Increased malonyl coenzyme A biosynthesis by tuning the Escherichia coli metabolic network and its application to flavanone production

Applied and Environmental Microbiology

Volumn 75, Issue 18, 2009, Pages 5831-5839

  Fowler, Zachary L ^a   Gikandi, William W ^a   Koffas, Mattheos A G ^a  

^a the State University of New York   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL-COA CARBOXYLASE; CARBON FLUXES; CO-EXPRESSION; COENZYME A; COFACTORS; E. COLI; END-PRODUCTS; EVOLUTIONARY DESIGN; EVOLUTIONARY SEARCH; FLAVONOIDS; GENE DELETION; METABOLIC NETWORK; METABOLITE PROFILES; NATURAL PRODUCTS; OVEREXPRESSIONS; PRODUCTION CAPACITY; RECOMBINANT STRAINS;

BIOCHEMISTRY; BIOSYNTHESIS; CRYPTOGRAPHY; EVOLUTIONARY ALGORITHMS; GENES; METABOLISM;

ESCHERICHIA COLI;

ACETYL COENZYME A CARBOXYLASE; ERIODICTYOL; MALONYL COENZYME A; NARINGENIN;

BACTERIUM; ENZYME ACTIVITY; METABOLISM; METABOLITE; RECOMBINATION;

ARTICLE; BACTERIAL GENE; BACTERIAL METABOLISM; BACTERIAL STRAIN; BATCH FERMENTATION; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME SYNTHESIS; ESCHERICHIA COLI; GENE DELETION; GENE OVEREXPRESSION; GENETIC ENGINEERING; GENOTYPE; NONHUMAN; OPTICAL DENSITY; PHENOTYPE; STOICHIOMETRY;

ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLAVANONES; GENE DELETION; GENE EXPRESSION; GENETIC ENGINEERING; MALONYL COENZYME A; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL;

ESCHERICHIA COLI;

EID: 67650660144     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.00270-09     Document Type: Article

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