Mitigation of mitochondrial dysfunction and regulation of eNOS expression during experimental myocardial necrosis by alpha-mangostin, a xanthonic derivative from Garcinia mangostana

Drug and Chemical Toxicology

Volumn 32, Issue 4, 2009, Pages 344-352

  Sampath, Pandima Devi ^a   Kannan, Vijayaragavan ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Alpha mangostin; Cytochromes; Endothelial nitric oxide synthase; Isoproterenol; Mitochondria; Myocardial necrosis; Respiratory chain

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA MANGOSTIN; CATALASE; CYTOCHROME B; CYTOCHROME C; CYTOCHROME C OXIDASE; CYTOCHROME C1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; ISOCITRATE DEHYDROGENASE; ISOPRENALINE; MALATE DEHYDROGENASE; OXOGLUTARATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SUCCINATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE; ANTIOXIDANT; MANGOSTIN; PLANT EXTRACT; PROTEIN KINASE INHIBITOR; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ISOLATION; ENZYME ACTIVITY; ENZYME ANALYSIS; GARCINIA MANGOSTANA; HEART MITOCHONDRION; HEART MUSCLE NECROSIS; LIPID PEROXIDATION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; ENZYMOLOGY; HEART INFARCTION; HEART MUSCLE; METABOLISM; PATHOLOGY; PHYTOTHERAPY; WISTAR RAT;

GARCINIA MANGOSTANA; RATTUS;

ANIMALS; ANTIOXIDANTS; FREE RADICAL SCAVENGERS; GARCINIA MANGOSTANA; MYOCARDIAL INFARCTION; MYOCARDIUM; NITRIC OXIDE SYNTHASE TYPE III; PHYTOTHERAPY; PLANT EXTRACTS; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR; XANTHONES;

EID: 74049123549     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540903159210     Document Type: Article

References (54)

1. Albrecht, E.W. J.A., Stegeman, C. A., Tiebosch, A.T. M.G., Tegzess, A. M., Van Goor, H., (2002). Expression of inducible and endothelial nitric oxide synthases, formation of peroxynitrite, and reactive oxygen species in human chronic renal transplant failure. Am J Transpl 2:448-453.
2. Asolkar, L. V., Kakkar, K. K., Chakra, O. J. (1992). Second Supplement to Glossary of Indian Medicinal Plants with Active Principles. Part I (A-K). New Delhi, India: Publication and Information Division, CSIR.
3. Bisi, A., Budriesi, R., Rampa, A., Fabbri, G., Chiarini, A., Valenti, P. (1996). Synthesis and pharmacological profile of some chloroxanthone-1,4- dihydropyridine derivatives. Arzneimittelforschung 46:848-851.
4. Bush, L. R., Shlafer, H., Haack, D. W., Lucchesi, B. R. (1980). Time-dependent changes in canine cardiac mitochondrial function and ultrastructure resulting from coronary occlusion and reperfusion. Basic Res Cardiol 75:553-571.
5. Capetenaki, Y. (2002). Desmin cytoskeleton: a potential regulator of muscle mitochondria behavior and function. Trends Cardiovas Med 12:339-348.
6. Cheng, Y. W., Kang, J. J. (1997). Mechanism of vasorelaxation of thoracic aorta caused by xanthone. Eur J Pharmacol 336:23-28.
7. Clementi, E., Nisoli, E. (2005). Nitric oxide and mitochondrial biogenesis: a key role to long-term regulation of cellular metabolism. Comp Biochem Physiol 142:102-110.
8. Ebenezar, K. K., Sathish, V., Devaki, T. (2003). Effect of arginine and cystine on mitochondrial function during isoproterenol induced myocardial infarction in rats. Nutr Res 23:1277-1296.
9. Ellman, G. L. (1959). Tissue sulfhydryl groups. Arch Biochem Biophys 82:70-77.
10. Habig, W. H., Pabst, M. J., Jakoby, W. B. (1974). Glutathione- Stransferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:71130-71139.
11. Hayat, M. A. (1970). Principles and Techniques of Electron Microscope: Biological Application, Vol.1. New York: Van Nostrand Reinhold: New York.
12. Ho, C. K., Huang, Y. L., Chen, C. C. (2002). Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Planta Med 68:975-979.
13. Johnson, D., Lardy, H. (1967). Isolation of liver or kidney mitochondria. In: Estabrook RW (Ed.), Methods in Enzymology (pp 94-96). London: Academic Press.
14. Jung, H. A., Su, B. N., Keller, W. J., Mehta, R. G., Kinghorn, A. D. (2006). Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J Agric Food Chem 54:2077-2082.
15. King, J. (1965). Isocitrate dehydrogenase. In: Kind JC, Van D (Eds.), Practical Clinical Enzymology (p 363). London: Nostrand.
16. Kurian, GA, Philips, Varghese T. (2005). Effect of aqueous extract of the desmodium of gangeticum DC root in the severity of myocardial infarction. J Ethnopharmacol 97:457-461.
17. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
18. Lowry, O. H., Rosebrough, N. J., Farr, A. I., Randall, R. J., et al. (1951). Protein measurement with folinphenol reagent. J Biol Chem 193:265-275.
19. Mahabusarakam, W., Iriyachitra, P., Taylor, W. C. (1987). Chemical constituents of Garcinia mangostana. J Nat Prod 50:474-478.
20. Mahabusarakam, W., Proudfoot, J., Taylor, W., Croft, K. (2000). Inhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin. Free Radic Res 33:643-659.
21. Mehler, A. H., Korenberg, A., Crisolia, S., Ocho, S. (1948). The enzymatic mechanism of oxidation reductions between malate or isocitrate or pyruvate. J Biol Chem 174:961-977.
22. Minaakami, S., Ringler, R. L., Singer, T. P. (1962). Studies on the respiratory chain-linked dihydrodiphosphophridine nucleotide dehydrogenase-assay of the enzyme in particulate and in soluble prepartions. J Biol Chem 237:569-576.
23. Misra, H. P., Fridovich, I. (1972). The role of superoxide anion in the auto-oxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170-3175.
24. Moongkarndi, P., Kosem, N., Kaslungka, S. (2004). Antiproliferation, antioxidation, and induction of apoptosis by Garcinia mangostana (Mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol 90:161-166.
25. Nabandith, V., Suzui, M., Morioka, T., Kaneshiro, T., Kinjo, T., Matsumoto, K., et al. (2004). Inhibitory effects of crude alphamangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1,2 dimethylhydrazine in the rat. Asian Pacific J Cancer Prev 5:433-438.
26. Nakatani, K., Atsumi, M., Arakawa, T., Oosawa, K., Shimura, S., Nakahata, N., et al. (2002). Inhibitions of histamine release and prostaglandin E2 synthesis by Mangosteen, a Thai medicinal plant. Biol Pharm Bull 25:1137-1141.
27. Ohkawa, H., Ohishi, N., Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358.
28. Padmanabhana, M., Stanely, P. (2007). S-allylcysteine ameliorates isoproterenol-induced cardiac toxicity in rats by stabilizing cardiac mitochondrial and lysosomal enzymes. Life Sci 80:972-978.
29. Paglia, D. E., Valentaine, W. N. (1967). Studies on the glutathione and glutathione characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158-169.
30. Pandima Devi, S., Kannan, V. (2007). Cardioprotective effect of alpha-mangostin, a xanthone derivative from Mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxic 6:336-339.
31. Pandima Devi,S., Kannan, V. (2008). Ameliorative prospective of alpha-mangostin, a xanthone derivative from Garcinia mangostana against β-adrenergic cathecolamine-induced myocardial toxicity and anomalous cardiac TNF-α and COX-2 expressions in rats. Exp Toxicol Pathol 60:357-364.
32. Pearl, W., Cancercao, J., Zweifach, B. W. (1963). Microdetermination of cytochrome oxidase in rat tissues by the oxidation on N-phenyl-p- phenylenediamine or ascorbic acid. J Histochem Cytochem 11:102-104.
33. Raghavendran, H. R. B., Sathivel, A., Devaki, T. (2005). Antioxidant effect of Sargassum polycystum against acetaminopheninduced changes in hepatic mitochondrial enzymes during toxic hepatitis. Chemosphere 61:276-281.
34. Reed, L. J., Mukherjee, R. B. (1969). αketoglutarate dehydrogenase complex from Escherichia coli. In: Lowenstein JM (Ed.), Methods in Enzymology, Vol.13 (pp 53-61). London: Academic Press.
35. Ruiz, G. C., Colell, A., Morales, A., Kaplowitz, N., Checa, J. C. F. (1995). Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor kappa B: studies with isolated mitochondria and rat hepatocytes.. Mol Pharmacol 48:825-834.
36. Sathish, V., Vimal, V., Ebenezar, K. K., Devaki, T. (2001). Synergistic effect of nicorandil and amlodipine on mitochondrial function during isoproterenol-induced myocardial infarction in rats. J Pharm Pharmacol 54:133-137.
37. Sathish, V., Ebenezar, K. K., Devaki, T. (2003). Synergistic effect of nicorandil and amlodipine on tissue defense system during experimental myocardial infarction in rats. Mol Cell Biochem 243:133-138. (Pubitemid 36240560)
38. Senthil, S., Verrappan, R. M., Rao, M. R., Pugalendi, K. V. (2004). Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction. Clin Chim Acta 348:131-137.
39. Slater, E. C., Bonner, W. D. (1952). The effect of fluoride on the succinate oxidase system. Biochem J 52:185-196.
40. Srinivasan, S., Hatley, M. E., Bolick, D. T., Palmer, L. A., Edelstein, D., Brownlee, M., et al. (2004). Hyperglycaemiainduced superoxide production decreases eNOS expression via AP1 activation in aortic endothelial cells. Diabetologia 47:1727-1734.
41. Steven, P. J., James, J. M. G., Rien, V. H, et al. (2003). Endothelial nitric oxide synthase over expression attenuates congestive heart failure in mice. Pharmacology 100:4891-4896.
42. 3- in aqueous and proteincontaining samples. Nitric Oxide 3:225-234.
43. Sushama Kumari, S., Jayadeep, A., Suresh Kumar, J. S., Menon, V. P. (1989). Effects of carnitine on malondialdehyde, taurine, and glutathione levels in heart of rats subjected to myocardial stress by isoproterenol. Ind J Exp Biol 27:134-137.
44. Takahara, S., Hamilton, B. H., Nell, J. V., Ogura, Y., Nishimura, E. T. (1960). Hypocatalasemia, a new genetic carrier state. J Clin Invest 29:610-619.
45. Tappel, A. L. (1973). Lipid peroxidation damages to cell components. Fed Proc 32:1870-1874.
46. Thyagarajan, B., Malli, R., Schmidt, K., Graier, W. F., Groschner, K. (2002). Nitric oxide inhibits capacitative calcium entry by suppression of mitochondrial calcium handling. Br J Pharmacol 137:821-830.
47. Timothy, E., Veronica, P., Hiroto, U., Albert, W., Chen, Y., Bradford, C. (1999). Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae. Circ Res 85:29-37.
48. Towbin, H., Staehelin, T., Gordon, J. (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 76:4350-4354.
49. 2+/ascorbate-induced peroxidation in rat liver mitochondria. Biomed Biochim Acta 47:933-939.
50. Turpaev, K. T. (1998). Nitric oxide in intercellular communication. Mol Biol 324:475-484.
51. Williams, J. N. (1964). A method for the simultaneous quantitative estimation of cytochromes a, b, c, and c1 in mitochondria. Arch Biochem Biophys 107:537-543.
52. Williamson, J. R., Corkey, B. E. (1969). Assays of intermediates of the citric acid cycle and related compounds by fluorimetric enzymes methods. In: Lowenstein, J. M. (Ed.), Methods in Enzymology (pp 488-491). New York: Academic Press.
53. Yates, J. C., Dhala, N. S. (1975). Induction of necrosis and failure in the isolated perfused rat heart with oxidized isoproterenol. J Mol Cell Cardiol 7:807-816.
54. Yogeeta, S. K., Gnanapragasam, A., Kumar, S. S., Subashini, R., Devaki, T. (2006). Synergistic interaction of ferulic acid with ascorbic acid: its cardio protective role during isoproterenol- induced myocardial infarction in rats. Mol Cell Biochem 283:139-146.