Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits

Clinical Nutrition

Volumn 23, Issue 5, 2004, Pages 1025-1034

  Jeon, Seon Min ^a   Park, Yong Bok ^a   Choi, Myung Sook ^a  

^a Kyungpook National University   (South Korea)

Author keywords

ACAT; HMG CoA reductase; Hypocholesterolemic effect; Lovastatin; Naringin

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; AURANTIIN; CHOLESTEROL ACYLTRANSFERASE; FAT DROPLET; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; STEROL;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA WALL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CELL INFILTRATION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; DRUG MECHANISM; ENZYME ACTIVITY; FECES ANALYSIS; HEART; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; LIVER LEVEL; MALE; NONHUMAN; RABBIT; TISSUE INJURY; TISSUE LEVEL; TISSUE STRUCTURE; VASCULAR ENDOTHELIUM;

ACYLTRANSFERASES; ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CHOLESTEROL, DIETARY; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FECES; FLAVANONES; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIVER; LOVASTATIN; MALE; RABBITS; RANDOM ALLOCATION; STEROL O-ACYLTRANSFERASE;

EID: 4544360864     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2004.01.006     Document Type: Article

References (49)

1. Mortality from coronary heart disease and acute myocardial infarction-United States, 1998. MMWR. Morb. Mortal. Wkly Rep 2001; 50(6): 90-3
2. Wald N.I. Law M.R. Serum cholesterol and ischemic heart disease Atherosclerosis 118 Suppl. 1995 1-5
3. Byington R.P. Jukema J.W. Salonen J.T. et al. Reduction in cardiovascular events during pravastatin therapy. Pooled analysis of clinical events of the pravastatin atherosclerosis intervention program Circulation 92 1995 2419-2425
4. Delsing D.J. Offerman E.H. van Duyvenvoorde W. et al. Acyl-CoA: cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice Circulation 103 13 2001 1778-1786
5. Kim D.H. Jung E.A. Song I.S. Han J.A. Kim T.H. Han M.J. Intestinal bacterial metabolism of flavonoids and its relation to some biological activities Arch Pharm Res 21 1998 17-23
6. Higashimoto M. Yamato H. Kinouchi T. Ohnish Y. Inhibitory effects of citrus fruits on the mutagenicity of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid treated with nitric in the presence of ethanol Mutat Res 415 1998 219-226
7. Le Marchand L. Murphy S.P. Hankin J.H. Wilkens L.R. Kolonel L.M. Intake of flavonoids and lung cancer J Natl Cancer Inst 92 2000 154-160
8. Tsai S.H. Lin-Shiau S.Y. Lin J.K. Suppression of nitric oxide synthase and the down-regulation of the activation of NF-kappaB in macrophages by resveratrol Br J Pharmacol 126 3 1999 673-680
9. Bok S.H. Shin Y.W. Bae K.H. et al. Effects of naringin and lovastatin on plasma and hepatic lipids in high-fat and high-cholesterol fed rats Nutr Res 20 2000 1007-1015
10. Shin Y.W. Bok S.H. Jeong T.S. et al. Hypocholesterolemic effect of naringin associated with hepatic cholesterol-regulating enzyme changes in rats Int J Vitam Nutr Res 69 1999 341-347
11. Allain C.C. Poon L.S. Chen C.S.G. Richmond W. Fu P.C. Enzymatic determination of total serum cholesterol Clin Chem 20 4 1974 470-475
12. Fossati P. Prencipe L. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide Clin Chem 28 1982 2077-2088
13. Burstein M. Scholnick H.R. Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions J Lipid Res 11 6 1970 583-595
14. Friedbald W.T. Levy R.I. Fredrickson D.A. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Clin Chem 18 1972 499-502
15. Yamajaki K. Murata M. Frequency of athegenic risk factors in Japanese obese children Diabes Res Clin Pract 10 1994 S211-S219
16. Folch J. Lees M. Sloane-Stanley G.H. A simple method for isolation and purification of total lipids from animal tissues J Biol Chem 226 1957 497-509
17. Sale F.O. Marchesine S.P. Fishman H.H. Berra B. A sensitive enzymatic assay for determination of cholesterol in lipid extract Anal Biochem 142 1983 347-350
18. Hulcher M.W. Oleson W.H. Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A J Lipid Res 14 1973 625-631
19. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248-254
20. Shapiro D.J. Nordstrom J.L. mitschelen J.J. Rodwell V.W. Schimke R.T. Microassay for 3-hydroxy-3-methylglutaryl CoA reductase in rat liver and in L-cell fibroblast Biochim Biophys Acta 370 1974 369-377
21. Erickson S.K. Schrewsbery M.A. Brooks C. Meyer D.J. Rat liver acyl-coenzyme A: cholesterol acyltransferase: its regulation in vivo and some of properties in vitro J Lipid Res 21 1980 930-941
22. Gillies P.J. Rathgeb K.A. Robinson C.S. Regulation of acyl-CoA: cholesterol acyltransferase activity in normal and atherosclerotic rabbit aortas: role of a cholesterol substrate pool Exp Mol Pathol 44 1986 320-339
23. Czubayko F. Beumers B. Lutjohann D. von Bergmann K. A simplified micromethod for quantification of fecal excretion of neutral and acidic sterols for outpatient studies in humans J Lipid Res 32 1992 1861-1867
24. Michael J.C. Ian A.M. Enzymatic determination of 3α-, 7α-, and 12α-hydroxyl groups of fecal bile salts Clin Chem 26 1980 1298-1300
25. Carleton M. Histological techniques. 4th ed. New York, Toronto: Oxford University Press 1967, p.166.
26. Havsteen B. Flavonoids, a class of natural product of high pharmacological potency Biochem Pharmacol 32 1983 1141-1148
27. Choi J.S. Yokozawa T. Oura H. Antihyperlipidemic effect of flavonoids from Prunus davidiana J Nat Prod 54 1991 218-224
28. Monforte M.T. Trovato A. Kirjavainen S. Forestieri A.M. Galati E.M. Lo Curt R.B. Biological effects of hesperidin, a citrus flavonoid. (note II): hypolipidemic activity on experimental hypercholesterolemia in rat Farmaco 50 1995 595-599
29. Kurowska E.M. Borradaile N.M. Spence J.D. Carroll K.K. Hypocholesterolemic effects of dietary citrus juices in rabbits Nutr Res 20 1 2000 121-129
30. Kritchevsky D. Dietary fat and experimental atherosclerosis Int J Tissue React 13 1991 59-65
31. Kroon P.A. De Martino J.A. Thomson G.M. Chao Y.S. Molecular cloning of partial cDNAs for rabbit liver apolipoprotein B and the regulation of its mRNA levels by dietary cholesterol Proc Natl Acad Sci USA 83 1986 5071-5075
32. Alegret M. Verd J.C. Diaz C. et al. Effect of hypolipidemic drugs on key enzyme activities related to lipid metabolism in normolipidemic rabbits Eur J Pharmacol 347 1998 283-291
33. Conde K. Roy S. Freake H.C. Newton R.S. Fernandez M.L. Atorvastatin and simvastatin have distinct effects on hydroxyl methylglutaryl-CoA reductase activity and mRNA abundance in the guinea pig Lipids 34 12 1999 1327-1332
34. Choi J.S. Yokozawa T. Oura H. Antihyperlipidemic effect of flavonoids from Prunus davidiana J Nat Prod 54 1991 218-224
35. Choi J.S. Yokozawa T. Oura H. Improvement of hyperglycemia and hyperlipidemia in streptozotocin-diabetic rats by a methanolic extract of Prunus davidiana stems and its main component, pruninn Plant Med 57 1991 208-211
36. Kurowska E.M. Jordan J. Spence J.D. et al. Effects of substituting dietary soybean protein and for milk protein and fat in subjects with hypercholesterolemia Clin Invest Med 20 1997 162-170
37. Kurowska E.M. Spence J.D. Jordan J. et al. HDL-choesterol-raising effect of orange juice in subjects with hyper-cholesterolemia Am J Clin Nutr 72 2000 1095-1100
38. Juhel C. Dubois C. Senft M. Levy E. Lafont H. Lairon D. Postprandial lipeamia is exacerbated in fat-cholesterol-fed rabbits: relationship to atheroma deposition Br J Nutr 78 1997 301-311
39. Tall A.R. Plasma cholesteryl ester transfer protein J Lipid Res 34 1993 1255-1274
40. Grogan W.M. Bailey M.L. Heuman D.M. Vlahcevic Z.R. Effects of perturbances in hepatic free and esterified cholesterol pools on bile acid synthesis, cholesterol 7 alpha-hydroxylase, HMG-CoA reductase, acyl-CoA: cholesterol acyltransferase and cytosolic cholesteryl ester hydrolase Lipids 26 1991 907-914
41. Garcia-Gonzalez M. Segovia J.L. Akejandro M.J. Homeostatic restoration of microsomal lipids and enzyme changes in HMG-CoA reductase and acyl-CoA: cholesterol acyltransferase in chick liver Mol Cell Biochem 115 1992 173-178
42. Wilcox L.J. Borradaile N.M. de Dreu L.E. Huff M.W. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP J Lipid Res 42 2001 725-734
43. Mortensen A. Breinholt V. Dalsgaard T. et al. 17 ß-Estradiol but not the phytoestrogen naringenin attenuates aortic cholesterol accumulation in WHHL rabbits J Lipid Res 42 2001 834 843
44. Nielson L.B. Stender S. Kjeldsen K. Effect of lovastatin on cholesterol absorption in cholesterol-fed rabbits Pharmacol Toxicol 72 1993 148-151
45. Zeiher A.M. Drexler H. Saurbier B. Just H. Endothelium-mediated coronary blood flow modulation in humans: effects of age, atherosclerosis, hypercholesterolemia, and hypertension J Clin Invest 92 1993 652-662
46. Quyyumi A. Effect of atherosclerosis on endothelium-dependent inhibition of platelet activation in humans Circulation 98 1998 17-24
47. La Ville A.E. Seddon A.M. Shaikh M. Rowles P.M. Woolf N. Lewis B. Primary prevention of atherosclerosis by lovastatin in a generally hyperlipidemic rabbit strain Atherosclerosis 78 1989 205-210
48. Kobayashi M. Ishida F. Takahashi T. et al. Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits Jpn J Pharmacol 49 1989 125-133
49. Kim H.J. Oh G.T. Park Y.B. Lee M.K. Seo H.J. Choi M.S. Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition Life Sci 74 2004 1621-1634