Endogenous BDNF regulates inhibitory synaptic transmission in the ventromedial nucleus of the hypothalamus

Journal of Neurophysiology

Volumn 107, Issue 1, 2012, Pages 42-49

  Jo, Young Hwan ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

GABA; Neural circuitry; Obesity; Presynaptic receptor; TrkB receptor

Indexed keywords

4 AMINOBUTYRIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; MELANOCORTIN 4 RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT BRAIN DERIVED NEUROTROPHIC FACTOR; STEROIDOGENIC FACTOR 1; TETRODOTOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN SLICE; GABAERGIC TRANSMISSION; HOMEOSTASIS; HYPOTHALAMUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; INHIBITORY POSTSYNAPTIC POTENTIAL; MOUSE; NERVE CELL; NERVE CELL EXCITABILITY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNAPSE; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION; WHOLE CELL;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; INHIBITORY POSTSYNAPTIC POTENTIALS; MICE; MICE, TRANSGENIC; NEURAL INHIBITION; NEURONAL PLASTICITY; SYNAPTIC TRANSMISSION; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 84255192924     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00353.2011     Document Type: Article

References (31)

1. Cohen-Cory S, Kidane AH, Shirkey NJ, Marshak S. Brain-derived neu-rotrophic factor and the development of structural neuronal connectivity. Dev Neurobiol 70: 271-288, 2010.
2. Davis AM, Seney ML, Stallings NR, Zhao L, Parker KL, Tobet SA. Loss of steroidogenic factor 1 alters cellular topography in the mouse ventrome-dial nucleus of the hypothalamus. J Neurobiol 60: 424-436, 2004.
3. Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S Jr, Elmquist JK, Lowell BB. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49: 191-203, 2006.
4. Fox EA, Byerly MS. A mechanism underlying mature-onset obesity: evidence from the hyperphagic phenotype of brain-derived neurotrophic factor mutants. Am J Physiol Regul Integr Comp Physiol 286: R994-R1004, 2004.
5. Fu LY, van den Pol AN. Agouti-related peptide and MC3/4 receptor agonists both inhibit excitatory hypothalamic ventromedial nucleus neurons. J Neu-rosci 28: 5433-5449, 2008.
6. Griffin GD, Flanagan-Cato LM. Ovarian hormone action in the hypotha-lamic ventromedial nucleus: remodelling to regulate reproduction. J Neu-roendocrinol 23: 465-471, 2011.
7. Horch HW, Katz LC. BDNF release from single cells elicits local dendritic growth in nearby neurons. Nat Neurosci 5: 1177-1184, 2002.
8. Kernie SG, Liebl DJ, Parada LF. BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19: 1290-1300, 2000.
9. King BM. The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. Physiol Behav 87: 221-244, 2006.
10. Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB, Elmquist JK. Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol 457: 213-235, 2003.
11. Komori T, Morikawa Y, Nanjo K, Senba E. Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus. Neurosci-ence 139: 1107-1115, 2006.
12. Kurrasch DM, Cheung CC, Lee FY, Tran PV, Hata K, Ingraham HA. The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. J Neurosci 27: 13624-13634, 2007.
13. Lipsky RH, Marini AM. Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann NY Acad Sci 1122: 130-143, 2007.
14. Liu W, Liu M, Fan W, Nawata H, Yanase T. The Gly146Ala variation in human SF-1 gene: its association with insulin resistance and type 2 diabetes in Chinese. Diabetes Res Clin Pract 73: 322-328, 2006.
15. Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW, Bora SH, Wihler C, Koliatsos VE, Tessarollo L. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci USA 96: 15239-15244, 1999.
16. Majdic G, Young M, Gomez-Sanchez E, Anderson P, Szczepaniak LS, Dobbins RL, McGarry JD, Parker KL. Knockout mice lacking steroid-ogenic factor 1 are a novel genetic model of hypothalamic obesity. Endocrinology 143: 607-614, 2002.
17. Matsuda N, Lu H, Fukata Y, Noritake J, Gao H, Mukherjee S, Nemoto T, Fukata M, Poo MM. Differential activity-dependent secretion of brain-derived neurotrophic factor from axon and dendrite. J Neurosci 29: 14185-14198, 2009.
18. Nakagawa T, Ogawa Y, Ebihara K, Yamanaka M, Tsuchida A, Taiji M, Noguchi H, Nakao K. Anti-obesity and anti-diabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance. Int J Obes Relat Metab Disord 27: 557-565, 2003.
19. Nicholson JR, Peter JC, Lecourt AC, Barde YA, Hofbauer KG. Melano-cortin-4 receptor activation stimulates hypothalamic brain-derived neu-rotrophic factor release to regulate food intake, body temperature and cardiovascular function. J Neuroendocrinol 19: 974-982, 2007.
20. Rios M, Fan G, Fekete C, Kelly J, Bates B, Kuehn R, Lechan RM, Jaenisch R. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 15: 1748-1757, 2001.
21. Segal JP, Stallings NR, Lee CE, Zhao L, Socci N, Viale A, Harris TM, Soares MB, Childs G, Elmquist JK, Parker KL, Friedman JM. Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus. J Neurosci 25: 4181-4188, 2005.
22. Shin SY, Yang JH, Lee H, Erdelyi F, Szabo G, Lee SY, Ryu PD. Identification of the adrenoceptor subtypes expressed on GABAergic neurons in the anterior hypothalamic area and rostral zona incerta of GAD65-eGFP transgenic mice. Neurosci Lett 422: 153-157, 2007.
23. Stallings NR, Hanley NA, Majdic G, Zhao L, Bakke M, Parker KL. Development of a transgenic green fluorescent protein lineage marker for steroidogenic factor 1. Mol Endocrinol 16: 2360-2370, 2002.
24. Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 5: 383-393, 2007.
25. Tran PV, Akana SF, Malkovska I, Dallman MF, Parada LF, Ingraham HA. Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage. J Comp Neurol 498: 637-648, 2006.
26. Tran PV, Lee MB, Marin O, Xu B, Jones KR, Reichardt LF, Rubenstein JR, Ingraham HA. Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons. Mol Cell Neurosci 22: 441-453, 2003.
27. Tsao D, Thomsen HK, Chou J, Stratton J, Hagen M, Loo C, Garcia C, Sloane DL, Rosenthal A, Lin JC. TrkB agonists ameliorate obesity and associated metabolic conditions in mice. Endocrinology 149: 1038-1048, 2008.
28. Unger TJ, Calderon GA, Bradley LC, Sena-Esteves M, Rios M. Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 27: 14265-14274, 2007.
29. Williams G, Bing C, Cai XJ, Harrold JA, King PJ, Liu XH. The hypothal-amus and the control of energy homeostasis: different circuits, different purposes. Physiol Behav 74: 683-701, 2001.
30. Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH, Reichardt LF. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6: 736-742, 2003.
31. Zhao L, Kim KW, Ikeda Y, Anderson KK, Beck L, Chase S, Tobet SA, Parker KL. Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior. Mol Endocrinol 22: 1403-1415, 2008.