Molecular mechanisms underlying the anti-obesity potential of prunetin, an O-methylated isoflavone

Biochemical Pharmacology

Volumn 85, Issue 10, 2013, Pages 1525-1533

  Ahn, Tae Gue ^a   Yang, Gabsik ^a   Lee, Heon Myung ^a   Kim, Myung Dong ^a   Choi, Ho Young ^b   Park, Kyoung Sik ^a   Lee, Sun Dong ^a   Kook, Yoon Bum ^a   An, Hyo Jin ^a  

^a Department of Computer and Electronic Physics   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

Adipogenic genes; Adiponectin receptors; AMP activated protein kinase (AMPK); High fat diet (HFD); Mice; Prunetin

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; ANTIOBESITY AGENT; CCAAT ENHANCER BINDING PROTEIN ALPHA; CHOLESTEROL; GLUCOSE; ISOFLAVONE; LEPTIN; LIVER X RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PRUNETIN;

ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; INTRAABDOMINAL FAT; LIPID DIET; LIPID METABOLISM; LIPID STORAGE; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; TREATMENT DURATION; UPREGULATION; WEIGHT GAIN;

ADIPOCYTES; ADIPOGENESIS; ADIPONECTIN; ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTI-OBESITY AGENTS; BLOOD GLUCOSE; DIET, HIGH-FAT; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION; ISOFLAVONES; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; OBESITY; RECEPTORS, ADIPONECTIN; WEIGHT GAIN;

EID: 84876667816     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.02.020     Document Type: Article

References (43)

1. M.E. Vazquez-Vela, N. Torres, and A.R. Tovar White adipose tissue as endocrine organ and its role in obesity Arch Med Res 39 2008 715 728
2. E.D. Rosen, C.J. Walkey, P. Puigserver, and B.M. Spiegelman Transcriptional regulation of adipogenesis Genes Dev 14 2000 1293 1307
3. M.I. Lefterova, and M.A. Lazar New developments in adipogenesis Trends Endocrinol Metab 20 2009 107 114
4. J.B. Kim, and B.M. Spiegelman ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism Genes Dev 10 1996 1096 1107
5. J.B. Seo, H.M. Moon, W.S. Kim, Y.S. Lee, H.W. Jeong, and E.J. Yoo Activated liver × receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression Mol Cell Biol 24 2004 3430 3444
6. C.J. Lyon, R.E. Law, and W.A. Hsueh Minireview: adiposity, inflammation, and atherogenesis Endocrinology 144 2003 2195 2200
7. E. Hu, P. Liang, and B.M. Spiegelman AdipoQ is a novel adipose-specific gene dysregulated in obesity J Biol Chem 271 1996 10697 10703
8. Y. Arita, S. Kihara, N. Ouchi, M. Takahashi, K. Maeda, and J. Miyagawa Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochem Biophys Res Commun 257 1999 79 83
9. T. Yamauchi, J. Kamon, Y. Ito, A. Tsuchida, T. Yokomizo, and S. Kita Cloning of adiponectin receptors that mediate antidiabetic metabolic effects Nature 423 2003 762 769
10. T. Yamauchi, J. Kamon, Y. Minokoshi, Y. Ito, H. Waki, and S. Uchida Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Nat Med 8 2002 1288 1295
11. E. Tomas, T.S. Tsao, A.K. Saha, H.E. Murrey, C. Zhang Cc, and S.I. Itani Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation Proc Natl Acad Sci U S A 99 2002 16309 16313
12. M.J. Yoon, G.Y. Lee, J.J. Chung, Y.H. Ahn, S.H. Hong, and J.B. Kim Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha Diabetes 55 2006 2562 2570
13. C.H. Wu, M.Y. Yang, K.C. Chan, P.J. Chung, T.T. Ou, and C.J. Wang Improvement in high-fat diet-induced obesity and body fat accumulation by a Nelumbo nucifera leaf flavonoid-rich extract in mice J Agric Food Chem 58 2010 7075 7081
14. H. Kamisoyama, K. Honda, Y. Tominaga, S. Yokota, and S. Hasegawa Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats Biosci Biotechnol Biochem 72 2008 3225 3231
15. K. Nakagawa, H. Kishida, N. Arai, T. Nishiyama, and T. Mae Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A(y) mice Biol Pharm Bull 27 2004 1775 1778
16. F. Aoki, S. Honda, H. Kishida, M. Kitano, N. Arai, and H. Tanaka Suppression by licorice flavonoids of abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice Biosci Biotechnol Biochem 71 2007 206 214
17. L.K. Han, Y.N. Zheng, B.J. Xu, H. Okuda, and Y. Kimura Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice J Nutr 132 2002 2241 2245
18. R.S. Surwit, C.L. Edwards, S. Murthy, and A.E. Petro Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice Diabetes 49 2000 1203 1208
19. J.E. Willson, D.E. Brown, and E.K. Timmens A toxicologic study of dimethyl sulfoxide Toxicol Appl Pharmacol 7 1965 104 112
20. S.W. Jacob, and D.C. Wood Dimethyl sulfoxide (DMSO). Toxicology, pharmacology, and clinical experience Am J Surg 114 1967 414 426
21. J.S. Kang, W.K. Lee, C.W. Lee, W.K. Yoon, N. Kim, and S.K. Park Improvement of high-fat diet-induced obesity by a mixture of red grape extract, soy isoflavone and l-carnitine: implications in cardiovascular and non-alcoholic fatty liver diseases Food Chem Toxicol 49 2011 2453 2458
22. Z.H. Yang, H. Miyahara, J. Takeo, A. Hatanaka, and M. Katayama Pollock oil supplementation modulates hyperlipidemia and ameliorates hepatic steatosis in mice fed a high-fat diet Lipids Health Dis 10 2011 189
23. A. Vidal-Puig, M. Jimenez-Linan, B.B. Lowell, A. Hamann, E. Hu, and B. Spiegelman Regulation of PPAR gamma gene expression by nutrition and obesity in rodents J Clin Invest 97 1996 2553 2561
24. J.P. Berger Role of PPARgamma, transcriptional cofactors, and adiponectin in the regulation of nutrient metabolism, adipogenesis and insulin action: view from the chair Int J Obes (Lond) 29 Suppl. 1 2005 S3 S4
25. P. Tontonoz, E. Hu, R.A. Graves, A.I. Budavari, and B.M. Spiegelman mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer Genes Dev 8 1994 1224 1234
26. J.E. Oben, J.L. Ngondi, and K. Blum Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and leptin genes and up-regulation of the adiponectin gene Lipids Health Dis 7 2008 44
27. Y.J. Kim, K.Y. Kim, M.S. Kim, J.H. Lee, K.P. Lee, and T. Park A mixture of the aqueous extract of Garcinia cambogia, soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet Genes Nutr 2 2008 353 358
28. R. Walczak, and P. Tontonoz PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism J Lipid Res 43 2002 177 186
29. M. Inoue, T. Ohtake, W. Motomura, N. Takahashi, Y. Hosoki, and S. Miyoshi Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice Biochem Biophys Res Commun 336 2005 215 222
30. K. Matsusue, M. Haluzik, G. Lambert, S.H. Yim, O. Gavrilova, and J.M. Ward Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes J Clin Invest 111 2003 737 747
31. S. Yu, K. Matsusue, P. Kashireddy, W.Q. Cao, V. Yeldandi, and A.V. Yeldandi Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression J Biol Chem 278 2003 498 505
32. C.S. Kumari, S. Govindasamy, and E. Sukumar Lipid lowering activity of Eclipta prostrata in experimental hyperlipidemia J Ethnopharmacol 105 2006 332 335
33. T.F. Osborne Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action J Biol Chem 275 2000 32379 32382
34. R.H. Unger The hyperleptinemia of obesity-regulator of caloric surpluses Cell 117 2004 145 146
35. W.J. Lee, M. Kim, H.S. Park, H.S. Kim, M.J. Jeon, and K.S. Oh AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1 Biochem Biophys Res Commun 340 2006 291 295
36. Y.S. Lee, W.S. Kim, K.H. Kim, M.J. Yoon, H.J. Cho, and Y. Shen Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states Diabetes 55 2006 2256 2264
37. A.M. Wolf, D. Wolf, M.A. Avila, A.R. Moschen, C. Berasain, and B. Enrich Up-regulation of the anti-inflammatory adipokine adiponectin in acute liver failure in mice J Hepatol 44 2006 537 543
38. R. Pineiro, M.J. Iglesias, R. Gallego, K. Raghay, S. Eiras, and J. Rubio Adiponectin is synthesized and secreted by human and murine cardiomyocytes FEBS Lett 579 2005 5163 5169
39. A.H. Berg, T.P. Combs, X. Du, M. Brownlee, and P.E. Scherer The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat Med 7 2001 947 953
40. J.M. Bruun, A.S. Lihn, C. Verdich, S.B. Pedersen, S. Toubro, and A. Astrup Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans Am J Physiol Endocrinol Metab 285 2003 E527 E533
41. T. Yamauchi, Y. Nio, T. Maki, M. Kobayashi, T. Takazawa, and M. Iwabu Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions Nat Med 13 2007 332 339
42. C. Bonnard, A. Durand, H. Vidal, and J. Rieusset Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice Diabetes Metab 34 2008 52 61
43. A.R. Nawrocki, M.W. Rajala, E. Tomas, U.B. Pajvani, A.K. Saha, and M.E. Trumbauer Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists J Biol Chem 281 2006 2654 2660