSE TISSUE; C57BL MOUSE; ENERGY METABOLISM; HEPG2 CELL LINE; INSULIN RESISTANCE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; TUMOR CELL LINE;

ADIPOSE TISSUE, BROWN; ANIMALS; CELL LINE, TUMOR; DIET, HIGH-FAT; DITERPENES; DOWN-REGULATION; ENERGY METABOLISM; GLUCOSE; HEP G2 CELLS; HUMANS; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; LIPIDS; LIVER; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; OXYGEN CONSUMPTION; STEROL REGULATORY ELEMENT BINDING PROTEINS; WEIGHT GAIN;

EID: 84908123327     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.217968     Document Type: Article

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