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Volumn 188, Issue , 2014, Pages 72-80

Systems metabolic engineering of microorganisms to achieve large-scale production of flavonoid scaffolds

Author keywords

Flavonoid scaffolds; Industrial scale; Microorganism; Production; Systems metabolic engineering

Indexed keywords

PRODUCTION;

EID: 84908067003     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2014.08.016     Document Type: Review
Times cited : (38)

References (70)
  • 1
    • 33746591715 scopus 로고    scopus 로고
    • Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice
    • Ae Park S., Choi M.-S., Cho S.-Y., Seo J.-S., Jung U.J., Kim M.-J., Sung M.-K., Park Y.B., Lee M.-K. Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice. Life Sci. 2006, 79:1207-1213.
    • (2006) Life Sci. , vol.79 , pp. 1207-1213
    • Ae Park, S.1    Choi, M.-S.2    Cho, S.-Y.3    Seo, J.-S.4    Jung, U.J.5    Kim, M.-J.6    Sung, M.-K.7    Park, Y.B.8    Lee, M.-K.9
  • 4
    • 84859768457 scopus 로고    scopus 로고
    • Parts plus pipes: synthetic biology approaches to metabolic engineering
    • Boyle P.M., Silver P.A. Parts plus pipes: synthetic biology approaches to metabolic engineering. Metab. Eng. 2012, 14:223-232.
    • (2012) Metab. Eng. , vol.14 , pp. 223-232
    • Boyle, P.M.1    Silver, P.A.2
  • 6
    • 79951565301 scopus 로고    scopus 로고
    • Design, construction and characterization of a set of insulated bacterial promoters
    • Davis J.H., Rubin A.J., Sauer R.T. Design, construction and characterization of a set of insulated bacterial promoters. Nucleic Acids Res. 2011, 39:1131-1141.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 1131-1141
    • Davis, J.H.1    Rubin, A.J.2    Sauer, R.T.3
  • 9
    • 67650660144 scopus 로고    scopus 로고
    • Increased malonyl coenzyme A biosynthesis by tuning the Escherichia coli metabolic network and its application to flavanone production
    • Fowler Z.L., Gikandi W.W., Koffas M.A.G. Increased malonyl coenzyme A biosynthesis by tuning the Escherichia coli metabolic network and its application to flavanone production. Appl. Environ. Microbiol. 2009, 75:5831-5839.
    • (2009) Appl. Environ. Microbiol. , vol.75 , pp. 5831-5839
    • Fowler, Z.L.1    Gikandi, W.W.2    Koffas, M.A.G.3
  • 10
    • 67650685038 scopus 로고    scopus 로고
    • Biosynthesis and biotechnological production of flavanones: current state and perspectives
    • Fowler Z.L., Koffas M.A.G. Biosynthesis and biotechnological production of flavanones: current state and perspectives. Appl. Microbiol. Biotechnol. 2009, 83:799-808.
    • (2009) Appl. Microbiol. Biotechnol. , vol.83 , pp. 799-808
    • Fowler, Z.L.1    Koffas, M.A.G.2
  • 11
    • 79960964285 scopus 로고    scopus 로고
    • Regulation and control of metabolic fluxes in microbes
    • Gerosa L., Sauer U. Regulation and control of metabolic fluxes in microbes. Curr. Opin. Biotechnol. 2011, 22:566-575.
    • (2011) Curr. Opin. Biotechnol. , vol.22 , pp. 566-575
    • Gerosa, L.1    Sauer, U.2
  • 14
    • 77957871769 scopus 로고    scopus 로고
    • Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARα, PPARγ and LXRα
    • Goldwasser J., Cohen P.Y., Yang E., Balaguer P., Yarmush M.L., Nahmias Y. Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARα, PPARγ and LXRα. PLoS ONE 2010, 5:e12399.
    • (2010) PLoS ONE , vol.5 , pp. e12399
    • Goldwasser, J.1    Cohen, P.Y.2    Yang, E.3    Balaguer, P.4    Yarmush, M.L.5    Nahmias, Y.6
  • 15
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon G.J. RNA interference. Nature 2002, 418:244-251.
    • (2002) Nature , vol.418 , pp. 244-251
    • Hannon, G.J.1
  • 16
    • 73149088132 scopus 로고    scopus 로고
    • Engineering static and dynamic control of synthetic pathways
    • Holtz W.J., Keasling J.D. Engineering static and dynamic control of synthetic pathways. Cell 2010, 140:19-23.
    • (2010) Cell , vol.140 , pp. 19-23
    • Holtz, W.J.1    Keasling, J.D.2
  • 17
    • 0037545559 scopus 로고    scopus 로고
    • Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster
    • Hwang E.I., Kaneko M., Ohnishi Y., Horinouchi S. Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster. Appl. Environ. Microbiol. 2003, 69:2699-2706.
    • (2003) Appl. Environ. Microbiol. , vol.69 , pp. 2699-2706
    • Hwang, E.I.1    Kaneko, M.2    Ohnishi, Y.3    Horinouchi, S.4
  • 18
    • 84866171028 scopus 로고    scopus 로고
    • One-step sequence-and ligation-independent cloning as a rapid and versatile cloning method for functional genomics studies
    • Jeong J.-Y., Yim H.-S., Ryu J.-Y., Lee H.S., Lee J.-H., Seen D.-S., Kang S.G. One-step sequence-and ligation-independent cloning as a rapid and versatile cloning method for functional genomics studies. Appl. Environ. Microbiol. 2012, 78:5440-5443.
    • (2012) Appl. Environ. Microbiol. , vol.78 , pp. 5440-5443
    • Jeong, J.-Y.1    Yim, H.-S.2    Ryu, J.-Y.3    Lee, H.S.4    Lee, J.-H.5    Seen, D.-S.6    Kang, S.G.7
  • 19
    • 20444422841 scopus 로고    scopus 로고
    • Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiae
    • Jiang H., Wood K.V., Morgan J.A. Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 2005, 71:2962-2969.
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 2962-2969
    • Jiang, H.1    Wood, K.V.2    Morgan, J.A.3
  • 20
    • 0141594681 scopus 로고    scopus 로고
    • Heterologous production of flavanones in Escherichia coli: potential for combinatorial biosynthesis of flavonoids in bacteria
    • Kaneko M., Hwang E.I., Ohnishi Y., Horinouchi S. Heterologous production of flavanones in Escherichia coli: potential for combinatorial biosynthesis of flavonoids in bacteria. J. Ind. Microbiol. Biotechnol. 2003, 30:456-461.
    • (2003) J. Ind. Microbiol. Biotechnol. , vol.30 , pp. 456-461
    • Kaneko, M.1    Hwang, E.I.2    Ohnishi, Y.3    Horinouchi, S.4
  • 21
    • 84859772410 scopus 로고    scopus 로고
    • Synthetic biology and the development of tools for metabolic engineering
    • Keasling J.D. Synthetic biology and the development of tools for metabolic engineering. Metab. Eng. 2012, 14:189-195.
    • (2012) Metab. Eng. , vol.14 , pp. 189-195
    • Keasling, J.D.1
  • 22
    • 1842834369 scopus 로고    scopus 로고
    • Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats
    • Kim H.K., Jeong T.-S., Lee M.-K., Park Y.B., Choi M.-S. Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats. Clin. Chim. Acta 2003, 327:129-137.
    • (2003) Clin. Chim. Acta , vol.327 , pp. 129-137
    • Kim, H.K.1    Jeong, T.-S.2    Lee, M.-K.3    Park, Y.B.4    Choi, M.-S.5
  • 23
    • 77951552860 scopus 로고    scopus 로고
    • OptORF: optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains
    • Kim J., Reed J. OptORF: optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains. BMC Syst. Biol. 2010, 4:53.
    • (2010) BMC Syst. Biol. , vol.4 , pp. 53
    • Kim, J.1    Reed, J.2
  • 27
    • 84861440312 scopus 로고    scopus 로고
    • Systems metabolic engineering of microorganisms for natural and non-natural chemicals
    • Lee J.W., Na D., Park J.M., Lee J., Choi S., Lee S.Y. Systems metabolic engineering of microorganisms for natural and non-natural chemicals. Nat. Chem. Biol. 2012, 8:536-546.
    • (2012) Nat. Chem. Biol. , vol.8 , pp. 536-546
    • Lee, J.W.1    Na, D.2    Park, J.M.3    Lee, J.4    Choi, S.5    Lee, S.Y.6
  • 28
    • 34250849659 scopus 로고    scopus 로고
    • Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli
    • Leonard E., Lim K.H., Saw P.N., Koffas M.A.G. Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli. Appl. Environ. Microbiol. 2007, 73:3877-3886.
    • (2007) Appl. Environ. Microbiol. , vol.73 , pp. 3877-3886
    • Leonard, E.1    Lim, K.H.2    Saw, P.N.3    Koffas, M.A.G.4
  • 29
    • 42549160614 scopus 로고    scopus 로고
    • Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids
    • Leonard E., Yan Y., Fowler Z.L., Li Z., Lim C.G., Lim K.H., Koffas M.A.G. Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids. Mol. Pharmacol. 2008, 5:257-265.
    • (2008) Mol. Pharmacol. , vol.5 , pp. 257-265
    • Leonard, E.1    Yan, Y.2    Fowler, Z.L.3    Li, Z.4    Lim, C.G.5    Lim, K.H.6    Koffas, M.A.G.7
  • 32
    • 79961008636 scopus 로고    scopus 로고
    • Natural products from synthetic biology
    • Mitchell W. Natural products from synthetic biology. Curr. Opin. Chem. Biol. 2011, 15:505-515.
    • (2011) Curr. Opin. Chem. Biol. , vol.15 , pp. 505-515
    • Mitchell, W.1
  • 34
    • 77950863739 scopus 로고    scopus 로고
    • Use of modular, synthetic scaffolds for improved production of glucaric acid in engineered E. coli
    • Moon T.S., Dueber J.E., Shiue E., Prather K.L.J. Use of modular, synthetic scaffolds for improved production of glucaric acid in engineered E. coli. Metab. Eng. 2010, 12:298-305.
    • (2010) Metab. Eng. , vol.12 , pp. 298-305
    • Moon, T.S.1    Dueber, J.E.2    Shiue, E.3    Prather, K.L.J.4
  • 36
    • 84873596341 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs
    • Na D., Yoo S.M., Chung H., Park H., Park J.H., Lee S.Y. Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs. Nat. Biotechnol. 2013, 31:170-174.
    • (2013) Nat. Biotechnol. , vol.31 , pp. 170-174
    • Na, D.1    Yoo, S.M.2    Chung, H.3    Park, H.4    Park, J.H.5    Lee, S.Y.6
  • 37
    • 84892459952 scopus 로고    scopus 로고
    • A vector library for silencing central carbon metabolism genes with antisense RNAs in Escherichia coli
    • Nakashima N., Ohno S., Yoshikawa K., Shimizu H., Tamura T. A vector library for silencing central carbon metabolism genes with antisense RNAs in Escherichia coli. Appl. Environ. Microbiol. 2014, 80:564-573.
    • (2014) Appl. Environ. Microbiol. , vol.80 , pp. 564-573
    • Nakashima, N.1    Ohno, S.2    Yoshikawa, K.3    Shimizu, H.4    Tamura, T.5
  • 38
    • 33845667323 scopus 로고    scopus 로고
    • Paired termini stabilize antisense RNAs and enhance conditional gene silencing in Escherichia coli
    • Nakashima N., Tamura T., Good L. Paired termini stabilize antisense RNAs and enhance conditional gene silencing in Escherichia coli. Nucleic Acids Res. 2006, 34:e138.
    • (2006) Nucleic Acids Res. , vol.34 , pp. e138
    • Nakashima, N.1    Tamura, T.2    Good, L.3
  • 39
  • 40
    • 79551667941 scopus 로고    scopus 로고
    • Circular polymerase extension cloning for high-throughput cloning of complex and combinatorial DNA libraries
    • Quan J.Y., Tian J.D. Circular polymerase extension cloning for high-throughput cloning of complex and combinatorial DNA libraries. Nat. Protoc. 2011, 6:242-251.
    • (2011) Nat. Protoc. , vol.6 , pp. 242-251
    • Quan, J.Y.1    Tian, J.D.2
  • 41
    • 84878836229 scopus 로고    scopus 로고
    • Systems metabolic engineering in an industrial setting
    • Sagt C.M.J. Systems metabolic engineering in an industrial setting. Appl. Microbiol. Biotechnol. 2013, 97:2319-2326.
    • (2013) Appl. Microbiol. Biotechnol. , vol.97 , pp. 2319-2326
    • Sagt, C.M.J.1
  • 42
    • 70349964350 scopus 로고    scopus 로고
    • Automated design of synthetic ribosome binding sites to control protein expression
    • Salis H.M., Mirsky E.A., Voigt C.A. Automated design of synthetic ribosome binding sites to control protein expression. Nat. Biotechnol. 2009, 27:946-950.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 946-950
    • Salis, H.M.1    Mirsky, E.A.2    Voigt, C.A.3
  • 43
    • 79958715193 scopus 로고    scopus 로고
    • Optimization of a heterologous pathway for the production of flavonoids from glucose
    • Santos C.N.S., Koffas M.A.G., Stephanopoulos G. Optimization of a heterologous pathway for the production of flavonoids from glucose. Metab. Eng. 2011, 13:392-400.
    • (2011) Metab. Eng. , vol.13 , pp. 392-400
    • Santos, C.N.S.1    Koffas, M.A.G.2    Stephanopoulos, G.3
  • 44
    • 42049116334 scopus 로고    scopus 로고
    • Contributions of conserved serine and tyrosine residues to catalysis, ligand binding, and cofactor processing in the active site of tyrosine ammonia lyase
    • Schroeder A.C., Kumaran S., Hicks L.M., Cahoon R.E., Halls C., Yu O., Jez J.M. Contributions of conserved serine and tyrosine residues to catalysis, ligand binding, and cofactor processing in the active site of tyrosine ammonia lyase. Phytochemistry 2008, 69:1496-1506.
    • (2008) Phytochemistry , vol.69 , pp. 1496-1506
    • Schroeder, A.C.1    Kumaran, S.2    Hicks, L.M.3    Cahoon, R.E.4    Halls, C.5    Yu, O.6    Jez, J.M.7
  • 45
    • 77952775122 scopus 로고    scopus 로고
    • Improving the anti-tumor effect of genistein with a biocompatible superparamagnetic drug delivery system
    • Si H.Y., Li D.P., Wang T.M., Zhang H.L., Ren F.Y., Xu Z.G., Zhao Y.Y. Improving the anti-tumor effect of genistein with a biocompatible superparamagnetic drug delivery system. J. Nanosci. Nanotechnol. 2010, 10:2325-2331.
    • (2010) J. Nanosci. Nanotechnol. , vol.10 , pp. 2325-2331
    • Si, H.Y.1    Li, D.P.2    Wang, T.M.3    Zhang, H.L.4    Ren, F.Y.5    Xu, Z.G.6    Zhao, Y.Y.7
  • 46
    • 79952645848 scopus 로고    scopus 로고
    • Informing biological design by integration of systems and synthetic biology
    • Smolke C.D., Silver P.A. Informing biological design by integration of systems and synthetic biology. Cell 2011, 144:855-859.
    • (2011) Cell , vol.144 , pp. 855-859
    • Smolke, C.D.1    Silver, P.A.2
  • 47
    • 84887993076 scopus 로고    scopus 로고
    • Polishing the craft of genetic diversity creation in directed evolution
    • Tee K.L., Wong T.S. Polishing the craft of genetic diversity creation in directed evolution. Biotechnol. Adv. 2013, 31:1707-1721.
    • (2013) Biotechnol. Adv. , vol.31 , pp. 1707-1721
    • Tee, K.L.1    Wong, T.S.2
  • 48
    • 84908071373 scopus 로고    scopus 로고
    • Predicting metabolic engineering knockout strategies for chemical production: accounting for competing pathways
    • Tepper N., Shlomi T. Predicting metabolic engineering knockout strategies for chemical production: accounting for competing pathways. Bioinformatics 2010, 26:53.
    • (2010) Bioinformatics , vol.26 , pp. 53
    • Tepper, N.1    Shlomi, T.2
  • 49
    • 84896919039 scopus 로고    scopus 로고
    • Reduction of ethanol yield and improvement of glycerol formation by adaptive evolution of the wine yeast Saccharomyces cerevisiae under hyperosmotic conditions
    • Tilloy V., Ortiz-Julien A., Dequin S. Reduction of ethanol yield and improvement of glycerol formation by adaptive evolution of the wine yeast Saccharomyces cerevisiae under hyperosmotic conditions. Appl. Environ. Microbiol. 2014, 80:2623-2632.
    • (2014) Appl. Environ. Microbiol. , vol.80 , pp. 2623-2632
    • Tilloy, V.1    Ortiz-Julien, A.2    Dequin, S.3
  • 50
    • 33847252518 scopus 로고    scopus 로고
    • Production of p-hydroxycinnamic acid from glucose in Saccharomyces cerevisiae and Escherichia coli by expression of heterologous genes from plants and fungi
    • Vannelli T., Wei Qi W., Sweigard J., Gatenby A.A., Sariaslani F.S. Production of p-hydroxycinnamic acid from glucose in Saccharomyces cerevisiae and Escherichia coli by expression of heterologous genes from plants and fungi. Metab. Eng. 2007, 9:142-151.
    • (2007) Metab. Eng. , vol.9 , pp. 142-151
    • Vannelli, T.1    Wei Qi, W.2    Sweigard, J.3    Gatenby, A.A.4    Sariaslani, F.S.5
  • 51
  • 52
    • 64549139321 scopus 로고    scopus 로고
    • Antiproliferation effect and mechanism of prostate cancer cell lines as affected by isoflavones from soybean cake
    • Wang B.F., Wang J.S., Lu J.F., Kao T.H., Chen B.H. Antiproliferation effect and mechanism of prostate cancer cell lines as affected by isoflavones from soybean cake. J. Agric. Food Chem. 2009, 57:2221-2232.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 2221-2232
    • Wang, B.F.1    Wang, J.S.2    Lu, J.F.3    Kao, T.H.4    Chen, B.H.5
  • 53
    • 84873412615 scopus 로고    scopus 로고
    • Overview of regulatory strategies and molecular elements in metabolic engineering of bacteria
    • Wang T.W., Ma X.Y., Du G.C., Chen J. Overview of regulatory strategies and molecular elements in metabolic engineering of bacteria. Mol. Biotechnol. 2012, 52:300-308.
    • (2012) Mol. Biotechnol. , vol.52 , pp. 300-308
    • Wang, T.W.1    Ma, X.Y.2    Du, G.C.3    Chen, J.4
  • 54
    • 80052033347 scopus 로고    scopus 로고
    • Stepwise increase of resveratrol biosynthesis in yeast Saccharomyces cerevisiae by metabolic engineering
    • Wang Y., Halls C., Zhang J., Matsuno M., Zhang Y., Yu O. Stepwise increase of resveratrol biosynthesis in yeast Saccharomyces cerevisiae by metabolic engineering. Metab. Eng. 2011, 13:455-463.
    • (2011) Metab. Eng. , vol.13 , pp. 455-463
    • Wang, Y.1    Halls, C.2    Zhang, J.3    Matsuno, M.4    Zhang, Y.5    Yu, O.6
  • 55
    • 80052644333 scopus 로고    scopus 로고
    • Metabolic engineering of flavonoids in plants and microorganisms
    • Wang Y.C., Chen S., Yu O. Metabolic engineering of flavonoids in plants and microorganisms. Appl. Microbiol. Biotechnol. 2011, 91:949-956.
    • (2011) Appl. Microbiol. Biotechnol. , vol.91 , pp. 949-956
    • Wang, Y.C.1    Chen, S.2    Yu, O.3
  • 56
    • 84855229099 scopus 로고    scopus 로고
    • Synthetic scaffolds increased resveratrol biosynthesis in engineered yeast cells
    • Wang Y.C., Yu O. Synthetic scaffolds increased resveratrol biosynthesis in engineered yeast cells. J. Biotechnol. 2011, 157:258-260.
    • (2011) J. Biotechnol. , vol.157 , pp. 258-260
    • Wang, Y.C.1    Yu, O.2
  • 57
    • 84872221971 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy
    • Wu J.J., Du G.C., Zhou J.W., Chen J. Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy. Metab. Eng. 2013, 16:48-55.
    • (2013) Metab. Eng. , vol.16 , pp. 48-55
    • Wu, J.J.1    Du, G.C.2    Zhou, J.W.3    Chen, J.4
  • 58
    • 84883232076 scopus 로고    scopus 로고
    • Multivariate modular metabolic engineering of Escherichia coli to produce resveratrol from l-tyrosine
    • Wu J.J., Liu P.R., Fan Y.M., Bao H., Du G.C., Zhou J.W., Chen J. Multivariate modular metabolic engineering of Escherichia coli to produce resveratrol from l-tyrosine. J. Biotechnol. 2013, 167:404-411.
    • (2013) J. Biotechnol. , vol.167 , pp. 404-411
    • Wu, J.J.1    Liu, P.R.2    Fan, Y.M.3    Bao, H.4    Du, G.C.5    Zhou, J.W.6    Chen, J.7
  • 59
    • 84903782489 scopus 로고    scopus 로고
    • Modular optimization of heterologous pathways for de novo synthesis of (2S)-naringenin in Escherichia coli
    • Wu J.J., Zhou T.T., Du G.C., Zhou J.W., Chen J. Modular optimization of heterologous pathways for de novo synthesis of (2S)-naringenin in Escherichia coli. PLOS ONE 2014, 9:e101492.
    • (2014) PLOS ONE , vol.9 , pp. e101492
    • Wu, J.J.1    Zhou, T.T.2    Du, G.C.3    Zhou, J.W.4    Chen, J.5
  • 60
    • 84873997973 scopus 로고    scopus 로고
    • Genome-scale metabolic model in guiding metabolic engineering of microbial improvement
    • Xu C., Liu L.L., Zhang Z., Jin D.F., Qiu J.P., Chen M. Genome-scale metabolic model in guiding metabolic engineering of microbial improvement. Appl. Microbiol. Biotechnol. 2013, 97:519-539.
    • (2013) Appl. Microbiol. Biotechnol. , vol.97 , pp. 519-539
    • Xu, C.1    Liu, L.L.2    Zhang, Z.3    Jin, D.F.4    Qiu, J.P.5    Chen, M.6
  • 61
    • 84874978130 scopus 로고    scopus 로고
    • Engineering plant metabolism into microbes: from systems biology to synthetic biology
    • Xu P., Bhan N., Koffas M.A.G. Engineering plant metabolism into microbes: from systems biology to synthetic biology. Curr. Opin. Biotechnol. 2013, 24:291-299.
    • (2013) Curr. Opin. Biotechnol. , vol.24 , pp. 291-299
    • Xu, P.1    Bhan, N.2    Koffas, M.A.G.3
  • 63
    • 80052021573 scopus 로고    scopus 로고
    • Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA
    • Xu P., Ranganathan S., Fowler Z.L., Maranas C.D., Koffas M.A.G. Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA. Metab. Eng. 2011, 13:578-587.
    • (2011) Metab. Eng. , vol.13 , pp. 578-587
    • Xu, P.1    Ranganathan, S.2    Fowler, Z.L.3    Maranas, C.D.4    Koffas, M.A.G.5
  • 64
    • 84868263016 scopus 로고    scopus 로고
    • EPathBrick: a synthetic biology platform for engineering metabolic pathways in E. coli
    • Xu P., Vansiri A., Bhan N., Koffas M.A.G. ePathBrick: a synthetic biology platform for engineering metabolic pathways in E. coli. ACS. Synth. Biol. 2012, 1:256-266.
    • (2012) ACS. Synth. Biol. , vol.1 , pp. 256-266
    • Xu, P.1    Vansiri, A.2    Bhan, N.3    Koffas, M.A.G.4
  • 65
    • 84896702596 scopus 로고    scopus 로고
    • Design and kinetic analysis of a hybrid promoter-regulator system for malonyl-CoA sensing in Escherichia coli
    • Xu P., Wang W.Y., Li L.Y., Bhan N., Zhang F., Koffas M.A.G. Design and kinetic analysis of a hybrid promoter-regulator system for malonyl-CoA sensing in Escherichia coli. ACS Chem. Biol. 2014, 9:451-458.
    • (2014) ACS Chem. Biol. , vol.9 , pp. 451-458
    • Xu, P.1    Wang, W.Y.2    Li, L.Y.3    Bhan, N.4    Zhang, F.5    Koffas, M.A.G.6
  • 66
    • 84859776222 scopus 로고    scopus 로고
    • The future of metabolic engineering and synthetic biology: towards a systematic practice
    • Yadav V.G., De Mey M., Giaw Lim C., Kumaran Ajikumar P., Stephanopoulos G. The future of metabolic engineering and synthetic biology: towards a systematic practice. Metab. Eng. 2012, 14:233-241.
    • (2012) Metab. Eng. , vol.14 , pp. 233-241
    • Yadav, V.G.1    De Mey, M.2    Giaw Lim, C.3    Kumaran Ajikumar, P.4    Stephanopoulos, G.5
  • 67
    • 25144431998 scopus 로고    scopus 로고
    • Biosynthesis of natural flavanones in Saccharomyces cerevisiae
    • Yan Y.J., Kohli A., Koffas M.A.G. Biosynthesis of natural flavanones in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 2005, 71:5610-5613.
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 5610-5613
    • Yan, Y.J.1    Kohli, A.2    Koffas, M.A.G.3
  • 68
    • 84883618380 scopus 로고    scopus 로고
    • Novel fermentation processes for manufacturing plant natural products
    • Zhou J.W., Du G.C., Chen J. Novel fermentation processes for manufacturing plant natural products. Curr. Opin. Biotechnol. 2014, 25:17-23.
    • (2014) Curr. Opin. Biotechnol. , vol.25 , pp. 17-23
    • Zhou, J.W.1    Du, G.C.2    Chen, J.3
  • 69
    • 84862800714 scopus 로고    scopus 로고
    • Engineering the robustness of industrial microbes through synthetic biology
    • Zhu L., Zhu Y., Zhang Y., Li Y. Engineering the robustness of industrial microbes through synthetic biology. Trends Microbiol. 2012, 20:94-101.
    • (2012) Trends Microbiol. , vol.20 , pp. 94-101
    • Zhu, L.1    Zhu, Y.2    Zhang, Y.3    Li, Y.4
  • 70
    • 84899085998 scopus 로고    scopus 로고
    • Efficient synthesis of eriodictyol from l-tyrosine in Escherichia coli
    • Zhu S.J., Wu J.J., Du G.C., Zhou J.W., Chen J. Efficient synthesis of eriodictyol from l-tyrosine in Escherichia coli. Appl. Environ. Microbiol. 2014, 80:3072-3080.
    • (2014) Appl. Environ. Microbiol. , vol.80 , pp. 3072-3080
    • Zhu, S.J.1    Wu, J.J.2    Du, G.C.3    Zhou, J.W.4    Chen, J.5


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