메뉴 건너뛰기




Volumn 155, Issue 11, 2014, Pages 4157-4167

Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; GLUCAGON; GLUCOSE; INSULIN; KETONE BODY; LEPTIN; MELANOCORTIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOTAN II; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; INTERMEDIN; MELANOCORTIN RECEPTOR;

EID: 84908032144     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-1169     Document Type: Article
Times cited : (20)

References (63)
  • 1
  • 2
    • 0033037727 scopus 로고    scopus 로고
    • Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat
    • Chinookoswong N, Wang JL, Shi ZQ. Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat. Diabetes. 1999;48:1487-1492.
    • (1999) Diabetes , vol.48 , pp. 1487-1492
    • Chinookoswong, N.1    Wang, J.L.2    Shi, Z.Q.3
  • 3
    • 52949140814 scopus 로고    scopus 로고
    • Making insulin-deficient type 1 diabetic rodents thrive without insulin
    • Yu X, Park BH, Wang MY, Wang ZV, Unger RH. Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci USA. 2008;105:14070-14075.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14070-14075
    • Yu, X.1    Park, B.H.2    Wang, M.Y.3    Wang, Z.V.4    Unger, R.H.5
  • 4
    • 33750266369 scopus 로고    scopus 로고
    • Chronic antidiabetic and cardiovascular actions of leptin: Role of CNS and increased adrenergic activity
    • da Silva AA, Tallam LS, Liu J, Hall JE. Chronic antidiabetic and cardiovascular actions of leptin: role of CNS and increased adrenergic activity. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1275-R1282.
    • (2006) Am J Physiol Regul Integr Comp Physiol , vol.291 , pp. R1275-R1282
    • Da Silva, A.A.1    Tallam, L.S.2    Liu, J.3    Hall, J.E.4
  • 5
    • 78049271280 scopus 로고    scopus 로고
    • Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice
    • Fujikawa T, Chuang JC, Sakata I, Ramadori G, Coppari R. Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice. Proc Natl Acad Sci USA. 2010;107:17391-17396.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 17391-17396
    • Fujikawa, T.1    Chuang, J.C.2    Sakata, I.3    Ramadori, G.4    Coppari, R.5
  • 6
    • 79951638003 scopus 로고    scopus 로고
    • Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia
    • German JP, Thaler JP, Wisse BE, et al. Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia. Endocrinology. 2011;152:394-404.
    • (2011) Endocrinology , vol.152 , pp. 394-404
    • German, J.P.1    Thaler, J.P.2    Wisse, B.E.3
  • 7
    • 18344374382 scopus 로고    scopus 로고
    • Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats
    • Hidaka S, Yoshimatsu H, Kondou S, et al. Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats. FASEB J. 2002;16:509-518.
    • (2002) FASEB J , vol.16 , pp. 509-518
    • Hidaka, S.1    Yoshimatsu, H.2    Kondou, S.3
  • 8
    • 0036084101 scopus 로고    scopus 로고
    • Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats
    • Lin CY, Higginbotham DA, Judd RL, White BD. Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats. Am J Physiol Endocrinol Metab. 2002;282:E1084-E1091.
    • (2002) Am J Physiol Endocrinol Metab , vol.282 , pp. E1084-E1091
    • Lin, C.Y.1    Higginbotham, D.A.2    Judd, R.L.3    White, B.D.4
  • 9
    • 0016614292 scopus 로고
    • Glucagon: Role in the hyperglycemia of diabetes mellitus
    • Dobbs R, Sakurai H, Sasaki H, et al. Glucagon: role in the hyperglycemia of diabetes mellitus. Science. 1975;187:544-547.
    • (1975) Science , vol.187 , pp. 544-547
    • Dobbs, R.1    Sakurai, H.2    Sasaki, H.3
  • 10
    • 0024416154 scopus 로고
    • The psychoneuroendocrinology of diabetes mellitus in rodents
    • Leedom LJ, Meehan WP. The psychoneuroendocrinology of diabetes mellitus in rodents. Psychoneuroendocrinology. 1989;14:275-294.
    • (1989) Psychoneuroendocrinology , vol.14 , pp. 275-294
    • Leedom, L.J.1    Meehan, W.P.2
  • 11
    • 0015122645 scopus 로고
    • The effect of experimental insulin deficiency on glucagon secretion
    • Müller WA, Faloona GR, Unger RH. The effect of experimental insulin deficiency on glucagon secretion. J Clin Invest. 1971;50:1992-1999.
    • (1971) J Clin Invest , vol.50 , pp. 1992-1999
    • Müller, W.A.1    Faloona, G.R.2    Unger, R.H.3
  • 12
    • 0031592890 scopus 로고    scopus 로고
    • Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes
    • Schwartz MW, Strack AM, Dallman MF. Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes. Regul Pept. 1997;72:105-112.
    • (1997) Regul Pept , vol.72 , pp. 105-112
    • Schwartz, M.W.1    Strack, A.M.2    Dallman, M.F.3
  • 13
    • 0026568311 scopus 로고
    • Hypothalamo-hypophysial-thyroid axis in streptozotocin-induced diabetes
    • Rondeel JM, de Greef WJ, Heide R, Visser TJ. Hypothalamo-hypophysial-thyroid axis in streptozotocin-induced diabetes. Endocrinology. 1992;130:216-220.
    • (1992) Endocrinology , vol.130 , pp. 216-220
    • Rondeel, J.M.1    De Greef, W.J.2    Heide, R.3    Visser, T.J.4
  • 14
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature. 1996;382:250-252.
    • (1996) Nature , vol.382 , pp. 250-252
    • Ahima, R.S.1    Prabakaran, D.2    Mantzoros, C.3
  • 15
    • 0031859473 scopus 로고    scopus 로고
    • Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: Reversal by insulin
    • Havel PJ, Uriu-Hare JY, Liu T, et al. Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin. Am J Physiol. 1998;274:R1482-R1491.
    • (1998) Am J Physiol , vol.274 , pp. R1482-R1491
    • Havel, P.J.1    Uriu-Hare, J.Y.2    Liu, T.3
  • 16
    • 84878199366 scopus 로고    scopus 로고
    • In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue
    • Matsen ME, Thaler JP, Wisse BE, et al. In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue. Am J Physiol Endocrinol Metab. 2013;304:E734-E746.
    • (2013) Am J Physiol Endocrinol Metab , vol.304 , pp. E734-E746
    • Matsen, M.E.1    Thaler, J.P.2    Wisse, B.E.3
  • 17
    • 84255199265 scopus 로고    scopus 로고
    • Central nervous control of energy and glucose balance: Focus on the central melanocortin system
    • Xu Y, Elmquist JK, Fukuda M. Central nervous control of energy and glucose balance: focus on the central melanocortin system. Ann NY Acad Sci. 2011;1243:1-14.
    • (2011) Ann NY Acad Sci , vol.1243 , pp. 1-14
    • Xu, Y.1    Elmquist, J.K.2    Fukuda, M.3
  • 18
    • 79955584321 scopus 로고    scopus 로고
    • Leptin and the central nervous system control of glucose metabolism
    • Morton GJ, Schwartz MW. Leptin and the central nervous system control of glucose metabolism. Physiol Rev. 2011;91:389-411.
    • (2011) Physiol Rev , vol.91 , pp. 389-411
    • Morton, G.J.1    Schwartz, M.W.2
  • 19
    • 0030775971 scopus 로고    scopus 로고
    • Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
    • Schwartz MW, Seeley RJ, Woods SC, et al. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes. 1997;46:2119-2123.
    • (1997) Diabetes , vol.46 , pp. 2119-2123
    • Schwartz, M.W.1    Seeley, R.J.2    Woods, S.C.3
  • 20
    • 0030729210 scopus 로고    scopus 로고
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
    • Thornton JE, Cheung CC, Clifton DK, Steiner RA. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology. 1997;138:5063-5066.
    • (1997) Endocrinology , vol.138 , pp. 5063-5066
    • Thornton, J.E.1    Cheung, C.C.2    Clifton, D.K.3    Steiner, R.A.4
  • 21
    • 0031443366 scopus 로고    scopus 로고
    • Melanocortin receptors in leptin effects
    • Seeley RJ, Yagaloff KA, Fisher SL, et al. Melanocortin receptors in leptin effects. Nature. 1997;390:349.
    • (1997) Nature , vol.390 , pp. 349
    • Seeley, R.J.1    Yagaloff, K.A.2    Fisher, S.L.3
  • 22
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann MM, Wilson BD, Yang YK, et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science. 1997;278:135-138.
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3
  • 23
    • 13344280346 scopus 로고    scopus 로고
    • Specificity of leptin action on elevated blood glucose levels and hypothalmic neuropeptide Y gene expression in ob/ob mice
    • Schwartz MW, Baskin DG, Bukowski TR, et al. Specificity of leptin action on elevated blood glucose levels and hypothalmic neuropeptide Y gene expression in ob/ob mice. Diabetes. 1996;45:531-535.
    • (1996) Diabetes , vol.45 , pp. 531-535
    • Schwartz, M.W.1    Baskin, D.G.2    Bukowski, T.R.3
  • 24
    • 0035873079 scopus 로고    scopus 로고
    • Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats
    • Adage T, Scheurink AJ, de Boer SF, et al. Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats. J Neurosci. 2001;21:3639-3645.
    • (2001) J Neurosci , vol.21 , pp. 3639-3645
    • Adage, T.1    Scheurink, A.J.2    De Boer, S.F.3
  • 25
    • 0033870091 scopus 로고    scopus 로고
    • Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade
    • Hagan MM, Rushing PA, Pritchard LM, et al. Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade. Am J Physiol Regul Integr Comp Physiol. 2000;279:R47-R52.
    • (2000) Am J Physiol Regul Integr Comp Physiol , vol.279 , pp. R47-R52
    • Hagan, M.M.1    Rushing, P.A.2    Pritchard, L.M.3
  • 26
    • 15144357684 scopus 로고    scopus 로고
    • A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of α-melanocyte stimulating hormone in vivo
    • Rossi M, Kim MS, Morgan DG, et al. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of α-melanocyte stimulating hormone in vivo. Endocrinology. 1998;139:4428-4431.
    • (1998) Endocrinology , vol.139 , pp. 4428-4431
    • Rossi, M.1    Kim, M.S.2    Morgan, D.G.3
  • 27
    • 0022873040 scopus 로고
    • Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
    • Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides. 1986;7:1189-1192.
    • (1986) Peptides , vol.7 , pp. 1189-1192
    • Stanley, B.G.1    Kyrkouli, S.E.2    Lampert, S.3    Leibowitz, S.F.4
  • 28
    • 0028263609 scopus 로고
    • Intracerebroventricular administration of neuropeptide Y to normal rats has divergent effects on glucose utilization by adipose tissue and skeletal muscle
    • Zarjevski N, Cusin I, Vettor R, Rohner Jeanrenaud F, Jeanrenaud B. Intracerebroventricular administration of neuropeptide Y to normal rats has divergent effects on glucose utilization by adipose tissue and skeletal muscle. Diabetes.1994;43:764-769.
    • (1994) Diabetes , vol.43 , pp. 764-769
    • Zarjevski, N.1    Cusin, I.2    Vettor, R.3    Rohner Jeanrenaud, F.4    Jeanrenaud, B.5
  • 30
    • 68049133174 scopus 로고    scopus 로고
    • A functional melanocortin system may be required for chronic CNS-mediated antidiabetic and cardiovascular actions of leptin
    • da Silva AA, do Carmo JM, Freeman JN, Tallam LS, Hall JE. A functional melanocortin system may be required for chronic CNS-mediated antidiabetic and cardiovascular actions of leptin. Diabetes. 2009;58:1749-1756.
    • (2009) Diabetes , vol.58 , pp. 1749-1756
    • Da Silva, A.A.1    Do Carmo, J.M.2    Freeman, J.N.3    Tallam, L.S.4    Hall, J.E.5
  • 31
    • 84883483789 scopus 로고    scopus 로고
    • Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin
    • Fujikawa T, Berglund ED, Patel VR, et al. Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab. 2013;18:431-444.
    • (2013) Cell Metab , vol.18 , pp. 431-444
    • Fujikawa, T.1    Berglund, E.D.2    Patel, V.R.3
  • 32
    • 0016846068 scopus 로고
    • Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon
    • Gerich JE, Lorenzi M, Bier DM, et al. Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon. N Engl J Med. 1975;292:985-989.
    • (1975) N Engl J Med , vol.292 , pp. 985-989
    • Gerich, J.E.1    Lorenzi, M.2    Bier, D.M.3
  • 34
    • 0036288345 scopus 로고    scopus 로고
    • Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice
    • Qian S, Chen H, Weingarth D, et al. Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol. 2002;22:5027-5035.
    • (2002) Mol Cell Biol , vol.22 , pp. 5027-5035
    • Qian, S.1    Chen, H.2    Weingarth, D.3
  • 37
    • 77954269929 scopus 로고    scopus 로고
    • Leptin deficiency causes insulin resistance induced by uncontrolled diabetes
    • German JP, Wisse BE, Thaler JP, et al. Leptin deficiency causes insulin resistance induced by uncontrolled diabetes. Diabetes. 2010;59:1626-1634.
    • (2010) Diabetes , vol.59 , pp. 1626-1634
    • German, J.P.1    Wisse, B.E.2    Thaler, J.P.3
  • 38
    • 84883172997 scopus 로고    scopus 로고
    • Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia
    • Meek TH, Matsen ME, Dorfman MD, et al. Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia. Endocrinology. 2013;154:3067-3076.
    • (2013) Endocrinology , vol.154 , pp. 3067-3076
    • Meek, T.H.1    Matsen, M.E.2    Dorfman, M.D.3
  • 39
    • 1542470485 scopus 로고    scopus 로고
    • Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis
    • Taicher GZ, Tinsley FC, Reiderman A, Heiman ML. Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis. Anal Bioanal Chem. 2003;377:990-1002.
    • (2003) Anal Bioanal Chem , vol.377 , pp. 990-1002
    • Taicher, G.Z.1    Tinsley, F.C.2    Reiderman, A.3    Heiman, M.L.4
  • 40
    • 0032872203 scopus 로고    scopus 로고
    • Involvement of agoutirelated protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action
    • Ebihara K, Ogawa Y, Katsuura G, et al. Involvement of agoutirelated protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action. Diabetes. 1999;48:2028-2033.
    • (1999) Diabetes , vol.48 , pp. 2028-2033
    • Ebihara, K.1    Ogawa, Y.2    Katsuura, G.3
  • 41
    • 0029954276 scopus 로고    scopus 로고
    • Modification of catecholamine-induced changes in heart function by food restriction in rats
    • McKnight KA, Rupp H, Beamish RE, Dhalla NS. Modification of catecholamine-induced changes in heart function by food restriction in rats. Cardiovasc Drugs Ther. 1996;10(suppl 1):239-246.
    • (1996) Cardiovasc Drugs Ther , vol.10 , pp. 239-246
    • McKnight, K.A.1    Rupp, H.2    Beamish, R.E.3    Dhalla, N.S.4
  • 42
    • 0021666946 scopus 로고
    • Stimulatory effect of norepinephrine on ketogenesis in normal and insulin-deficient humans
    • Keller U, Gerber PP, Stauffacher W. Stimulatory effect of norepinephrine on ketogenesis in normal and insulin-deficient humans. Am J Physiol. 1984;247:E732-E739.
    • (1984) Am J Physiol , vol.247 , pp. E732-E739
    • Keller, U.1    Gerber, P.P.2    Stauffacher, W.3
  • 43
    • 0033969423 scopus 로고    scopus 로고
    • Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats
    • Havel PJ, Hahn TM, Sindelar DK, et al. Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats. Diabetes. 2000;49:244-252.
    • (2000) Diabetes , vol.49 , pp. 244-252
    • Havel, P.J.1    Hahn, T.M.2    Sindelar, D.K.3
  • 44
    • 0018122474 scopus 로고
    • Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes
    • Raskin P, Unger RH. Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes. N Engl J Med. 1978;299:433-436.
    • (1978) N Engl J Med , vol.299 , pp. 433-436
    • Raskin, P.1    Unger, R.H.2
  • 45
    • 84866299596 scopus 로고    scopus 로고
    • Metabolic manifestations of insulin deficiency do not occur without glucagon action
    • Lee Y, Berglund ED, Wang MY, et al. Metabolic manifestations of insulin deficiency do not occur without glucagon action. Proc Natl Acad Sci USA. 2012;109:14972-14976.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 14972-14976
    • Lee, Y.1    Berglund, E.D.2    Wang, M.Y.3
  • 46
    • 79551600048 scopus 로고    scopus 로고
    • Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice
    • Lee Y, Wang MY, Du XQ, Charron MJ, Unger RH. Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice. Diabetes. 2011;60:391-397.
    • (2011) Diabetes , vol.60 , pp. 391-397
    • Lee, Y.1    Wang, M.Y.2    Du, X.Q.3    Charron, M.J.4    Unger, R.H.5
  • 47
    • 84863267488 scopus 로고    scopus 로고
    • Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice
    • Berglund ED, Vianna CR, Donato J Jr, et al. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J Clin Invest. 2012;122:1000-1009.
    • (2012) J Clin Invest , vol.122 , pp. 1000-1009
    • Berglund, E.D.1    Vianna, C.R.2    Donato, J.3
  • 48
    • 84876561914 scopus 로고    scopus 로고
    • BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production
    • Meek TH, Wisse BE, Thaler JP, et al. BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production. Diabetes. 2013;62:1512-1518.
    • (2013) Diabetes , vol.62 , pp. 1512-1518
    • Meek, T.H.1    Wisse, B.E.2    Thaler, J.P.3
  • 49
    • 0032900284 scopus 로고    scopus 로고
    • Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
    • Marsh DJ, Hollopeter G, Huszar D, et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet. 1999;21:119-122.
    • (1999) Nat Genet , vol.21 , pp. 119-122
    • Marsh, D.J.1    Hollopeter, G.2    Huszar, D.3
  • 50
    • 77950860422 scopus 로고    scopus 로고
    • Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs
    • Nillni EA. Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs. Front Neuroendocrinol. 2010;31:134-156.
    • (2010) Front Neuroendocrinol , vol.31 , pp. 134-156
    • Nillni, E.A.1
  • 51
    • 31644446219 scopus 로고    scopus 로고
    • Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis
    • Lechan RM, Fekete C. Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis. Peptides. 2006;27:310-325.
    • (2006) Peptides , vol.27 , pp. 310-325
    • Lechan, R.M.1    Fekete, C.2
  • 52
    • 78649413249 scopus 로고    scopus 로고
    • Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity
    • Ghamari-Langroudi M, Vella KR, Srisai D, et al. Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity. Mol Endocrinol. 2010;24:2366-2381.
    • (2010) Mol Endocrinol , vol.24 , pp. 2366-2381
    • Ghamari-Langroudi, M.1    Vella, K.R.2    Srisai, D.3
  • 54
    • 9644307899 scopus 로고    scopus 로고
    • Melanocortin-independent effects of leptin on hepatic glucose fluxes
    • Gutiérrez-Juárez R, Obici S, Rossetti L. Melanocortin-independent effects of leptin on hepatic glucose fluxes. J Biol Chem. 2004;279:49704-49715.
    • (2004) J Biol Chem , vol.279 , pp. 49704-49715
    • Gutiérrez-Juárez, R.1    Obici, S.2    Rossetti, L.3
  • 56
    • 0032899719 scopus 로고    scopus 로고
    • Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
    • Haynes WG, Morgan DA, Djalali A, Sivitz WI, Mark AL. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension. 1999;33:542-547.
    • (1999) Hypertension , vol.33 , pp. 542-547
    • Haynes, W.G.1    Morgan, D.A.2    Djalali, A.3    Sivitz, W.I.4    Mark, A.L.5
  • 57
    • 0038149085 scopus 로고    scopus 로고
    • Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
    • Rahmouni K, Haynes WG, Morgan DA, Mark AL. Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. J Neurosci. 2003;23:5998-6004.
    • (2003) J Neurosci , vol.23 , pp. 5998-6004
    • Rahmouni, K.1    Haynes, W.G.2    Morgan, D.A.3    Mark, A.L.4
  • 58
    • 2942733252 scopus 로고    scopus 로고
    • Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    • Balthasar N, Coppari R, McMinn J, et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 2004;42:983-991.
    • (2004) Neuron , vol.42 , pp. 983-991
    • Balthasar, N.1    Coppari, R.2    McMinn, J.3
  • 59
    • 41549111593 scopus 로고    scopus 로고
    • Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
    • van de Wall E, Leshan R, Xu AW, et al. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 2008;149:1773-1785.
    • (2008) Endocrinology , vol.149 , pp. 1773-1785
    • Van De Wall, E.1    Leshan, R.2    Xu, A.W.3
  • 60
    • 42449086900 scopus 로고    scopus 로고
    • Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome
    • Bingham NC, Anderson KK, Reuter AL, Stallings NR, Parker KL. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology. 2008;149:2138-2148.
    • (2008) Endocrinology , vol.149 , pp. 2138-2148
    • Bingham, N.C.1    Anderson, K.K.2    Reuter, A.L.3    Stallings, N.R.4    Parker, K.L.5
  • 61
    • 30644473109 scopus 로고    scopus 로고
    • Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    • Dhillon H, Zigman JM, Ye C, et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006;49:191-203.
    • (2006) Neuron , vol.49 , pp. 191-203
    • Dhillon, H.1    Zigman, J.M.2    Ye, C.3
  • 62
    • 84859560308 scopus 로고    scopus 로고
    • Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin
    • Liao GY, An JJ, Gharami K, et al. Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin. Nat Med. 2012;18:564-571.
    • (2012) Nat Med , vol.18 , pp. 564-571
    • Liao, G.Y.1    An, J.J.2    Gharami, K.3
  • 63
    • 84255192924 scopus 로고    scopus 로고
    • Endogenous BDNF regulates inhibitory synaptic transmission in the ventromedial nucleus of the hypothalamus
    • Jo YH. Endogenous BDNF regulates inhibitory synaptic transmission in the ventromedial nucleus of the hypothalamus. J Neurophysiol. 2012;107:42-49.
    • (2012) J Neurophysiol , vol.107 , pp. 42-49
    • Jo, Y.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.