α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo

Drug Design, Development and Therapy

Volumn 8, Issue , 2014, Pages 1629-1647

  Ibrahim, Mohamed Yousif ^a   Hashim, Najihah Mohd ^a   Mohan, Syam ^b   Abdulla, Mahmood Ameen ^a   Kamalidehghan, Behnam ^a   Ghaderian, Mostafa ^a,c   Dehghan, Firouzeh ^a   Ali, Landa Zeenelabdin ^a   Arbab, Ismail Adam ^d   Yahayu, Maizatulakmal ^e   Lian, Gwendoline Ee Cheng ^f   Ahmadipour, Fatemeh ^a   Ali, Hapipah Mohd ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b JAZAN UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF MALAYA   (Malaysia)

^d UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^e UNIVERSITI TEKNOLOGI MALAYSIA   (Malaysia)

^f UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Apoptosis; Caspace 3 7; Mitochondria; NF B; Protein array; Mangostin

Indexed keywords

ALPHA MANGOSTIN; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYCLINE; CYTOCHROME C; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT MEDICINAL PRODUCT; PROTEIN BAX; PROTEIN BCL 2; TAMOXIFEN; UNCLASSIFIED DRUG; MANGOSTIN; REACTIVE OXYGEN METABOLITE; XANTHONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CLUSIACEAE; CONTROLLED STUDY; CRATOXYLUM ARBORESCENS; CYTOTOXICITY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFICACY; DRUG ISOLATION; DRUG MEGADOSE; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MCF 7 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; S PHASE CELL CYCLE CHECKPOINT; TUMOR VOLUME; UPREGULATION; WESTERN BLOTTING; ANIMAL; BREAST NEOPLASMS; CELL CULTURE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; MAMMARY NEOPLASMS, ANIMAL; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BREAST NEOPLASMS; CELL PROLIFERATION; CELLS, CULTURED; CLUSIACEAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MAMMARY NEOPLASMS, ANIMAL; MCF-7 CELLS; MOLECULAR STRUCTURE; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHONES;

EID: 84908069751     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S66105     Document Type: Article

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