TGF-β1-elevated TRPM7 channel regulates collagen expression in hepatic stellate cells via TGF-β1/Smad pathway

Toxicology and Applied Pharmacology

Volumn 280, Issue 2, 2014, Pages 335-344

  Fang, Ling ^a   Huang, Cheng ^a   Meng, Xiaoming ^a   Wu, Baoming ^a   Ma, Taotao ^a   Liu, Xuejiao ^a   Zhu, Qian ^a   Zhan, Shuxiang ^a   Li, Jun ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Col1 1; HSC; Liver fibrosis; Smad signaling; TGF 1; TRPM7

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA 1; COLLAGENASE 3; MESSENGER RNA; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7; UNCLASSIFIED DRUG; ACTIN; COLLAGEN TYPE I, ALPHA 1 CHAIN; SMOOTH MUSCLE ACTIN, RAT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM7 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL STIMULATION; COLLAGEN DEGRADATION; CONTROLLED STUDY; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIVER FIBROSIS; MALE; MYOFIBROBLAST; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STELLATE CELL; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACTINS; ANIMALS; COLLAGEN; COLLAGEN TYPE I; HEPATIC STELLATE CELLS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; TRPM CATION CHANNELS;

EID: 84908025562     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.08.006     Document Type: Article

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